IL-23R Protein, Cynomolgus (HEK293, Fc)

IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived IL-23R protein, expressed by HEK293, with C-hFc labeled tag.

The IL-23R Protein forms the interleukin-23 receptor in association with IL12RB1. Acting as a binding site for IL23, this receptor mediates stimulation in T-cells, NK cells, and possibly certain macrophage/myeloid cells, likely through the activation of the Jak-Stat signaling cascade. IL-23R plays a crucial role in both innate and adaptive immunity and may contribute to the acute response to infection in peripheral tissues. Additionally, IL-23R has been implicated in autoimmune inflammatory diseases and is thought to be significant in tumorigenesis. Operating as a heterodimer with IL12RB1, the IL-23R complex, when exposed to IL23, forms the functional IL23 receptor. Furthermore, IL-23R interacts with JAK2 and, in the presence of IL23, associates with STAT3, contributing to downstream signaling processes (By similarity).

Cynomolgus

HEK293

C-hFc

G7NWY5 (G24-D353)

102133210

Approximately 90-100 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.