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Isoforms Recommended:	NEK7

Results for "

NEK7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (2) Apoptosis (3) Autophagy (1) Interleukin Related (1) Molecular Glues (3) NEKs (10) NOD-like Receptor (NLR) (7) Pyroptosis (1) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Inflammation/Immunology (10) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-172162

LC-04-045	NEKs Interleukin Related	Inflammation/Immunology
LC-04-045 is a NEK7 (NIMA-related kinase 7) molecular glue degrader (MGD). LC-04-045 demonstrates potent activity of *NEK7* degradation with a DC₅₀ (half-maximal degradation) of 7 nM and a D_max (maximum degradation) of 90% in MOLT-4 cells. LC-04-045 displays high selectivity for *NEK7* across the proteome. LC-04-045 degrades *NEK7* mediated by the ubiquitin-proteasome system (UPS) and relies on the glycine 57 (G57)-containing degron motif in *NEK7. LC-04-045 effectively inhibits secretion of IL-1β* and IL-18 with IC₅₀s of 33.03 nM and 32.99 nM, respectively. LC-04-045 is potential for inflammatory diseases research .

HY-159520

Ofirnoflastum Ofirnoflast	NEKs	Inflammation/Immunology
Ofirnoflastum (Ofirnoflast) is a serine/ threonine-protein kinase Nek7 inhibitor, with anti inflammatory effect .

HY-163358

SLC3037 1 Publications Verification	NOD-like Receptor (NLR) NEKs	Cardiovascular Disease Neurological Disease Inflammation/Immunology
SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to *NEK7* or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. SLC3037 can be used for research of gout, cardiovascular diseases, metabolic syndrome or neurodegenerative diseases .

HY-RS09198

NEK7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NEK7 Human Pre-designed siRNA Set A contains three designed siRNAs for NEK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NEK7 Human Pre-designed siRNA Set A NEK7 Human Pre-designed siRNA Set A

HY-RS17220

Nek7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nek7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nek7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nek7 Mouse Pre-designed siRNA Set A Nek7 Mouse Pre-designed siRNA Set A

HY-RS23673

Nek7 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Nek7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nek7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nek7 Rat Pre-designed siRNA Set A Nek7 Rat Pre-designed siRNA Set A

HY-168737

NEK7-IN-2	NOD-like Receptor (NLR) NEKs	Inflammation/Immunology
NEK7-IN-2 (compound 23) is a potent inhibitor of *NLRP3-NEK7* interaction. NEK7-IN-2 can enhance the thermal stability of NEK7 and regulatie NLRP3 inflammasome assembly. NEK7-IN-2 inhibits IL-1β releases .

HY-169933

NEK7-IN-1	NEKs	Inflammation/Immunology Cancer
NEK7-IN-1 (Compound I-15) is the inhibitor for NIMA-related kinase 7 *NEK7* with IC₅₀ <100 nM. NEK7-IN-1 inhibits the IL-1β release with IC₅₀ <50 nM .

HY-175283

ABT-002	Molecular Glues NEKs	Cancer
ABT-002 is a molecular glue degrader targeting GSPT1 and *NEK7*. ABT-002 is promising for research of hepatocellular carcinoma (HCC) .

HY-175452

MRT-3486	Molecular Glues NEKs	Inflammation/Immunology
MRT-3486 (Compound 5) is a cereblon-based *NEK7* molecular glue degrader. MRT-3486 can be used for autoinflammatory diseases research .

HY-173154

NK7-902	Molecular Glues NEKs	Inflammation/Immunology
NK7-902 is a CRBN molecular glue degrader of *NEK7. NK7-902 fully degrades NEK7* in human primary monocytes and whole blood but only partially inhibits NLRP3-dependent IL-1β production. NK7-902 leads to profound and long-lasting NEK7 degradation but only transiently blocks NLRP3 inflammasome activation in non-human primates by oral administration. NK7-902 shows activity in murine systems .

HY-163756

NLRP3-IN-43	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-43 (compound II-8) is a poteny inhibitor of NLRP3 inflammasome activation that binds to the LRR domain, and disrupts *NLRP3-NEK7* interaction .

HY-174270

NLRP3-IN-79	NOD-like Receptor (NLR) NEKs	Inflammation/Immunology
NLRP3-IN-79 (Compound B6) is a selective NLRP3 inflammasome inhibitor with an IC₅₀ value of 10.69 nM. NLRP3-IN-79 blocks the assembly of the NLRP3 inflammasome by disrupting the NEK7-NLRP3 interaction. NLRP3-IN-79 is promising for research of NLRP3-driven inflammatory diseases such as systemic inflammation, peritonitis, and colitis .

HY-N0373

Licochalcone B Maximum Cited Publications 9 Publications Verification	Amyloid-β Apoptosis NOD-like Receptor (NLR)	Neurological Disease
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .

HY-122639

ZINC05007751 2 Publications Verification	NEKs	Cancer
ZINC05007751 is a potent NIMA-related kinase *NEK6* inhibitor with an IC₅₀ of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9 .

HY-N0373R

Licochalcone B (Standard)	Reference Standards Amyloid-β Apoptosis NOD-like Receptor (NLR)	Neurological Disease
Licochalcone B (Standard) is the analytical standard of Licochalcone B. This product is intended for research and analytical applications. Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .

HY-N3005

Britannin 1 Publications Verification	Apoptosis Autophagy NOD-like Receptor (NLR) Pyroptosis	Inflammation/Immunology Cancer
Britannin is an NLRP3 inhibitor with an IC₅₀ of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and *NEK7*. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics .

Licochalcone B 5+ Cited Publications	Structural Classification Chalcones Flavonoids Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch.	Amyloid-β Apoptosis NOD-like Receptor (NLR)
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .

Britannin 1 Publications Verification	Phyllodium pulchellum (L.) Desv. Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Inflammation/Immunology Disease Research Fields	Apoptosis Autophagy NOD-like Receptor (NLR) Pyroptosis
Britannin is an NLRP3 inhibitor with an IC₅₀ of 3.630 μM, exhibiting anti-inflammatory activity. Britannin inhibits the activation and assembly of the NLRP3 inflammasome by blocking the interaction between NLRP3 and *NEK7*. Additionally, Britannin demonstrates antitumor activity by inhibiting the proliferation of tumor cells through blocking the interaction between HIF-1α and Myc, thereby suppressing PD-L1 expression and enhancing cytotoxic T lymphocyte activity. Britannin can also induce apoptosis and autophagy in liver cancer cells by activating ROS-regulated AMPK. Britannin holds promise for research in the fields of anti-inflammatory and antitumor therapeutics .

Licochalcone B (Standard)	Structural Classification Chalcones Flavonoids Leguminosae Source classification Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch.	Reference Standards Amyloid-β Apoptosis NOD-like Receptor (NLR)
Licochalcone B (Standard) is the analytical standard of Licochalcone B. This product is intended for research and analytical applications. Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction .

Recombinant Proteins Recommended:

NEK7

Species:	Human (3)
Tag:	His (3) SUMO (1) GST (1)
Source:	Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75935

	NEK7 Protein, Human (sf9, His-GST) Serine/threonine-protein kinase NEK7; NimA-related protein kinase 7; NEK7	Human	Sf9 insect cells
	The NEK7 protein is a key kinase that crucially drives mitotic cell cycle progression by enhancing centrosomal microtubule nucleation, ensuring robust spindle formation, and aiding in cytokinesis. Phosphorylation of EML4 at “Ser-146” promotes chromosome aggregation. NEK7 Protein, Human (sf9, His-GST) is the recombinant human-derived NEK7 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701253

	NEK7 Protein, Human (His-SUMO) Serine/threonine-protein kinase NEK7; NimA-related protein kinase 7; NEK7	Human	E. coli
	The NEK7 protein is a key kinase that crucially drives mitotic cell cycle progression by enhancing centrosomal microtubule nucleation, ensuring robust spindle formation, and aiding in cytokinesis. Phosphorylation of EML4 at “Ser-146” promotes chromosome aggregation. NEK7 Protein, Human (His-SUMO) is the recombinant human-derived NEK7 protein, expressed by E. coli , with N-6*His-SUMO labeled tag.

HY-P702740

	NEK7 Protein, Human (His) NEK7; NIMA related kinase 7	Human	E. coli
	The NEK7 protein is a key kinase that crucially drives mitotic cell cycle progression by enhancing centrosomal microtubule nucleation, ensuring robust spindle formation, and aiding in cytokinesis. Phosphorylation of EML4 at “Ser-146” promotes chromosome aggregation. NEK7 Protein, Human (His) is the recombinant human-derived NEK7, expressed by E. coli, with His labeled tag.

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HY-P81615

	NEK7 Antibody (YA1360) NEK7; NimA related protein kinase 7	WB, IP	Mouse, Rat
	NEK7 Antibody (YA1360) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1360), targeting NEK7, with a predicted molecular weight of 35 kDa (observed band size: 35 kDa). NEK7 Antibody (YA1360) can be used for WB, IP experiment in mouse, rat background.

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NEK7 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NEK7 Human Pre-designed siRNA Set A contains three designed siRNAs for NEK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nek7 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Nek7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nek7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Nek7 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Nek7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nek7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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