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Results for "

MuRF1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Inhibitory Antibodies

2

Natural
Products

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129531
    MuRF1-IN-1

    		E1/E2/E3 Enzyme Neurological Disease
    MuRF1-IN-1 is an orally active MuRF1 inhibitor. MuRF1-IN-1 can inhibit the interaction between MuRF1 and titin as well as E3 ligase activity. MuRF1-IN-1 can alleviate skeletal muscle atrophy and dysfunction in cardiac cachexia [1].
    MuRF1-IN-1
  • HY-W184800
    MuRF1-IN-2

    		Bacterial E1/E2/E3 Enzyme Inflammation/Immunology
    MuRF1-IN-2 (Example 3) is a MuRF1 inhibitor. MuRF1-IN-2 can be used for research of muscle wasting conditions, of skeletal or cardial muscle atrophy [1].
    MuRF1-IN-2
  • HY-164027
    MyoMed 205

    		Proteasome Others
    MyoMed-205 is an inhibitor targeting the activity of MuRF1. MyoMed-205 prevents early diaphragmatic systolic dysfunction and atrophy due to unilateral diaphragmatic nerve denervation 12 hours later. MyoMed-205 reduces ubiquitination and subsequent proteasomal degradation of muscle proteins by inhibiting MuRF1 activity. MyoMed-205 increases levels of a protein that phosphorylates Akt (ser473), an important signaling molecule for muscle growth and maintenance. MyoMed-205 can be used to study and treat diaphragmatic dysfunction and atrophy (DIDD) caused by early apraxia, especially in clinical situations such as diaphragmatic paralysis or mechanical ventilation [1].
    MyoMed 205
  • HY-P990165
    Anti-Mouse RANKL/CD254 Antibody (IK22/5)

    		RANKL/RANK E1/E2/E3 Enzyme NF-κB Inflammation/Immunology Cancer
    Anti-Mouse RANKL/CD254 Antibody (IK22/5) is an anti-mouse RANKL/CD254 IgG2a monoclonal antibody. Anti-Mouse RANKL/CD254 Antibody (IK22/5) inhibits osteoclast formation and activity by specifically blocking the binding of RANKL and RANK. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can inhibit the expression of MuRF1/Trogin-1 and activation of NF-κB. Anti-Mouse RANKL/CD254 Antibody (IK22/5) can be used for research on cancer such as melanoma or colon cancer and osteoporosis [1] .
    Anti-Mouse RANKL/CD254 Antibody (IK22/5)
  • HY-N0677
    Dehydroandrographolide succinate

    		Influenza Virus Prostaglandin Receptor Akt GSK-3 Infection Inflammation/Immunology Cancer
    Dehydroandrographolide succinate can be extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used in research for viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect. Dehydroandrographolide succinate exerts antithrombotic effect. Dehydroandrographolide succinate significantly inhibits the platelet aggregation rate (ED50 = 386.9 mg/kg) by decreasing TXB2 levels. Dehydroandrographolide succinate mitigates muscle astrophy via the Akt/GSK3β and MuRF-1 pathways [1] .
    Dehydroandrographolide succinate
  • HY-156661
    MurF-IN-1

    		E1/E2/E3 Enzyme Infection
    MurF-IN-1 (Compound 7) is a MurF inhibitor with an pIC50 of 5.19 against S. pneumoniae MurF .
    MurF-IN-1
  • HY-108943
    Sabinene
    2 Publications Verification

    		 p38 MAPK Others
    Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways [1] .
    Sabinene
  • HY-RS15063
    TRIM63 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TRIM63 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM63 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TRIM63 Human Pre-designed siRNA Set A
    TRIM63 Human Pre-designed siRNA Set A

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