G-CSF

By Targets:	c-Fms (3) Antibiotic (2) Apoptosis (1) Bacterial (2) Biochemical Assay Reagents (1) Calcium Channel (1) CXCR (2) DNA/RNA Synthesis (2) EGFR (1) ERK (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (2) JAK (1) MMP (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) Reference Standards (1) STAT (3) Topoisomerase (2)
By Research Areas:	Cancer (6) Endocrinology (2) Infection (5) Inflammation/Immunology (9)

Targets Recommended: c-Fms

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99879

Efbemalenograstim alfa Benegrastim; Bineuta; F 627	STAT	Inflammation/Immunology
Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells .

HY-P99440

Anumigilimab CSL-324	c-Fms JAK STAT	Inflammation/Immunology
Anumigilimab (CSL-324) is an human IgG4 mAb against human *granulocyte colony-stimulating factor (G-CSF) receptor*. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation .

HY-112288

C188-9 20+ Cited Publications TTI-101	STAT Apoptosis	Cancer
C188-9 (TTI-101) is a STAT3 inhibitor, with a K_d of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts .

HY-10046

Plerixafor 75+ Cited Publications AMD 3100; JM3100; SID791	CXCR HIV	Infection Inflammation/Immunology Endocrinology Cancer
Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC₅₀ of 1-10 nM .

HY-P10408

Candidalysin	EGFR MMP Calcium Channel NOD-like Receptor (NLR) ERK p38 MAPK	Infection Inflammation/Immunology
Candidalysin is a cytolytic peptide toxin secreted by the fungus Candida albicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and ERK1/2 respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity

HY-P99458

Balugrastim CG 10639	c-Fms	Cancer
Balugrastim (CG 10639) is a novel long-acting recombinant granulocyte colony-stimulating factor (G-CSF) obtained by means of a genetic fusion between recombinant human serum albumin and granulocyte colony-stimulating factor. Balugrastim can be used for the research of breast cancer .

HY-139410

Sodium caseinates	Biochemical Assay Reagents	Inflammation/Immunology
Sodium caseinates, the salt of casein, are the main milk protein. Sodium caseinate are able to induce proliferation and activation of granulocytes as well as increase the serum concentration of two key cytokines, GM-CSF and G-CSF. Sodium caseinate induces mouse granulopoiesis .

HY-P99913

Eflapegrastim	c-Fms	Inflammation/Immunology Cancer
Eflapegrastim is a human IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia .

HY-172257

HIF-PHD-IN-4	HIF/HIF Prolyl-Hydroxylase	Cancer
HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC₅₀ of 100 nM. HIF-PHD-IN-4 can effectively enhance the mobilization of hematopoietic stem cells induced by G-CSF in mice at a dose of 2 mg/kg. HIF-PHD-IN-4 is suitable for research in the field of tumor therapy .

HY-10046R

Plerixafor (Standard) AMD 3100 (Standard); JM3100 (Standard); SID791 (Standard)	Reference Standards CXCR HIV	Infection Inflammation/Immunology Endocrinology Cancer
Plerixafor (Standard) is the analytical standard of Plerixafor. This product is intended for research and analytical applications. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC₅₀ of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC₅₀ of 1-10 nM .

HY-17028A

(Rac)-Besifloxacin hydrochloride	Bacterial Antibiotic DNA/RNA Synthesis Topoisomerase	Infection Inflammation/Immunology
(Rac)-Besifloxacin Hydrochloride is a fourth generation fluoroquinolone antibiotic. (Rac)-Besifloxacin Hydrochloride is a DNA gyrase and topoisomerase IV inhibitor. (Rac)-Besifloxacin Hydrochloride has broad-spectrum antibacterial activity, it is effective against Gram-negative and Gram-positive aerobic and anaerobic strains and reduces the incidence of drug resistance. (Rac)-Besifloxacin Hydrochloride has anti-inflammatory activity. Besifloxacin Hydrochloride can be used in bacterial conjunctivitis research .

HY-17028

Besifloxacin Hydrochloride	Bacterial Antibiotic DNA/RNA Synthesis Topoisomerase	Infection Inflammation/Immunology
Besifloxacin Hydrochloride is a fourth generation fluoroquinolone antibiotic. Besifloxacin Hydrochloride is a DNA gyrase and topoisomerase IV inhibitor. Besifloxacin Hydrochloride has broad-spectrum antibacterial activity, it is effective against Gram-negative and Gram-positive aerobic and anaerobic strains and reduces the incidence of drug resistance. Besifloxacin Hydrochloride has anti-inflammatory activity. Besifloxacin Hydrochloride can be used in bacterial conjunctivitis research .

Cat. No.	Product Name	Type

HY-139410

Sodium caseinates	Cell Assay Reagents
Sodium caseinates, the salt of casein, are the main milk protein. Sodium caseinate are able to induce proliferation and activation of granulocytes as well as increase the serum concentration of two key cytokines, GM-CSF and G-CSF. Sodium caseinate induces mouse granulopoiesis .

Cat. No.	Product Name	Target	Research Area

HY-P10408

Candidalysin	EGFR MMP Calcium Channel NOD-like Receptor (NLR) ERK p38 MAPK	Infection Inflammation/Immunology
Candidalysin is a cytolytic peptide toxin secreted by the fungus Candida albicans. Candidalysin drives epithelial immune responses by activating the EGFR-MAPK signaling pathway, inducing MMP expression and calcium influx, and regulating the c-Fos transcription factor and MKP1 via p38 MAPK and ERK1/2 respectively. Candidalysin is essential for mucosal and systemic infections, activating NLRP3 to promote inflammatory responses, neutrophil recruitment, and Th17 immunity. Candidalysin activates LDH causing membrane damage and exhibiting cytotoxicity

Cat. No.	Product Name	Target	Research Area

HY-P99879

Efbemalenograstim alfa Benegrastim; Bineuta; F 627	STAT	Inflammation/Immunology
Efbemalenograstim alfa (F 627) is a recombinant fusion protein. Efbemalenograstim alfa is a long acting dimeric granulocyte colony-stimulating factor (G-CSF) that contains two human G-CSF fused to a human immunoglobulin G2 (hIgG2)-Fc fragment with a peptide linker. Efbemalenograstim alfa induces the production of white blood cells .

HY-P99440

Anumigilimab CSL-324	c-Fms JAK STAT	Inflammation/Immunology
Anumigilimab (CSL-324) is an human IgG4 mAb against human *granulocyte colony-stimulating factor (G-CSF) receptor*. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation .

HY-P99458

Balugrastim CG 10639	c-Fms	Cancer
Balugrastim (CG 10639) is a novel long-acting recombinant granulocyte colony-stimulating factor (G-CSF) obtained by means of a genetic fusion between recombinant human serum albumin and granulocyte colony-stimulating factor. Balugrastim can be used for the research of breast cancer .

HY-P99913

Eflapegrastim	c-Fms	Inflammation/Immunology Cancer
Eflapegrastim is a human IgG4 monoclonal antibody, is also a granulocyte colony-stimulating factor (G-CSF). Eflapegrastim targets to G-CSF receptor (c-Fms). Eflapegrastim stimulates proliferation and differentiation of neutrophil progenitor cells and maintains stable numbers of mature and functional neutrophils. Eflapegrastim also shortens the duration of neutropenia .

Recombinant Proteins Recommended:

G-CSF

Species:	Human (11) Rhesus Macaque (1) Mouse (4) Rat (1)
Tag:	His (8) Tag Free (6) Fc (2) Flag (1)
Source:	HEK293 (10) CHO (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P70554

	G-CSF Protein, Mouse (HEK293, His) 1 Publications Verification Granulocyte colony-stimulating factor; CSF3; G-CSF	Mouse	HEK293
	The G-CSF Protein, a monomeric cytokine in the granulocyte/macrophage colony-stimulating factor family, crucially regulates hematopoiesis by orchestrating the production, differentiation, and function of granulocytes and monocytes-macrophages. Its production emphasizes its significance in maintaining immune system balance and functionality. G-CSF Protein, Mouse (HEK293, His) is the recombinant mouse-derived G-CSF protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70422

	G-CSF Protein, Human 1 Publications Verification Granulocyte Colony-Stimulating Factor; G-CSF; Pluripoietin; Filgrastim; Lenograstim; CSF3; C17orf33; GCSF	Human	E. coli
	Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein secreted by the cells of the immune system, fibroblasts and endothelium, which acts as a hematopoietic and endothelial precursor cells cytokine. G-CSF stimulates maturation of progenitor cells in the bone marrow into differentiated granulocytes, macrophages and the T cells. G-CSF also shows to convey neuroprotection to central neurons upon increases in phosphorylation of PI3K/Akt pathway and regulates epithelial to mesenchymal transition in cancer. G-CSF Protein (Human) is a recombinant protein with tag free that consists of 200 or 204 amino acids, which is expressed in E. coli.

HY-P73523

	G-CSF Protein, Human (HEK293) Granulocyte Colony-Stimulating Factor; G-CSF; CSF3; C17orf33	Human	HEK293
	G-CSF, a pivotal cytokine, regulates hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. This monomeric protein specifically promotes granulocyte development, playing a crucial role in immune system regulation and blood cell formation. G-CSF Protein, Human (HEK293) is the recombinant human-derived G-CSF protein, expressed by HEK293 , with tag free.

HY-P73073

	G-CSF Protein, Human (HEK293, Fc) Granulocyte Colony-Stimulating Factor; G-CSF; CSF3; C17orf33	Human	HEK293
	G-CSF, a pivotal cytokine, regulates hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. This monomeric protein specifically promotes granulocyte development, playing a crucial role in immune system regulation and blood cell formation. G-CSF Protein, Human (HEK293, Fc) is the recombinant human-derived G-CSF protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P7068

	G-CSF Protein, Mouse (CHO) 1 Publications Verification rMuG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim	Mouse	CHO
	G-CSF Protein, Mouse (CHO) is a polypeptide growth factor that regulates the production of neutrophilic granulocytes.

HY-P7093A

	G-CSF Protein, Rat (HEK293) rRtG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim	Rat	HEK293
	G-CSF Protein, Rat (HEK293) is a glycoprotein, acting to stimulate granulopoiesis, the innate immunity, and the differentiation of neural progenitor cells.

HY-P700725

	G-CSFR/CD114 Protein, Mouse (HEK293, His) G-CSF-R; G-CSF R; CD114; G CSF R; CSF3R; CSFgr; GCSFR	Mouse	HEK293
	The G-CSFR/CD114 protein serves as a receptor for granulocyte colony-stimulating factor (CSF3) and plays a key role in granulocyte development and function. As a homodimer, it binds two CSF3 molecules and transduces signals. G-CSFR/CD114 Protein, Mouse (HEK293, His) is the recombinant mouse-derived G-CSFR/CD114 protein, expressed by HEK293 , with C-His labeled tag.

HY-P7015A

	G-CSF Protein, Human (CHO) rHuG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim	Human	CHO
	G-CSF Protein, Human (CHO) is a polypeptide growth factor that regulates the production of neutrophilic granulocytes.

HY-P700528

	G-CSFR/CD114 Protein, Human (HEK293, His-Flag) colony stimulating factor 3 receptor (granulocyte); CD114; granulocyte colony-stimulating factor receptor; GCSFR; G-CSF-R; CD114 antigen; G-CSF receptor;	Human	HEK293
	The G-CSFR/CD114 protein, as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocyte maturation and plays a key role in the proliferation, differentiation, and survival of neutrophil lineage cells. Furthermore, it may be involved in cell surface adhesion or recognition events. G-CSFR/CD114 Protein, Human (HEK293, His-Flag) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293 , with C-6*His, C-Flag labeled tag.

HY-P703081

	G-CSF Protein, Rhesus Macaque Granulocyte colony-stimulating factor; CSF3	Rhesus Macaque	E. coli
	CSF3 Protein, a member of the IL-6 superfamily, is a vital granulocyte/macrophage colony-stimulating factor influencing hematopoiesis. It regulates the production, differentiation, and function of granulocytes and monocytes-macrophages, playing a key role in the intricate balance of hematopoietic processes. CSF3's significance within the IL-6 superfamily extends to orchestrating immune system components for optimal functionality. G-CSF Protein, Rhesus Macaque is the recombinant rhesus macaque-derived G-CSF, expressed by E. coli , with tag Free labeled tag.

HY-P75692

	G-CSFR/CD114 Protein, Human (HEK293) Granulocyte colony-stimulating factor receptor; G-CSF-R; CD114; CSF3R; GCSFR	Human	HEK293
	The G-CSFR/CD114 protein, as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocyte maturation and plays a key role in the proliferation, differentiation, and survival of neutrophil lineage cells. Furthermore, it may be involved in cell surface adhesion or recognition events. G-CSFR/CD114 Protein, Human (HEK293) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293 , with tag free.

HY-P72634

	G-CSFR/CD114 Protein, Human (HEK293, Fc) Granulocyte colony-stimulating factor receptor; G-CSF-R; CD114; CSF3R; GCSFR	Human	HEK293
	The G-CSFR/CD114 protein, as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocyte maturation and plays a key role in the proliferation, differentiation, and survival of neutrophil lineage cells. Furthermore, it may be involved in cell surface adhesion or recognition events. G-CSFR/CD114 Protein, Human (HEK293, Fc) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P75694

	G-CSFR/CD114 Protein, Human (HEK293, His) Granulocyte colony-stimulating factor receptor; G-CSF-R; CD114; CSF3R; GCSFR	Human	HEK293
	The G-CSFR/CD114 protein, as a receptor for granulocyte colony-stimulating factor (CSF3), is essential for granulocyte maturation and plays a key role in the proliferation, differentiation, and survival of neutrophil lineage cells. Furthermore, it may be involved in cell surface adhesion or recognition events. G-CSFR/CD114 Protein, Human (HEK293, His) is the recombinant human-derived G-CSFR/CD114 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700083AF

	*Animal-Free G-CSF* Protein, Human (His)** CSF-3; MGI-1G; GM-CSF beta; pluripoietin	Human	E. coli
	G-CSF, a pivotal cytokine, regulates hematopoiesis by controlling the production, differentiation, and function of granulocytes and monocytes-macrophages. This monomeric protein specifically promotes granulocyte development, playing a crucial role in immune system regulation and blood cell formation. Animal-Free G-CSF Protein, Human (His) is the recombinant human-derived animal-FreeG-CSF protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P700178AF

	*Animal-Free G-CSF* Protein, Mouse (His)** rMuG-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim	Mouse	E. coli
	The G-CSF Protein, a monomeric cytokine in the granulocyte/macrophage colony-stimulating factor family, crucially regulates hematopoiesis by orchestrating the production, differentiation, and function of granulocytes and monocytes-macrophages. Its production emphasizes its significance in maintaining immune system balance and functionality. Animal-Free G-CSF Protein, Mouse (His) is the recombinant mouse-derived animal-FreeG-CSF protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P700082AF

	Animal-Free Galectin-9/LGALS9 Protein, Human (His) G-CSF; CSF-3; MGI-1G; Pluripoietin; Molgramostin; Sargramostim	Human	E. coli
	Galectin-9/LGALS9 Protein acts as an eosinophil chemoattractant, recruiting and migrating eosinophils, key immune cells in inflammatory responses. It also serves as an angiogenesis inhibitor, regulating blood vessel formation and impacting vascular processes. Functioning as a regulatory modulator, Galectin-9/LGALS9 suppresses interferon-gamma (IFNG) production by natural killer cells, exerting control over immune signaling pathways. Animal-Free Galectin-9/LGALS9 Protein, Human (His) is the recombinant human-derived animal-FreeGalectin-9/LGALS9 protein, expressed by E. coli , with N-His labeled tag. This product is for cell culture use only.

HY-P71179

	OLFM4 Protein, Human (HEK293, His) Olfactomedin-4; OLM4; Antiapoptotic protein GW112; G-CSF-stimulated clone 1 protein; hGC-1; hOLfD; OLFM4; GW112	Human	HEK293
	OLFM4 protein may promote the proliferation of pancreatic cancer cells by affecting the transition from S phase to G2/M phase, highlighting its role in cancer cell cycle dynamics. In myeloid leukemia cell lines, OLFM4 exhibits dual effects of inhibiting growth and inducing differentiation and apoptosis. OLFM4 Protein, Human (HEK293, His) is the recombinant human-derived OLFM4 protein, expressed by HEK293 , with C-10*His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83562

	G-CSF Antibody (YA3307) G-CSF; CSF beta; CSF3; CSF3OS; CSFg; Filgrastim; GCSA; GCSF; MGI 2; Pluripoietin	WB, ICC/IF, IP	Human, Mouse, Rat
	G-CSF Antibody (YA3307) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3307), targeting G-CSF, with a predicted molecular weight of 22 kDa (observed band size: 25 kDa). G-CSF Antibody (YA3307) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

HY-P83628

	G-CSF Receptor Antibody (YA3373) CD 114 antibody; CD114 antibody; CD114 antigen antibody; Colony stimulating factor 3 receptor (granulocyte) antibody; Colony stimulating factor 3 receptor antibody; CSF 3R antibody; CSF3R antibody; CSF3R_HUMAN antibody; CSFgr antibody; G CSF R antibody; G-CSF receptor antibody; G-CSF-R antibody; GCSFR antibody; Granulocyte colony stimulating factor receptor antibody; Granulocyte colony-stimulating factor receptor antibody; OTTHUMP00000009703 antibody; OTTHUMP00000009704 antibody; OTTHUMP00000009705 antibody	WB, FC	Human
	G-CSF Receptor Antibody (YA3373) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3373), targeting G-CSF Receptor, with a predicted molecular weight of 92 kDa (observed band size: 92 kDa). G-CSF Receptor Antibody (YA3373) can be used for WB, FC experiment in human background.

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