FH | MedChemExpress (MCE) Life Science Reagents

By Targets:	Biochemical Assay Reagents (1) Complement System (1) DNA Stain (1) Endogenous Metabolite (2) Fungal (1) Glutathione S-transferase (2) Influenza Virus (1) PPAR (1) Quinone Reductase (1) Reactive Oxygen Species (1) Small Interfering RNA (siRNA) (3) Virus Protease (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (5) Inflammation/Immunology (3) Metabolic Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15721

FH535 10+ Cited Publications	PPAR Wnt β-catenin	Cancer
FH535 is an inhibitor of Wnt/β-catenin and PPAR with anti-tumor activities .

HY-12346

FH1 NSC 12407; BRD-K4477	Quinone Reductase	Others
FH1 (NSC 12407) enhances hepatocyte functions, and promotes the differentiation of induced pluripotent stem (iPS)-derived hepatocytes toward a phenotype more mature and the maturation of well-differentiated cultures of hepatocyte-like cells (iHeps) .

HY-E70062

α-2,3-Sialyltransferase, pasteurella multocida FH8-PmST3	Endogenous Metabolite	Metabolic Disease
alpha-2,3-Sialyltransferase (PmST3) (EC 2.4.99.4) is a beta-galactoside. alpha-2,3-Sialyltransferase (PmST3) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids .

HY-160874

GST-FH.4	Glutathione S-transferase	Metabolic Disease
GST-FH.4 is a GST-FH compound, a complex that produces frequent false positive hits (FH) in the interaction between glutathione S-transferase (GST) and glutathione (GSH) . GST-FH.4 inhibits glutathione S-transferase (GST) activity with an IC₅₀ of 24.38 μM .

HY-160875

GST-FH.1	Glutathione S-transferase	Metabolic Disease
GST-FH.1 is a GST-FH compound, a complex that produces frequent false positive hits (FH) in the interaction between glutathione S-transferase (GST) and glutathione (GSH) . GST-FH.4 inhibits glutathione S-transferase (GST) activity with an IC₅₀ of 0.32 μM .

HY-N0842

Bevirimat 1 Publications Verification PA-457; MPC-4326; YK FH312	Virus Protease	Infection
Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies .

HY-RS17117

fh Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
fh Mouse Pre-designed siRNA Set A contains three designed siRNAs for fh gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

fh Mouse Pre-designed siRNA Set A fh Mouse Pre-designed siRNA Set A

HY-RS04930

FH Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FH Human Pre-designed siRNA Set A contains three designed siRNAs for FH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FH Human Pre-designed siRNA Set A FH Human Pre-designed siRNA Set A

HY-RS23562

Fh Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fh Rat Pre-designed siRNA Set A contains three designed siRNAs for Fh gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fh Rat Pre-designed siRNA Set A Fh Rat Pre-designed siRNA Set A

HY-N0842R

Bevirimat (Standard) PA-457 (Standard); MPC-4326 (Standard); YK FH312 (Standard)	Virus Protease	Infection
Bevirimat (Standard) is the analytical standard of Bevirimat. This product is intended for research and analytical applications. Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies[1][2][3][4].

HY-N8378

Clonostachydiol	Others	Infection
Clonostachydiol is an anthelmintic macrodiolide from the fungus Clonostachys cylindrospora (strain FH-A 6607) .

HY-P991067

Vensobafusp alfa KP-104	Complement System	Inflammation/Immunology
Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .

HY-150686

Chitin synthase inhibitor 4	Fungal	Infection
Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture .

HY-W028210

O-Phthalimide-C5-acid	Biochemical Assay Reagents	Inflammation/Immunology
6-N-Phthalimidoy hexanoic acid (compound FH) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 6-N-Phthalimidoy hexanoic acid can be combined with carrier proteins and used in antigen design .

HY-P2969

Complement factor I	Endogenous Metabolite	Metabolic Disease
Complement factor I is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH), complement receptor 1 (CR1/CD35), C4 binding protein (C4BP) or membrane cofactor protein (MCP/CD46) .

HY-N9220

6-Epi-albassitriol	Influenza Virus	Infection
6-Epi-albassitriol can be isolated from Aspergillus sp. FH-A 6357. 6-Epi-albassitriol inhibits the cholesterol synthesis with an inhibition rate of 40% at a concentration of 10 nM in HepG2. 6-Epi-albassitriol exhibits antiviral activity against influenza A virus and parainfluenza virus with MIC of 44.4-133.3 µg/mL .

HY-34350

2-(Aminomethyl)phenol 2-Hydroxybenzylamine; o-Hydroxybenzylamine; 2-HOBA	Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
2-(Aminomethyl)phenol (2-Hydroxybenzylamine), a selective dicarbonyl scavenger, is an antioxidant and scavanger of free radicals and isolevuglandins (IsoLGs). 2-(Aminomethyl)phenol can be used in the research of inflammation and cardiovascular disease, such as atherosclerosis, early recurrence of atrial fibrillation (AF) and arrhythmias .

HY-D0917

TO-PRO 1	DNA Stain	Cancer
TO-PRO 1 is a DNA-binding fluorescent dye for non-living cells (Ex/Em=515 nm/531 nm). TO-PRO 1 can intercalate into base pairs of double-stranded DNA and produce stronger fluorescence. TO-PRO 1 is suitable for necrotic cells or late apoptotic cells with damaged cell membranes, showing green fluorescence under fluorescence microscopy or flow cytometry. TO-PRO 1 can be used to distinguish live cells from dead cells and distinguish cell membrane integrity. TO-PRO 1 can be attached to the surface of Feraheme (FH) nanoparticles (NPs) to obtain fluorescent dye-functionalized NPs for drug delivery studies .

Cat. No.	Product Name	Type

HY-D0917

TO-PRO 1	DNA Stain
TO-PRO 1 is a DNA-binding fluorescent dye for non-living cells (Ex/Em=515 nm/531 nm). TO-PRO 1 can intercalate into base pairs of double-stranded DNA and produce stronger fluorescence. TO-PRO 1 is suitable for necrotic cells or late apoptotic cells with damaged cell membranes, showing green fluorescence under fluorescence microscopy or flow cytometry. TO-PRO 1 can be used to distinguish live cells from dead cells and distinguish cell membrane integrity. TO-PRO 1 can be attached to the surface of Feraheme (FH) nanoparticles (NPs) to obtain fluorescent dye-functionalized NPs for drug delivery studies .

TO-PRO 1

DNA Stain

TO-PRO 1 is a DNA-binding fluorescent dye for non-living cells (Ex/Em=515 nm/531 nm). TO-PRO 1 can intercalate into base pairs of double-stranded DNA and produce stronger fluorescence. TO-PRO 1 is suitable for necrotic cells or late apoptotic cells with damaged cell membranes, showing green fluorescence under fluorescence microscopy or flow cytometry. TO-PRO 1 can be used to distinguish live cells from dead cells and distinguish cell membrane integrity. TO-PRO 1 can be attached to the surface of Feraheme (FH) nanoparticles (NPs) to obtain fluorescent dye-functionalized NPs for drug delivery studies .

Cat. No.	Product Name	Target	Research Area

HY-P991067

Vensobafusp alfa KP-104	Complement System	Inflammation/Immunology
Vensobafusp alfa (KP-104) is a fusion protein composed of an IgG4 monoclonal antibody directed against terminal complement protein C5 fused to the complement factor H 1-5 domain (FH1-5). Vensobafusp alfa shows anti-inflammatory and immunomodulatory activities. The isotype control for Vensobafusp alfa can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) . .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0842

Bevirimat 1 Publications Verification PA-457; MPC-4326; YK FH312	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Myrtaceae Plants Syzygium aromaticum Disease Research Fields	Virus Protease
Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies .

HY-34350

2-(Aminomethyl)phenol 2-Hydroxybenzylamine; o-Hydroxybenzylamine; 2-HOBA	Cardiovascular Disease Structural Classification Monophenols Reseda odorata L. Oleaceae Classification of Application Fields Phenols Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
2-(Aminomethyl)phenol (2-Hydroxybenzylamine), a selective dicarbonyl scavenger, is an antioxidant and scavanger of free radicals and isolevuglandins (IsoLGs). 2-(Aminomethyl)phenol can be used in the research of inflammation and cardiovascular disease, such as atherosclerosis, early recurrence of atrial fibrillation (AF) and arrhythmias .

HY-N0842R

Bevirimat (Standard) PA-457 (Standard); MPC-4326 (Standard); YK FH312 (Standard)	Triterpenes Structural Classification Terpenoids Source classification Myrtaceae Plants Syzygium aromaticum	Virus Protease
Bevirimat (Standard) is the analytical standard of Bevirimat. This product is intended for research and analytical applications. Bevirimat (PA-457, MPC-4326, YK FH312) is an inhibitor of HIV-1 viral particle maturation.Bevirimat specifically inhibits the final rate-limiting step in Gag processing, preventing the release of the mature capsid protein (CA) from its precursor (CA-SP1), resulting in the production of immature non-infectious viral particles. Bevirimat can be used in HIV-1 infection studies[1][2][3][4].

HY-N8378

Clonostachydiol	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Others
Clonostachydiol is an anthelmintic macrodiolide from the fungus Clonostachys cylindrospora (strain FH-A 6607) .

Species:	Human (6) Mouse (1) Cynomolgus (1)
Tag:	His (6) Tag Free (1) Avi (2) Fc (1)
Source:	HEK293 (6) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70267

	Fumarate hydratase/FH Protein, Human rHuFumarate hydratase/FH; Fumarate Hydratase Mitochondrial; Fumarase; FH	Human	E. coli
	The fumarate hydratase/FH protein plays a key role in cellular processes as it catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle, which is essential for energy production through the production of NADH . Fumarate hydratase/FH Protein, Human is the recombinant human-derived Fumarate hydratase/FH protein, expressed by E. coli , with tag free.

HY-P73062

	Fumarate Hydratase/FH Protein, Human (His) Fumarate Hydratase; Fumarase; HsFH; FH	Human	E. coli
	The fumarate hydratase/FH protein plays a key role in cellular processes as it catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle, which is essential for energy production through the production of NADH . Fumarate Hydratase/FH Protein, Human (His) is the recombinant human-derived Fumarate Hydratase/FH protein, expressed by E. coli , with C-His labeled tag.

HY-P78663

	PCSK9 Protein, Human (D374Y, HEK293, His) PCSK9; FH3; HCHOLA3; LDLCQ1; NARC1; PC9	Human	HEK293
	The PCSK9 protein is an important regulator of plasma cholesterol homeostasis, affecting LDL receptor family members such as LDLR and VLDLR. It promotes their intracellular degradation and enhances hepatic LDLR degradation through non-proteolytic mechanisms. PCSK9 Protein, Human (D374Y, HEK293, His) is the recombinant human-derived PCSK9 protein, expressed by HEK293 , with C-10*His labeled tag and D374Y mutation.

HY-P78824

	PCSK9 Protein, Human (Biotinylated, HEK293, D374Y, His-Avi) PCSK9; FH3; HCHOLA3; LDLCQ1; NARC1; PC9	Human	HEK293
	The PCSK9 protein is an important regulator of plasma cholesterol homeostasis, affecting LDL receptor family members such as LDLR and VLDLR. It promotes their intracellular degradation and enhances hepatic LDLR degradation through non-proteolytic mechanisms. PCSK9 Protein, Human (Biotinylated, HEK293, D374Y, His-Avi) is the recombinant human-derived PCSK9 protein, expressed by HEK293 , with C-Avi, C-His labeled tag and D374Y, , , , mutation.

HY-P72946

	Complement factor H/CFH Protein, Human (372a.a, HEK293, His) Complement factor H; H factor 1; CFH; HF; HF1; HF2	Human	HEK293
	Complement factor H/CFH proteins regulate complement activation and act as soluble inhibitors to prevent complement amplification on the cell surface. Complement factor H/CFH Protein, Human (372a.a, HEK293, His) is the recombinant human-derived Complement factor H/CFH protein, expressed by HEK293 , with C-His labeled tag.

HY-P74232

	Complement factor H/CFH Protein, Mouse (HEK293, Fc) Complement factor H; Protein beta-1-H; CFH	Mouse	HEK293
	Complement factor H (CFH) protein has C3b and heparin-binding activity and plays a multifaceted role in various processes such as organ development, complement activation, and vasculature development. It is present in different cellular compartments and expressed in different structures, including the adrenal gland, bone, central nervous system, humeral cartilage condensation, and metanephros. Complement factor H/CFH Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Complement factor H/CFH protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77735

	LDLR Protein, Cynomolgus (HEK293, His) LDLR; FHC; LDL R; LDL receptor; LDLCQ2; FH	Cynomolgus	HEK293
	LDLR Protein plays a pivotal role in cholesterol homeostasis, binding to LDL and mediating cellular uptake through endocytosis. Clustering into clathrin-coated pits is essential for internalization. In microbial infection, LDLR acts as a receptor for hepatitis C virus in hepatocytes, emphasizing its dual functionality in cholesterol metabolism and the cellular response to viral infections. LDLR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived LDLR protein, expressed by HEK293 , with C-His labeled tag.

HY-P700860

	LDLR Protein, Human (HEK293, Avi-His) LDLR; FHC; LDL R; LDL receptor; LDLCQ2; FH	Human	HEK293
	LDLR Protein plays a pivotal role in cholesterol homeostasis, binding to LDL and mediating cellular uptake through endocytosis. Clustering into clathrin-coated pits is essential for internalization. In microbial infection, LDLR acts as a receptor for hepatitis C virus in hepatocytes, emphasizing its dual functionality in cholesterol metabolism and the cellular response to viral infections. LDLR Protein, Human (HEK293, Avi-His) is the recombinant human-derived LDLR protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83717

	LDLR Antibody (YA3452) LDLR_HUMAN; Low-density lipoprotein receptor; LDL receptor; FH; FHC; FHCL1; LDLCQ2; low density lipoprotein receptor;	WB, IHC-P	Human, Mouse
	LDLR Antibody is an unconjugated, approximately 92 kDa, rabbit-derived, anti-LDLR monoclonal antibody. LDLR Antibody can be used for: WB, IHC-P expriments in human, mouse background without labeling.

HY-P80672

	FH Antibody (YA763) Fumarate hydratase; mitochondrial; Fumarase	WB, ICC/IF	Human, Mouse, Rat
	FH Antibody (YA763) is a non-conjugated and Mouse origined monoclonal antibody about 55 kDa, targeting to FH (2A3). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

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Cat. No.	Product Name		Classification

HY-RS17117

fh Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
fh Mouse Pre-designed siRNA Set A contains three designed siRNAs for fh gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04930

FH Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FH Human Pre-designed siRNA Set A contains three designed siRNAs for FH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23562

Fh Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Fh Rat Pre-designed siRNA Set A contains three designed siRNAs for Fh gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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FH

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