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Results for "

LFA-1

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

7

Inhibitory Antibodies

1

Natural
Products

3

Isotope-Labeled Compounds

6

Antibodies

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-120628
    BMS-587101

    		Integrin Inflammation/Immunology
    BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research [1] .
    BMS-587101
  • HY-139202
    XVA143

    		Integrin Inflammation/Immunology
    XVA143, an α/β I-like allosteric antagonist, inhibits LFA-1 dependent firm adhesion, while at the same time it enhances adhesion in shear flow and rolling both in vitro and in vivo [1].
    XVA143
  • HY-110117
    BIRT 377
    4 Publications Verification

    		 Integrin Interleukin Related Inflammation/Immunology
    BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders [1].
    BIRT 377
  • HY-P990288
    Anti-Mouse CD18 Antibody (M18/2)

    		Integrin Transmembrane Glycoprotein Inflammation/Immunology
    Anti-Mouse CD18 Antibody (M18/2) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD18. Anti-Mouse CD18 Antibody (M18/2) can neutralize lymphocyte function-associated antigen 1 (LFA-1). Anti-Mouse CD18 Antibody (M18/2) can be used for the researches of immunology, such as heart transplantation [1] .
    Anti-Mouse CD18 Antibody (M18/2)
  • HY-19344
    Lifitegrast
    Maximum Cited Publications
    10 Publications Verification

    SAR 1118; SHP-606

    		 Integrin Inflammation/Immunology
    Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease [1].
    Lifitegrast
  • HY-19344A
    Lifitegrast sodium
    Maximum Cited Publications
    10 Publications Verification

    SAR 1118 sodium; SHP-606 sodium

    		 Integrin Inflammation/Immunology
    Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease [1].
    Lifitegrast sodium
  • HY-107587
    A-286982
    2 Publications Verification

    		 Integrin Inflammation/Immunology
    A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively [1] .
    A-286982
  • HY-124040
    BI-1950

    		Integrin Inflammation/Immunology
    BI-1950, a chemical probe, is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor. LFA-1 is an essential component in normal immune system function and a target for agent discovery [1].
    BI-1950
  • HY-122192
    ICAM-1988

    		Integrin Inflammation/Immunology
    ICAM-1988 is a small molecule lymphocyte function-associated antigen-1 (LFA-1) antagonist that disrupts the LFA-1/ICAM-1 interaction and has anti-inflammatory activity [1].
    ICAM-1988
  • HY-19344R
    Lifitegrast (Standard)

    SAR 1118 (Standard); SHP-606 (Standard)

    		 Reference Standards Integrin Inflammation/Immunology
    Lifitegrast (Standard) is the analytical standard of Lifitegrast. This product is intended for research and analytical applications. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease [1].
    Lifitegrast (Standard)
  • HY-P990857
    Anti-CD54/ICAM-1 Antibody (R6-5-D6)

    		Integrin Inflammation/Immunology
    Anti-CD54/ICAM-1 Antibody (R6-5-D6) is a kind of mouse IgG2a chimeric antibody inhibitor, targeting to human CD54/ICAM-1. Anti-CD54/ICAM-1 Antibody (R6-5-D6) can block CD54 binding to its ligand Lymphocyte Function-Associated Antigen 1 (LFA-1). Anti-CD54/ICAM-1 Antibody (R6-5-D6) can be used for the researches of inflammation and immunology [1] .
    Anti-CD54/ICAM-1 Antibody (R6-5-D6)
  • HY-P9947
    Efalizumab
    1 Publications Verification

    		 Integrin Others
    Efalizumab is a targeted T cell modulator, and is a humanized monoclonal antibody of CD11a, the α subunit of LFA-1. Efalizumab inhibits T cell activation, cutaneous T cell trafficking, and T cell adhesion to keratinocytes, can be used for plaque psoriasis research [1].
    Efalizumab
  • HY-P990871
    Anti-CD11a/LFA-1α Antibody (R7-1)

    		Integrin Inflammation/Immunology
    Anti-CD11a/LFA-1α Antibody (R7-1) is a kind of mouse IgG1 chimeric antibody inhibitor, targeting to human CD11a/LFA-1α. Anti-CD11a/LFA-1α Antibody (R7-1) can neutralize LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. Anti-CD11a/LFA-1α Antibody (R7-1) can be used for the research of inflammation [1].
    Anti-CD11a/LFA-1α Antibody (R7-1)
  • HY-19151
    Fuzapladib

    IS-741

    		 Integrin Phospholipase Inflammation/Immunology
    Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site [1] .
    Fuzapladib
  • HY-19151A
    Fuzapladib sodium

    IS-741 sodium

    		 Integrin Phospholipase Inflammation/Immunology
    Fuzapladib (IS-741) sodium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib sodium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib sodium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site [1] .
    Fuzapladib sodium
  • HY-19151B
    Fuzapladib potassium

    IS-741 potassium

    		 Integrin Phospholipase Inflammation/Immunology
    Fuzapladib (IS-741) potassium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib potassium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib potassium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site [1] .
    Fuzapladib potassium
  • HY-19151C
    Fuzapladib calcium

    IS-741 calcium

    		 Integrin Phospholipase Inflammation/Immunology
    Fuzapladib calcium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib calcium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib calcium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site [1] .
    Fuzapladib calcium
  • HY-P990835
    Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13)

    		Integrin Infection Inflammation/Immunology
    Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) is a kind of mouse IgG1 chimeric antibody inhibitor, targeting to human LFA-1α/CD11a. Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) reacts with human LFA-1α (lymphocyte function-associated antigen 1 alpha) also known as integrin alpha L chain and CD11a. Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13) can be used for the researches of immunology and infection, such as human immunodeficiency virus (HIV) [1] .
    Anti-LFA-1α/CD11a Antibody (TS-1/22.1.1.13)
  • HY-P990801
    Anti-Mouse CD11a/LFA-1α Antibody (M17/4)

    		Integrin Parasite Bacterial Infection Neurological Disease Inflammation/Immunology Cancer
    Anti-Mouse CD11a/LFA-1α Antibody (M17/4) is an anti-mouse CD11a/LFA-1α IgG2a monoclonal antibody. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can reduce the recruitment of effector memory CD8 T cells. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) promotes the formation of xenograft tumors by reducing immune rejection reactions. Anti-Mouse CD11a/LFA-1α Antibody (M17/4) can be used for researches on cancer, infection conditions and immunology such as glioblastoma, parasitic and bacterial infections. The recommend isotype control of Anti-Mouse CD11a/LFA-1α Antibody (M17/4): Rat IgG2a kappa, Isotype Control (HY-P990679) [1] .
    Anti-Mouse CD11a/LFA-1α Antibody (M17/4)
  • HY-19344S2
    Lifitegrast-d4-1

    		Isotope-Labeled Compounds Integrin Inflammation/Immunology
    Lifitegrast-d4-1 is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease [1] .
    Lifitegrast-d4-1
  • HY-19344S1
    Lifitegrast-d6

    SAR 1118-d6; SHP-606-d6

    		 Isotope-Labeled Compounds Inflammation/Immunology
    Lifitegrast-d6 (SAR 1118-d6) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease [1] .
    Lifitegrast-d6
  • HY-19344S
    Lifitegrast-d4

    SAR 1118-d4; SHP-606-d4

    		 Isotope-Labeled Compounds Inflammation/Immunology
    Lifitegrast-d4 (SAR 1118-d4) is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease [1] .
    Lifitegrast-d4
  • HY-N14915
    Adxanthromycin A

    		Integrin Cancer
    Adxanthromycin A, a microbial metabolite, is a ICAM-1/LFA-1 mediated cell adhesion inhibitor [1].
    Adxanthromycin A
  • HY-110086
    RWJ 50271

    		Integrin Inflammation/Immunology
    RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion [1].
    RWJ 50271
  • HY-10596
    BMS-688521
    1 Publications Verification

    		 Integrin Inflammation/Immunology
    BMS-688521 is a highly potent, orally active inhibitor of the LFA-1/ICAM interaction, with an IC50 of 2.5 nM in the adhesion assay and an IC50 of 60 nM in the MLR assay. BMS-688521 is efficacious in a mouse allergic eosinophilic lung inflammation model [1].
    BMS-688521
  • HY-RS26938
    Itgal Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Itgal Rat Pre-designed siRNA Set A contains three designed siRNAs for Itgal gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Itgal Rat Pre-designed siRNA Set A
    Itgal Rat Pre-designed siRNA Set A
  • HY-P99120
    Anti-Mouse CD11a Antibody (FD441.8)

    		Integrin Inflammation/Immunology Cancer
    Anti-Mouse CD11a Antibody (FD441.8) is an anti-mouse CD11a IgG2b antibody inhibitor derived from the host Rat. Anti-Mouse CD11a Antibody (FD441.8) can neutralize CD11a also known as LFA-1α (lymphocyte function-associated antigen 1 alpha). Anti-Mouse CD11a Antibody (FD441.8) can be used for the researches of inflammation, immunology and cancer, such as transplant and leukemia [1] .
    Anti-Mouse CD11a Antibody (FD441.8)
  • HY-RS06959
    ITGAL Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ITGAL Human Pre-designed siRNA Set A contains three designed siRNAs for ITGAL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ITGAL Human Pre-designed siRNA Set A
    ITGAL Human Pre-designed siRNA Set A
  • HY-RS20429
    Itgal Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Itgal Mouse Pre-designed siRNA Set A contains three designed siRNAs for Itgal gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Itgal Mouse Pre-designed siRNA Set A
    Itgal Mouse Pre-designed siRNA Set A
  • HY-RS16847
    Itgb2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Itgb2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Itgb2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Itgb2 Mouse Pre-designed siRNA Set A
    Itgb2 Mouse Pre-designed siRNA Set A
  • HY-RS06965
    ITGB2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ITGB2 Human Pre-designed siRNA Set A contains three designed siRNAs for ITGB2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ITGB2 Human Pre-designed siRNA Set A
    ITGB2 Human Pre-designed siRNA Set A

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