LDLR Protein, Rabbit (HEK293, Fc)

LDLR Protein binds LDL, transporting cholesterol via endocytosis. Clustering in clathrin-coated pits initiates internalization. Interactions include DAB2 (via PID domain) through the NPXY motif, hindered by tyrosine phosphorylation. LDLR also interacts with LDLRAP1 (via PID domain) through the NPXY motif, ARRB1, SNX17, and the full-length immature PCSK9 through the C-terminus. LDLR Protein, Rabbit (HEK293, Fc) is the recombinant Rabbit-derived LDLR protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LDLR Protein, Rabbit (HEK293, Fc) is 757 a.a., with molecular weight of 120-140 kDa.

LDLR protein functions by binding to LDL, the primary lipoprotein responsible for carrying cholesterol in the bloodstream, and facilitating its uptake into cells through endocytosis. For internalization to occur, the receptor-ligand complexes must cluster within clathrin-coated pits. It engages in interactions with various proteins, including DAB2 (via PID domain) through the NPXY motif, although tyrosine phosphorylation of the NPXY motif can hinder this interaction. LDLR also interacts with LDLRAP1 (via PID domain) via the NPXY motif, as well as with ARRB1 and SNX17. Additionally, it interacts with the full-length immature form of PCSK9, specifically through the C-terminus.

Rabbit

HEK293

C-hFc

P20063 (A9-G765)

100009086

120-140 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.