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P2Y6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Apoptosis (4) Autophagy (1) Calcium Channel (2) DNA/RNA Synthesis (4) Endogenous Metabolite (7) ERK (2) Isotope-Labeled Compounds (3) NF-κB (2) P2X Receptor (1) P2Y Receptor (35) p38 MAPK (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4) Cardiovascular Disease (10) Inflammation/Immunology (12) Metabolic Disease (6) Neurological Disease (6)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-168098

P2Y6R antagonist 1	P2Y Receptor	Inflammation/Immunology
P2Y6R antagonist 1 (compound 5ab) is a selective, orally active *P2Y6R* antagonist with an IC₅₀ value of 19.6 nM. P2Y6R antagonist 1 has anti-inflammatory activity .

HY-W010832

Uridine-5'-diphosphate disodium salt 1 Publications Verification	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Uridine-5'-diphosphate disodium salt is a potent, selective *P2Y₆* receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52 for human P2Y₆ receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis .

HY-176143

*P2Y1/P2Y6* antagonist 1**	P2Y Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
P2Y1/P2Y6 antagonist 1 (Compound 3h) is an indolesulfonylhydrazide derivative. P2Y1/P2Y6 antagonist 1 is an orally active tP2Y1 and rP2Y6 antagonist (IC₅₀ of 9.72 and 1.89 μM, respectively). P2Y1/P2Y6 antagonist 1 can be used in the study of neurological diseases, inflammation, cardiovascular diseases and cancer .

HY-W010832R

Uridine-5'-diphosphate disodium salt (Standard)	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis .

HY-108650

2-Thio-UTP tetrasodium 2-Thiouridine 5′-triphosphate tetrasodium	P2Y Receptor	Cancer
2-Thio-UTP tetrasodium is a potent P2Y₂, P2Y₄ and *P2Y₆* agonist, which an be used for the research of cancer .

HY-113359

Uridine 5'-diphosphate	P2Y Receptor Endogenous Metabolite	Others
Uridine 5'-diphosphate is a *P2Y₆* receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor .

HY-117356B

MRS2693 trisodium	P2Y Receptor NF-κB ERK	Cardiovascular Disease
MRS2693 trisodium is a selective *P2Y6* agonist with an EC₅₀ value of 0.015 μM. MRS2693 trisodium can reduce the activation of NF-kappaB and activate the ERK1/2 pathway, and has a cytoprotective effect on mouse hindlimb skeletal muscle ischemia-reperfusion injury model .

HY-137608

Uridine 5'-O-thiodiphosphate UDP-β-S	P2Y Receptor	Cardiovascular Disease
Uridine 5'-O-thiodiphosphate (UDP-β-S) is a stable analog of UDP. As a selective agonist of *P2Y6* receptor, Uridine 5'-O-thiodiphosphate has higher metabolic stability and can be used in the study of cardiovascular diseases .

HY-113359AS3

Uridine 5'-diphosphate-15N2 dilithium	Isotope-Labeled Compounds Endogenous Metabolite P2Y Receptor	Others
Uridine 5'-diphosphate- ¹⁵N₂ dilithium is ¹⁵N labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a *P2Y₆* receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

HY-113359AS1

Uridine 5'-diphosphate-13C9 dilithium	Isotope-Labeled Compounds Endogenous Metabolite P2Y Receptor	Others
Uridine 5'-diphosphate- ¹³C₉ dilithium is ¹³C-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a *P2Y₆* receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

HY-108663

5-OMe-UDP 5-Methoxyuridine 5'-trihydrogen diphosphate	P2Y Receptor	Neurological Disease Metabolic Disease
5-OMe-UDP (5-methoxyuridine 5'-trihydrogen diphosphate) is a *P2Y6* receptor agonist (EC₅₀=0.08 μM). 5-OMe-UDP activates the *P2Y6* receptor by binding to it, which triggers signaling pathways within the cell. This activation can lead to an increase in intracellular calcium ion concentration, which in turn regulates cellular function. The methoxy groups of 5-OMe-UDP provide additional activity and selectivity, contributing to the binding of 5-OMe-UDP to the *P2Y6* receptor. 5-OMe-UDP can be used to study diseases related to *P2Y6* receptor function, such as diabetes, inflammatory bowel disease, Alzheimer's disease, etc .

HY-113359AS2

Uridine 5'-diphosphate-13C9,15N2 dilithium	Isotope-Labeled Compounds Endogenous Metabolite P2Y Receptor	Others
Uridine 5'-diphosphate- ¹³C₉, ¹⁵N₂ dilithium is ¹³C and ¹⁵N-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a *P2Y₆* receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

HY-W010820

Uridine 5'-diphosphate sodium salt 1 Publications Verification	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
Uridine 5'-diphosphate sodium salt is a potent, selective *P2Y₆* receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis .

HY-137608A

Uridine 5'-O-thiodiphosphate trisodium UDP-β-S trisodium	P2Y Receptor DNA/RNA Synthesis	Cardiovascular Disease
Uridine 5'-O-thiodiphosphate (trisodium) (UDP-β-S (trisodium)) is a purinergic *P2Y6* receptor agonist. Uridine 5'-O-thiodiphosphate (trisodium) selectively induces accumulation of inositol phosphates in 1321N1 cells expressing P2Y6 receptors (EC₅₀ = 28 nM). Uridine 5'-O-thiodiphosphate (trisodium) induces DNA synthesis in rat aortic smooth muscle cells .

HY-108664

MRS2957	P2Y Receptor	Metabolic Disease
MRS2957 is a P2Y6 receptor agonist that activates AMPK in pancreatic β-cells, promoting insulin secretion and reducing apoptosis, thereby holding potential as a therapeutic target for type 2 diabetes.

HY-110089

mrs 4062 TFA	P2Y Receptor	Inflammation/Immunology
mrs 4062 (TFA) is a selective P2Y₄ receptor agonist with an EC₅₀ of 23 nM. mrs 4062 (TFA) has EC₅₀s of 640 nM and 740 nM for P2Y₂ and P2Y₆, respectively .

HY-108654

PSB 0474	P2Y Receptor Apoptosis	Neurological Disease
PSB 0474 (3-phenacyl-UDP) is a selective and potent *P2Y₆* receptor agonist with an EC₅₀ of 70 nM . PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis .

HY-137607A

UDP trisodium	P2Y Receptor	Inflammation/Immunology
UDP trisodium (Compound 3), a nucleotide, is a P2Y₁₄ receptor agonist with an EC₅₀ of 160  nM for P2Y₁₄ receptor over the P2Y₆ receptor. UDP trisodium can be used for pain, diabetes, cystic fibrosis and other pulmonary diseases research .

HY-110369

MRS2905 trisodium a,β-Methylene-2-thio-UDP trisodium	P2Y Receptor	Inflammation/Immunology
MRS2905 (α,β-Methylene-2-thio-UDP) trisodium is a selective P2Y14R agonist with an EC₅₀ of 0.92 nM. MRS2905 trisodium is inactive at the UDP-activated P2Y6 receptor, and at other P2Y receptors .

HY-13104

MRS 2578 Maximum Cited Publications 10 Publications Verification	P2Y Receptor Apoptosis	Cardiovascular Disease
MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC₅₀s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors .

HY-110092A

PSB-1114 triethylamine	P2Y Receptor	Cancer
PSB-1114 triethylamine is a potent, enzymatically stable, and subtype-selective P2Y₂ receptor agonist with an EC₅₀ of 134 nM. PSB-1114 triethylamine displays >50-fold selectivity versus the P2Y₄ (EC₅₀ of 9.3 μM) and *P2Y₆* (EC₅₀ of 7.0 μM) receptors .

HY-110092

PSB-1114 tetrasodium	P2Y Receptor	Metabolic Disease
PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y₂ receptor agonist with an EC₅₀ of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y₄ (EC₅₀ of 9.3 μM) and P2Y₆ (EC₅₀ of 7.0 μM) receptors .

HY-13104R

MRS 2578 (Standard)	P2Y Receptor Apoptosis	Cardiovascular Disease
MRS 2578 (Standard) is the analytical standard of MRS 2578. This product is intended for research and analytical applications. MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors .

HY-110322A

PPTN 2 Publications Verification	P2Y Receptor	Inflammation/Immunology
PPTN, a chemical probe, is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity .

HY-110322

PPTN hydrochloride 2 Publications Verification	P2Y Receptor	Inflammation/Immunology
PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity .

HY-103055

PPTN mesylate	P2Y Receptor	Inflammation/Immunology
PPTN mesylate is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a K_B value of 434 pM. PPTN mesylate exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity .

HY-117356A

MRS2693 ammonium	P2Y Receptor NF-κB ERK Apoptosis	Inflammation/Immunology
MRS2693 ammonium is the ammonium dalt form of MRS2693 (HY-117356). MRS2693 ammonium is a selective agonist for P2Y6 with an EC₅₀ of 0.015 μM. MRS2693 ammonium protects C2C12 skeletal muscle cells from TNFα-induced apoptosis. MRS2693 ammonium reduces the activation of NF-kB, activates the ERK1/2 pathway, and has a cytoprotective effect on mouse ischemia-reperfusion injury model [2].

HY-101308

MRS2179 tetrasodium	P2Y Receptor	Cardiovascular Disease
MRS2179 tetrasodium is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors . MRS2179 tetrasodium inhibits platelet aggregation .

HY-101308A

MRS2179 tetrasodium hydrate 2 Publications Verification	P2Y Receptor	Cardiovascular Disease
MRS2179 tetrasodium hydrate is a competitive P2Y1 receptor antagonist, with a K_b of 102 nM and a pA₂ of 6.99 for turkey P2Y1 receptor. MRS2179 tetrasodium hydrate is selective for P2Y1 over P2X1 (IC₅₀=1.15 µM), P2X3 (12.9 µM), P2X2, P2X4, P2Y2, P2Y4, and P2Y6 receptors . MRS2179 tetrasodium hydrate inhibits platelet aggregation .

HY-108648

2-MeS-ADP trisodium 2-Methylthioadenosine diphosphate trisodium; 2-Methylthio-ADP trisodium	P2Y Receptor	Neurological Disease
2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC₅₀s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC₅₀s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .

HY-108648A

2-MeSADP 2-Methylthioadenosine diphosphate; 2-Methylthio-ADP	P2Y Receptor	Neurological Disease
2-MeSADP (2-Methylthioadenosine diphosphate; 2-Methylthio-ADP) is a potent purinergic P2Y receptors agonist, with EC₅₀s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-MeSADP has pEC₅₀s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-MeSADP induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1 .

HY-134807

Indophagolin	P2X Receptor 5-HT Receptor Autophagy	Cancer
Indophagolin is a potent, indoline-containing autophagy inhibitor (IC₅₀=140 nM). Indophagolin antagonizes the purinergic receptor P2X₄ as well as P2X₁ and P2X₃ with IC₅₀s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the G_q-protein-coupled P2Y₄, P2Y₆, and P2Y₁₁ receptors (IC₅₀s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT₆ (IC₅₀=1.0 μM) and a moderate effect on receptors 5-HT_1B, 5-HT_2B, 5-HT_4e, and 5-HT₇ .

HY-RS09934

P2RY6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
P2RY6 Human Pre-designed siRNA Set A contains three designed siRNAs for P2RY6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

P2RY6 Human Pre-designed siRNA Set A P2RY6 Human Pre-designed siRNA Set A

HY-RS09936

P2ry6 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
P2ry6 Rat Pre-designed siRNA Set A contains three designed siRNAs for P2ry6 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

P2ry6 Rat Pre-designed siRNA Set A P2ry6 Rat Pre-designed siRNA Set A

HY-RS09935

P2ry6 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
P2ry6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for P2ry6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

P2ry6 Mouse Pre-designed siRNA Set A P2ry6 Mouse Pre-designed siRNA Set A

HY-131821

5'-TMPS Thymidine-5'-O-monophosphorothioate	P2Y Receptor	Others
5'-TMPS (Thymidine-5'-O-monophosphorothioate) is a selective partial agonist of *P2Y₆R* and an antagonist of P2Y₁₄R. Additionally, 5'-TMPS acts as a positive regulator of angiogenesis, exhibiting pro-angiogenic effects

HY-178006

MRS4917	P2Y Receptor	Neurological Disease
MRS4917 is an orally active, potent selective P2Y₁₄ receptor (hP2Y₁₄R) antagonist (IC₅₀ = 2.88 nM, K_i = 1.67 nM) that shows >18,000 fold selectivity against P2Y₆R (IC50 = 54 μM). MRS4917 demonstrates oral efficacy in reversing established mechanoallodynia in the chronic constriction injury (CCI) mouse model, while having no effect on thermoregulation. MRS4917 can be used for neurological diseases research .

HY-116295A

MRS2690 disodium	P2Y Receptor p38 MAPK Calcium Channel	Cardiovascular Disease
MRS2690 disodium is a selective P2Y14 receptor agonist. MRS2690 disodium inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 disodium induces intracellular calcium mobilization, activates P38 and stimulates [ ³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690 disodium can be used for ischemic heart disease .

HY-116295

MRS2690	P2Y Receptor p38 MAPK Calcium Channel	Cardiovascular Disease
MRS2690 is a selective P2Y14 receptor agonist. MRS2690 inhibits adenylyl cyclase activity, thereby reducing intracellular cAMP levels and mediating concentration-dependent vasoconstriction of porcine coronary arteries. MRS2690 induces intracellular calcium mobilization, activates P38 and stimulates [ ³⁵S]GTPγS binding to RBL-2H3 cell membranes. MRS2690 enhances antigen (NP-BSA)-, C3a-induced β-hexosaminidase (β-Hex) release. MRS2690can be used for ischemic heart disease .

Uridine-5'-diphosphate disodium salt 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite
Uridine-5'-diphosphate disodium salt is a potent, selective *P2Y₆* receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52 for human P2Y₆ receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis .

Uridine 5'-diphosphate sodium salt 1 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite
Uridine 5'-diphosphate sodium salt is a potent, selective *P2Y₆* receptor native agonist (EC₅₀=300 nM; pEC₅₀=6.52) and a potent P2Y₁₄ antagonist (pEC₅₀=7.28). Uridine 5'-diphosphate sodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis .

Uridine-5'-diphosphate disodium salt (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	P2Y Receptor DNA/RNA Synthesis Endogenous Metabolite
Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis .

Uridine 5'-diphosphate	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	P2Y Receptor Endogenous Metabolite
Uridine 5'-diphosphate is a *P2Y₆* receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor .

Cat. No.	Product Name	Chemical Structure

HY-113359AS2

Uridine 5'-diphosphate-13C9,15N2 dilithium
Uridine 5'-diphosphate- ¹³C₉, ¹⁵N₂ dilithium is ¹³C and ¹⁵N-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a *P2Y₆* receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

HY-113359AS3

Uridine 5'-diphosphate-15N2 dilithium
Uridine 5'-diphosphate- ¹⁵N₂ dilithium is ¹⁵N labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a *P2Y₆* receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

HY-113359AS1

Uridine 5'-diphosphate-13C9 dilithium
Uridine 5'-diphosphate- ¹³C₉ dilithium is ¹³C-labeled Uridine 5'-diphosphate (HY-113359). Uridine 5'-diphosphate is a *P2Y₆* receptor agonist with an EC₅₀ of 0.013 μM for human P2Y₆ receptor.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81946

	P2Y6 Antibody (YA1691) P2ry6; P2Y6; P2Y6 receptor; PP2891	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	P2Y6 Antibody (YA1691) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to P2Y6.

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