Search Result

Isoforms Recommended:	IL-23

Results for "

IL23

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aryl Hydrocarbon Receptor (1) CD22 (1) CXCR (1) Cytochrome P450 (1) Epigenetic Reader Domain (1) G Protein-coupled Receptor Kinase (GRK) (1) IFNAR (6) Integrin (1) Interleukin Related (34) IRAK (4) JAK (6) mRNA (2) NOD-like Receptor (NLR) (1) Phosphodiesterase (PDE) (2) PIKfyve (3) ROR (3) Salt-inducible Kinase (SIK) (1) Small Interfering RNA (siRNA) (7) STAT (4) TNF Receptor (3)
By Research Areas:	Cancer (6) Infection (1) Inflammation/Immunology (41) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) mRNA (2) Human Pre-designed siRNA Sets (3) siRNAs (7)

Inhibitors & Agonists

Screening Libraries

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10723

IL-23R inhibitor peptide-1	Interleukin Related	Inflammation/Immunology
IL-23R inhibitor peptide-1 (comp 475) is an interleukin-23 receptor inhibitor, with an IC₅₀ of 0.0069 μM .

HY-P990217

*Anti-Mouse IL-23* p19 Antibody (G23-8)**	Interleukin Related	Inflammation/Immunology
Anti-Mouse IL-23 p19 Antibody (G23-8) is a rat-derived anti-mouse IL-23 p19 IgG1 monoclonal antibody. Anti-Mouse IL-23 p19 Antibody (G23-8) alleviates inflammation by restoring CLDN8 expression. Anti-Mouse IL-23 p19 Antibody (G23-8) can be used for research on inflammation conditions such as colitis and asthma .

HY-P11039

IL-23 cyclic peptide inhibitor 281	Interleukin Related	Inflammation/Immunology
IL-23 cyclic peptide inhibitor 281, a cyclic peptide, is an *IL-23* inhibitor. IL-23 cyclic peptide inhibitor 281 can be used for inflammatory disorders like inflammatory bowel disease (IBD) research .

HY-P11038

IL-23 cyclic peptide inhibitor 105	Interleukin Related	Inflammation/Immunology
IL-23 cyclic peptide inhibitor 105, a cyclic peptide, is an *IL-23* inhibitor. IL-23 cyclic peptide inhibitor 105 can be used for inflammatory disorders like inflammatory bowel disease (IBD) research .

HY-RS06740

Il23a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il23a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il23a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il23a Mouse Pre-designed siRNA Set A Il23a Mouse Pre-designed siRNA Set A

HY-RS06739

IL23A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
IL23A Human Pre-designed siRNA Set A contains three designed siRNAs for IL23A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL23A Human Pre-designed siRNA Set A IL23A Human Pre-designed siRNA Set A

HY-RS06741

Il23a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il23a Rat Pre-designed siRNA Set A contains three designed siRNAs for Il23a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il23a Rat Pre-designed siRNA Set A Il23a Rat Pre-designed siRNA Set A

HY-RS06742

IL23R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL23R Human Pre-designed siRNA Set A contains three designed siRNAs for IL23R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL23R Human Pre-designed siRNA Set A IL23R Human Pre-designed siRNA Set A

HY-RS16795

Il23r Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il23r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il23r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il23r Mouse Pre-designed siRNA Set A Il23r Mouse Pre-designed siRNA Set A

HY-RS23236

Il23r Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il23r Rat Pre-designed siRNA Set A contains three designed siRNAs for Il23r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il23r Rat Pre-designed siRNA Set A Il23r Rat Pre-designed siRNA Set A

HY-P99256

Tildrakizumab SCH 900222; MK 3222; Anti-Human IL23 Recombinant Antibody	Interleukin Related	Inflammation/Immunology Cancer
Tildrakizumab (SCH 900222) is a humanized anti-IL-23 (p19 subunit) monoclonal antibody. IL-23 is a critical cytokine to maintain the Th17 cell phenotype. Tildrakizumab has high-affinity for single-chain IL-23 (K_d: 136 pM). Tildrakizumab is effective against moderate to severe plaque psoriasis .

HY-174617

*Human IL23A mRNA*	mRNA	Inflammation/Immunology
Human IL23A mRNA encodes the human interleukin 23A (IL23A) protein, a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23A associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.

HY-174616

*Human IL23R mRNA*	mRNA	Inflammation/Immunology
Human IL23R mRNA encodes the human interleukin 23 receptor (IL23R) protein, a subunit of the receptor for IL23A/IL23. IL23R pairs with the receptor molecule IL12RB1/IL12R beta1, and both are required for IL23A signaling.

HY-P99737

Mirikizumab LY3074828	Interleukin Related	Inflammation/Immunology
Mirikizumab (LY3074828) is a humanized IgG4 monoclonal antibody that targets the p19 subunit of interleukin 23 (IL-23). Mirikizumab binds to human and monkey *IL-23* with high affinity, with K_d values of 21 pM and 55 pM, respectively. By inhibiting the binding of *IL-23* to *IL-23R*, Mirikizumab modulates the immune response and holds potential for research in ulcerative colitis and Crohn's disease .

HY-P99485

Brazikumab AMG 139; MEDI2070	Interleukin Related	Inflammation/Immunology
Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of *IL-23, with a K_D* of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease .

HY-P9931

Guselkumab CNTO 1959	Interleukin Related	Inflammation/Immunology
Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab binds to human and cynomolgus monkey IL-23 with K_d values of 3.3 and 1.9 pmol/L, respectively. Guselkumab inhibits production of cytokines lying downstream of the IL-23 signaling pathway and can be used for psoriatic arthritis research .

HY-P99248

Risankizumab Risankizumab rzaa; BI 655066; ABBV-066	Interleukin Related	Inflammation/Immunology
Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting *IL-23* p19 subunit (K_d <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC₅₀ = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis .

HY-P991275

CNTO4088	Interleukin Related	Inflammation/Immunology
CNTO4088 is a monoclonal antibody inhibitor targeting interleukin-23 (IL-23). CNTO4088 is promising for research of autoimmune diseases such as psoriasis and rheumatoid arthritis .

HY-P991276

FM-303	Interleukin Related	Inflammation/Immunology
FM-303 is a monoclonal antibody inhibitor targeting interleukin-23 (IL-23). FM-303 is promising for research of immune system diseases and diseases of digestive system .

HY-150732

IRAK4-IN-18	IRAK	Inflammation/Immunology
IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease .

HY-150733

IRAK4-IN-19	IRAK	Inflammation/Immunology
IRAK4-IN-19 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC₅₀ value of 4.3 nM. IRAK4-IN-19 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-19 can be used for researching arthritis disease .

HY-P991277

QX-004N HS-20137	Interleukin Related	Inflammation/Immunology
QX-004N (HS-20137) is a monoclonal antibody inhibitor targeting the p19 subunit of interleukin-23 (IL-23). QX-004N is promising for research of immune system diseases and diseases of digestive system .

HY-163314S

Tyk2-IN-18-d3	JAK Interleukin Related IFNAR	Inflammation/Immunology
Tyk2-IN-18-d3 (Compound 18) is a Tyk2 inhibitor with an IC₅₀ value of < 30 nM for both *IL-23* and IFNα. Tyk2-IN-18-d3 can be used for research on autoimmune diseases .

HY-P99486

Briakinumab ABT-874	Interleukin Related	Inflammation/Immunology
Briakinumab (ABT-874) is a fully human anti-IL-12/23p40 monoclonal antibody. Briakinumab targets and neutralizes IL-12 and IL-23. Briakinumab can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis .

HY-P991274

BMS-986010	Interleukin Related	Inflammation/Immunology
BMS-986010 is a monoclonal antibody inhibitor targeting the p19 subunit of interleukin-23 (IL-23). BMS-986010 reduces IL-23-induced STAT3 phosphorylation and inhibits Th17 cell differentiation and the release of proinflammatory cytokines (such as IL-17 and TNF-α). BMS-986010 is promising for research of autoimmune diseases such as psoriasis and Crohn's disease .

HY-130243

RORγt Inverse agonist 6	ROR	Inflammation/Immunology
RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo .

HY-P10587

Icotrokinra JNJ-77242113; JNJ-2113; PN-235	Interleukin Related STAT	Inflammation/Immunology
Icotrokinra (JNJ-77242113) is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC₅₀=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC₅₀ of 18.4 pM. In addition, Icotrokinra exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease .

HY-151363

IRAK4-IN-21	IRAK	Inflammation/Immunology
IRAK4-IN-21 (compound 17) is an orally active, potent and selective IRAK4 inhibitor with IC₅₀ values of 5 and 56 nM for IRAK4 and TAK1, respectively. IRAK4-IN-21 effectively inhibits IL-23 production (IC₅₀=0.17 μM) and can be used in studies of autoimmune diseases such as plaque psoriasis and psoriatic arthritis .

HY-151365

IRAK4-IN-22	IRAK	Inflammation/Immunology
IRAK4-IN-22 (compound 18) is an orally active, potent and selective IRAK4 inhibitor with IC₅₀ values of 3 and 17 nM for IRAK4 and TAK1, respectively. IRAK4-IN-21 effectively inhibits IL-23 production (IC₅₀=0.10 µM) and can be used in studies of autoimmune diseases such as plaque psoriasis and psoriatic arthritis .

HY-P990781

Suciraslimab SM03	CD22 NOD-like Receptor (NLR) Interleukin Related Integrin	Neurological Disease Inflammation/Immunology
Suciraslimab (SM03) is an anti-human CD22 monoclonal antibody. Suciraslimab inhibits NLRP3 and ASC signaling. Suciraslimab suppresses cytokine (IL-1β, IL-12, *IL-23) secretion and α4 integrin* expression. Suciraslimab improves working memory and neuroinflammation . Suciraslimab isotype control product: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-126252

A-9758	ROR Interleukin Related	Inflammation/Immunology
A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC₅₀=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation .

HY-117287A

Deucravacitinib hydrochloride BMS-986165 hydrochloride	Interleukin Related JAK IFNAR	Inflammation/Immunology
Deucravacitinib hydrochloride (BMS-986165 hydrochloride) is a highly selective all-site inhibitor with potent inhibitory activity against TYK2. Deucravacitinib hydrochloride can effectively block IL-12, IL-23 and type I interferon signaling. Deucravacitinib hydrochloride demonstrates significant efficacy in preclinical models of inflammatory bowel disease. Deucravacitinib hydrochloride demonstrated superiority over placebo and apremilast on multiple efficacy endpoints in moderate to severe plaque psoriasis. Deucravacitinib hydrochloride was well tolerated in inhibition .

HY-101762

TyK2-IN-2	JAK Phosphodiesterase (PDE)	Inflammation/Immunology
TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC₅₀s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, *IL-23* and IFNα, respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC₅₀ of 62 nM. TyK2-IN-2 can be used for the research of inflammatory and autoimmune diseases .

HY-126242S

Tyk2-IN-7	JAK IFNAR Interleukin Related	Inflammation/Immunology
Tyk2-IN-7 is an orally active TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC₅₀ and K_i.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 can inhibit the *IL-23* and IFN-α signaling pathways. Tyk2-IN-7 is commonly used in the study of inflammatory conditions such as colitis .

HY-155830

Morcamilast ME3183; PDE4-IN-14	Phosphodiesterase (PDE) Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Morcamilast (ME3183) is a selective and orally active PDE4 inhibitor, with IC₅₀s of 1.28 nM (PDE4A1A), 2.33 nM (PDE4B1), and 1.63 nM (PDE4D2) respectively. Morcamilast shows weak inhibition of PDEs other than PDE4s Morcamilast is an anti-inflammatory agent and inhibits LPS (HY-D1056)-induced release of TNF-α, *IL-12/23p40, IL-23, and IL-17A* in human PBMCs and T cells. Morcamilast has antipruritic effect and can be used in the study of psoriasis, atopic dermatitis, and other inflammatory diseases .

HY-168971

Paeoniflorin-6′-O-benzene sulfonate CP-25	IFNAR STAT TNF Receptor Interleukin Related CXCR JAK G Protein-coupled Receptor Kinase (GRK)	Inflammation/Immunology
Paeoniflorin-6′-O-benzene sulfonate (CP-25) is the inhibitor for G protein-coupled receptor kinase 2 (GRK2) that inhibits the translocation of GRK2 to the cell membrane, inhibits JAK1/STAT3 signaling pathway. Paeoniflorin-6′-O-benzene sulfonate inhibits IL-17A/CXCL2-induced proliferation of HaCaT. Paeoniflorin-6′-O-benzene sulfonate reduces the levels of inflammatory factors and chemokines such as IL-17A, IL-17F, IFN-γ, TNF-α, IL-22, IL-23, CXCL2, CXCL3 and CXCL9, alleviates Imiquimod (HY-B0180)-induced psoriasis in mouse model .

HY-171591

SIK2-IN-4	Salt-inducible Kinase (SIK) Interleukin Related TNF Receptor	Infection
SIK2-IN-4 (Compound 4) is a highly selective SIK1/2 inhibitor (IC_50s 0.143 and 0.076 μM, respectively). SIK2-IN-4 reduces the phosphorylation of transcription coactivator 3 (CRTC3) by targeting SIK1/2, thereby regulating cAMP response element binding protein (CREB)-dependent transcriptional activity. SIK2-IN-4 inhibits the production of pro-inflammatory cytokines such as TNF (IC₅₀: 0.11 µM), IL-12/23 p40 (IC₅₀: 0.25 µM), and IL-23 (IC₅₀: 0.47 µM), while inducing the expression of the anti-inflammatory cytokine IL-10. SIK2-IN-4 can be used to study intestinal inflammation and other chronic inflammatory diseases .

HY-156466

QL-1200186	STAT Interleukin Related IFNAR	Inflammation/Immunology
QL-1200186 is a selective, orally active, allosteric inhibitor targeting the tyrosine kinase TYK2 pseudokinase domain JH2 (IC₅₀=0.06 nM, TYK2 JH2), with 164-fold selectivity over TYK1 JH2 (IC₅₀=9.85 nM，TYK1 JH2). QL-1200186 first stabilizes the TYK2 JH2 conformation, inhibits the activity of the JH1 catalytic domain, and blocks the IFNα, *IL-12/IL-23*-mediated JAK-STAT signaling pathway. QL-1200186 can inhibit the production of Th1/Th17 cell-related cytokines (such as IFNγ, *IL-23*), reduce immune cell activation, and has no significant effect on JAK1/2/3 kinase activity. QL-1200186 can significantly improve skin inflammation in the Imiquimod (HY-B0180)-induced psoriasis mouse model and reduce the Psoriasis Area and Severity Index (PASI) score. QL-1200186 can be used in the study of autoimmune diseases such as psoriasis and systemic lupus erythematosus (SLE) .

HY-P9909

Ustekinumab 3 Publications Verification CNTO-1275; L04AC05; TT-20	Interleukin Related	Inflammation/Immunology Cancer
Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

HY-P990057

Picankibart	Interleukin Related	Cancer
Picankibart is a human-derived IgG1κ antibody targeting *IL23A*.

HY-14644A

Apilimod mesylate Maximum Cited Publications 36 Publications Verification STA 5326 mesylate; LAM-002A; AIT-101 mesylate	Interleukin Related PIKfyve	Inflammation/Immunology Cancer
Apilimod (STA 5326) mesylate is a potent *IL-12/IL-23* inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

HY-14644

Apilimod Maximum Cited Publications 36 Publications Verification STA 5326; LAM-002A free base; AIT-101	Interleukin Related PIKfyve	Inflammation/Immunology Cancer
Apilimod (STA 5326) is a potent *IL-12/IL-23* inhibitor, and strongly inhibits IL-12 with IC₅₀s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively . Apilimod is a potent and highly selective PIKfyve inhibitor.

HY-15982

APY0201 4 Publications Verification	PIKfyve Interleukin Related	Inflammation/Immunology
APY0201 is a potent PIKfyve inhibitor, which inhibits the conversion of PtdIns3P to PtdIns(3,5)P₂ in the presence of in the presence of [ ³³P]ATP with an IC₅₀ of 5.2 nM. APY0201 also inhibits *IL-12/IL-23* production.

HY-133552

RORγt Inverse agonist 10	ROR	Inflammation/Immunology
RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC₅₀ of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R

HY-P991408

DLX-105	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
DLX-105 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa. DLX-105 reduces skin epidermal thickness and the expression of K16 and Ki67. DLX-105 down-regulates the mRNA levels of IL-17, TNF-α, IL-23p19, IL-12p40, and IFN-γ. DLX-105 can be used in psoriasis research .

HY-131968

BMS-986202	JAK Cytochrome P450	Inflammation/Immunology
BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC₅₀ value of 0.19 nM and a K_i of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC₅₀ value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium .

HY-176535

KB-0118 BBC0115	Epigenetic Reader Domain Interleukin Related STAT	Inflammation/Immunology
KB-0118 (BBC0115) is an orally active BET bromodomain inhibitor. KB-0118 selective binds to BRD2 and BRD4 over BRD3, with K_d values of 36.7 μM for BRD2 BD1 and 47.4 μM for BRD4 BD1. KB-0118 inhibits pro-inflammatory cytokines, including TNF, IL-1β, and *IL-23a* and selectively suppresses Th17 cell differentiation. KB-0118 modulates Th17-driven inflammation occurs through epigenetic suppression of BRD4, confirmed by downregulation of STAT3 and BRD4 target genes. KB-0118 has immunomodulatory effects in inflammatory bowel disease (IBD) model.

HY-N10295

Flavipin	Aryl Hydrocarbon Receptor	Inflammation/Immunology
Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4 ⁺ T cells and CD11b ⁺ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA . Flavipin exhibits the DPPH free radical scavenging ability with IC₅₀ value of 7.2 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 33.8 μM .

HY-RS06763

IL37 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL37 Human Pre-designed siRNA Set A contains three designed siRNAs for IL37 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL37 Human Pre-designed siRNA Set A IL37 Human Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L156

Autoimmune Disease Compound Library

770 compounds

Autoimmune disease is a pathological disease characterized by inflammatory disorders targeting autoantigens. The routine treatment of autoimmune diseases suppresses general immune function to regulate uncontrolled inflammation. The current targeted immunotherapy suppresses the main pro-inflammatory signaling pathways by blocking inflammatory cytokines, cell surface molecules, and intracellular kinases. As key participants in innate immunity, macrophages and dendritic cells (DCs) are crucial for Ag presentation and pro-inflammatory cytokine production, such as TNF and IL-1 β、 IL-6, IL-23, B cell activating factor (BAFF), and the proliferation-inducing ligand (APRIL, also known as TNFSF13A).

MCE designs a unique collection of 770 autoimmune disease-related compounds, covering multiple targets and subtypes, such as TNF Receptor, IFNAR, JAK, Btk, TLR, IL-6, IL-17, IL-23, etc. It is a useful tool for screening autoimmune disease drugs.

Cat. No.	Product Name	Target	Research Area

HY-P10723

IL-23R inhibitor peptide-1	Interleukin Related	Inflammation/Immunology
IL-23R inhibitor peptide-1 (comp 475) is an interleukin-23 receptor inhibitor, with an IC₅₀ of 0.0069 μM .

HY-P10587

Icotrokinra JNJ-77242113; JNJ-2113; PN-235	Interleukin Related STAT	Inflammation/Immunology
Icotrokinra (JNJ-77242113) is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC₅₀=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC₅₀ of 18.4 pM. In addition, Icotrokinra exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease .

HY-P11039

IL-23 cyclic peptide inhibitor 281	Interleukin Related	Inflammation/Immunology
IL-23 cyclic peptide inhibitor 281, a cyclic peptide, is an *IL-23* inhibitor. IL-23 cyclic peptide inhibitor 281 can be used for inflammatory disorders like inflammatory bowel disease (IBD) research .

HY-P11038

IL-23 cyclic peptide inhibitor 105	Interleukin Related	Inflammation/Immunology
IL-23 cyclic peptide inhibitor 105, a cyclic peptide, is an *IL-23* inhibitor. IL-23 cyclic peptide inhibitor 105 can be used for inflammatory disorders like inflammatory bowel disease (IBD) research .

Cat. No.	Product Name	Target	Research Area

HY-P990217

*Anti-Mouse IL-23* p19 Antibody (G23-8)**	Interleukin Related	Inflammation/Immunology
Anti-Mouse IL-23 p19 Antibody (G23-8) is a rat-derived anti-mouse IL-23 p19 IgG1 monoclonal antibody. Anti-Mouse IL-23 p19 Antibody (G23-8) alleviates inflammation by restoring CLDN8 expression. Anti-Mouse IL-23 p19 Antibody (G23-8) can be used for research on inflammation conditions such as colitis and asthma .

HY-P99256

Tildrakizumab SCH 900222; MK 3222; Anti-Human IL23 Recombinant Antibody	Interleukin Related	Inflammation/Immunology Cancer
Tildrakizumab (SCH 900222) is a humanized anti-IL-23 (p19 subunit) monoclonal antibody. IL-23 is a critical cytokine to maintain the Th17 cell phenotype. Tildrakizumab has high-affinity for single-chain IL-23 (K_d: 136 pM). Tildrakizumab is effective against moderate to severe plaque psoriasis .

HY-P99737

Mirikizumab LY3074828	Interleukin Related	Inflammation/Immunology
Mirikizumab (LY3074828) is a humanized IgG4 monoclonal antibody that targets the p19 subunit of interleukin 23 (IL-23). Mirikizumab binds to human and monkey *IL-23* with high affinity, with K_d values of 21 pM and 55 pM, respectively. By inhibiting the binding of *IL-23* to *IL-23R*, Mirikizumab modulates the immune response and holds potential for research in ulcerative colitis and Crohn's disease .

HY-P99485

Brazikumab AMG 139; MEDI2070	Interleukin Related	Inflammation/Immunology
Brazikumab (AMG 139) is a human IgG2 monoclonal antibody, selectively binds the p19 subunit of *IL-23, with a K_D* of 0.138 nM for human IL-23. Brazikumab can be used for the research of Crohn's disease .

HY-P9931

Guselkumab CNTO 1959	Interleukin Related	Inflammation/Immunology
Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab binds to human and cynomolgus monkey IL-23 with K_d values of 3.3 and 1.9 pmol/L, respectively. Guselkumab inhibits production of cytokines lying downstream of the IL-23 signaling pathway and can be used for psoriatic arthritis research .

HY-P99248

Risankizumab Risankizumab rzaa; BI 655066; ABBV-066	Interleukin Related	Inflammation/Immunology
Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting *IL-23* p19 subunit (K_d <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC₅₀ = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis .

HY-P99486

Briakinumab ABT-874	Interleukin Related	Inflammation/Immunology
Briakinumab (ABT-874) is a fully human anti-IL-12/23p40 monoclonal antibody. Briakinumab targets and neutralizes IL-12 and IL-23. Briakinumab can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis .

HY-P991275

CNTO4088	Interleukin Related	Inflammation/Immunology
CNTO4088 is a monoclonal antibody inhibitor targeting interleukin-23 (IL-23). CNTO4088 is promising for research of autoimmune diseases such as psoriasis and rheumatoid arthritis .

HY-P991276

FM-303	Interleukin Related	Inflammation/Immunology
FM-303 is a monoclonal antibody inhibitor targeting interleukin-23 (IL-23). FM-303 is promising for research of immune system diseases and diseases of digestive system .

HY-P991277

QX-004N HS-20137	Interleukin Related	Inflammation/Immunology
QX-004N (HS-20137) is a monoclonal antibody inhibitor targeting the p19 subunit of interleukin-23 (IL-23). QX-004N is promising for research of immune system diseases and diseases of digestive system .

HY-P991274

BMS-986010	Interleukin Related	Inflammation/Immunology
BMS-986010 is a monoclonal antibody inhibitor targeting the p19 subunit of interleukin-23 (IL-23). BMS-986010 reduces IL-23-induced STAT3 phosphorylation and inhibits Th17 cell differentiation and the release of proinflammatory cytokines (such as IL-17 and TNF-α). BMS-986010 is promising for research of autoimmune diseases such as psoriasis and Crohn's disease .

HY-P990616

LY2525623	Inhibitory Antibodies	Inflammation/Immunology
LY2525623 is a humanized antibody expressed in CHO targeting *IL-23*. LY2525623 has a huIgG1 type heavy chain and huκ type light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for LY2525623 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990781

Suciraslimab SM03	CD22 NOD-like Receptor (NLR) Interleukin Related Integrin	Neurological Disease Inflammation/Immunology
Suciraslimab (SM03) is an anti-human CD22 monoclonal antibody. Suciraslimab inhibits NLRP3 and ASC signaling. Suciraslimab suppresses cytokine (IL-1β, IL-12, *IL-23) secretion and α4 integrin* expression. Suciraslimab improves working memory and neuroinflammation . Suciraslimab isotype control product: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P9909

Ustekinumab 3 Publications Verification CNTO-1275; L04AC05; TT-20	Interleukin Related	Inflammation/Immunology Cancer
Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.

HY-P990057

Picankibart	Interleukin Related	Cancer
Picankibart is a human-derived IgG1κ antibody targeting *IL23A*.

HY-P991408

DLX-105	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
DLX-105 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa. DLX-105 reduces skin epidermal thickness and the expression of K16 and Ki67. DLX-105 down-regulates the mRNA levels of IL-17, TNF-α, IL-23p19, IL-12p40, and IFN-γ. DLX-105 can be used in psoriasis research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10295

Flavipin	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Inflammation/Immunology Disease Research Fields	Aryl Hydrocarbon Receptor
Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4 ⁺ T cells and CD11b ⁺ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA . Flavipin exhibits the DPPH free radical scavenging ability with IC₅₀ value of 7.2 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 33.8 μM .

Recombinant Proteins Recommended:

IL-23

Species:	Human (15) Marmoset (1) Rhesus Macaque (1) Rat (5) Mouse (9) Cynomolgus (3) Rabbit (1) Canine (1)
Tag:	His (20) Strep (1) Tag Free (3) Avi (4) Fc (10)
Source:	HEK293 (31) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73193

	IL-23 Protein, Human (HEK293, His) IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. IL-23 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived IL-23 alpha & IL-12 beta, expressed by HEK293 , with C-His labeled tag.

HY-P73195

	IL-23 Protein, Rat (HEK293, His) 1 Publications Verification IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Rat	HEK293
	IL-23 alpha protein has cytokine activity and binds to the interleukin 23 receptor. It regulates cytokine production, lymphocyte activation, and peptidyl tyrosine phosphorylation. IL-23 Protein, Rat (HEK293, His) is a recombinant protein dimer complex containing rat-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P73887

	IL-23 Protein, Rabbit (HEK293, His) IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Rabbit	HEK293
	IL-23 alpha protein is part of the IL-6 superfamily and contains IL-23 alpha and IL-12 beta subunits that form a biologically active complex. It has a crucial impact on the differentiation and activation of Th17 cells associated with autoimmune diseases. IL-23 Protein, Rabbit (HEK293, His) is a recombinant protein dimer complex containing Rabbit-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293 , with C-His labeled tag.

HY-P74816

	IL-23 Protein, Human (Biotinylated, HEK293, His) IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. IL-23 Protein, Human (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing human-derived IL-23 alpha & IL-12 beta, expressed by HEK293 , with C-His labeled tag.

HY-P74814

	IL-23 Protein, Mouse (HEK293, His) IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Mouse	HEK293
	IL-23 alpha is a key component that binds to IL12B to produce IL-23 interleukin, a heterodimeric cytokine critical in innate and adaptive immunity. IL-23 functions together with IL-17 in peripheral tissues to respond acutely to infection.IL-23 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived IL-23 alpha & IL-12 beta, expressed by HEK293 , with C-His labeled tag.

HY-P700745

	IL-23 Protein, Human (Biotinylated, HEK293, His-Avi) IL23 alpha; IL12 beta; IL23 alpha&IL12 beta ; IL12 β; IL23 alpha&IL12 β; IL-23A&IL-12B; IL23A&IL12B	Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. IL-23 Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived IL-23 alpha & IL-12 beta, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78470

	IL-23R Protein, Human (HEK293, mFc) IBD17; IL-23 R; IL-23 receptor	Human	HEK293
	The IL-23R protein is critical in immune responses by binding to IL12RB1 to form the interleukin 23 receptor. It binds to IL23 and activates T cells, NK cells and potentially macrophages/myeloid cells through Jak-Stat signaling. IL-23R Protein, Human (HEK293, mFc) is the recombinant human-derived IL-23R protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P701011

	IL-23R Protein, Canine (HEK293, His) IBD17; IL-23 R; IL-23 receptor	Canine	HEK293
	IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Canine (HEK293, His) is the recombinant canine-derived IL-23R protein, expressed by HEK293 , with C-His labeled tag.

HY-P73194

	IL-23 Protein, Marmoset (HEK293, His) IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Marmoset	HEK293
	IL-23 alpha protein, a member of the IL-6 superfamily, is featured. IL-23 Protein, Marmoset (HEK293, His) is a recombinant protein dimer complex containing Marmoset-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293 , with C-His labeled tag. IL-23 Protein, Marmoset (HEK293, His), has molecular weight of ~22 & 45 kDa, respectively.

HY-P78856

	IL-23R Protein, Human (Biotinylated, HEK293, Fc-Avi) IL-23 R; IL-23 Receptor	Human	HEK293
	The IL-23R protein is critical in immune responses by binding to IL12RB1 to form the interleukin 23 receptor. It binds to IL23 and activates T cells, NK cells and potentially macrophages/myeloid cells through Jak-Stat signaling. IL-23R Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived IL-23R protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P704701

	IL-23R Protein, Cynomolgus (HEK293, Fc) IBD17; IL-23 R; IL-23 receptor	Cynomolgus	HEK293
	IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived IL-23R protein, expressed by HEK293, with C-hFc labeled tag.

HY-P700889

	IL-23R Protein, Cynomolgus (HEK293, C-His) IBD17; IL-23 R; IL-23 receptor	Cynomolgus	HEK293
	IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Cynomolgus (HEK293, C-His) is the recombinant cynomolgus-derived IL-23R protein, expressed by HEK293 , with C-His labeled tag.

HY-P70604

	IL-23 Protein, Mouse (HEK293, C-His) SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2; IL-23; Interleukin-23	Mouse	HEK293
	IL-23 alpha is a key component that binds to IL12B to produce IL-23 interleukin, a heterodimeric cytokine critical in innate and adaptive immunity. IL-23 functions together with IL-17 in peripheral tissues to respond acutely to infection. IL-23 Protein, Mouse (HEK293, C-His) is a recombinant protein dimer complex containing mouse-derived IL-23 alpha, expressed by HEK293 , with C-6*His labeled tag.

HY-P700746

	IL-23R Protein, Mouse (HEK293, His) IBD17; IL-23 R; IL-23 receptor; IL23r; Interleukin-23 receptor	Mouse	HEK293
	IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-23R protein, expressed by HEK293 , with C-His labeled tag.

HY-P76432

	IL-23 alpha Protein, Human (HEK293, Fc) Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; SGRF; IL-23p19	Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. IL-23 alpha Protein, Human (HEK293, Fc) is the recombinant human-derived IL-23 alpha protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72556

	IL-23R Protein, Mouse (HEK293, Fc) Interleukin-23 receptor; IL23r; IL-23 receptor	Mouse	HEK293
	IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P78152

	IL-23 alpha Protein, Mouse (Biotinylated, HEK293, His-Avi) Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19; IL23p19; IL23A; P19; SGRF	Mouse	HEK293
	IL-23 alpha is a key component that binds to IL12B to produce IL-23 interleukin, a heterodimeric cytokine critical in innate and adaptive immunity. IL-23 functions together with IL-17 in peripheral tissues to respond acutely to infection. IL-23 alpha Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived IL-23 alpha protein, expressed by HEK293 , with C-His, C-Avi labeled tag.

HY-P73196

	IL-23R Protein, Human (HEK293, Fc) Interleukin 23 receptor; IL 23R; IL-23 receptor; IL-23R	Human	HEK293
	IL-23R Protein, critical in immune response, forms the interleukin-23 receptor by associating with IL12RB1. Binding to IL23, it activates T-cells, NK cells, and potentially macrophage/myeloid cells through Jak-Stat signaling. Associated with autoimmune diseases and tumorigenesis, IL-23R, in the presence of IL12RB1, forms a heterodimeric IL-23 receptor, interacting with JAK2 and activating STAT3. IL-23R Protein, Human (HEK293, Fc) is the recombinant human-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73197

	IL-23R Protein, Rat (HEK293, Fc) Interleukin 23 receptor; IL 23R; IL-23 receptor; IL-23R	Rat	HEK293
	IL-23R Protein, critical in immune response, forms the interleukin-23 receptor by associating with IL12RB1. Binding to IL23, it activates T-cells, NK cells, and potentially macrophage/myeloid cells through Jak-Stat signaling. Associated with autoimmune diseases and tumorigenesis, IL-23R, in the presence of IL12RB1, forms a heterodimeric IL-23 receptor, interacting with JAK2 and activating STAT3. IL-23R Protein, Rat (HEK293, Fc) is the recombinant rat-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73885

	IL-23R Protein, Rat (HEK293, His) Interleukin 23 receptor; IL 23R; IL-23 receptor; IL-23R	Rat	HEK293
	IL-23R Protein, critical in immune response, forms the interleukin-23 receptor by associating with IL12RB1. Binding to IL23, it activates T-cells, NK cells, and potentially macrophage/myeloid cells through Jak-Stat signaling. Associated with autoimmune diseases and tumorigenesis, IL-23R, in the presence of IL12RB1, forms a heterodimeric IL-23 receptor, interacting with JAK2 and activating STAT3. IL-23R Protein, Rat (HEK293, His) is the recombinant rat-derived IL-23R protein, expressed by HEK293 , with C-His labeled tag.

HY-P73886

	IL-23R Protein, Human (HEK293, His) Interleukin 23 receptor; IL 23R; IL-23 receptor; IL-23R	Human	HEK293
	The IL-23R protein is critical in immune responses by binding to IL12RB1 to form the interleukin 23 receptor. It binds to IL23 and activates T cells, NK cells and potentially macrophages/myeloid cells through Jak-Stat signaling. IL-23R Protein, Human (HEK293, His) is the recombinant human-derived IL-23R protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P703678

	IL-23R Protein, Rat (HEK293, hFc) Interleukin 23 receptor; IL 23R; IL-23 receptor; IL-23R	Rat	HEK293
	IL-23R Protein, Rat (HEK293, hFc) is the recombinant rat-derived IL-23R protein, expressed by HEK293, with C-hFc tag.

HY-P70680

	IL-23R Protein, Human (330a.a, HEK293, Fc) Interleukin-23 receptor; IL23R; IL-23 receptor; IL-23R	Human	HEK293
	The IL-23R protein is critical in immune responses by binding to IL12RB1 to form the interleukin 23 receptor. It binds to IL23 and activates T cells, NK cells and potentially macrophages/myeloid cells through Jak-Stat signaling. IL-23R Protein, Human (330a.a, HEK293, Fc) is the recombinant human-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75857

	IL-23R Protein, Rhesus Macaque (HEK293, Fc) Interleukin 23 receptor; IL 23R; IL-23 receptor; IL-23R	Rhesus Macaque	HEK293
	Interleukin 23 receptor is a subunit of the receptor for IL23A/IL23. Interleukin 23 receptor associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. IL-23R Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704382

	IL-23 alpha Protein, Human (HEK293) IL-23 alpha (306a.a) & IL-12 beta (170a.a) Heterodimer; SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2	Human	HEK293

HY-P70736

	IL-23 Protein, Human (HEK293, C-His) IL-23 alpha (306a.a) & IL-12 beta (170a.a) Heterodimer; SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2	Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. IL-23 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived IL-23 alpha & IL-12 beta protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70421

	IL-23 Protein, Mouse (sf9) SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2	Mouse	Sf9 insect cells
	IL-23 alpha is a key component that binds to IL12B to produce IL-23 interleukin, a heterodimeric cytokine critical in innate and adaptive immunity. IL-23 functions together with IL-17 in peripheral tissues to respond acutely to infection. IL-23 Protein, Mouse (sf9) is a recombinant protein dimer complex containing mouse-derived IL-23 alpha, expressed by sf9 insect cells , with tag free.

HY-P70709

	IL-23 Protein, Mouse (HEK293) SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2	Mouse	HEK293
	IL-23 alpha is a key component that binds to IL12B to produce IL-23 interleukin, a heterodimeric cytokine critical in innate and adaptive immunity. IL-23 functions together with IL-17 in peripheral tissues to respond acutely to infection. IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (HEK293) is a recombinant protein dimer complex containing mouse-derived IL-23 alpha, expressed by HEK293 , with tag free.

HY-P74874

	*Human IL-23* alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His)** IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Mouse;Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His) is a recombinant protein dimer complex containing mouse, human-derived Human IL-23 alpha & Mouse IL-12 beta Heterodimer protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77703

	*Cynomolgus IL-23* alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His)** IL23 alpha; IL12 beta; IL23 alpha&IL12 beta	Cynomolgus	HEK293
	IL-23 alpha and IL-12 beta are the IL-23p19 and IL-12p40 subunits, respectively, composing IL-23 via heterodimerization manner. IL-23 binds to a heterodimeric receptor composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, acts on memory CD4(+) T cells preferentially. IL-23 also involves in activation of several pathways including p38 MAPK or NF-κB and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. Cynomolgus IL-23 alpha & Mouse IL-12 beta Heterodimer Protein is produced in HEK293 cells, with total length of 481 amino acids and a N-Terminal His-tag.

HY-P77712

	*Human IL-23* alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His-Avi)** IL23 alpha; IL12 beta; IL23 alpha&IL12 beta	Human;Mouse	HEK293
	IL-23 alpha and IL-12 beta are the IL-23p19 and IL-12p40 subunits, respectively, composing IL-23 via heterodimerization manner. IL-23 binds to a heterodimeric receptor composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, acts on memory CD4(+) T cells preferentially. IL-23 also involves in activation of several pathways including p38 MAPK or NF-κB and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein is produced in HEK293 cells, with a C-Terminal Avi and His-tag.

HY-P700114AF

	*Animal-Free IL-23* alpha Protein, Human (His)** Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; SGRF; IL-23p19	Human	E. coli
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. Animal-Free IL-23 alpha Protein, Human (His) is the recombinant human-derived animal-FreeIL-23 p19 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P704402

	*Human IL-23* alpha & Rat IL-12 beta Heterodimer Protein (HEK293, His)** Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; SGRF; IL-23p19	Human;Rat	HEK293

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-126242S

Tyk2-IN-7

Tyk2-IN-7 is an orally active TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC₅₀ and K_i.app of 0.00053 μM and 0.00007 μM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 can inhibit the IL-23 and IFN-α signaling pathways. Tyk2-IN-7 is commonly used in the study of inflammatory conditions such as colitis .

HY-131968

BMS-986202

BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC₅₀ value of 0.19 nM and a K_i of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC₅₀ value of 14 μM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium .