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Results for "

NADPH oxidase (NOX2)

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Peptides

1

Isotope-Labeled Compounds

3

Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160524
    NOX2-IN-3

    		NADPH Oxidase Cancer
    NOX2-IN-3 (compound 3) is an inhibitor of NOX2 (NADPH Oxidase 2). NOX2-IN-3 sensitizes tumor cells to MRTX1133 (HY-134813) .
    NOX2-IN-3
  • HY-18950
    GSK2795039
    Maximum Cited Publications
    68 Publications Verification

    		 NADPH Oxidase Reactive Oxygen Species (ROS) Apoptosis Cancer
    GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption . GSK2795039 reduces apoptosis .
    GSK2795039
  • HY-152026
    NADPH oxidase-IN-1

    		NADPH Oxidase Neurological Disease
    NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC50s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .
    NADPH oxidase-IN-1
  • HY-119576
    Phox-I2
    1 Publications Verification

    		 NADPH Oxidase Reactive Oxygen Species (ROS) Inflammation/Immunology
    Phox-I2 is a selective inhibitor of p67 phox-Rac1 interaction, binds to p67 phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production .
    Phox-I2
  • HY-120801
    APX-115
    2 Publications Verification

    Ewha-18278

    		 NADPH Oxidase Metabolic Disease Inflammation/Immunology
    APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury .
    APX-115
  • HY-120801A
    APX-115 free base
    2 Publications Verification

    Ewha-18278 free base; Isuzinaxib free base

    		 NADPH Oxidase Inflammation/Immunology Endocrinology
    APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury .
    APX-115 free base
  • HY-P5381
    gp91 ds-tat
    1 Publications Verification

    		 NADPH Oxidase Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase TRP Channel Cardiovascular Disease Neurological Disease Inflammation/Immunology
    gp91 ds-tat, a biological active peptide, is a NADPH oxidase 2 (Nox2) inhibitor. gp91 ds-tat blocks NADPH oxidase-dependent superoxide production. gp91 ds-tat ameliorates high glucose-induced increase in total ROS, LPOs and iron levels. gp91 ds-tat inhibits homocysteine (Hcy)-induced activation of NLRP3 inflammasomes and restores Hcy-inhibited lysosomal TRPML1 channel activity. gp91 ds-tat improves cerebrovascular and cognitive function in APP/PS1 mice. gp91 ds-tat can be used for the study of Alzheimer’s disease (AD), glomerular inflammation and cardiovascular disease .
    gp91 ds-tat
  • HY-B0203B
    (Rac)-Nebivolol

    (Rac)-R 065824

    		 Adrenergic Receptor NADPH Oxidase Cardiovascular Disease
    (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
    (Rac)-Nebivolol
  • HY-B0203BS2
    (Rac)-Nebivolol-d2,15N

    (Rac)-R 065824-d2,15N

    		 NADPH Oxidase Adrenergic Receptor Isotope-Labeled Compounds Cardiovascular Disease
    (Rac)-Nebivolol-d2, 15N is 15N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .
    (Rac)-Nebivolol-d2,15N
  • HY-136271
    MJ33

    		Phospholipase NADPH Oxidase p38 MAPK Akt NF-κB AP-1 Reactive Oxygen Species (ROS) Cardiovascular Disease Inflammation/Immunology Cancer
    MJ-33 is a competitive phospholipase A₂ (PLA₂) inhibitor. MJ-33 inhibits the activation of NOX2 by blocking the PLA₂ activity of Prdx6, thereby reducing the production of ROS. MJ-33 effectively inhibits the activity of acidic PLA₂ (pH 4.0), reduces the degradation of pulmonary surfactant phosphatidylcholine (PC), but has no effect on alkaline PLA₂ (pH 8.5). MJ-33 significantly alleviates lung oxidative damage induced by ischemia-reperfusion (I/R). MJ-33 significantly inhibits the invasive, migratory and adhesive abilities of prostate cancer cells by suppressing the MAPK, AKT, NF-κB and AP-1 signaling pathways. MJ-33 can be used to study ROS-related diseases and prostate cancer .
    MJ33

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