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Results for "

IAP Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IAP (23) SNIPERs (15) Akt (4) Amino Acid Derivatives (1) Apoptosis (16) Autophagy (2) Bcr-Abl (13) Caspase (6) Drug Derivative (1) Drug Intermediate (2) Estrogen Receptor/ERR (1) FLT3 (1) FXR (2) JNK (2) Ligands for E3 Ligase (3) Ligands for Target Protein for PROTAC (5) MHC (3) NF-κB (2) P-glycoprotein (2) PARP (1) PI3K (2) PROTACs (3) Proteasome (1) RAR/RXR (1) Ras (1) Reference Standards (2) Survivin (1)
By Research Areas:	Cancer (49) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

By Targets:

IAP (23)

SNIPERs (15)

Akt (4)

Amino Acid Derivatives (1)

Apoptosis (16)

Autophagy (2)

Bcr-Abl (13)

Caspase (6)

Drug Derivative (1)

Drug Intermediate (2)

Estrogen Receptor/ERR (1)

FLT3 (1)

FXR (2)

JNK (2)

Ligands for E3 Ligase (3)

Ligands for Target Protein for PROTAC (5)

MHC (3)

NF-κB (2)

P-glycoprotein (2)

PARP (1)

PI3K (2)

PROTACs (3)

Proteasome (1)

RAR/RXR (1)

Ras (1)

Reference Standards (2)

Survivin (1)

By Research Areas:

Cancer (49)

Inflammation/Immunology (3)

Metabolic Disease (1)

Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: IAP SNIPERs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124181

SM-1295	IAP Apoptosis	Cancer
SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with K_d values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively .

HY-13638

GDC-0152 10+ Cited Publications	IAP	Cancer
GDC-0152 is a potent *IAPs* inhibitor, and binds to the BIR3 domains of XIAP, cIAP1, cIAP2 and the BIR domain of *ML-IAP* with K_i values of 28 nM, 17 nM, 43 nM and 14 nM, respectively.

HY-16701

BV6 20+ Cited Publications	IAP	Cancer
BV6 is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.

HY-111872

SNIPER(ABL)-020	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-020, conjugating Dasatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein .

HY-113534

MV1	IAP Apoptosis	Cancer
MV1 is an antagonist of *IAP* (inhibitor of apoptosis protein), leads to protein knockdown of HaloTag-fused proteins when combined with HaloTag ligand .

HY-120434

AEG40826 HGS1029	IAP	Cancer
AEG40826 (HGS1029), a second mitochondria-derived activator of caspases (SMAC) mimetic, is an **inhibitor of apoptosis (IAP)** inhibitor. AEG40826 degrades cellular IAP1 (cIAP1) and blocks TNF-α pro-survival signaling. AEG40826 can be used for cancer research .

HY-150825

CST530	IAP Ligands for E3 Ligase	Cancer
CST530 is an inhibitor of apoptosis protein (IAP) antagonist. CST530 is an IAP-type Ligands for E3 Ligase. CST530 binds to the BIR3 domain of IAP and interferes with its function, thereby promoting the ubiquitination and degradation of cIAP1. CST530 can be used to prepare PROTACs .

HY-139865

142I5	Apoptosis	Cancer
142I5 is a potent *ML-IAP* Lys-covalent inhibitor with an IC₅₀ value of 11 nM.

HY-118522

TP-110	Proteasome NF-κB Caspase PARP IAP Apoptosis	Cancer
TP-110 is a proteasome inhibitor. TP-110 specifically inhibits the protease-like activity of the 20S proteasome, but does not affect the trypsin-like or peptidyl-glutamyl peptide hydrolysis activity. TP-110 inhibits the NF-κB pathway, activates caspase-8, -9, and -3, and causes PARP cleavage, significantly reducing the levels of cIAP-1 and XIAP. TP-110 causes cell cycle arrest at the G2/M phase and promotes apoptosis of cancer cells. TP-110 can be used in cancer research of prostate cancer and multiple myeloma, etc .

HY-111850

Bestatin-amido-Me PROTAC IAP binding moiety 1	Ligands for E3 Ligase	Cancer
Bestatin-amido-Me, the Bestatin-based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER .

HY-111857

Dasatinib carbaldehyde BMS-354825 carbaldehyde; PROTAC ABL binding moiety 4	Ligands for Target Protein for PROTAC	Cancer
Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .

HY-111844

PROTAC RAR Degrader-1	PROTACs SNIPERs RAR/RXR	Neurological Disease Metabolic Disease Cancer
PROTAC RAR degrader-1 (Compound 9) is a potent and selective RAR PROTAC Degrader consisting of apoptotic protein inhibitors (IAPs) ligands. IAPs-based degraders are also known as SNIPERs. PROTAC RAR Degrader-1 reduces RARα levels in HT1080 cells in a concentration-dependent manner but is blocked by the proteasome inhibitor MG132 (HY-13259). PROTAC RAR Degrader-1 can be used in the study of nuclear receptor-related diseases. (Pink: RAR ligand 1 (HY-111843); Black: Linker (HY-140189); Blue: IAPs Ligand (HY-B0134)) .

HY-111858

SNIPER(ABL)-050	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-050, conjugating Imatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein .

HY-111852

GNF5-amido-Me PROTAC ABL binding moiety 2	Ligands for Target Protein for PROTAC	Cancer
GNF5-amido-Me, the GNF5 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .

HY-111853

MV-1-NH-Me PROTAC IAP binding moiety 2	Ligands for E3 Ligase	Cancer
MV-1-NH-Me, the MV-1 based IAP ligand, binds to ABL inhibitor via a linker to form SNIPER .

HY-15518

LCL161 Maximum Cited Publications 37 Publications Verification	IAP	Cancer
LCL161 is a *IAP* inhibitor which inhibits XIAP in HEK293 cell and cIAP1 in MDA-MB-231 cell with IC₅₀s of 35 and 0.4 nM, respectively.

HY-111849

Imatinib carbaldehyde CGP-57148B carbaldehyde; STI571 carbaldehyde; PROTAC ABL binding moiety 1	Ligands for Target Protein for PROTAC	Cancer
Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .

HY-151966

TD1092	PROTACs IAP Caspase	Cancer
TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via *IAP* degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research .

HY-111851

SNIPER(ABL)-049	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-049, conjugating Imatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 100 μM .

HY-111860

SNIPER(ABL)-013	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-013, conjugating GNF5 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 20 μM .

HY-111855

HG-7-85-01-Decyclopropane PROTAC ABL binding moiety 3	Ligands for Target Protein for PROTAC	Cancer
HG-7-85-01-Decyclopropane, the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .

HY-111859

SNIPER(ABL)-058	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-058, conjugating Imatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 μM .

HY-111861

SNIPER(ABL)-024	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 5μM .

HY-111873

SNIPER(ABL)-019	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-019, conjugating Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 0.3 μM .

HY-111854

SNIPER(ABL)-015	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-015, conjugating GNF5 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 5 μM .

HY-111862

SNIPER(ABL)-044	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-044, conjugating HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 μM .

HY-131178

HG-7-85-01-NH2	SNIPERs Ligands for Target Protein for PROTAC Bcr-Abl	Cancer
HG-7-85-01-NH2 is the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .

HY-138059

SM-433	IAP Apoptosis	Cancer
SM-433, a Smac mimetic, function as inhibitor of **inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC₅₀**<1 μM (patent WO2008128171A2) .

HY-111863

SNIPER(ABL)-047	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-047, conjugating HG-7-85-01 (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 2 μM .

HY-78144

4-Methylsalicylic acid	Drug Derivative Drug Intermediate	Inflammation/Immunology
4-Methylsalicylic acid is a methyl derivative of Salicylic acid (HY-B0167). 4-Methylsalicylic acid derivatives inhibit the activity of alkaline phosphatases such as TNAP and IAP. 4-Methylsalicylic acid derivatives exhibit immunosuppressive activity .

HY-110346

AZD5582 dihydrochloride 10+ Cited Publications	IAP Apoptosis	Cancer
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC₅₀s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis .

HY-12600

AZD5582 10+ Cited Publications	IAP Apoptosis	Cancer
AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC₅₀s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis .

HY-138059A

SM-433 hydrochloride	IAP Apoptosis	Cancer
SM-433 hydrochlorid, a Smac mimetic, function as inhibitor of **inhibitor of apoptosis proteins (IAPs). SM-433 hydrochlorid exhibits strong binding affinity XIAP BIR3 protein with an IC₅₀**<1 μM (patent WO2008128171A2) .

HY-12842

UC-112	IAP Apoptosis	Cancer
UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM).

HY-W008235

Fmoc-N-Me-Ala-OH	Amino Acid Derivatives Drug Intermediate	Cancer
Fmoc-N-Me-Ala-OH, an N-Fmoc-N-methyl amino acid, is available for the peptide-coupling reaction. Fmoc-N-Me-Ala-OH is a drug intermediate that can be used to synthesize ML-IAP Lys-covalent inhibitor .

HY-123870

MX107	Survivin IAP NF-κB	Inflammation/Immunology Cancer
MX107 is a selective and potent survivin inhibitor that suppresses triple-negative breast cancer (TNBC) cell proliferation. MX107 induces degradation of survivin and inhibitor-of-apoptosis proteins (IAPs), which inhibits nuclear factor κB (NF-κB) activation induced by DNA damage. MX107 enhances tumoricidal efficacy of genotoxic treatments synergized with chemotherapeutic drugs .

HY-111874

SNIPER(ABL)-039	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 nM. IC₅₀s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively .

HY-155019

Anticancer agent 128	IAP	Cancer
Anticancer agent 128 (compound 1) is an *IAP* inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC₅₀s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively .

HY-153821

PROTAC KRAS G12C degrader-2	Ras PROTACs	Cancer
PROTAC KRAS G12C degrader-2 (compound 432) is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS .

HY-15519

LBW242	IAP FLT3	Cancer
LBW242, a 3-mer and Smac mimetic, is a potent and orally active proapoptotic *IAP* inhibitor. LBW242 shows effects on mutant FLT3-expressing cells. LBW242 has activity against multiple myeloma, and potentiates TRAIL- and anticancer agent-mediated cell death of ovarian cancer cells .

HY-155018

Anticancer agent 127	IAP	Cancer
Anticancer agent 127 (142D6) is an *IAP* inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC₅₀s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects .

HY-111871

SNIPER(ABL)-033	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 0.3 μM (ABL inhibitor: HY-15814; ABL inhibitor activity control: HY-131178; E3 ligase ligand: HY-128808; linker: HY-130500; E3 ligase ligand + linker: HY-128819) .

HY-175446

GDC-0152-acetamide	IAP Apoptosis	Cancer
GDC-0152-acetamide is a pan-inhibitor of apoptosis protein (IAP) antagonist. GDC-0152-acetamide induces cIAP1/2 autoubiquitination and degradation, activating the non-canonical NF-κB pathway to promote TNF-α secretion and tumor cell apoptosis. GDC-0152-acetamide is promising for research of ERα-positive breast cancer .

HY-N6064

Polygalacin D 2 Publications Verification	Apoptosis IAP	Cancer
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the *IAP* family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis

HY-13208

Xevinapant hydrochloride 5+ Cited Publications AT-406 hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride	IAP Apoptosis	Cancer
Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins *(IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with K_is of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits* cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors .

HY-129619

SNIPER(ER)-87	SNIPERs Estrogen Receptor/ERR	Cancer
SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC₅₀=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation .

HY-W009141

1-Monopalmitin Glyceryl palmitate	P-glycoprotein IAP PI3K Akt Caspase Apoptosis	Cancer
1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting *IAPs* protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC₅₀=50-58 μg/mL), with low toxicity to normal cells .

HY-W009141R

1-Monopalmitin (Standard) Glyceryl palmitate (Standard)	Reference Standards Apoptosis P-glycoprotein PI3K IAP Caspase Akt	Cancer
1-Monopalmitin (Glyceryl palmitate) (Standard) is the analytical standard of 1-Monopalmitin (HY-W009141). This product is intended for research and analytical applications. 1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting *IAPs* protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC₅₀=50-58 μg/mL), with low toxicity to normal cells .

HY-107738

Guggulsterone 15+ Cited Publications Z/E-Guggulsterone	Apoptosis JNK Akt Caspase FXR Autophagy	Cancer
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .

HY-P990184

Anti-Mouse MHC Class II (βchain) Antibody (KL277)	MHC	Others
Anti-Mouse MHC Class II (βchain) Antibody (KL277) is a hamster/mouse-derived IgG type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (βchain) Antibody (KL277) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Ap, I-Aq, I-Abu, and I-Abw. Anti-Mouse MHC Class II (βchain) Antibody (KL277) does not react with I-Aa, I-Ak, I-Af, I-Aj, I-As, or I-Atl haplotypes. Anti-Mouse MHC Class II (βchain) Antibody (KL277) can be used for western blot experiments .

Cat. No.	Product Name

HY-L128

E3 Ligase Ligand Library

96 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation.

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 96 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

Cat. No.	Product Name	Target	Research Area

HY-P990188

Anti-Mouse MHC class II (I-A) Antibody (Y-3P)	MHC	Inflammation/Immunology
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .

HY-P990184

Anti-Mouse MHC Class II (βchain) Antibody (KL277)	MHC	Others
Anti-Mouse MHC Class II (βchain) Antibody (KL277) is a hamster/mouse-derived IgG type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (βchain) Antibody (KL277) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Ap, I-Aq, I-Abu, and I-Abw. Anti-Mouse MHC Class II (βchain) Antibody (KL277) does not react with I-Aa, I-Ak, I-Af, I-Aj, I-As, or I-Atl haplotypes. Anti-Mouse MHC Class II (βchain) Antibody (KL277) can be used for western blot experiments .

HY-P990186

Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2)	MHC	Others
Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) is a mouse-derived IgG2c κ type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) reacts with mouse MHC Class II haplotypes I-Ak, I-Ar, I-Af, I-As, and I-Ag7. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) does not react with I-Ab, I-Ad, I-Ap, or I-Aq haplotypes. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) blocks MHC Class II and inhibits antigen proliferation responses. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) can be used for the research of immunology .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6064

Polygalacin D 2 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Source classification Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer	Apoptosis IAP
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the *IAP* family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis

HY-W009141

1-Monopalmitin Glyceryl palmitate	Source classification Plants	P-glycoprotein IAP PI3K Akt Caspase Apoptosis
1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting *IAPs* protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC₅₀=50-58 μg/mL), with low toxicity to normal cells .

HY-107738

Guggulsterone 15+ Cited Publications Z/E-Guggulsterone	Triterpenes Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt . Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .

HY-W009141R

1-Monopalmitin (Standard) Glyceryl palmitate (Standard)	Source classification Plants	Reference Standards Apoptosis P-glycoprotein PI3K IAP Caspase Akt
1-Monopalmitin (Glyceryl palmitate) (Standard) is the analytical standard of 1-Monopalmitin (HY-W009141). This product is intended for research and analytical applications. 1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp). 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting *IAPs* protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC₅₀=50-58 μg/mL), with low toxicity to normal cells .

HY-107738R

Guggulsterone (Standard)	Triterpenes Terpenoids Plants Burseraceae Commiphora wightii	Apoptosis JNK Akt Caspase FXR Autophagy Reference Standards
Guggulsterone (Standard) is the analytical standard of Guggulsterone (HY-107738). This product is intended for research and analytical applications. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively.

Species:	Human (2) Mouse (1)
Tag:	His (2) SUMO (1) Tag Free (1)
Source:	P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P7645

	BIRC5 Protein, Human rHuBIRC5; Baculoviral IAP Repeat-Containing Protein 5; Apoptosis Inhibitor 4; BIRC5; Survivin; BIRC5	Human	E. coli
	BIRC5 Protein, Human, a protein in the intrinsic apoptotic pathway that interacts with XIAP and DIABLO leading to caspase-3 and caspase-9 inactivation. BIRC5 (survivin) is also involved in stabilizing the microtubule-kinetochore dynamics.

HY-P702495

	BIRC5 Protein, Human (His-SUMO) rHuBIRC5; Baculoviral IAP Repeat-Containing Protein 5; Apoptosis Inhibitor 4; BIRC5; Survivin; BIRC5	Human	E. coli
	The BIRC5 protein has dual roles in cell proliferation and prevention of apoptosis. It is an important CPC component and guides chromosome alignment and segregation during mitosis. It directs CPC movement, contributes to central spindle organization, and recruits CPC to centromeres. BIRC5 Protein, Human (His-SUMO) is the recombinant human-derived BIRC5 protein, expressed by E. coli , with labeled tag.

HY-P71717

	*Apoptosis inhibitor* 4/Birc5 Protein, Mouse (P.pastoris, His)** Birc5; Api4; IAP4Baculoviral IAP repeat-containing protein 5; Apoptosis Inhibitor 4; Apoptosis Inhibitor survivin; TIAP	Mouse	P. pastoris
	Apoptosis inhibitor 4/Birc5 has the dual effects of promoting cell proliferation and inhibiting apoptosis. As an important component of the chromosomal channel protein complex (CPC), Birc5 coordinates chromosome alignment and segregation during mitosis and cytokinesis. Apoptosis inhibitor 4/Birc5 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Apoptosis inhibitor 4/Birc5 protein, expressed by P. pastoris , with N-His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82755

	cIAP1 Antibody (YA2500) cIAP1; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; hIAP2; API1; IAP2; MIHB; RNF48	WB, ICC/IF	Human
	cIAP1 Antibody (YA2500) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to cIAP1.

HY-P80618

	cIAP2 Antibody (YA795) cIAP2; AIP1; API2; BIRC3; CIAP2; HAIP1; IAP homolog C; RNF49; MIHC; MALT2; Apoptosis Inhibitor 2; IAP2	WB	Human, Monkey
	cIAP2 Antibody (YA795) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to cIAP2.

HY-P80906

	Survivin/BIRC5 Antibody (YA665) BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis Inhibitor 4; Apoptosis Inhibitor survivin	WB, IHC-P	Human, Rat
	Survivin/BIRC5 Antibody (YA665) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Survivin/BIRC5.

HY-P85731

	Survivin/BIRC5 Antibody (YA5423) BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis Inhibitor 4; Apoptosis Inhibitor survivin	WB, IHC-P, ICC/IF	Human, Rat
	Survivin/BIRC5 Antibody (YA5423) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Survivin/BIRC5.

HY-P86537

	Survivin/BIRC5 Antibody (YA6229) BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis Inhibitor 4; Apoptosis Inhibitor survivin	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Survivin/BIRC5 Antibody (YA6229) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Survivin/BIRC5.

HY-P86214

	XIAP Antibody (YA5906) XIAP; API3; BIRC4; IAP3; E3 ubiquitin-protein ligase XIAP; Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked Inhibitor of apoptosis protein; X-linked I	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	XIAP Antibody (YA5906) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to XIAP.

HY-P87097

	Survivin Antibody (YA6790) API4 antibody; Apoptosis Inhibitor 4 antibody; Apoptosis Inhibitor survivin antibody; Apoptosis Inhibitor4 antibody; Baculoviral IAP repeat containing 5 antibody; Baculoviral IAP repeat containing protein 5 antibody; Baculoviral IAP repeat-containing protein 5 antibody; BIRC 5 antibody; BIRC5 antibody; BIRC5_HUMAN antibody; API4 antibody; Apoptosis Inhibitor 4 antibody; Apoptosis Inhibitor survivin antibody; Apoptosis Inhibitor4 antibody; Baculoviral IAP repeat containing 5 antibody; Baculoviral IAP repeat containing protein 5 antibody; Baculoviral IAP repeat-containing protein 5 antibody; BIRC 5 antibody; BIRC5 antibody; BIRC5_HUMAN antibody; EPR 1 antibody; IAP4 antibody; Survivin variant 3 alpha antibody; SVV antibody; TIAP antibody;	WB, IHC-P, IP	Mouse, Rat
	Survivin Antibody (YA6790) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Survivin.

HY-P86950

	Livin Antibody (YA6643) Baculoviral IAP repeat containing 7 antibody; Baculoviral IAP repeat containing protein 7 antibody; Baculoviral IAP repeat-containing protein 7 antibody; BIRC 7 antibody; birc7 antibody; BIRC7_HUMAN antibody; KIAP antibody; Kidney Inhibitor of apoptosis protein antibody; Livin antibody; Livin Inhibitor of apotosis antibody; Baculoviral IAP repeat containing 7 antibody; Baculoviral IAP repeat containing protein 7 antibody; Baculoviral IAP repeat-containing protein 7 antibody; BIRC 7 antibody; birc7 antibody; BIRC7_HUMAN antibody; KIAP antibody; Kidney Inhibitor of apoptosis protein antibody; Livin antibody; Livin Inhibitor of apotosis antibody; Melanoma Inhibitor of apoptosis protein antibody; ML IAP antibody; ML-IAP antibody; MLIAP antibody; RING finger protein 50 antibody; RNF 50 antibody; RNF50 antibody;	WB, IHC-P, IP	Human
	Livin Antibody (YA6643) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Livin.

HY-P85568

	cIAP2 Antibody (YA5260) AIP 1; AIP1; API 2; API2; API2; Apoptosis Inhibitor 2; Baculoviral IAP repeat containing 3; Baculoviral IAP repeat containing protein 3; Baculoviral IAP repeat-containing protein 3; BIRC 3; BIRC3; BIRC3; BIRC3_HUMAN; C IAP2; C-IAP2; CIAP 2; CIAP 2; CIAP2; HAIP 1; HAIP1; HAIP1; HIAP 1; HIAP-1; HIAP1; IAP homolog C; IAP-1; Inhibitor of apoptosis protein 1; Inhibitor of apoptosis protein 1; MALT 2; MALT2; Mammalian IAP homolog C; MIHC; MIHC; RING finger protein 49; RNF49; TNFR2 TRAF signaling complex protein 1; TNFR2 TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 1.	WB	Human, Monkey
	cIAP2 Antibody (YA5260) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to cIAP2.