2. GPCR/G Protein TGF-beta/Smad Stem Cell/Wnt MAPK/ERK Pathway
  3. P2Y Receptor PKA Raf MEK ERK
  4. HDB-1

HDB-1 is a selective inhibitor of the P2Y14 receptor (P2Y14R) with an IC50 of 26 pM. HDB-1 shows no significant inhibition on P2Y1R, P2Y2R, P2Y4R, P2Y6R, and P2Y12R. HDB-1 blocks the activation of hepatic stellate cells (HSC) by inhibiting the PKA/Raf1/MEK/ERK signaling pathway mediated by P2Y14R, thereby alleviating the core pathological process of liver fibrosis. HDB-1 can be used for the study of liver fibrosis.

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HDB-1

HDB-1 Chemical Structure

CAS No. : 3021527-82-9

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HDB-1 Related Antibodies

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P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

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PKA PKAR PKACα

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B-Raf C-Raf Raf

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MEK1 MEK2 MEK5 MEK MAP2K4/MEK4

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ERK ERK1 ERK2 ERK5 ERK8

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Description

HDB-1 is a selective inhibitor of the P2Y14 receptor (P2Y14R) with an IC50 of 26 pM. HDB-1 shows no significant inhibition on P2Y1R, P2Y2R, P2Y4R, P2Y6R, and P2Y12R. HDB-1 blocks the activation of hepatic stellate cells (HSC) by inhibiting the PKA/Raf1/MEK/ERK signaling pathway mediated by P2Y14R, thereby alleviating the core pathological process of liver fibrosis. HDB-1 can be used for the study of liver fibrosis[1].

Molecular Weight

319.31

Formula

C18H13N3O3
CAS No.
SMILES

CC1=CC=C(C=C1)NC2=C(C(C2=O)=O)NC3=CC=C4N=COC4=C3
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDB-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDB-13021527-82-9HDB1HDB 1P2Y ReceptorPKARafMEKERKProtein kinase ARaf kinasesMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesliver fibrosisbenzoxazole-squaramide hybridsstructure-activity relationshiphepatic stellate cellsPKA/Raf1/MEK/ERK pathwaymolecular dockingInhibitorinhibitorinhibit

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