Search Result

Isoforms Recommended:	IL-5

Results for "

IL-5

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (23) Amyloid-β (1) Apoptosis (4) Bacterial (1) c-Fms (1) Endogenous Metabolite (3) Glucosylceramide Synthase (GCS) (1) GSNOR (1) IFNAR (1) Influenza Virus (1) Liposome (1) LPL Receptor (2) Monoamine Oxidase (1) Phosphatase (2) Phosphodiesterase (PDE) (1) Ser/Thr Protease (2) Small Interfering RNA (siRNA) (6) Src (2) Tyrosinase (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (2) Inflammation/Immunology (28) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) Cholesterol (1) siRNAs (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9945A

*Mepolizumab (anti-IL5)*	Interleukin Related	Inflammation/Immunology
Mepolizumab (anti-IL5) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .

HY-19969

YM-90709 1 Publications Verification	Interleukin Related	Inflammation/Immunology
YM-90709 is a novel *IL-5* inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [ ¹²⁵I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC₅₀ values of 1.0 and 0.57 μM .

HY-RS06772

Il5 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il5 Rat Pre-designed siRNA Set A Il5 Rat Pre-designed siRNA Set A

HY-RS06771

Il5 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il5 Mouse Pre-designed siRNA Set A Il5 Mouse Pre-designed siRNA Set A

HY-RS06770

IL5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
IL5 Human Pre-designed siRNA Set A contains three designed siRNAs for IL5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL5 Human Pre-designed siRNA Set A IL5 Human Pre-designed siRNA Set A

HY-RS26191

Il5ra Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il5ra Rat Pre-designed siRNA Set A contains three designed siRNAs for Il5ra gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il5ra Rat Pre-designed siRNA Set A Il5ra Rat Pre-designed siRNA Set A

HY-RS19696

Il5ra Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il5ra Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il5ra gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il5ra Mouse Pre-designed siRNA Set A Il5ra Mouse Pre-designed siRNA Set A

HY-RS06773

IL5RA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL5RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL5RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL5RA Human Pre-designed siRNA Set A IL5RA Human Pre-designed siRNA Set A

HY-P990452

*Anti-IL-5* Antibody**	Interleukin Related	Inflammation/Immunology
Anti-IL-5 Antibody is a CHO-expressed humanized antibody that targets *IL-5. The Anti-IL-5* Antibody is composed of huIgG4 heavy chains and huκ light chains, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-IL-5 Antibody can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

HY-P991144

Lasrekibart	Interleukin Related	Inflammation/Immunology
Lasrekibart is a humanized monoclonal antibody targeting human interleukin 5 (IL-5). Lasrekibart specifically binds to *IL-5, blocking the interaction between IL-5* and its receptor, thus exerting immunosuppressive and anti-inflammatory activities. Lasrekibart is promising for research of allergic and inflammatory diseases, such as asthma .

HY-110295

SPL-334	GSNOR	Inflammation/Immunology
SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation .

HY-P990094

Trabikibart CSL311	c-Fms	Inflammation/Immunology
Trabikibart (CSL311), a βc (CSF2RB)-specific, fully human monoclonal antibody, binds to a unique epitope that is specific to the cytokine-binding site of the human βc receptor. Trabikibart has picomolar binding affinity for the human βc receptor. Trabikibart is a potent inhibitor of the combined effects of IL-3, GM-CSF and IL-5 on the survival of eosinophils. Trabikibart has the potential for chronic inflammatory diseases research .

HY-P9945

Mepolizumab SB 240563	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .

HY-P9949

Reslizumab Sch 55700	Interleukin Related	Inflammation/Immunology
Reslizumab (Sch 55700) is humanized monoclonal antibodies that target **interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with K_D** values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively .

HY-19472A

RWJ-58643 hydrochloride	Ser/Thr Protease	Inflammation/Immunology
RWJ-58643 hydrochloride is a β-trypsin inhibitor that inhibits allergic inflammation. RWJ-58643 hydrochloride (100 mg) significantly reduces nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 hydrochloride causes late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 hydrochloride modulates allergic reactions by inhibiting the release of β-trypsin from mast cells.

HY-19472

RWJ-58643	Ser/Thr Protease	Inflammation/Immunology
RWJ-58643 is a β-trypsin inhibitor that suppresses allergic inflammation. RWJ-58643 (100 mg) significantly reduced nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 resulted in late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 modulates allergic responses by inhibiting the release of β-trypsin from mast cells .

HY-P990058

Varokibart	Interleukin Related	Inflammation/Immunology
Varokibart (TEV-53275) is a human IgG4λ antibody targeting *IL5* .

HY-N8309

Luteolin-4'-O-glucoside	Interleukin Related	Inflammation/Immunology Cancer
Luteolin-4'-O-glucoside is an *IL-5* inhibitor with an IC₅₀ of 3.7 μM. Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. Luteolin-4'-O-glucoside shows anticancer activity .

HY-P9923A

*Benralizumab (anti-IL5RA )* MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA )	Interleukin Related	Inflammation/Immunology
Benralizumab (anti-IL5RA ) (MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA )) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study .

HY-P1111

Lyn peptide inhibitor	Src Interleukin Related	Inflammation/Immunology
Lyn peptide inhibitor is a potent and cell-permeable inhibitor of *Lyn-coupled IL-5* receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase** to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of asthma, allergic, and other eosinophilic disorders .

HY-P1111A

Lyn peptide inhibitor TFA	Src Interleukin Related	Inflammation/Immunology
Lyn peptide inhibitor TFA is a potent and cell-permeable inhibitor of *Lyn-coupled IL-5* receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor TFA blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase** to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor TFA can be used for study of asthma, allergic, and other eosinophilic disorders .

HY-17002

Suplatast (Tosilate) 1 Publications Verification IPD 1151T	Interleukin Related	Inflammation/Immunology
Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosilate is an anti-allergic agent. Suplatast Tosilate has antiasthmatic, anti-inflammatory and antifibrotic activity .

HY-N8309R

Luteolin-4'-O-glucoside (Standard)	Interleukin Related	Inflammation/Immunology Cancer
Luteolin-4'-O-glucoside (Standard) is the analytical standard of Luteolin-4'-O-glucoside. This product is intended for research and analytical applications. Luteolin-4'-O-glucoside is an IL-5 inhibitor with an IC₅₀ of 3.7 μM. Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. Luteolin-4'-O-glucoside shows anticancer activity .

HY-147660

IMMH001	LPL Receptor	Inflammation/Immunology
IMMH001, also called SYL930, is an orally active, potent and selective S1P1 (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research .

HY-N1938

D(+)-Raffinose pentahydrate D-Raffinose pentahydrate	Endogenous Metabolite Glucosylceramide Synthase (GCS) Bacterial Phosphodiesterase (PDE) Interleukin Related	Infection Inflammation/Immunology
D(+)-Raffinose pentahydrate is an orally active inhibitor of LecA (K_d = 32 μM) and GtfC. D(+)-Raffinose pentahydrate reduces cyclic diguanylate (c-di-GMP) by increased activity of a c-di-GMP specific phosphodiesterase. D(+)-Raffinose pentahydrate interferes with GTF function. D(+)-Raffinose pentahydrate decreases IL-4 and *IL-5* mRNA. D(+)-Raffinose pentahydrate exhibits biofilm-inhibitory activity against Pseudomonas aeruginosa and Streptococcus mutans and inhibits allergic airway eosinophilia .

HY-W585843

1,1′-Ethylidenebis[L-tryptophan]	Interleukin Related	Inflammation/Immunology
1,1′-Ethylidenebis[L-tryptophan] is an impurity in the synthesis of L-tryptophan. 1,1′-Ethylidenebis[L-tryptophan] promotes the proliferation of eosinophilic leukemia cells, induces the release of eosinophil cationic protein from eosinophils, and stimulates T cells to produce *IL-5*. 1,1′-Ethylidenebis[L-tryptophan] (40 µg/kg) can induce fascia thickening, mast cell infiltration, and fibrosis in adipose and subcutaneous muscle tissues in mice. 1,1′-Ethylidenebis[L-tryptophan] can be used in immunology and inflammation research .

HY-N0646

Silydianin 1 Publications Verification	Phosphatase Endogenous Metabolite Tyrosinase Apoptosis Interleukin Related	Inflammation/Immunology Cancer
Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC₅₀ of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC₅₀s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and *IL-5*). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research ^[5] .

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride	Amyloid-β Liposome IFNAR Interleukin Related	Neurological Disease Inflammation/Immunology
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-169864

KRO-105714	LPL Receptor	Inflammation/Immunology
KRO-105714 is the antagonist for sphingosine phosphocholine receptor (SPC Receptor) and sphingosine-1-phosphate receptor 1 (S1P1 Receptor) (IC₅₀=79.2 nM). KRO-105714 inhibits SPC-induced proliferation of NIH3T3 (IC₅₀=5.6 nM), inhibits SPC-induced cell migration (IC₅₀=0.59 μM) and tube formation in HUVECs. KRO-105714 inhibits SPC-induced generation of IL-4 and IL-5, exhibits anti-inflammtory efficacy in mouse atopic dermatitis models .

HY-165484

AVP-13358	Interleukin Related	Inflammation/Immunology
AVP-13358 is an orally active IgE inhibitor that effectively suppresses immunoglobulin E (IgE)-mediated immune responses, with IC₅₀ values of 8 and 3 nM for IgE inhibition in vivo and in vitro in BALB/c mice, respectively. AVP-13358 acts directly on T cells, inhibiting the production and release of IL-4, *IL-5, and IL-13. It also targets other markers critical for the development of allergic responses, including the B cell IgE* receptor (CD23) in human monocytes and the CD23 and IL-4 receptors in mouse B cells. AVP-13358 can be used in research related to anti-allergic responses .

HY-N0646R

Silydianin (Standard)	Phosphatase Endogenous Metabolite Tyrosinase Apoptosis Interleukin Related	Inflammation/Immunology Cancer
Silydianin (Standard) is the analytical standard of Silydianin (HY-N0646). This product is intended for research and analytical applications. Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC₅₀ of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC₅₀s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and *IL-5*). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research ^[5] .

HY-P9923

Benralizumab MEDI-563; BIW-8405	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma .

HY-P99371

Lirentelimab AK002; Antolimab	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-114203

Eckol	Monoamine Oxidase Influenza Virus	Infection Neurological Disease Inflammation/Immunology
Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC₅₀s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects .

Cat. No.	Product Name	Type

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride	Drug Delivery
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

DC-Chol hydrochloride

DC-Cholesterol hydrochloride

Drug Delivery

DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

Cat. No.	Product Name	Target	Research Area

HY-P1111A

Lyn peptide inhibitor TFA	Src Interleukin Related	Inflammation/Immunology
Lyn peptide inhibitor TFA is a potent and cell-permeable inhibitor of *Lyn-coupled IL-5* receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor TFA blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase** to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor TFA can be used for study of asthma, allergic, and other eosinophilic disorders .

*HOLO Human Interleukin-5 (IL-5) Detection Kit*
MCE HOLO Human Interleukin-5 (IL-5) Detection Kit is a homogeneous luminescence-based assay used for the quantitative detection of human IL-5 concentrations in biological samples such as buffer solutions, cell culture supernatants, or serum.

Cat. No.	Product Name	Target	Research Area

HY-P990213

*Anti-Mouse/Human IL-5* Antibody (TRFK5)**	Inhibitory Antibodies	Others
Anti-Mouse/Human IL-5 Antibody (TRFK5) is a rat-derived IgG1, κ type antibody inhibitor, targeting to mouse/human IL-5.

HY-P9945A

*Mepolizumab (anti-IL5)*	Interleukin Related	Inflammation/Immunology
Mepolizumab (anti-IL5) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .

HY-P990094

Trabikibart CSL311	c-Fms	Inflammation/Immunology
Trabikibart (CSL311), a βc (CSF2RB)-specific, fully human monoclonal antibody, binds to a unique epitope that is specific to the cytokine-binding site of the human βc receptor. Trabikibart has picomolar binding affinity for the human βc receptor. Trabikibart is a potent inhibitor of the combined effects of IL-3, GM-CSF and IL-5 on the survival of eosinophils. Trabikibart has the potential for chronic inflammatory diseases research .

HY-P9945

Mepolizumab SB 240563	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .

HY-P9949

Reslizumab Sch 55700	Interleukin Related	Inflammation/Immunology
Reslizumab (Sch 55700) is humanized monoclonal antibodies that target **interleukin-5 (IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with K_D** values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively .

HY-P9923A

*Benralizumab (anti-IL5RA )* MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA )	Interleukin Related	Inflammation/Immunology
Benralizumab (anti-IL5RA ) (MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA )) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study .

HY-P990452

*Anti-IL-5* Antibody**	Interleukin Related	Inflammation/Immunology
Anti-IL-5 Antibody is a CHO-expressed humanized antibody that targets *IL-5. The Anti-IL-5* Antibody is composed of huIgG4 heavy chains and huκ light chains, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-IL-5 Antibody can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).

HY-P991144

Lasrekibart	Interleukin Related	Inflammation/Immunology
Lasrekibart is a humanized monoclonal antibody targeting human interleukin 5 (IL-5). Lasrekibart specifically binds to *IL-5, blocking the interaction between IL-5* and its receptor, thus exerting immunosuppressive and anti-inflammatory activities. Lasrekibart is promising for research of allergic and inflammatory diseases, such as asthma .

HY-P990058

Varokibart	Interleukin Related	Inflammation/Immunology
Varokibart (TEV-53275) is a human IgG4λ antibody targeting *IL5* .

HY-P9923

Benralizumab MEDI-563; BIW-8405	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma .

HY-P99371

Lirentelimab AK002; Antolimab	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

Recombinant Proteins Recommended:

IL-5

Species:	Human (13) Mouse (9) Rat (3) Cynomolgus (1) Rabbit (1) Pig (1) Canine (1)
Tag:	His (20) Tag Free (7) Avi (6) Fc (2)
Source:	HEK293 (16) CHO (3) Sf9 insect cells (4) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P70612

	IL-5 Protein, Human (HEK293, His) Interleukin-5; IL-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Human	HEK293
	The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. IL-5 Protein, Human (HEK293, His) is the recombinant human-derived IL-5 protein, expressed by HEK293 , with C-His labeled tag.

HY-P73219

	IL-5 Protein, Mouse (sf9, His) Interleukin-5; IL-5; EDF; Eo-CSF; TRF	Mouse	Sf9 insect cells
	IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis. In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells. IL-5 Protein, Mouse (sf9, His) is the recombinant mouse-derived IL-5 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P78608

	IL-5 Protein, Rabbit (HEK293, His) IL-5; TRF; IL5; Interleukin-5	Rabbit	HEK293
	The IL5 protein is a cytokine that plays a key role in regulating the growth and differentiation of eosinophils, a type of white blood cell involved in allergic reactions and asthma. Dysregulation of IL5 protein is associated with a variety of allergic and inflammatory diseases. IL-5 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived IL-5 protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P7102

	IL-5 Protein, Rat rRtIL-5; EDF; BCDFII; TRF	Rat	E. coli
	IL-5 Protein, Rat, a T-cell derived cytokine, stimulates B cell growth and increases immunoglobulin secretion.

HY-P7043

	IL-5 Protein, Human rHuIL-5; EDF; BCDFII; TRF	Human	E. coli
	IL-5 Protein, Human is a selective activator of human eosinophil function.

HY-P7081

	IL-5 Protein, Mouse rMuIL-5; EDF; BCDFII; TRF	Mouse	E. coli
	IL-5 Protein, Mouse is a hematopoietic growth factor expressed in Th2, mast cells and eosinophils.

HY-P7102A

	IL-5 Protein, Rat (CHO) rRtIL-5; EDF; BCDFII; TRF	Rat	CHO
	IL-5 Protein, Rat (CHO), a CHO cell derived cytokine, stimulates B cell growth and increases immunoglobulin secretion.

HY-P71630

	IL-5 Protein, Pig (His) IL5; Interleukin-5; IL-5; EosinophIL differentiation factor; T-cell replacing factor; TRF	Pig	E. coli
	IL-5 Protein, expressed by T-lymphocytes and NK cells, is vital for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production and growth. IL-5 Protein activates kinases LYN, SYK, and JAK2 through IL5RA and CSF2RB subunits, signaling via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Pig (His) is the recombinant pig-derived IL-5 protein, expressed by E. coli , with N-His labeled tag.

HY-P73218

	IL-5 Protein, Canine (sf9, His) Interleukin-5; IL-5; EDF; Eo-CSF; TRF	Canine	Sf9 insect cells
	IL-5 protein is expressed by T lymphocytes and NK cells and plays a crucial role in eosinophil survival, differentiation, and chemotaxis. It also promotes immunoglobulin production, growth and differentiation in B cells. IL-5 Protein, Canine (sf9, His) is the recombinant canine-derived IL-5 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P73878

	IL-5 Protein, Cynomolgus (sf9, His) Interleukin-5; IL-5; EDF; Eo-CSF; TRF	Cynomolgus	Sf9 insect cells
	IL-5 Protein, produced by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It stimulates immunoglobulin production and growth in B-cells. IL-5 Protein activates kinases (LYN, SYK, and JAK2) through a receptor (IL5RA and CSF2RB subunits), propagating signals via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived IL-5 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P7043A

	IL-5 Protein, Human (CHO) rHuIL-5; EDF; BCDFII; TRF	Human	CHO
	IL-5 Protein, Human (CHO) is a selective activator of human eosinophil function.

HY-P7081A

	IL-5 Protein, Mouse (CHO) rMuIL-5; EDF; BCDFII; TRF	Mouse	CHO
	IL-5 Protein, Mouse (CHO) is a CHO cell derived hematopoietic growth factor expressed in Th2, mast cells and eosinophils.

HY-P72387

	IL-5 Protein, Human (Biotinylated, HEK293, His-Avi) Interleukin-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Human	HEK293
	The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. IL-5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-5 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P70746

	IL-5 Protein, Mouse (HEK293, His) Interleukin-5; IL-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Mouse	HEK293
	IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis.In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells.IL-5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-5 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P78314

	IL-5 Protein, Mouse (HEK293, His-Avi) Interleukin-5; IL-5; T-cell replacing factor; TRF; EDF	Mouse	HEK293
	IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis.In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells.IL-5 Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived IL-5 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P78467

	IL-5 Protein, Human (HEK293, His-Avi) Interleukin-5; IL-5; T-cell replacing factor; TRF; EDF	Human	HEK293
	The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. IL-5 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-5 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P78155

	IL-5 Protein, Mouse (Biotinylated, HEK293, His-Avi) Interleukin-5; IL-5; T-cell replacing factor; TRF; EDF	Mouse	HEK293
	IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis.In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells.IL-5 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived IL-5 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P704394

	IL-5 Protein, Human (HEK293) Interleukin-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Human	HEK293

HY-P78162

	IL-5R alpha Protein, Human (Biotinylated, HEK293, His-Avi) CD125; CDw125CD125; HSIL5R3; IL-5 R alpha; IL-5R subunit alpha; IL5R; IL5RA; IL-5Ra; MGC26560	Human	HEK293
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation.IL-5R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is expressed by HEK293 cells with His-Avi tags.

HY-P78471

	IL-5R alpha Protein, Human (HEK293, His-Avi) CD125; CDw125CD125; HSIL5R3; IL-5 R alpha; IL-5R subunit alpha; IL5R; IL5RA; IL-5Ra; MGC26560	Human	HEK293
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation.IL-5R alpha Protein, Human (HEK293, His-Avi) is expressed by HEK293 cells with His-Avi tags.

HY-P72539

	IL-5R alpha Protein, Human (HEK293, His) Interleukin-5 receptor subunit alpha; IL-5R-alpha; IL-5RA; CDw125; CD125; IL5R	Human	HEK293
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation.IL-5R alpha Protein, Human (HEK293, His) is expressed by HEK293 cells with a C-6*His tag.

HY-P72540

	IL-5R alpha Protein, Mouse (HEK293, His) Interleukin-5 receptor subunit alpha; IL-5R-alpha; IL-5RA; CDw125; CD125; IL5R	Mouse	HEK293
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation. IL-5R alpha Protein, Mouse (HEK293, His) is expressed by HEK293 cells and is a transmembrane protein with a C-6*His tag.

HY-P75864

	IL-5R alpha Protein, Mouse (sf9, His) Interleukin-5 receptor subunit alpha; IL-5R-alpha; IL-5RA; CDw125; CD125; IL5R	Mouse	Sf9 insect cells
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation. IL-5R alpha Protein, Mouse (sf9, His) is expressed by Sf9 insect cells and is a transmembrane protein (L340-C361) with a His tag.

HY-P74800

	IL-5R alpha Protein, Human (Q01344-2, HEK293, His) Interleukin-5 receptor subunit alpha; IL-5RA; CD125; IL5R	Human	HEK293
	IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation. IL-5R alpha Protein, Human (Q01344-2, HEK293, His) is expressed by HEK293 cells with a C-His tag.

HY-P700215AF

	*Animal-Free IL-5* Protein, Mouse (His)** Interleukin-5; IL-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Mouse	E. coli
	IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis.In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells.Animal-Free IL-5 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-5 protein, expressed by E.coli , with C-His labeled tag.This product is for cell culture use only.

HY-P700131AF

	*Animal-Free IL-5* Protein, Human (His)** Interleukin-5; B-cell differentiation factor I; EosinophIL differentiation factor; T-cell replacing factor; TRF; IL5	Human	E. coli
	The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. Animal-Free IL-5 Protein, Human (His) is the recombinant human-derived animal-FreeIL-5 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P76195

	CD131 Protein, Rat (HEK293, Fc) Cytokine receptor common subunit beta; CD131; CSF2RB; IL3RB; IL5RB	Rat	HEK293
	The CD131 protein is a cell surface receptor that plays a critical role in the immune response and controls the generation and differentiation of hematopoietic progenitor cells. CD131 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD131 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75608

	CD131 Protein, Human (HEK293, His) Cytokine receptor common subunit beta; CDw131; CD131; CSF2RB; IL3RB; IL5RB	Human	HEK293
	The CD131 protein is a cell surface receptor that plays a critical role in the immune response and controls the generation and differentiation of hematopoietic progenitor cells. CD131 Protein, Human (HEK293, His) is the recombinant human-derived CD131 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P704440

	CD131 Protein, Human (HEK293, hFc) Cytokine receptor common subunit beta; CDw131; CD131; CSF2RB; IL3RB; IL5RB	Human	HEK293

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HY-P83661

	IL-3RB Antibody(YA3396) CSF2RB; IL3RB; IL5RB; SMDP5; CDw131; CD131; betaGMR	WB, IHC-P, FC, ELISA	Human, Mouse, Rat
	IL-3RB Antibody is a non-conjugated and mouse origined monoclonal antibody about 97 kDa, targeting to IL-3RB. It can be used for WB,IHC-P,FC,ELISA assays with tag free, in the background of Huma,Mouse,Rat.

HY-P81483

	IL-5 Receptor alpha Antibody (YA1228) IL-5 Receptor alpha; interleukin 5 receptor; alpha; IL5R; CD125; CDw125; HSIL5R3	IHC-P	Human
	IL-5 Receptor alpha Antibody (YA1228) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1228), targeting IL-5 Receptor alpha. IL-5 Receptor alpha Antibody (YA1228) can be used for IHC-P experiment in human background.

HY-P84264

	CD131 Antibody (YA3961) CSF2RB; IL3RB; IL5RB; SMDP5; CDw131; betaGMR	WB, IHC-P, FC, ELISA	Human, Mouse, Rat

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Free Sample	Yes No
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Cat. No.	Product Name		Classification

HY-137131

DC-Chol hydrochloride DC-Cholesterol hydrochloride		Cholesterol
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .

HY-RS06772

Il5 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Il5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06771

Il5 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Il5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06770

IL5 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IL5 Human Pre-designed siRNA Set A contains three designed siRNAs for IL5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS26191

Il5ra Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Il5ra Rat Pre-designed siRNA Set A contains three designed siRNAs for Il5ra gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19696

Il5ra Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Il5ra Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il5ra gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06773

IL5RA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IL5RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL5RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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