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DPPH radical scavenging activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) Akt (3) Aldose Reductase (2) AMPK (2) Amylases (1) AP-1 (2) Apoptosis (5) Autophagy (1) Bacterial (8) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (2) Cholinesterase (ChE) (3) COX (4) Cytochrome P450 (2) EGFR (2) Elastase (1) Endogenous Metabolite (2) ERK (1) Fatty Acid Synthase (FASN) (1) Fluorescent Dye (1) Fungal (6) FXR (1) Glycosidase (2) HIV (1) HMG-CoA Reductase (HMGCR) (1) IFNAR (3) Influenza Virus (1) Interleukin Related (5) JNK (1) Microphthalmia Associated Transcription Factor (MITF) (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) NF-κB (1) NO Synthase (5) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (1) p38 MAPK (2) Parasite (1) PD-1/PD-L1 (2) PERK (1) Phosphodiesterase (PDE) (1) PI3K (1) PKA (1) PPAR (1) Raf (1) Ras (2) Reactive Oxygen Species (26) Reference Standards (2) STAT (2) Tim3 (2) TNF Receptor (2) TRP Channel (1) TrxR (1) Tyrosinase (3) Urease (1) Wnt (2)
By Research Areas:	Cancer (24) Cardiovascular Disease (2) Infection (13) Inflammation/Immunology (36) Metabolic Disease (13) Neurological Disease (11)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111898

Epirosmanol	Others	Cancer
Epirosmanol is a nature diterpene lactone from S. officinalis. Epirosmanol shows anti-cancer activity and inhibits melanin biosynthesis against melanoma cells. Epirosmanol also exhibits DPPH radical scavenging activity .

HY-N3141

Olivil (-)-Olivile; Vladinol C	Others	Others
Olivil ((-)-Olivile) is a lignan that has weak DPPH radical-scavenging activity (EC₅₀: 176 μM) .

HY-N6043

Hydroxytyrosol acetate	Others	Inflammation/Immunology
Hydroxytyrosol acetate is found in the olive oil with an antioxidant activity. Hydroxytyrosol acetate had a weaker DPPH radical scavenging activity than hydroxytyrosol .

HY-N10927

2,11,12-Trihydroxy-7,20-epoxy-8,11,13-abietatriene	Others	Others
2,11,12-Trihydroxy-7,20-epoxy-8,11,13-abietatriene, a diterpenoid, has significant effects on DPPH radical scavenging activity with an IC₅₀ value of 20.0 µM. 2,11,12-Trihydroxy-7,20-epoxy-8,11,13-abietatriene shows potent antioxidant activity .

HY-146172

Antioxidant agent-3	Reactive Oxygen Species	Inflammation/Immunology Cancer
Antioxidant agent-3 (Compound 14q), an potent antioxidant, displays potent **DPPH radicals scavenging** activity and ABTS ⁺ scavenging activity with IC₅₀s of 26.58 and 30.31 μM, respectively. Antioxidant agent-3 (Compound 14q) increases reactive oxygen species (ROS), superoxide dismutase (SOD) and glutathione (GSH), and reduced lactate dehydrogenase (LDH) in H₂O₂-treated HepG2 cells .

HY-N9814

Shanciol B	NO Synthase	Inflammation/Immunology
Shanciol B, isolated from the ethyl acetate extract of the air-dried whole plant of Pholidota imbricate Hook, inhibits nitric oxide (NO) production and 1,1-diphenyl-2-picrylhydrazil (DPPH) radical scavenging activity . Shanciol B is a microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with anti-inflammatory activity .

HY-121153

Altenusin Alutenusin	FXR	Others
Altenusin shows markedly DPPH radical scavenging activities.

HY-133183

Urolignoside	Biochemical Assay Reagents	Others
Urolignoside is an antioxidant with free radical scavenging activity. Urolignoside potently scavenges DPPH radical, and exhibits antioxidant to β-carotene-lineoleate model .

HY-155346

Free radical scavenger 1	Others	Others
Free radical scavenger 1 (compound 8) shows scavenging activity against the *DPPH* radical, with the IC₅₀ of 43.39 μg/ml .

HY-W018643A

(E)-Ferulic acid methyl ester Methyl (E)-ferulate	COX	Others
(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) exhibits strong DPPH and ABTS ⁺ radical scavenging activities .

HY-N9447

Norbergenin 1 Publications Verification	Reactive Oxygen Species	Neurological Disease
Norbergenin, the O-demethyl derivative of bergenin, shows moderate antioxidant activity (IC₅₀ 13 μM in DPPH radical scavenging; 32 μM in superoxide anion scavenging) .

HY-N11895

Isorabaichromone	Reactive Oxygen Species	Inflammation/Immunology
Isorabaichromone is a potent antioxidant agent. Isorabaichromone shows a potent antioxidative activity and exhibits DPPH radical and superoxide anion scavenging activities .

HY-111523

Isomahanine	p38 MAPK Apoptosis Autophagy Caspase	Metabolic Disease
Isomahanine, carbazole alkaloid, is an antioxidative agent. Isomahanine has DPPH radical scavenging activity with an IC₅₀ value of 24 μM .

HY-N7931

Regaloside A 1 Publications Verification	NO Synthase NF-κB	Inflammation/Immunology
Regaloside A, a phenylpropanoid, shows significant DPPH radical scavenging activity of 58.0% at 160 ppm. Regaloside A has anti-inflammatory activity .

HY-N3349A

(-)-Lyoniresinol	Reactive Oxygen Species	Others
(-)-Lyoniresinol is a lignan isolated from the Tarenna attenuata with antioxidant activities. (-)-Lyoniresinol has radical scavenging activities against DPPH with an IC₅₀ of 82.4 μM .

HY-N3349

Lyoniresinol	Others	Others
Lyoniresinol is a lignan isolated from the Tarenna attenuata with antioxidant activities. Lyoniresinol has radical scavenging activities against DPPH with an IC₅₀ of 82.4 μM .

HY-N3985

Gyrophoric acid	Others	Cancer
Gyrophoric acid is a good ultraviolet filter in lichen populations. Gyrophoric acid shows **DPPH radical scavenging** activity with an IC₅₀ value of 105.75 μg/ml .

HY-124496

Piperitenone	Mitochondrial Metabolism Reactive Oxygen Species	Others
Piperitenone is a terpenoid, and exhibits antioxidant activity. Piperitenone scavenges DPPH free radicals with an IC₅₀ of 22.7 μg/mL, and inhibits the peroxidation of linoleic acid .

HY-N4111

Wushanicaritin 1 Publications Verification	Others	Inflammation/Immunology Cancer
Wushanicaritin exhibits significant antioxidant activity (IC₅₀=35.3 μM) in DPPH radical scavenging activity tests. Antitumor effects and anti-inflammatory property .

HY-112053R

DPPH (Standard)	Reactive Oxygen Species	Metabolic Disease
DPPH (Standard) is the analytical standard of DPPH. This product is intended for research and analytical applications. DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants .

HY-N8169

10-O-Trans-p-methoxycinnamoylcatalpol	Others	Others
10-O-Trans-p-methoxycinnamoylcatalpol has antioxidant activity with the IC₅₀ value of 0.37 μM/mL in DPPH free radical scavenging assay .

HY-N7518

Eulophiol	Others	Inflammation/Immunology
Eulophiol shows the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity with an EC₅₀ of 27.7μM. Antioxidant activity .

HY-112053

DPPH Maximum Cited Publications 23 Publications Verification 2,2-Diphenyl-1-picrylhydrazyl	Reactive Oxygen Species	Metabolic Disease
DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that can be used to measure the radical scavenging activity of antioxidants. The odd electron of nitrogen atom in DPPH is reduced by receiving a hydrogen atom from antioxidants to the corresponding hydrazine. DPPH method may be utilized in aqueous and nonpolar organic solvents and can be used to examine both hydrophilic and lipophilic antioxidants .

HY-N13128

Icaritin-3-O-rhamnoside	Others	Others
Icaritin-3-O-rhamnoside (compound 20) is a flavonoid compound that exhibits DPPH radical scavenging activity (IC50=227.9 μM) .

HY-N12941

Macarangin	Reactive Oxygen Species NOD-like Receptor (NLR)	Inflammation/Immunology
Macarangin can be isolated from propolis. Macarangin has DPPH radical-scavenging activity and shows anti-inflammatory activities via inhibiting the activation process of NLRP3 inflammasome .

HY-N12897

JBIR-94	Others	Others
JBIR-94 is a phenolic compound and can be isolated from Streptomyces. JBIR-94 has DPPH radical scavenging activity with an IC₅₀ value of 11.4 μM .

HY-121811

Pongamol Lanceolatin C	Glycosidase	Metabolic Disease Inflammation/Immunology
Pongamol (Lanceolatin C) is potent α-glucosidase inhibitor (IC₅₀=103.5 μM) and has free-radical (DPPH) scavenging,antihyperglycemic, and antihyperglycemic activities .

HY-130294

Pyracrenic acid	Elastase	Inflammation/Immunology
Pyracrenic acid is an elastase inhibitor (IC₅₀ = 2.42 µM), can be obtained from the bark of Pyracantha crenulata. Pyracrenic acid has DPPH free radical scavenging activity and anti-inflammatory activity .

HY-N8194

Syringetin-3-O-glucoside Syringetin 3-O-β-D-glucoside	Others	Neurological Disease
Syringetin-3-O-glucosid (Syringetin 3-O-β-D-glucoside), a flavonol glycoside, shows relatively weak DPPH and ABTS radical scavenging activity .

HY-N1417

Sesamol 1 Publications Verification	Apoptosis	Cancer
Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC₅₀=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities . Anticancer activities .

HY-W001542

5-Hydroxyoxindole	Reactive Oxygen Species	Neurological Disease Metabolic Disease Cancer
5-Hydroxyoxindole is a structural analog of uric acid. 5-Hydroxyoxindole has *DPPH* radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders .

HY-W274194

Antioxidant agent-7	Reactive Oxygen Species	Others
Antioxidant agent-7 (SD-7) is a benzodiazepine derivative with antioxidant activity with an IC₅₀ value of 470 nM to scavenge DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical .

HY-172604

Neuroprotective agent 10	Others	Neurological Disease Inflammation/Immunology
Neuroprotective agent 10 (Compound 11c) is a brain-penetrant neuroprotective agent. Neuroprotective agent 10 scavenges ABTS radicals (scavenging IC₅₀: 9.20 μM), DPPH radicals (scavenging IC₅₀: 7.09 μM) and superoxide anion radicals (inhibition percentage: 48.4%). Neuroprotective agent 10 also alleviates H₂O₂-induced oxidative damage and LPS-induced neuroinflammation with antiepileptic activity. Neuroprotective agent 10 is promising for research of epilepsy and neuroprotection .

HY-W357738

Urease-IN-14	Bacterial Urease	Infection
Urease-IN-14 (compound 15) is an urease inhibitor and antioxidant. Urease-IN-14 shows DPPH radical scavenging and urease inhibitory activities with IC₅₀ values 151.7 μM and 41.6 μM, respectively .

HY-W416228

1-O-Caffeoyl-β-D-glucopyranose	Reactive Oxygen Species	Others
1-O-Caffeoyl-β-D-glucopyranose, a phenylpropanoid compound derived from Illicium majus, exhibits significant antioxidant activity and can scavenge DPPH radicals in vitro, with an IC₅₀ value of 37.7 μM .

HY-N8254

Haginin A	Others	Others
Haginin A (compound 3）can be isolated from the EtOAc fraction of Lespedeza cyrtobotrya. Haginin A has **radical scavenging activity with IC₅₀ values of 9.0 μM and 37.7 μM in the ABTS system and DPPH system, respectively .**

HY-W714006

Cochliodinol	Reactive Oxygen Species	Metabolic Disease
Cochliodinol (compound 1) is a metabolite derived from the Apis mellifera ligustica. Cochliodinol has strong free radical scavenging activity of 2, 2-diphenyl-1-picrohydrazine (DPPH) (IC₅₀=3.06 μg/mL) .

HY-N12443

Antioxidant agent-18	Cytochrome P450	Inflammation/Immunology
Antioxidant agent-18 (compound 5) is a flavonol glycoside with antioxidant activity isolated from Ginkgo biloba. Antioxidant agent-18 scavenges DPPH radicals (IC₅₀: 15.8 μM) and reduces cytochrome c (IC₅₀: 14.7 μM).

HY-N9895

3,5-Dicaffeoyl-epi-quinic acid	Others	Infection Inflammation/Immunology
3,5-Dicaffeoyl-epi-quinic acid can be extracted from Chrysanthemum morifolium. 3,5-Dicaffeoyl-epi-quinic acid has antioxidant activities. 3,5-Dicaffeoyl-epi-quinic acid can scavenge *DPPH* radical and superoxide anion radical, with IC₅₀s of 5.6 and 2.9 μg/mL respectively .

HY-N1994

Swertianine	Reactive Oxygen Species	Inflammation/Immunology
Swertianine is a hydroxyexanthone that can be isolated from Swertia decussata. Swertianine has antioxidant activity by inhibiting lipid peroxidation, scavenging DPPH and superoxide free radicals. Swertianine also inhibits γ-ray induced DNA damage of pBR322 with protective effect .

HY-N13707

3′-Hydroxytectorigenin-7-O-β-D-xylosyl-(1→6)-β-D-glucopyranoside	Reactive Oxygen Species	Others
3′-Hydroxytectorigenin-7-O-β-D-xylosyl-(1→6)-β-D-glucopyranoside is an antioxidant that can be found in Pueraria montana var. lobata. It exhibits *DPPH* radical scavenging activity, with an IC₅₀ value of 42 μg/mL .

HY-N10742

Maritimetin	Reactive Oxygen Species	Cardiovascular Disease
Maritimein is an aurone that can be isolated from Coreopsis tinctoria. Maritimein shows strong diphenyl(2,4,6-trinitrophenyl)iminoazanium (DPPH) radical-scavenging activity with an IC₅₀ value of 4.12 μM. Maritimein can be used for the research of cardiovascular disease .

HY-156711

Ternatumoside II	IFNAR	Inflammation/Immunology
Ternatumoside II is a flavonoid glycoside that can be isolated from R. crenulata. Ternatumoside II can stimulate IFN-γ expression. Ternatumoside II has radical-scavenging activities (IC₅₀s: 260.5 μM and 320.2 μM for DPPH and ABTS) .

HY-N10294

Epicoccone B	HIV	Infection Inflammation/Immunology
Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC₅₀ value of 10.8 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 27.3 μM. Anti-HIV activity .

HY-N13169

Quercetin 3-O-(6-O-malonyl-β-D-galactoside)	Others	Others
Quercetin 3-O-(6-O-malonyl-β-D-galactoside) is an antioxidant derived from Apocynum venetum that exhibits strong scavenging activity against DPPH (HY-112053) free radicals, with an EC₅₀ value of 11.4 μM .

HY-N1417R

Sesamol (Standard)	Reference Standards Apoptosis	Cancer
Sesamol (Standard) is the analytical standard of Sesamol. This product is intended for research and analytical applications. Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities . Anticancer activities .

HY-131803

3'-Azido-3'-deoxyguanosine	Nucleoside Antimetabolite/Analog	Inflammation/Immunology
Urolignoside is an antioxidant with free radical scavenging activity. Urolignoside potently scavenges DPPH radical, and exhibits antioxidant to β-carotene-lineoleate model . 3'-Azido-3'-deoxyguanosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-136593

(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid (S)-3-(4-Hydroxyphenyl)lactic acid	Reactive Oxygen Species	Others
(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid (compound 1) is a metabolite isolated from the culture medium of Leuconostoc mesenteroides. (S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid has high DPPH radical-scavenging activities and antioxidative activities .

HY-N0539

Calceolarioside B	Aldose Reductase	Cancer
Calceolarioside B is a natural product isolated from Akebia quinata leaves. Calceolarioside B exhibits significant inhibitory activity against rat lens aldose reductase (RLAR) with an IC₅₀ of 23.99 μM. Calceolarioside B displays inhibitory effect on DPPH radical scavenging activity with an IC₅₀ of 94.60 μM .

HY-N7648

Atherosperminine Atherospermine	Parasite	Infection
Atherosperminine (Atherospermine) is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC₅₀ of 5.80 μM. Atherosperminine is a good reductant with the ability to chelate metals. Atherosperminine has scavenging activity towards the free radical *DPPH, with an IC₅₀* of 29.56 μg/mL. Atherosperminine exerts a non-specific relaxant effect on the trachealis .

Cat. No.	Product Name	Type

HY-D0168

Orcinol

3,5-Dihydroxytoluene

Dyes

Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases .

Cat. No.	Product Name	Target	Research Area

HY-P1934A

Cyclo(L-Phe-L-Pro)	Fungal Bacterial IFNAR Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-P1934AR

Cyclo(L-Phe-L-Pro) (Standard)	Fungal Bacterial IFNAR Reactive Oxygen Species	Infection Inflammation/Immunology Cancer
Gallic acid (hydrate) (Standard) is the analytical standard of Gallic acid (hydrate). This product is intended for research and analytical applications. Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

Cat. No.	Product Name		Classification

HY-131803

3'-Azido-3'-deoxyguanosine		Azide
Urolignoside is an antioxidant with free radical scavenging activity. Urolignoside potently scavenges DPPH radical, and exhibits antioxidant to β-carotene-lineoleate model . 3'-Azido-3'-deoxyguanosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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