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Results for "

P2X

" in MedChemExpress (MCE) Product Catalog:

By Targets:	P2X Receptor (106) 5-HT Receptor (5) Adiponectin Receptor (1) Angiotensin Receptor (1) Antibiotic (1) Apoptosis (9) Autophagy (3) Bacterial (1) Calcium Channel (2) CaMK (1) COX (2) Dengue Virus (1) Drug Isomer (1) Endogenous Metabolite (1) Flavivirus (1) Fluorescent Dye (1) Gap Junction Protein (1) Glutathione Peroxidase (1) Histamine Receptor (2) HIV (2) HSV (1) IFNAR (1) Influenza Virus (2) Interleukin Related (4) Isotope-Labeled Compounds (1) Melatonin Receptor (2) MicroRNA (2) Mitophagy (1) MMP (1) Na+/Ca2+ Exchanger (1) NOD-like Receptor (NLR) (1) P2Y Receptor (4) p38 MAPK (2) Parasite (1) PERK (2) Reactive Oxygen Species (ROS) (1) Reference Standards (3) SARS-CoV (1) Sodium Channel (3) Topoisomerase (2) TRP Channel (2) α-synuclein (2)
By Research Areas:	Cancer (21) Cardiovascular Disease (10) Infection (5) Inflammation/Immunology (47) Metabolic Disease (3) Neurological Disease (52)

By Targets:

P2X Receptor (106)

5-HT Receptor (5)

Adiponectin Receptor (1)

Angiotensin Receptor (1)

Antibiotic (1)

Apoptosis (9)

Autophagy (3)

Bacterial (1)

Calcium Channel (2)

CaMK (1)

COX (2)

Dengue Virus (1)

Drug Isomer (1)

Endogenous Metabolite (1)

Flavivirus (1)

Fluorescent Dye (1)

Gap Junction Protein (1)

Glutathione Peroxidase (1)

Histamine Receptor (2)

HIV (2)

HSV (1)

IFNAR (1)

Influenza Virus (2)

Interleukin Related (4)

Isotope-Labeled Compounds (1)

Melatonin Receptor (2)

MicroRNA (2)

Mitophagy (1)

MMP (1)

Na+/Ca2+ Exchanger (1)

NOD-like Receptor (NLR) (1)

P2Y Receptor (4)

p38 MAPK (2)

Parasite (1)

PERK (2)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

SARS-CoV (1)

Sodium Channel (3)

Topoisomerase (2)

TRP Channel (2)

α-synuclein (2)

By Research Areas:

Cancer (21)

Cardiovascular Disease (10)

Infection (5)

Inflammation/Immunology (47)

Metabolic Disease (3)

Neurological Disease (52)

119

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: P2X Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18725A

P2X7-IN-2 TFA	P2X Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
P2X7-IN-2 TFA (compound 58) is a *P2X7* receptor inhibitor. P2X7-IN-2 TFA inhibits IL-Iβ release with an IC₅₀ value of 0.01 nM. P2X7-IN-2 TFA can be used for the research of autoimmunity, inflammation and cardiovascular disease .

HY-135976

P2X3 antagonist 34	P2X Receptor	Neurological Disease Inflammation/Immunology
P2X3 antagonist 34 is a potent, selective and orally active P2X3 homotrimeric receptor antagonist with IC₅₀s of 25 nM, 92 nM and 126 nM for human P2X3, rat P2X3 and guinea pig P2X3 receptors, respectively. P2X3 antagonist 34 is less active against human, rat and guinea pig P2X2/3 heterotrimeric receptors. P2X3 antagonist 34 has strong anti-tussive effect .

HY-160645

P2X4 antagonist-1	P2X Receptor	Inflammation/Immunology
P2X4 antagonist-1 (Compound 24) is an antagonist for *P2X4* with IC₅₀ of 15 nM .

HY-139627

P2X receptor-1	P2X Receptor	Inflammation/Immunology
P2X receptor-1 is a potential inhibitor of P2X receptor for the research of pain and inflammation.

HY-161914

P2X3 antagonist 39	P2X Receptor	Neurological Disease
P2X3 antagonist 39 (compound 26a) is a selective *P2X3* receptor antagonist with an IC₅₀ value of 54.9 nM. P2X3 antagonist 39 can be used in the study of neuropathic pain model .

HY-128402

P2X3-IN-1	P2X Receptor	Neurological Disease
P2X3-IN-1 (example 7) is an inhibitor of P2X3 receptor. P2X3-IN-1 can be used for neurogenic diseases research .

HY-176195

P2X4-IN-1	P2X Receptor	Others
P2X4-IN-1 (Compound 1) is an orally active *P2X4* inhibitor. P2X4-IN-1 can be used in the study of prophylaxis disease .

HY-18725

P2X7-IN-2	P2X Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
P2X7-IN-2 (compound 58) is a *P2X7* receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC₅₀ value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease .

HY-153548

P2X2/3 modulator-1	P2X Receptor	Neurological Disease Inflammation/Immunology
P2X2/3 modulator-1 (Compound 46) is a *P2X2/3* modulator. P2X2/3 modulator-1 can be used in the study of pain, central nervous system disorders and inflammation .

HY-160677

P2X4 antagonist-2	P2X Receptor	Neurological Disease
P2X4 antagonist-2 is an antagonist for *P2X4* with an IC₅₀ of 24 nM .

HY-170804

P2X4 antagonist-3	P2X Receptor	Neurological Disease Inflammation/Immunology Cancer
P2X4 antagonist-3 (Compound 14c) is a *P2X4* antagonist with an IC₅₀ value of 1.2 μM. P2X4 antagonist-3 is promising for research of neuroinflammation, chronic pain, and cancer progression .

HY-148558

P2X7 receptor antagonist-3	P2X Receptor	Neurological Disease
P2X7 receptor antagonist-3 is a potent *P2X7* receptor antagonist with P2X7R IC₅₀ values of 4.2 nM in humans and 6.8 nM in rats .

HY-168474

P2X4 antagonist-4	P2X Receptor	Inflammation/Immunology
P2X4 antagonist-4 (compound 64) is a potent *P2X4R* antagonist with an IC₅₀ value of 8 µM. P2X4 antagonist-4 blocks the ATP-induced NLRP3 inflammasome activation and release of IL-1β .

HY-150059

P2X7 receptor antagonist-2	P2X Receptor	Neurological Disease Inflammation/Immunology
P2X7 receptor antagonist-2 is a potent P2X7 receptor antagonist with a pIC₅₀ value of 6.5-7.5. P2X7 receptor antagonist-2 has efficacy of combating neuroinflammation .

HY-W097612

P2X4 antagonist-5	P2X Receptor	Others
P2X4 antagonist-5 (compound 63) is a control compound for *P2X4* antagonists (IC₅₀>100 μM, hP2X4) .

HY-162951

P2X7 receptor antagonist-5	P2X Receptor	Cancer
P2X7 receptor antagonist-5 (compund 13a) is a potent, orally active and long-lasting *P2X7* receptor antagonist .

HY-143568

P2X3 antagonist 36	P2X Receptor	Inflammation/Immunology
P2X3 antagonist 36 is a *P2X3* antagonist extracted from patent WO2019081343A1 compound 156 .

HY-143576

P2X3 antagonist 37	P2X Receptor	Neurological Disease
P2X3 antagonist 37 is a potent P2X3 receptor antagonist with an IC₅₀ of 32.45 nM for hP2X3 (WO2021115225A1, example 68) .

HY-153710

P2X3 antagonist 38	P2X Receptor	Inflammation/Immunology
P2X3 antagonist 38 (compound 4) is a potent and orally active *P2X3* antagonist with IC₅₀ values of 0.132, 0.165, 0.421 µM for hP2X3, rP2X3, gpP2X3, respectively .

HY-101077

Iso-PPADS tetrasodium	P2X Receptor	Inflammation/Immunology
Iso-PPADS tetrasodium is a *P2X-purinoceptor* antagonist. Iso-PPADS tetrasodium inhibits P2X1 and P2X3 receptor with IC₅₀s of 43 nM and 84 nM. Iso-PPADS tetrasodium is protective against ventilator-induced brain injury (VIBI) ^[2].

HY-134370

Ap4G	P2X Receptor	Cardiovascular Disease
Ap4G is a dinucleoside polyphosphate compound with vasoconstrictor activity. Ap4G regulates vasoconstriction through P2 receptors, especially *P2X* receptors, and is an important tool for studying vascular physiology and pathology .

HY-159832

Relicpixant	P2X Receptor	Neurological Disease
Relicpixant is a potent purinoreceptor (P2X) antagonist .

HY-130605

BAY-1797 2 Publications Verification	P2X Receptor	Neurological Disease
BAY-1797 is a potent, orally active, and selective *P2X4* antagonist, with an IC₅₀ of 211 nM against human P2X4. BAY-1797 displays no or very weak activity on the other P2X ion channels. BAY-1797 shows anti-nociceptive and anti-inflammatory effects .

HY-108667

TNP-ATP triethylammonium	P2X Receptor	Others
TNP-ATP triethylammonium is a selective P2X receptor antagonist. TNP-ATP triethylammonium shows antinociceptive effects in rats .

HY-N5025

Bullatine A	P2X Receptor Apoptosis	Inflammation/Immunology Cancer
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent *P2X7* antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses . Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed ^[2].

HY-108652

α,β-Methylene-ATP trisodium	P2X Receptor	Inflammation/Immunology
α,β-Methylene-ATP trisodium is an agonist of *P2X1* and *P2X3* receptors and can cross the blood-brain barrier. α,β-Methylene-ATP trisodium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP trisodium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP trisodium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system ^[2] .

HY-134440A

α,β-Methylene-ATP	P2X Receptor	Inflammation/Immunology
α,β-Methylene-ATP is an agonist of *P2X1* and *P2X3* receptors and can cross the blood-brain barrier. α,β-Methylene-ATP can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system ^[2] .

HY-134440

α,β-Methylene-ATP dilithium	P2X Receptor	Inflammation/Immunology
α,β-Methylene-ATP dilithium is an agonist of *P2X1* and *P2X3* receptors and can cross the blood-brain barrier. α,β-Methylene-ATP dilithium can trigger a reflex pressor response by activating P2X receptors in peripheral muscles and the central locus coeruleus (LC); this effect can be blocked by the P2X antagonist PPADS (HY-108960). α,β-Methylene-ATP dilithium also activates noradrenergic neurons in the central locus coeruleus, mediating antinociceptive effects; this effect can be attenuated by the locus coeruleus damaging agent DSP-4 (HY-103210/HY-121602). α,β-Methylene-ATP dilithium can be used to study the pathological mechanisms of neuropathic pain, cardiovascular reflex regulation, and antinociceptive effects of the central nervous system ^[2] .

HY-134262

8-Bromo-ATP 8-Bromoadenosine 5'-triphosphate; 8-Br-ATP	P2X Receptor	Cancer
8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC₅₀ of 23.1 μM ^[2] .

HY-136254

BzATP triethylammonium salt 5+ Cited Publications	P2X Receptor	Inflammation/Immunology Cancer
BzATP triethylammonium salt acts as a P2X receptor agonist with pEC₅₀s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively . BzATP triethylammonium salt is potent at P2X7 receptors with EC₅₀s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively ^[2].

HY-18745

BzATP triethylammonium Benzoylbenzoyl-ATP triethylammonium	P2X Receptor	Inflammation/Immunology Cancer
BzATP triethylammonium acts as a P2X receptor agonist with pEC₅₀s of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively . BzATP triethylammonium is potent at P2X7 receptors with EC₅₀s of 3.6 μM and 285 μM for rat P2X7 and mouse P2X7, respectively ^[2].

HY-19978

RO-3	P2X Receptor	Neurological Disease
RO-3 is a potent, CNS-penetrant, and orally active *P2X₃* and *P2X_2/3* antagonist with pIC₅₀s of 5.9 and 7.0 for human homomultimeric P2X₃ and heteromultimeric P2X_2/3 receptors, respectively. RO-3 shows selectivity for P2X₃ and P2X_2/3 over all other functional homomultimeric P2X receptors (IC₅₀ >10?μM at P2X_1,2,4,5,7) .

HY-101044

PPADS tetrasodium 5 Publications Verification	P2X Receptor Na+/Ca2+ Exchanger	Neurological Disease
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC₅₀s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC₅₀~0.9 mM) and recombinant P2Y4 (IC₅₀~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca ²⁺ exchanger in guinea pig airway smooth muscle ^[2].

HY-137325A

2-Chloro-ATP sodium	Calcium Channel	Metabolic Disease
2-Chloro-ATP sodium (2-Chloro ATP) is an adenine nucleotide and an analog of ATP. It is an antagonist of the purinergic P2Y1 receptor and inhibits intracellular calcium mobilization induced by ADP (HY-W010918) in Jurkat cells expressing the human receptor (Ki=2.3 μM). 2-Chloro-ATP sodium is an agonist of the purinergic P2X receptor and induces inward currents in HEK293 cells expressing human bladder smooth muscle or rat PC12 forms of the receptor (EC50=0.5 and 2.5 μM). 2-Chloro-ATP sodium induces relaxation of precontracted guinea pig cecal strips in a concentration-dependent manner. 2-Chloro-ATP sodium has been used to study the substrate specificity of cyclic nucleotide-dependent protein kinases such as protein kinase A (PKA) and PKG.

HY-101588

Gefapixant 2 Publications Verification MK-7264; AF-219	P2X Receptor	Inflammation/Immunology
Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC₅₀ values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis ^[2] .

HY-101588A

Gefapixant citrate 2 Publications Verification MK-7264 citrate; AF-219 citrate	P2X Receptor	Inflammation/Immunology
Gefapixant citrate is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC₅₀ values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant citrate can be used for the research of chronic cough and knee osteoarthritis ^[2] .

HY-131502

Taspine	P2X Receptor	Inflammation/Immunology
Taspine is a natural product with anti-inflammatory activity. Taspine suppresses *P2X4* receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage .

HY-101588R

Gefapixant (Standard) MK-7264 (Standard); AF-219 (Standard)	Reference Standards P2X Receptor	Inflammation/Immunology
Gefapixant (Standard) is the analytical standard of Gefapixant. This product is intended for research and analytical applications. Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC₅₀ values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis ^[2] .

HY-14485

Ro-51	P2X Receptor	Neurological Disease
Ro-51 is a potent and selective dual P2X₃/P2X_2/3 antagonist, with IC₅₀ of 2 nM and 5 nM for P2X₃ and P2X_2/3, respectively. Ro-51 can be used for the research for pain ^[2].

HY-14483A

AF-353 hydrochloride Ro-4 hydrochloride	P2X Receptor	Cancer
AF-353 hydrochloride is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC₅₀ of 8.0 for both human and rat P2X3, and with a pIC₅₀ of 7.3 for human P2X2/3 ^[2].

HY-14483

AF-353 1 Publications Verification Ro-4	P2X Receptor	Cancer
AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC₅₀ of 8.0 for both human and rat P2X3, and with a pIC₅₀ of 7.3 for human P2X2/3 ^[2].

HY-108673

Ro 0437626	P2X Receptor	Cancer
Ro 0437626 is a selective purinergic *(P2X₁)* receptor antagonist (IC₅₀ = 3 μM), but shows low affinity for P2X2, P2X3 and P2X2/3 receptors (IC₅₀ > 100 μM) .

HY-108676

NF023 hexasodium 1 Publications Verification	P2X Receptor	Neurological Disease
NF023 hexasodium is a selective and competitive P2X₁ receptor antagonist, with IC₅₀ values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X₁, P2X₃, P2X₂, and P2X₄-mediated responses respectively ^[2] .

HY-137451

Sivopixant S-600918	P2X Receptor	Neurological Disease
Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 *IC₅₀*=4.2 nM; P2X2/3 IC₅₀=1100 nM). Sivopixant shows strong analgesic effect .

HY-101910

PSB-12062 N-(p-Methylphenylsulfonyl)phenoxazine	P2X Receptor	Neurological Disease
PSB-12062 is a potent and selective *P2X4* antagonist with an IC₅₀ of 1.38 μM for human P2X4.

HY-122575

Aurintricarboxylic acid 2 Publications Verification	P2X Receptor Influenza Virus Topoisomerase MicroRNA Apoptosis	Infection Neurological Disease Inflammation/Immunology
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive *P2X1Rs* and *P2X3Rs, with IC₅₀s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively . Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase* ^[2]. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis . Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway . Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC₅₀ of 0.6 μM . Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC₅₀ of 0.47 µM .

HY-15568A

A-317491 sodium salt hydrate 4 Publications Verification	P2X Receptor	Neurological Disease Inflammation/Immunology
A-317491 sodium salt hydrate is a potent, selective and non-nucleotide antagonist of *P2X₃* and P2X_2/3 receptors, with K_is of 22, 22, 9, and 92 nM for *hP2X₃, rP2X₃, hP2X_2/3, and rP2X_2/3, respectively. A-317491 sodium salt hydrate is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 sodium salt hydrate reduces inflammatory and neuropathic pain by blocking P2X₃* and P2X_2/3 receptor-mediated calcium flux ^[2].

HY-15568

A-317491 4 Publications Verification	P2X Receptor	Neurological Disease Inflammation/Immunology
A-317491 is a potent, selective and non-nucleotide antagonist of *P2X₃* and P2X_2/3 receptors, with K_is of 22, 22, 9, and 92 nM for *hP2X₃, rP2X₃, hP2X_2/3, and rP2X_2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X₃* and P2X_2/3 receptor-mediated calcium flux ^[2].

HY-D0976

NF279	P2X Receptor HIV	Infection
NF279 is a potent selective and reversible P2X1 receptor antagonist, with an IC₅₀ of 19 nM. NF279 displays good selectivity over P2X2, P2X3 (IC₅₀=1.62 μM), P2X4 (IC₅₀>300 μM). NF279 is a dual HIV-1 coreceptor inhibitor that interferes with the functional engagement of CCR5 and CXCR4 by Env ^[2].

HY-122575R

Aurintricarboxylic acid (Standard)	P2X Receptor Influenza Virus Topoisomerase MicroRNA Apoptosis	Infection Neurological Disease Inflammation/Immunology
Aurintricarboxylic acid (Standard) is the analytical standard of Aurintricarboxylic acid. This product is intended for research and analytical applications. Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively . Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase ^[2]. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis . Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway . Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM . Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 μM .

Cat. No.	Product Name	Type

HY-D0169A

Phenol Red sodium salt 1 Publications Verification Phenolsulfonephthalein sodium salt	Dyes
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye. Phenol Red sodium salt is also an antagonist of rat *P2X1R. Phenol Red sodium salt enhances the halogenating activity of myeloperoxidase*. Phenol Red sodium salt shows a distinct color change from pink to yellow in a positive pH reaction ^[2] .

HY-D0914

Fast Green FCF

FD&C Green No. 3; Food green 3; C.I. 42053

Dyes

Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF inhibits α-synuclein aggregation, as well as Aβ and P2X4 receptor, and TLR4/Myd88/NF-κB. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function ^[2] .

HY-D0914A

Fast green FCF free acid

Dyes

Fast green FCF free acid is a dye that is acid-resistant. Fast Green FCF free acid inhibits α-synuclein aggregation, as well as Aβ, P2X4 receptor and TLR4/Myd88/NF-κB. Fast Green FCF free acid is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF free acid improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function ^[2] .

Cat. No.	Product Name	Target	Research Area

HY-P1137

10Panx	Gap Junction Protein	Others
10Panx is a competitive inhibitor of selective Pannexin 1 (PANX1) channels. 10Panx blocks the opening of PANX1 channels, inhibits ATP release and downstream P2X7 receptor-mediated signaling pathways, thereby reducing cell death and inflammatory responses. 10Panx can be used in the study of diseases such as neuropathic pain, inflammatory bowel disease, and Clostridioides difficile infection. 10Panx can effectively reduce mechanical hyperalgesia and enhanced C-reflexes, and inhibit the expression of pro-inflammatory factors such as *IL-6*[1][2][3].

HY-P1441A

Mambalgin 1 TFA	Sodium Channel	Neurological Disease
Mambalgin 1 TFA is a selective ASIC1a inhibitor (IC₅₀ values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Mambalgin 1 TFA binds to closed/inactive channel. Mambalgin 1 TFA is selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Mambalgin 1 TFA increases latency of withdrawal response in mouse tail-flick and paw-flick tests.

HY-P1330

Purotoxin 1	P2X Receptor	Inflammation/Immunology
Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5025

Bullatine A	Structural Classification Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Inflammation/Immunology Disease Research Fields	P2X Receptor Apoptosis
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent *P2X7* antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses . Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed ^[2].

HY-N1478

Gardenoside 1 Publications Verification	Structural Classification Iridoids Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis	P2X Receptor Reactive Oxygen Species (ROS)
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI)-induced neuropathic pain by regulating the *P2X3* and *P2X7* receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA)-induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS). Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study ^[2] .

HY-N7740

Adenosine 2',5'-diphosphate sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	P2Y Receptor Endogenous Metabolite
Adenosine 2',5'-diphosphate sodium is a competitive *P2Y1* antagonist. Adenosine 2',5'-diphosphate sodium exhibits non-selective antagonism at recombinant and human platelet *P2X1* receptors ^[2].

HY-N9182

Zeaxanthin dipalmitate Physalien	Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Solanaceae Lycium chinense Miller Disease Research Fields Inflammation/Immunology	Adiponectin Receptor P2X Receptor Autophagy
Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (K_d=81.2 nM) and adiponectin receptor 1 (AdipoR1; K_d=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP) ^[2].

HY-15310

Ivermectin 25+ Cited Publications MK-933; CD-5024; K-237	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer	Flavivirus Dengue Virus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of *P2X₄* and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import ^[2] . Ivermectin is a candidate therapeutic against *SARS-CoV-2/COVID-19* .

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HY-P703172

	P2X3 Protein, Human (HEK293) P2X purinoceptor 3; ATP receptor; Purinergic receptor; P2RX3; Homo sapiens; Human; P2X3; Ion channel; Ligand-gated ion channel; Receptor	Human	HEK293
	P2X3 Protein, Human (HEK293) is the recombinant human-derived P2X3, expressed by HEK293 , with tag Free labeled tag. ,

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HY-16322S

Minodronic acid-d4
Minodronic acid-d₄ is deuterium labeled Minodronic acid. Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain ^[2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80737

	Ku80 Antibody (YA714) XRCC5; G22P2; X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair pr	WB, ICC/IF, IP, ChIP	Human, Monkey
	Ku80 Antibody (YA714) is a non-conjugated and Mouse origined monoclonal antibody about 83 kDa, targeting to Ku80 (8H1). It can be used for WB,ICC/IF,IP,ChIP assays with tag free, in the background of Human, Monkey.

HY-P84752

	P2RX7 Antibody (YA4449) P2X7	WB, IHC-P, FC, ELISA	Human, Mouse, Rabbit

HY-P85251

	Ku-80 Antibody (YA4943) XRCC5; G22P2; X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair pr	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse