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Results for "

PC 3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (5) AMPK (2) Androgen Receptor (2) Apoptosis (31) Autophagy (3) Bacterial (6) Bcl-2 Family (3) Biochemical Assay Reagents (4) Bombesin Receptor (1) c-Met/HGFR (1) Calcium Channel (1) Carbonic Anhydrase (1) Caspase (5) Cathepsin (1) CDK (3) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (3) Drug Derivative (1) EGFR (5) Endogenous Metabolite (1) Epigenetic Reader Domain (10) Estrogen Receptor/ERR (1) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (3) Fungal (3) Glutaminase (1) Glutathione S-transferase (1) Histone Acetyltransferase (1) Histone Demethylase (3) Histone Methyltransferase (1) HSP (4) IAP (1) ICMT (3) Insecticide (1) Interleukin Related (2) Isotope-Labeled Compounds (1) JAK (1) Keap1-Nrf2 (1) mAChR (1) MAGL (1) MDM-2/p53 (2) Microtubule/Tubulin (3) MMP (2) mTOR (2) NADPH Oxidase (1) Necroptosis (2) NF-κB (1) NO Synthase (1) Opioid Receptor (2) p38 MAPK (1) Paraptosis (1) Parasite (3) PI3K (2) Pim (4) PKC (3) Polo-like Kinase (PLK) (1) PROTAC-Linker Conjugates for PAC (1) PROTACs (12) Proteasome (1) PSMA (3) Radionuclide-Drug Conjugates (RDCs) (1) Raf (3) Ras (2) Reactive Oxygen Species (7) ROCK (1) ROS Kinase (1) SGK (1) Small Interfering RNA (siRNA) (3) SOS1 (1) STAT (2) Survivin (1) TGF-beta/Smad (1) TGF-β Receptor (1) Topoisomerase (1) VEGFR (3) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (117) Cardiovascular Disease (1) Endocrinology (1) Infection (5) Inflammation/Immunology (13) Metabolic Disease (3) Neurological Disease (7)
Click Chemistry:	Azide (1) Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Phospholipids (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

127

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Pyruvate Carboxylase (PC)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3320

Phytochelatin 3 PC 3	Biochemical Assay Reagents	Others
Phytochelatin 3 (PC 3) is the small metal chelating peptide that can be used for chelating heavy metals .

HY-13626

Spisulosine ES-285	PKC Apoptosis	Cancer
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-W725327

1,2-Dipropionyl-sn-glycero-3-phosphocholine 1,2-Dipropionyl-sn-glycero-3-Phosphatidylcholine; 1,2-Dipropionyl-sn-glycero-3-Phosphocholine; PC(3:0/3:0)	Endogenous Metabolite	Metabolic Disease
1,2-Dipropionyl-sn-glycero-3-PC is a phospholipid containing propionic acid at the sn-1 and sn-2 positions. It has been used to study the interaction between water and the phosphocholine headgroup in aqueous solutions.

HY-RS27449

G6pc3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G6pc3 Rat Pre-designed siRNA Set A contains three designed siRNAs for G6pc3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

G6pc3 Rat Pre-designed siRNA Set A G6pc3 Rat Pre-designed siRNA Set A

HY-RS20932

G6pc3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G6pc3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for G6pc3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

G6pc3 Mouse Pre-designed siRNA Set A G6pc3 Mouse Pre-designed siRNA Set A

HY-RS05193

G6PC3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G6PC3 Human Pre-designed siRNA Set A contains three designed siRNAs for G6PC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

G6PC3 Human Pre-designed siRNA Set A G6PC3 Human Pre-designed siRNA Set A

HY-142958

NF-κB-IN-2	NF-κB	Neurological Disease
NF-κB-IN-2 inhibits TNF-α-induced canonical NF-κB signaling in PC-3 cells.

HY-13626S

Spisulosine-d3 ES-285-d₃	Isotope-Labeled Compounds PKC Apoptosis	Cancer
Spisulosine-d₃ (ES-285-d₃) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-173039

α-Tubulin polymerization-IN-1	Microtubule/Tubulin Keap1-Nrf2 Reactive Oxygen Species Apoptosis	Cancer
α-Tubulin polymerization-IN-1 (Compound 8l) is an inhibitor for α-Tubulin polymerization. α-Tubulin polymerization-IN-1 modulates the NRF2/KEAP-1 signaling pathway, induces ROS generation in PC-3 cell, thereby inducing apoptosis in PC-3. α-Tubulin polymerization-IN-1 inhibits the proliferation of PC-3 cell with a GI₅₀ of 0.17 µM, arrests the cell cycle at G2/M phase. α-Tubulin polymerization-IN-1 exhibits antitumor efficacy in mouse model .

HY-146038

Antitumor agent-55	Apoptosis ROS Kinase MDM-2/p53 Bcl-2 Family	Cancer
Antitumor agent-55 (compound 5q) is a potent antitumor agent. Antitumor agent-55 effectively inhibits PC3, with an IC₅₀ of 0.91 μM. Antitumor agent-55 effectively inhibits the colony formation, suppresses the cell migration in PC3. Antitumor agent-55 induces G1/S phase arrest and apoptosis in PC3 .

HY-N12124

Monascuspiloin Monascinol	Akt mTOR AMPK Androgen Receptor Apoptosis Autophagy	Cancer
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC₅₀ of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC₅₀ of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice .

HY-149976

Pim-1 kinase inhibitor 4	Pim	Cancer
Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC₅₀: 17.01 nM). Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC₅₀ of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer .

HY-146985

Cathepsin X-IN-1 1 Publications Verification	Cathepsin	Neurological Disease Cancer
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor with an IC₅₀ of 7.13 µM. Cathepsin X-IN-1 decreases PC-3 cell migration with low cytotoxic .

HY-133222

STX140	Estrogen Receptor/ERR Microtubule/Tubulin Apoptosis	Cancer
STX140 is an orally active microtubule disruptor. STX140 induces apoptosis in the hormone-independent PC-3 prostate cell lines. STX140 has anti-angiogenic and anti-tumour activities .

HY-N4029

Humulene oxide II	Others	Cancer
Humulene oxide II is an essential oil component from Zingiber striolatum Diels flowers, leaves and stems. Humulene oxide II has cytotoxicity against A549, PC-3 and K562 cell lines .

HY-N7019

19-Hydroxybufalin	Others	Cancer
19-Hydroxybufalin is a bufadienolide, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells .

HY-N10687

Saprorthoquinone NSC 648341	Others	Cancer
Saprorthoquinone (NSC 648341) is a diterpenoid that can be found in salvia atropatana. Saprorthoquinone shows cytotoxicity for PC3 cells .

HY-143641

Anticancer agent 25	Others	Cancer
Anticancer agent 25 exhibits the strongest cytotoxicity against PC3 cells with an IC₅₀ value of 0.19 μM.

HY-141863

Lepidozin G	Apoptosis	Cancer
Lepidozin G inhibits the growth of a panel of cancer cell lines with IC₅₀ values ranging from 4.2 ± 0.2 to 5.7 ± 0.5 μM. Lepidozin G induces PC-3 cell death via mitochondrial-related apoptosis.

HY-137225

HTS07944 HTS07944SC	Caspase Interleukin Related	Inflammation/Immunology Cancer
HTS07944 (HTS07944SC, C3) is a potent modulator of laminin receptor (37 LR). HTS07944 (HTS07944SC, C3) possesses anti-cancer activity in PC-3 cells and activates Caspase 3/7 .

HY-113796

Kopsoffinol	Others	Cancer
Kopsoffinol, a bisindole alkaloid, shows in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells .

HY-143882

MS5033	PROTACs Akt	Cancer
MS5033 is a potent PROTAC-based AKT (protein kinase B) degrader, with a DC₅₀ of 430 nM in PC3 cells .

HY-N7972

19-Oxocinobufotalin	Others	Cancer
19-Oxocinobufotalin is capable of suppressing EMT (Epithelial-mesenchymal transition) and weakening the migratory and invasive potential of PC3 cells .

HY-N3544

Caryophyllene oxide (-)-Caryophyllene oxide	Apoptosis Bacterial Fungal Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Caryophyllene oxide ((-)-Caryophyllene oxide) is a bicyclic sesquiterpene with anticancer effects. Caryophyllene oxide induces apoptosis of PC-3 cells. Caryophyllene oxide shows analgesic and anti-inflammatory activities. Caryophyllene oxide has insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic properties .

HY-172366

BQ0413	PSMA	Cancer
BQ0413 exhibits good affinity to PSMA with a K_D of 89 pM. BQ0413 exhibits good uptake and internalization property with an internalization rate of 44% in PC3-pip cell. BQ0413 can be used as tumor imaging agent when labeled with 99mTc .

HY-12842

UC-112	IAP Apoptosis	Cancer
UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM).

HY-N11651

Peganumine A	Others	Others
Peganumine A is a natural product that can be found in Peganum harmala. Peganumine A shows cytotoxicity with IC₅₀s of5.8, 38.5, 40.2, 55.4 µM for HL-60, MCF-7, PC-3, and HepG2 cells ,respectively .

HY-153910

AGPS-IN-1	Others	Cancer
AGPS-IN-1 (Compound 2i) is an effective AGPS binder. AGPS-IN-1 reduces ether lipids levels and cell migration rate. AGPS-IN-1 inhibits epithelial-mesenchymal transition (EMT) in prostate PC-3 and breast MDA-MB-231 cancer cells .

HY-147734

Calpain Inhibitor-2	Calcium Channel	Cancer
Calpain Inhibitor-2 (compound 5) is a peptide inhibitor of μ-calpain (Ki=9 nM). Calpain Inhibitor-2 exhibits antiproliferative activity against melanoma cell lines (A-375 and B-16F1) and PC-3 prostate cancer cells in vitro .

HY-171616

DCEM1	HSP β-catenin	Cancer
DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction of HSP60 with ClpP, thereby blocking the mitochondrial unfolded protein response. DCEM1 inhibits β-catenin expression and ATP production in PC-3 and TKO cells. DCEM1 can be used in prostate cancer research .

HY-155610

VEGFR-2-IN-32	VEGFR	Cancer
VEGFR-2-IN-32 (Comp 3a) is an inhibitor of VEGFR-2 with an IC₅₀ of 8.93 nM. VEGFR-2-IN-32 has cytotoxic activity against PC-3 cells with an IC₅₀ of 1.22 μM. VEGFR-2-IN-32 can be used for anti-prostate cancer research .

HY-162380

Topoisomerase II inhibitor 18	Topoisomerase	Cancer
Topoisomerase II inhibitor 18 (Compound IV) is a Quinoxaline derivative, which inhibits topoisomerase II with IC₅₀ of 7.5 μM. Topoisomerase II inhibitor 18 inhibits proliferation, cell cycle at S phase and induces apoptosis in PC-3 cells. Topoisomerase II inhibitor 18 reveals antitumor activity against cancer .

HY-118147

ML356	Fatty Acid Synthase (FASN)	Cancer
ML356 (Compound 16) is an inhibitor for fatty acid synthase (FAS), that inhibits the thioesterase domain of FAS (FAS TE) with an IC₅₀ of 0.334 μM, and blocks the de novo palmitate synthesis in PC-3 cell with an IC₅₀ of 20 μM. ML356 exhibits good membrane permeability, and good stability in human and mouse plasma .

HY-107640

WAY-170523	MMP	Cancer
WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC₅₀ of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research .

HY-162304

MAGL-IN-14	MAGL	Neurological Disease
MAGL-IN-14 (compound 2) is a potent inhibitor of MAGL, with IC₅₀ of 0.00289 μM and 0.002 μM in HEK293 and PC3 cells, respectively .

HY-122678

LQZ-7F	Survivin Apoptosis	Cancer
LQZ-7F, a survivin dimerization inhibitor, induces spontaneous apoptosis and synergizes with Docetaxel in prostate cancer cells. LQZ-7F dose-dependently inhibits survival of both PC-3 and C4-2 cells with IC₅₀s of 2.99 and 2.47 µM, respectively .

HY-108361

CCG-203971 1 Publications Verification	Ras	Inflammation/Immunology Cancer
CCG-203971 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC₅₀ =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC₅₀ of 4.2 μM. Potential anti-metastasis Agent .

HY-144808

Anticancer agent 40	Microtubule/Tubulin	Cancer
Anticancer agent 40 (compound 3e) is a potent anticancer agent. Anticancer agent 40 shows anticancer activities with IC₅₀s of 0.94, 0.98, 0.96, 0.95, 2.13 nM for SKBR-3, SKOV-3, PC-3, U-87, HDF cells, respectively .

HY-102067

3289-8625	Wnt	Cancer
3289-8625 is an inhibitor of the PDZ domain of Dishevelled (Dvl) protein (K_d=10.6 μM) and has an inhibitory effect on Wnt signaling. In addition, 3289-8625 can slow the growth of prostate cancer PC-3 cells (IC₅₀=12.5 μM). 3289-8625 can be used in the study of embryonic development and cancer .

HY-168757

PSMA precursor-1	PSMA	Cancer
PSMA precursor-1 is a precursor in the synthesis of prostate-specific membrane antigen (PSMA) ligands and fluorescent probes that have been used in the detection of PSMA in LNCaP and PC3 cells .

HY-101947

SMI-16a 4 Publications Verification PIM1/2 Kinase Inhibitor VI	Pim	Cancer
SMI-16a is a selective Pim kinase inhibitor with IC₅₀ values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively.

HY-121619

Jacaric acid	Apoptosis	Inflammation/Immunology Cancer
Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC₅₀ is 11.8 μM), LNCaP (IC₅₀ is 2.2 μM) and DLD-1, induces apoptosis and necrosis . Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma . Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator . Jacaric acid is orally active.

HY-N12821

visamminol-3'-O-glucoside	Others	Cancer
Visamminol-3'-O-glucoside (Compound 4) is a chromone glycoside, which is initially isolated from Saposhnikovia divaricata. Visamminol-3'-O-glucoside exhibits weak cytotoxicity against cancer cells PC-3, SK-OV-3 and H460, with IC₅₀s of 93.91, >100 and >100 μM, respectively .

HY-161859

VEGFR-2/STAT-3-IN-1	VEGFR STAT	Cancer
VEGFR-2/STAT-3-IN-1 (Compound 9f) is a dual inhibitor for VEGFR-2 (IC₅₀=26.3 nM) and STAT-3 (IC₅₀=5.63 nM). VEGFR-2/STAT-3-IN-1 inhibits the proliferation of cancer cells PANC1 and PC3 with IC₅₀ of 0.14 and 0.10 µM. VEGFR-2/STAT-3-IN-1 induces apoptosis in PC3 .

HY-149149

Incadronic acid	Bacterial	Infection Metabolic Disease Cancer
Incadronic acid inhibits growth of Dictyostelium discoideum with an IC₅₀ of 1.6 μM. Incadronic acid binds the farnesyl diphosphate synthase (FPPS) in Leishmania major with the K_i of 23 nM. Incadronic acid inhibits the bone resorption and reduces bone loss, that can be used in osteoporosis research. Incadronic acid inhibits the proliferation of cells RAW264.7, PC-3 and MCF-7 with IC₅₀ of 48 to 228.6 µM .

HY-N3544R

Caryophyllene oxide (Standard) (-)-Caryophyllene oxide (Standard)	Apoptosis Bacterial Fungal Parasite	Infection Neurological Disease Inflammation/Immunology Cancer
Caryophyllene oxide (Standard) ((-)-Caryophyllene oxide (Standard)) is the analytical standard of Caryophyllene oxide (HY-N3544). This product is intended for research and analytical applications. Caryophyllene oxide is a bicyclic sesquiterpene with anticancer effects. Caryophyllene oxide induces apoptosis of PC-3 cells. Caryophyllene oxide shows analgesic and anti-inflammatory activities. Caryophyllene oxide has insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic properties.

HY-147854

B-Raf IN 9	Raf Apoptosis	Cancer
B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC₅₀ of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC₅₀ of 7.83 µM .

HY-12364

C75 Maximum Cited Publications 29 Publications Verification	Fatty Acid Synthase (FASN)	Cancer
C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC₅₀ of 35 μM . C75 is a potent CPT1A activator .

HY-14307

Necrocide 1	Necroptosis	Cancer
Necrocide 1 (compound (S)-38) a potent anticancer agent. Necrocide 1 has antiproliferative activity with an IC₅₀ value of 0.48 and 2 nM for MCF-7 and PC3, respectively .

HY-W778562

10-Deacetyl-13-oxobaccatin III	Others	Cancer
10-Deacetyl-13-oxobaccatin III is an taxane that can be isolated from Taxus sumatrana. 10-Deacetyl-13-oxobaccatin III (30 μg/mL) shows cytotoxicity against A498, NCI-H226, A549, PC-3 cells, with inhibition a rate of 29.7%, 49.2%, 43.9%, 65.3% .

Cat. No.	Product Name	Target	Research Area

HY-P3320

Phytochelatin 3 PC 3	Biochemical Assay Reagents	Others
Phytochelatin 3 (PC 3) is the small metal chelating peptide that can be used for chelating heavy metals .

HY-P1793A

α-Casein (90-95) TFA	Opioid Receptor Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology Cancer
α-Casein (90-95) TFA is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) TFA inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC₅₀= 0.1 μM. α-Casein (90-95) TFA inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC₅₀ of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) TFA activates G_i-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) TFA can be used in the study of the mechanisms of allergic diseases and prostate cancer .

HY-P1793

α-Casein (90-95)	Opioid Receptor Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology Cancer
α-Casein (90-95) is a partial agonist of opioid receptors and a copper ion ligand, with opioid activity. α-Casein (90-95) inhibits the secretion of β-hexosaminidase by rat peritoneal mast cells (PMC) with IC₅₀= 0.1 μM. α-Casein (90-95) inhibits the proliferation of prostate cancer cells LNCaP, DU145, and PC3 with IC₅₀ of 0.94 nM, 137 nM, and 6.92 nM, respectively. α-Casein (90-95) activates G_i-like proteins through a membrane-assisted, receptor-independent pathway, or reversibly binds to opioid receptors, inducing intracellular calcium release and conformational changes, and exerts the activity of promoting mast cell secretion and inhibiting tumor cell proliferation. α-Casein (90-95) can be used in the study of the mechanisms of allergic diseases and prostate cancer .

HY-P3320A

Phytochelatin 3 TFA PC 3 TFA	Peptides	Others
Phytochelatin 3 (PC 3) TFA is the small metal chelating peptide that can be used for chelating heavy metals .

Cat. No.	Product Name	Target	Research Area

HY-P991316

KD014 DX-2400; DX-2410	MMP TGF-β Receptor TGF-beta/Smad NO Synthase	Cancer
KD014 (DX-2400) is a human monoclonal antibody (mAb) targeting MMP14 (K_i: 0.9 nM). KD014 inhibits TGFβ and SMAD2/3 activity, increases macrophage numbers and iNOS expression, and shifts macrophage phenotype toward anti-tumor M1-like. KD014 has anti-tumor activity in three different tumor models (MDA-MB-231, MDA-MB-435, and PC3). KD014 can be used in breast cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13626

Spisulosine ES-285	Alkaloids Animals Classification of Application Fields Other Alkaloids Marine natural products Source classification Other marine organisms Disease Research Fields Cancer	PKC Apoptosis
Spisulosine (ES-285) is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

HY-N7019

19-Hydroxybufalin	Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Others
19-Hydroxybufalin is a bufadienolide, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells .

HY-N7972

19-Oxocinobufotalin	Structural Classification Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	Others
19-Oxocinobufotalin is capable of suppressing EMT (Epithelial-mesenchymal transition) and weakening the migratory and invasive potential of PC3 cells .

HY-N3544

Caryophyllene oxide (-)-Caryophyllene oxide	Structural Classification Hymenaea courbaril L. Classification of Application Fields Leguminosae Terpenoids Sesquiterpenes Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Apoptosis Bacterial Fungal Parasite
Caryophyllene oxide ((-)-Caryophyllene oxide) is a bicyclic sesquiterpene with anticancer effects. Caryophyllene oxide induces apoptosis of PC-3 cells. Caryophyllene oxide shows analgesic and anti-inflammatory activities. Caryophyllene oxide has insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic properties .

HY-N12124

Monascuspiloin Monascinol	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Akt mTOR AMPK Androgen Receptor Apoptosis Autophagy
Monascuspiloin (Monascinol) exhibits anti-androgenic activity with an IC₅₀ of 7 μM. Monascuspiloin inhibits viability of PC-3 and LNCaP with IC₅₀ of 45 and 47 μM. Monascuspiloin induces apoptosis in LNCaP through inhibition of Akt/mTOR signaling pathway, induces autophagy through activation AMPK signaling pathway and arrest cell cycle at G2/M phase in PC-3. Monascuspiloin exhibits antitumor efficacy in mice .

HY-N4029

Humulene oxide II	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Humulene oxide II is an essential oil component from Zingiber striolatum Diels flowers, leaves and stems. Humulene oxide II has cytotoxicity against A549, PC-3 and K562 cell lines .

HY-N10687

Saprorthoquinone NSC 648341	Quinones Structural Classification Labiatae Source classification Plants Naphthalene Quinones Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Others
Saprorthoquinone (NSC 648341) is a diterpenoid that can be found in salvia atropatana. Saprorthoquinone shows cytotoxicity for PC3 cells .

HY-113796

Kopsoffinol	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Kopsia pauciflora Hook.f. Plants	Others
Kopsoffinol, a bisindole alkaloid, shows in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells .

HY-121619

Jacaric acid	Structural Classification Caprifoliaceae Ketones, Aldehydes, Acids Source classification Plants Centranthus ruber (L.) DC	Apoptosis
Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC₅₀ is 11.8 μM), LNCaP (IC₅₀ is 2.2 μM) and DLD-1, induces apoptosis and necrosis . Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma . Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator . Jacaric acid is orally active.

HY-N12821

visamminol-3'-O-glucoside	Structural Classification Ophryosporus axilliflorus Hieron. Source classification Umbelliferae Plants Saccharides Monosaccharides	Others
Visamminol-3'-O-glucoside (Compound 4) is a chromone glycoside, which is initially isolated from Saposhnikovia divaricata. Visamminol-3'-O-glucoside exhibits weak cytotoxicity against cancer cells PC-3, SK-OV-3 and H460, with IC₅₀s of 93.91, >100 and >100 μM, respectively .

HY-N3544R

Caryophyllene oxide (Standard) (-)-Caryophyllene oxide (Standard)	Structural Classification Hymenaea courbaril L. Leguminosae Terpenoids Sesquiterpenes Source classification Plants Endogenous metabolite	Apoptosis Bacterial Fungal Parasite
Caryophyllene oxide (Standard) ((-)-Caryophyllene oxide (Standard)) is the analytical standard of Caryophyllene oxide (HY-N3544). This product is intended for research and analytical applications. Caryophyllene oxide is a bicyclic sesquiterpene with anticancer effects. Caryophyllene oxide induces apoptosis of PC-3 cells. Caryophyllene oxide shows analgesic and anti-inflammatory activities. Caryophyllene oxide has insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic properties.

HY-W778562

10-Deacetyl-13-oxobaccatin III	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus baccata L.	Others
10-Deacetyl-13-oxobaccatin III is an taxane that can be isolated from Taxus sumatrana. 10-Deacetyl-13-oxobaccatin III (30 μg/mL) shows cytotoxicity against A498, NCI-H226, A549, PC-3 cells, with inhibition a rate of 29.7%, 49.2%, 43.9%, 65.3% .

HY-N12004

19-Hydroxy-10-deacetylbaccatin III	Structural Classification Terpenoids Source classification Taxaceae Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	Others
19-Hydroxy-10-deacetylbaccatin III (compound 13) is a taxane with potential antitumor activity. 19-Hydroxy-10-deacetylbaccatin III has weak cytotoxicity against A498 and NCI-H226 cell lines. The study found that the inhibition rates of 30 μg/mL 19-Hydroxy-10-deacetylbaccatin III on A498, NCI-H226 and PC-3 were 16.6% and 32% respectively .

HY-N13772

3'-O-Methyltaxifolin (+)-Dihydroisorhamnetin	Structural Classification Flavanonols Flavonoids Pulicaria jaubertii E.Gamal-Eldin Source classification Asteraceae Plants	Apoptosis
3'-O-Methyltaxifolin ((+)-Dihydroisorhamnetin) is a dihydroflavanol found in Pulicaria jaubertii. A mixture of these alcohol compounds including 3'-O-Methyltaxifolin found in Pulicaria jaubertii exhibits antitumor activity with IC₅₀ values of 19.1 μg, 20.0 μg, and 24.1 μg against prostate cancer (PC-3), breast cancer (MCF-7), and hepatocellular carcinoma (HepG-2) cell lines, respectively. Furthermore, 3'-O-Methyltaxifolin can induce cell apoptosis, making it a promising candidate for anticancer research. .

HY-N12466

3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine	Structural Classification Alkaloids Microorganisms Source classification Indole Alkaloids	PKC p38 MAPK ROCK
3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine (Compound 7) is an inhibitor of protein kinases, with IC₅₀s of 0.092, 0.26, 0.77 μM for PKC-α, ROCK, ASK1. 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine shows potent cytotoxicity against PC-3 cancer cells with an IC₅₀ value of 0.16 μM .

HY-N1107

Uzarigenin NSC 119993; NSC 277290; Odorigeni	Apocynaceae Structural Classification Cardiacglycosides Source classification Plants Steroids	Others
Uzarigenin (NSC 119993; NSC 277290; Odorigeni) is a carnolide can be isolated from Pergularia tomentosa and exhibits antiproliferative activity. Uzarigenin resists the proliferation of PC3 cells, HeLa cells, Calu-1 cells, MCF-7 cells and U251MG cells, with IC₅₀ values of 0.3 μM, 3.0 μM, 8.0 μM, 6.0 μM and 6.0 μM respectively .

HY-N7535

Chlorovaltrate K	Structural Classification Valeriana jatamansi Jones Iridoids Terpenoids Source classification Plants Valerianaceae	Others
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

HY-W437569

Melicopine	Structural Classification Alkaloids Cornaceae Cornus officinalis Sieb. et Zucc. Source classification Acridone Alkaloids Plants	Parasite Insecticide
Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC₅₀ values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC₅₀ values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC₅₀ greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields .

HY-W748509

Pipernonaline	Piper longum Linn. Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-N12606

Neodidymelliosides A	Structural Classification Microorganisms Source classification Saccharides Monosaccharides	Fungal
Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candida albicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .

Cat. No.	Product Name	Chemical Structure

HY-13626S

Spisulosine-d3
Spisulosine-d₃ (ES-285-d₃) is deuterium labeled Spisulosine (HY-13626). Spisulosine is an antiproliferative (antitumoral) compound of marine origin. Spisulosine inhibits the growth of the prostate PC-3 and LNCaP cells through intracellular ceramide accumulation and PKCζ activation. Spisulosine induces apoptosis in PC-3 and LNCaP cells .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80556

	ATG3 Antibody (YA602) APG3; APG3L; PC3-96; APG3-LIKE	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	ATG3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to ATG3. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P84807

	CBX8 Antibody (YA4504) PC3; RC1	WB, FC, ELISA	Human

HY-P82941

	ACTR1B Antibody (YA2686) PC3; ARP1B; CTRN2	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	ACTR1B Antibody (YA2686) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2686), targeting ACTR1B, with a predicted molecular weight of 42 kDa (observed band size: 42 kDa). ACTR1B Antibody (YA2686) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

HY-P83921

	KRT6A Antibody (YA3618) KRT6A; K6A; K6C; K6D; PC3; CK6C; CK6D; CK-6C; CK-6E; KRT6C; KRT6D	WB, ICC/IF, FC, ELISA	Human

HY-P84825

	ATG3 Antibody (YA4522) APG3; APG3L; PC3-96; APG3-LIKE	WB, IHC-P, ICC/IF, ELISA	Human, Monkey

HY-P84826

	ATG3 Antibody (YA4523) APG3; APG3L; PC3-96; APG3-LIKE	WB, IHC-P, ICC/IF, FC, ELISA	Human

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Cat. No.	Product Name		Classification

HY-169098

HSP90/LSD1-IN-1		Alkynes
HSP90/LSD1-IN-1 (compound 6) is a HSP90/LSD1 dual inhibitor. HSP90/LSD1-IN-1 inhibits the proliferation of prostate cancer cell lines PC-3 and DU145, with GI₅₀ values of 0.24 and 0.30 μM, respectively .

HY-157880

N3-PC Azido-PC		Azide
N3-PC (Azido-PC) is a photoactivatable phosphatidylcholine that can be used in the synthesis of cell membrane structures. N3-PC (Azido-PC) is a click chemistry reagent containing an azide group .

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