Search Result

Results for "

Muscarinic receptor agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mAChR (102) 5-HT Receptor (14) Adrenergic Receptor (17) Apoptosis (5) Bacterial (2) Calcium Channel (3) Cholinesterase (ChE) (1) Dopamine Receptor (11) Dopamine Transporter (4) Drug Metabolite (6) Histamine Receptor (6) Isotope-Labeled Compounds (7) MARCKS (2) Mitosis (1) nAChR (4) Potassium Channel (5) Reference Standards (14) Serotonin Transporter (5) Sigma Receptor (7) Sodium Channel (5) Trace Amine-associated Receptor (TAAR) (1) Trk Receptor (5)
By Research Areas:	Cancer (20) Cardiovascular Disease (8) Endocrinology (7) Infection (4) Inflammation/Immunology (17) Metabolic Disease (4) Neurological Disease (92)
Click Chemistry:	Alkynes (2)

109

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: mAChR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116480

LY593093	mAChR	Neurological Disease
LY593093 is a selective, orally active, and brain-penetrant **muscarinic M1 receptor** agonist with an EC₅₀ of 22.8 nM. LY593093 can be utilized in Alzheimer’s disease research .

HY-107650A

Milameline hydroiodide CI 979 hydroiodide; RU 35926 hydroiodide	mAChR	Neurological Disease
Milameline (CI 979; RU35926) hydroiodide is a nonselective, partical and orally active **muscarinic receptor** agonist that improves cognition. Milameline hydroiodide has equal affinity for different subtypes of human muscarinic receptors with IC₅₀ of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydroiodide has a higher affinity for sites [ ³H]CMD (IC₅₀ = 20 nM), than [ ³H]QNB, (IC₅₀ = 3059 nM). Milameline hydroiodide produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydroiodide can be used for the study of Alzheimer’s Disease .

HY-B0726A

Pilocarpine 35+ Cited Publications	mAChR	Neurological Disease Cancer
Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B0726

Pilocarpine Hydrochloride 35+ Cited Publications	mAChR	Cardiovascular Disease Neurological Disease Cancer
Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B1006

Pilocarpine nitrate 35+ Cited Publications	mAChR	Neurological Disease Cancer
Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-101372A

Oxotremorine M iodide	mAChR	Neurological Disease
Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms .

HY-W909173

TAAR1 agonist 2	Trace Amine-associated Receptor (TAAR) Histamine Receptor mAChR	Neurological Disease
TAAR1 agonist 2 (compound 30) is a full agonist of trace amine-associated receptor 1 (TAAR1) (pEC₅₀=7.5). TAAR1 agonist 2 also exhibits agonist activity at H1 receptors and activates several members of the muscarinic acetylcholine receptor family, such as the M2 receptor (pEC₅₀=5). TAAR1 agonist 2 can be used in the study of neuropsychiatric diseases .

HY-107650

Milameline hydrochloride CI 979 hydrochloride; RU 35926 hydrochloride	mAChR	Neurological Disease
Milameline (CI 979; RU35926) hydrochloride is a nonselective, partical and orally active **muscarinic receptor** agonist that improves cognition. Milameline hydrochloride has equal affinity for different subtypes of human muscarinic receptors with IC₅₀ of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydrochloride has a higher affinity for sites [ ³H]CMD (IC₅₀ = 20 nM), than [ ³H]QNB, (IC₅₀ = 3059 nM). Milameline hydrochloride produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydrochloride can be used for the study of Alzheimer’s Disease .

HY-135460

Milameline CI-979; RU35926	mAChR	Neurological Disease
Milameline (CI-979; RU35926) is a nonselective, partical and orally active **muscarinic receptor** agonist that improves cognition. Milameline has equal affinity for different subtypes of human muscarinic receptors with IC₅₀ of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline has a higher affinity for sites [ ³H]CMD (IC₅₀ = 20 nM), than [ ³H]QNB, (IC₅₀ = 3059 nM). Milameline produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline can be used for the study of Alzheimer’s Disease .

HY-120418

L-687306	mAChR	Others
L-687306 is a high affinity muscarinic M1 receptor partial agonist with activity as a partial agonist of M1 receptors in rat ganglia and as a high affinity competitive antagonist at guinea pig cardiac M2 and ileal M3 muscarinic receptors, useful for studying the receptor reserve of muscarinic receptors.

HY-U00230

CDD0102 CDD0102A	mAChR	Neurological Disease
CDD0102 is a potent M₁ Muscarinic receptor agonist.

HY-U00230A

CDD0102 hydrochloride	mAChR	Neurological Disease
CDD0102 Hydrochloride is a potent M₁ Muscarinic receptor agonist.

HY-B0726S

Pilocarpine-d3 hydrochloride	Isotope-Labeled Compounds mAChR	Neurological Disease
Pilocarpine-d₃ (hydrochloride) is deuterium labeled Pilocarpine (Hydrochloride). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-100916

Arecaidine-propargyl ester tosylate	mAChR	Neurological Disease
Arecaidine-propargyl ester tosylate is a potent muscarinic receptor (mAChR) agonist .

HY-U00038

ENS-163 phosphate ENS 213-163; Sandoz ENS 163 phosphate; Thiopilocarpine phosphate	mAChR	Neurological Disease
ENS-163 phosphate is a selective **muscarinic M1 receptor** agonist.

HY-139126

(±)-Muscarine chloride DL-Muscarin chloride	mAChR	Neurological Disease
(±)-Muscarine chloride is the racemate of Muscarine chloride. Muscarine is a prototype muscarinic acetylcholine receptor agonist .

HY-172418

Betovumeline	mAChR	Neurological Disease
Betovumeline is the agonist for **muscarinic receptor** and can be used for researchs of neurological disorders .

HY-B0726R

Pilocarpine Hydrochloride (Standard)	Reference Standards mAChR	Neurological Disease Cancer
Pilocarpine (Hydrochloride) (Standard) is the analytical standard of Pilocarpine (Hydrochloride). This product is intended for research and analytical applications. Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B0726S1

Pilocarpine-d5 hydrochloride	mAChR Isotope-Labeled Compounds	Neurological Disease Cancer
Pilocarpine-d₅ hydrochloride is deuterated labeled Pilocarpine hydrochloride (HY-B0726). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B1006R

Pilocarpine nitrate (Standard)	Reference Standards mAChR	Neurological Disease Cancer
Pilocarpine (nitrate) (Standard) is the analytical standard of Pilocarpine (nitrate). This product is intended for research and analytical applications. Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-100336

AC260584 1 Publications Verification	mAChR	Neurological Disease
AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC₅₀ of 7.6.

HY-76772A

(+)-Cevimeline hydrochloride hemihydrate (+)-SNI-2011; (+)-AF102B hydrochloride hemihydrate	mAChR	Neurological Disease
(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011), a potent muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.

HY-15885

LY2119620	mAChR	Neurological Disease
LY2119620 is a high-affinity muscarinic M₂/M₄ receptor agonist.

HY-76772B

(-)-Cevimeline hydrochloride hemihydrate (-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate	mAChR	Neurological Disease
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.

HY-148524

β2AR/M-receptor agonist-1	mAChR Adrenergic Receptor	Cardiovascular Disease
β2AR/M-receptor agonist-1 (example 131) is a *muscarinic* antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-1 shows potency to β2 adrenoceptor with an EC₅₀ value of 9.2 nM. β2AR/M-receptor agonist-1 also has potency to muscarinic receptor with a K_i value of 30.2 nM. β2AR/M-receptor agonist-1 shows MABA potency with an EC₅₀ value of 4.0 nM .

HY-100234A

DREADD agonist 21 dihydrochloride 1 Publications Verification	mAChR	Neurological Disease
DREADD agonist 21 dihydrochloride is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

HY-100234

DREADD agonist 21 1 Publications Verification	mAChR	Neurological Disease
DREADD agonist 21 is a potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist (EC₅₀=1.7 nM) .

HY-N5016

Guvacoline hydrochloride	mAChR	Cardiovascular Disease
Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors .

HY-17366A

Clozapine N-oxide dihydrochloride Maximum Cited Publications 122 Publications Verification	mAChR Dopamine Receptor Drug Metabolite	Neurological Disease
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a *human muscarinic* designer receptors (DREADDs)** agonist. Clozapine N-oxide dihydrochloride activates the *DREADD receptor* hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀*=11 nM) agonist* .

HY-17366

Clozapine N-oxide Maximum Cited Publications 122 Publications Verification	Drug Metabolite mAChR Dopamine Receptor	Neurological Disease
Clozapine N-oxide is a major metabolite of Clozapine and a *human muscarinic* designer receptors (DREADDs)** agonist. Clozapine N-oxide activates the *DREADD receptor* hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀*=11 nM) agonist* .

HY-107654

Muscarine iodide 1 Publications Verification (+)-Muscarine iodide	mAChR	Neurological Disease
Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype **muscarinic acetylcholine receptor** agonist .

HY-17366R

Clozapine N-oxide (Standard)	Reference Standards mAChR Dopamine Receptor Drug Metabolite	Neurological Disease
Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].

HY-17366AR

Clozapine N-oxide dihydrochloride (Standard)	Reference Standards mAChR Dopamine Receptor Drug Metabolite	Neurological Disease
Clozapine N-oxide (dihydrochloride) (Standard) is the analytical standard of Clozapine N-oxide (dihydrochloride). This product is intended for research and analytical applications. Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].

HY-110239

Perlapine MP-11	mAChR	Neurological Disease
Perlapine is a potent muscarinic DREADD (Designer Receptors Exclusively Activated by Designer agents) agonist Perlapine exhibits >10000-fold selectivity for hM₃D_q over hM₃ receptors .

HY-105296

Blarcamesine 3 Publications Verification	Sigma Receptor mAChR	Cancer
Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and **muscarinic receptor** modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome .

HY-120329

Lu 26-046	mAChR	Others
Lu 26-046 is the agonist for **muscarinic M1 receptor** and M2 receptor and a weak antagonist for M3 receptor, with K_i of 0.51, 26 and 5 nM, respectively. Lu 26-046 exhibits specific stimulus property, that can be recognized by rats .

HY-106432A

Sabcomeline hydrochloride SB-202026 hydrochloride; Memric hydrochloride	mAChR	Neurological Disease
Sabcomeline (SB-202026) hydrochloride is a potent and functionally selective **muscarinic M1 receptor** partial agonist that improve cognition. Sabcomeline hydrochloride can be used for Alzheimer's disease research .

HY-106432

Sabcomeline SB-202026; Memric	mAChR	Neurological Disease
Sabcomeline (SB-202026) is a potent and functionally selective **muscarinic M1 receptor** partial agonist that improve cognition. Sabcomeline can be used for Alzheimer's disease research .

HY-14539B

Clozapine dihydrochloride HF 1854 dihydrochloride	Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor	Neurological Disease Cancer
Clozapine (HF 1854) dihydrochloride is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine inhibits the **muscarinic M1 receptor** and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the **muscarinic M4 receptor (EC₅₀**=11 nM) .

HY-14539

Clozapine 5+ Cited Publications HF 1854	Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor	Neurological Disease Cancer
Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine inhibits the **muscarinic M1 receptor** and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the **muscarinic M4 receptor (EC₅₀**=11 nM) .

HY-14539A

Clozapine hydrochloride HF 1854 hydrochloride	Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor	Neurological Disease
Clozapine hydrochloride (HF 1854 hydrochloride) is an antipsychotic used for the research of schizophrenia. Clozapine hydrochloride has high affinity for a number of neuroreceptors. Clozapine hydrochloride is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine hydrochloride inhibits the **muscarinic M1 receptor** and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively . Clozapine hydrochloride is also a potent and selective agonist at the **muscarinic M4 receptor (EC₅₀**=11 nM) .

HY-W748582

Clozapine N-oxide-d8	Isotope-Labeled Compounds Dopamine Receptor mAChR Drug Metabolite	Neurological Disease
Clozapine N-oxide-d₈ is the deuterium labeled Clozapine N-oxide (HY-17366). Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

HY-13410

Xanomeline oxalate 4 Publications Verification LY246708 oxalate	mAChR	Neurological Disease
Xanomeline oxalate (LY246708 oxalate) is a potent and selective **muscarinic receptor** agonist (SMRA) and stimulates phosphoinositide hydrolysis in vivo. Xanomeline oxalate can be used for the research of Alzheimer’s disease .

HY-B1789

Telenzepine	mAChR	Neurological Disease
Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM) .

HY-106949

Tazomeline	mAChR	Neurological Disease
Tazomeline is a selective M1 muscarinic receptor agonist. Tazomeline inhibits twitch height in rabbit vas deferens(IC₅₀= 0.001 nM). Tazomeline can be used for research of neuropsychiatric disorders .

HY-116586

AF710B	Sigma Receptor	Neurological Disease
AF710B is a highly potent and selective allosteric M1 muscarinic and σ1 receptor agonist. AF710B can be used for the research of Alzheimer’s disease .

HY-101078A

(±)-Epibatidine dihydrochloride CMI 545 dihydrochloride	Dopamine Receptor	Neurological Disease
(±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. (±)-Epibatidine (CMI 545) dihydrochloride is an alkaloid originally characterized from frog skin. (±)-Epibatidine (CMI 545) dihydrochloride have little or no activity at a variety of other central receptors, including opioid receptors, muscarinic receptors, adrenergic receptors, dopamine receptors, serotonin receptors, and gamma-aminobutyric acid receptors .

HY-148525

PF-4348235 β2AR/M-receptor agonist-2	mAChR Adrenergic Receptor	Cardiovascular Disease Inflammation/Immunology
β2AR/M-receptor agonist-2 (compound 15) is a *muscarinic* antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC₅₀ value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a K_i value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD) .

HY-107654S

Muscarine-d9 iodide (+)-Muscarine-d₉ iodide	Isotope-Labeled Compounds mAChR	Neurological Disease
Muscarine-d₉ (iodide) is the deuterium labeled Muscarine iodide. Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist .

HY-12980

Batefenterol GSK961081; TD-5959	Adrenergic Receptor mAChR	Inflammation/Immunology Endocrinology
Batefenterol (GSK961081;TD-5959) is a novel *muscarinic* receptor antagonist and β₂-adrenoceptor agonist; displays high affinity for hM2, hM3 muscarinic and hβ₂-adrenoceptor with K_i values of 1.4, 1.3 and 3.7 nM, respectively.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0726

Pilocarpine Hydrochloride Maximum Cited Publications 37 Publications Verification	Alkaloids other families Other Alkaloids Source classification Plants	mAChR
Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B1006

Pilocarpine nitrate Maximum Cited Publications 37 Publications Verification	Alkaloids other families Other Alkaloids Source classification Plants	mAChR
Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-N5016

Guvacoline hydrochloride	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Plants Palmae Areca triandra Roxb. Disease Research Fields	mAChR
Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors .

HY-N2364

Arecoline 3 Publications Verification	Infection Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Areca catechu L. Source classification Metabolic Disease Palmae Plants Inflammation/Immunology Disease Research Fields	mAChR nAChR
Arecoline, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and **muscarinic acetylcholine receptor**. Arecoline exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline also can induce oxidative stress .

HY-B0489

Arecoline hydrobromide 3 Publications Verification methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide	Infection Alkaloids Neurological Disease Classification of Application Fields Areca catechu L. Other Alkaloids Source classification Metabolic Disease Palmae Plants Inflammation/Immunology Disease Research Fields	mAChR nAChR
Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and **muscarinic acetylcholine receptor**. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress .

HY-B0726R

Pilocarpine Hydrochloride (Standard)	Alkaloids other families Other Alkaloids Source classification Plants	Reference Standards mAChR
Pilocarpine (Hydrochloride) (Standard) is the analytical standard of Pilocarpine (Hydrochloride). This product is intended for research and analytical applications. Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B1006R

Pilocarpine nitrate (Standard)	Alkaloids other families Other Alkaloids Source classification Plants	Reference Standards mAChR
Pilocarpine (nitrate) (Standard) is the analytical standard of Pilocarpine (nitrate). This product is intended for research and analytical applications. Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-101078A

(±)-Epibatidine dihydrochloride CMI 545 dihydrochloride	Alkaloids Animals Source classification Pyridine Alkaloids	Dopamine Receptor
(±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. (±)-Epibatidine (CMI 545) dihydrochloride is an alkaloid originally characterized from frog skin. (±)-Epibatidine (CMI 545) dihydrochloride have little or no activity at a variety of other central receptors, including opioid receptors, muscarinic receptors, adrenergic receptors, dopamine receptors, serotonin receptors, and gamma-aminobutyric acid receptors .

HY-B0489A

Arecoline hydrochloride	Infection Alkaloids Neurological Disease Classification of Application Fields Areca catechu L. Other Alkaloids Source classification Metabolic Disease Palmae Plants Inflammation/Immunology Disease Research Fields	mAChR nAChR
Arecoline hydrochloride, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and **muscarinic acetylcholine receptor**. Arecoline hydrochloride exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrochloride also can induce oxidative stress .

HY-B0489R

Arecoline hydrobromide (Standard) methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide (Standard)	Alkaloids Areca catechu L. Other Alkaloids Source classification Palmae Plants	Reference Standards mAChR nAChR
Arecoline (hydrobromide) (Standard) is the analytical standard of Arecoline (hydrobromide). This product is intended for research and analytical applications. Arecoline hydrobromide, a naturally occurring psychoactive alkaloid, is a partial agonist of nicotinic and muscarinic acetylcholine receptor. Arecoline hydrobromide exhibits stimulation, alertness, anxiolysis and anti-parasitic effects. Arecoline hydrobromide also can induce oxidative stress .

HY-N4157

Isopteropodine	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Source classification Rubiaceae Plants	mAChR 5-HT Receptor Bacterial
Isopteropodine is a positive modulator that selectively acts on muscarinic M₁ and 5-HT₂ receptors. Isopteropodine has an EC₅₀ of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .

HY-N4157R

Isopteropodine (Standard)	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Iridoids Terpenoids Source classification Rubiaceae Plants	Reference Standards mAChR 5-HT Receptor Bacterial
Isopteropodine (Standard) is the analytical standard of Isopteropodine (HY-N4157). This product is intended for research and analytical applications. Isopteropodine is a positive modulator that selectively acts on muscarinic M₁ and 5-HT₂ receptors. Isopteropodine has an EC₅₀ of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research .

Cat. No.	Product Name	Chemical Structure

HY-B0527AS

Amitriptyline-d6 hydrochloride

Amitriptyline-d₆ hydrochloride is the deuterium labeled Amitriptyline hydrochloride (HY-B0527A). Amitriptyline hydrochloride is an orally active tricyclic antidepressant (TCA). Amitriptyline hydrochloride mainly exerts its antidepressant effect by blocking SERT (K_i = 3.45 nM) and NET (K_i = 13.3 nM), thereby increasing the concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in the synaptic cleft. Amitriptyline hydrochloride is also an agonist at α2A and TrkA/TrkB receptors, thereby exerting analgesic and neurotrophic activities (inhibiting cell apoptosis). Amitriptyline hydrochloride can reduce inflammation, angiogenesis and fibrosis. Amitriptyline hydrochloride binds to DAT (with K_i = 2.58 μM). Amitriptyline hydrochloride has high affinity for a series of receptors and can antagonize muscarinic cholinergic receptors (M1/M2/M3/M4/M5 receptors) (K_i = 11-24 nM), H1 receptors (K_i = 0.5-1.1 nM), adrenergic α1 receptors (K_i = 4.4 nM), etc., resulting in a series of side effects. Amitriptyline hydrochloride can block sodium channels and hERG potassium channel (IC₅₀ = 4.78 μM) and it has cardiotoxicity.

HY-B0726S

Pilocarpine-d3 hydrochloride
Pilocarpine-d₃ (hydrochloride) is deuterium labeled Pilocarpine (Hydrochloride). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-B0726S1

Pilocarpine-d5 hydrochloride
Pilocarpine-d₅ hydrochloride is deuterated labeled Pilocarpine hydrochloride (HY-B0726). Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.

HY-W748582

Clozapine N-oxide-d8

Clozapine N-oxide-d₈ is the deuterium labeled Clozapine N-oxide (HY-17366). Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

HY-107654S

Muscarine-d9 iodide
Muscarine-d₉ (iodide) is the deuterium labeled Muscarine iodide. Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist .

HY-14539S3

Clozapine-d3

Clozapine-d₃ (HF 1854-d₃) is deuterium labeled Clozapine. Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a K_i of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with K_is of 9.5 nM and 4 nM, respectively . Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC₅₀=11 nM) .

HY-105182S1

Xanomeline-d3
Xanomeline-d₃ (LY-246708-d₃) is deuterium labeled Xanomeline. Xanomeline, as an effective and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist, increases neuronal excitability. Xanomeline can be used for the research of neurological disorders, such as schizophrenia .

Cat. No.	Product Name		Classification

HY-134061

Arecaidine propargyl ester hydrobromide		Alkynes
Arecaidine propargyl ester hydrobromide is an agonist of M2 muscarinic acetylcholine receptors and has the activity of inhibiting tumor cell proliferation. The application of arecaidine propargyl ester hydrobromide has shown that it can reduce the number of ovarian cancer cells in vitro and induce apoptosis and the production of reactive oxygen species (ROS) at specific concentrations. Arecaidine propargyl ester hydrobromide can also arrest cells at the G2/M phase of the cell cycle and increase the percentage of abnormal mitosis. Arecaidine propargyl ester hydrobromide is more sensitizing to ovarian surface epithelial cells with higher M2 receptor levels than to cancer cells. Arecaidine propargyl ester hydrobromide exhibits the effect of lowering arterial blood pressure when interacting with the cardiovascular system in a natural physiological state, indicating its potential pharmacological application .

HY-120329

Lu 26-046		Alkynes
Lu 26-046 is the agonist for **muscarinic M1 receptor** and M2 receptor and a weak antagonist for M3 receptor, with K_i of 0.51, 26 and 5 nM, respectively. Lu 26-046 exhibits specific stimulus property, that can be recognized by rats .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks