G3BP1

By Targets:	Apoptosis (1) Cyclophilin (1) DNA/RNA Synthesis (3) Ligands for Target Protein for PROTAC (1) LPL Receptor (1) MDM-2/p53 (1) PROTACs (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (5) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162289

FAZ-3780 1 Publications Verification	DNA/RNA Synthesis	Cancer
FAZ-3780 (compound G3Ib) is an inhibitor of binding to the NTF2L domain of *G3BP1/2* that binds to G3BP1 with a K_d of 0.15 μM. FAZ-3780 targets the protein-protein interaction domain of G3BP1/2 and specifically inhibits co-condensation of G3BP1, caprin 1, and RNA in vitro .

HY-162288

FAZ-3532 1 Publications Verification	DNA/RNA Synthesis	Cancer
FAZ-3532 is a *G3BP* inhibitor (K_d = 0.54 μM) which binds to the NTF2L nsP3 binding pocket in G3BP1. FAZ-3532 disrupts the co-condensation of RNA, G3BP1, and caprin 1. FAZ-3532 inhibits G3BP-driven stress granule formation. FAZ-3532 can be studied as a powerful tool to probe the biology of stress granules and a promising interventions designed to modulate stress granule formation .

HY-RS17909

G3bp1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G3bp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for G3bp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

G3bp1 Mouse Pre-designed siRNA Set A G3bp1 Mouse Pre-designed siRNA Set A

HY-RS24378

G3bp1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G3bp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for G3bp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

G3bp1 Rat Pre-designed siRNA Set A G3bp1 Rat Pre-designed siRNA Set A

HY-RS05189

G3BP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
G3BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for G3BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

G3BP1 Human Pre-designed siRNA Set A G3BP1 Human Pre-designed siRNA Set A

HY-170873

G3BP1/2-Targeting ligand-1	Ligands for Target Protein for PROTAC	Cancer
G3BP1/2-Targeting ligand-1 is the ligand for *G3BP1/2* that can be used as target protein ligand for synthesis of G3BP1/2 PROTAC degrader PT-129 (HY-170872) .

HY-170872

PT-129	PROTACs DNA/RNA Synthesis	Cancer
PT-129 is an RPOTAC degrader targeting the NTF2 domain (protein-RNA interaction site) of *G3BP1/2, which mediates the disassembly of intracellular stress granules. PT-129 can inhibit the formation of stress granules in stressed cells and disassemble existing stress granules, and can disrupt the transmission of ATF4, thereby inhibiting the proliferation of cancer cells. Stress granules (SGs) are membrane-less cytoplasmic compartments formed under stress stimuli. SGs promote the transmission of ATF4 from fibroblasts to tumor cells through a migratory effect, mediating fibroblast-related tumor growth. And G3BP1/2 is a central protein of the SGs network, and the inhibition of G3BP1/2 may reduce the stress resistance of cancer cells in the tumor microenvironment. PT-129 is composed of a target protein ligand (red part) G3BP1*/2-Targeting ligand-1 (HY-170873), an E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a PROTAC linker (black part) Amino-PEG3-C2-acid (HY-W040165); among them, the E3 ligase ligand + linker form a complex Thalidomide-NH-PEG3-propionic acid (HY-136166) .

HY-124072

HL001	Cyclophilin LPL Receptor MDM-2/p53 Apoptosis Reactive Oxygen Species	Cancer
HL001 is an orally active small molecule inhibitor of Cyclophilin A (CypA) and a receptor antagonist of Lysophosphatidic acid 1 (LPA1). HL001 induces cell cycle arrest and apoptosis of tumor cells by p53. HL001 stabilizes p53 by down-regulating *G3BP1, inducing reactive oxygen species* and DNA damage. HL001 disrupts the interaction between MDM2 and p53-72R in a CypA dependent manner. HL001 has antitumor activity. HL001 can also be used to study pulmonary fibrosis .

Cat. No.	Product Name	Target	Research Area

HY-P5118A

Tat-peptide 190-208 TFA	Peptides	Neurological Disease
Tat-peptide 190-208 TFA is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 190-208 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 190-208 TFA increases axon growth and increases the number of neurites per neuron. Tat-peptide 190-208 TFA likely exhibits an axon intrinsic mechanism. Tat-peptide 190-208 TFA can be used for ischemic protection during endovascular repair for intracranial aneurysms .

HY-P5119

Tat-peptide control 168-189	Peptides	Neurological Disease
Tat-peptide 168-189 is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 168-189 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 168-189 is the negtive control of Tat-peptide 190-208 (HY-P5118), as Tat-peptide 190-208 increases axon growth and increases the number of neurites per neuron .

HY-P5119A

Tat-peptide control 168-189 TFA	Peptides	Neurological Disease
Tat-peptide 168-189 is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 168-189 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 168-189 is the negtive control of Tat-peptide 168-189 TFA (HY-P5118A), as Tat-peptide 168-189 TFA increases axon growth and increases the number of neurites per neuron .

HY-P5118

Tat-peptide 190-208	Peptides	Neurological Disease
Tat-peptide 190-208 is a cell-permeable and Tat-labeled fusion peptide, corresponding to residues 190-208 of rat G3BP1. Tat sequence from HIV, is placed at the least conserved end of the sequence, for cell permeability. Tat-peptide 190-208 increases axon growth and increases the number of neurites per neuron. Tat-peptide 190-208 likely exhibits an axon intrinsic mechanism. Tat-peptide 190-208 can be used for ischemic protection during endovascular repair for intracranial aneurysms .

Cat. No.	Compare	Product Name	Species	Source

HY-P702856

	G3BP1 Protein, Human (466a.a, His) G3BP-1; ATP-dependent DNA helicase VIII; hDH VIII; GAP SH3 domain-binding protein 1	Human	E. coli
	G3BP1 Protein, Human (His) is the recombinant human-derived G3BP1, expressed by E. coli , with N-6*His labeled tag.

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HY-P82687

	G3BP Antibody (YA2432) G3BP1; G3BP; Ras GTPase-activating protein-binding protein 1; G3BP-1; ATP-dependent DNA helicase VIII; hDH VIII; GAP SH3 domain-binding protein 1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	G3BP Antibody (YA2432) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2432), targeting G3BP, with a predicted molecular weight of 52 kDa (observed band size: 68 kDa). G3BP Antibody (YA2432) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-RS17909

G3bp1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
G3bp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for G3bp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24378

G3bp1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
G3bp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for G3bp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05189

G3BP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
G3BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for G3BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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