DDB1

By Targets:	Apoptosis (5) Autophagy (3) CDK (4) DNA/RNA Synthesis (1) EGFR (2) FAK (2) Fluorescent Dye (1) Ligands for E3 Ligase (4) Molecular Glues (6) PROTACs (5) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (12) Inflammation/Immunology (4)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-161166

MM-02-57	Others	Others
MM-02-57 is a covalent DDB1 CUL4A adaptor protein recruiter ^[1].

HY-163944

LL-K12-18	Molecular Glues CDK	Cancer
LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the *CDK12-DDB1* complex, stabilizing the *CDK12-DDB1* complex and promoting the degradation of cyclin K (EC₅₀=0.37 nM). LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research ^[1].

HY-14658

Thalidomide 15+ Cited Publications	Ligands for E3 Ligase Autophagy Apoptosis Molecular Glues	Inflammation/Immunology Cancer
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a K_d of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.

HY-144981

HQ461	CDK Molecular Glues	Cancer
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death ^[1].

HY-RS03606

DDB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DDB1 Human Pre-designed siRNA Set A contains three designed siRNAs for DDB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DDB1 Human Pre-designed siRNA Set A DDB1 Human Pre-designed siRNA Set A

HY-RS24422

Ddb1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ddb1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ddb1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddb1 Rat Pre-designed siRNA Set A Ddb1 Rat Pre-designed siRNA Set A

HY-RS17951

Ddb1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ddb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ddb1 Mouse Pre-designed siRNA Set A Ddb1 Mouse Pre-designed siRNA Set A

HY-161167

MM-02-08	PROTACs	Cancer
MM-02-08 is the potent BRD4 degrader and binds to DDB1 ^[1].

HY-150641

CDK-IN-9	CDK Apoptosis DNA/RNA Synthesis Molecular Glues	Cancer
CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC₅₀ values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II ^[1].

HY-14658S

Thalidomide-d4	Molecular Glues Ligands for E3 Ligase Autophagy Apoptosis	Inflammation/Immunology Cancer
Thalidomide-d₄ is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties ^[1] .

HY-14658R

Thalidomide (Standard)	Ligands for E3 Ligase Autophagy Apoptosis Reference Standards	Inflammation/Immunology Cancer
Thalidomide (Standard) is the analytical standard of Thalidomide. This product is intended for research and analytical applications. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a K_d of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.

HY-161633

PROTAC EGFR degrader 11	PROTACs EGFR FAK	Cancer
PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC₅₀ <100 nM. PROTAC EGFR degrader 11 binds CRBN-DDB1 with a K_i of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC₅₀ <100 nM.

HY-161632

PROTAC EGFR degrader 10	PROTACs EGFR FAK	Cancer
PROTAC EGFR degrader 10 (Compound B56) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC₅₀ <100 nM. PROTAC EGFR degrader 10 binds CRBN-DDB1 with a K_i of 37 nM. PROTAC EGFR degrader 10 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC₅₀ <150 nM ^[1].

HY-122653

CCT367766	PROTACs	Cancer
CCT367766 is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an IC₅₀ value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with K_d values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein ^[1].

HY-122653A

CCT367766 formic	PROTACs	Cancer
CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC₅₀ value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with K_d values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein ^[1].

HY-W181530

NCT02	Molecular Glues CDK Apoptosis Ligands for E3 Ligase	Cancer
NCT02 is a molecular glue degrader based on the E3 ubiquitin ligase *DDB1* that targets CDK12 and its binding partner CCNK. NCT02 triggers the ubiquitination and proteasomal degradation of CCNK, thereby downregulating CDK12 protein levels and inhibiting its downstream signaling pathways. NCT02 can induce tumor cell apoptosis, arrest the cell cycle, and selectively inhibit the proliferation of colorectal cancer cells carrying TP53 defects or belonging to the consensus molecular subtype CMS4. NCT02 has the potential to inhibit tumor growth in in vitro and in vivo models ^[1] .

HY-133870

Itaconate-alkyne 2 Publications Verification ITalk	Fluorescent Dye	Inflammation/Immunology
Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate ^[1]. Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Species:	Human (19)
Tag:	His (12) Strep (7) Tag Free (5) Avi (3) Flag (1)
Source:	HEK293 (1) Sf9 insect cells (18)

Cat. No.	Compare	Product Name	Species	Source

HY-P703563

	DDB1 Protein, Human (sf9, His) XAP1	Human	Sf9 insect cells
	DDB1 Protein, Human (sf9, His) is the recombinant human-derived DDB1, expressed by sf9 insect cells , with His labeled tag.

HY-P701520

	*DCAF15-DDB1* Protein, Human (sf9, His, StrepⅡ)** DCAF15-DDB1 complex; DCAF15; DDB1- and CUL4-associated factor 15	Human	Sf9 insect cells
	DCAF15 serves as a substrate recognition component in the DCX (DCAF15) complex, coordinating the ubiquitination and degradation of target proteins and may affect NK cell function and APC-NK cell interactions. Notably, arylsulfonamide anticancer drugs alter the substrate specificity of the complex, promoting ubiquitination and degradation of RBM39, RBM23, and PRPF39. DCAF15-DDB1 Protein, Human (sf9, His, Strep) is the recombinant human-derived DCAF15-DDB1 protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.

HY-P701517

	DCAF16 Protein, Human (sf9) DCAF16; DDB1- and CUL4-associated factor 16	Human	Sf9 insect cells
	DCAF16 Protein, a vital component in the CUL4-DDB1 E3 ubiquitin-protein ligase complex, serves as a crucial substrate recognition element. It plays a central role in ubiquitination and subsequent proteasome-dependent degradation of nuclear proteins, emphasizing its key involvement in protein modification processes, particularly in the regulation of protein ubiquitination. DCAF16 Protein, Human (sf9) is the recombinant human-derived DCAF16 protein, expressed by sf9 insect cells , with tag free.

HY-P701519

	DCAF15 Protein, Human (sf9) DCAF15; DDB1- and CUL4-associated factor 15	Human	Sf9 insect cells
	DCAF15 serves as a substrate recognition component in the DCX (DCAF15) complex, coordinating the ubiquitination and degradation of target proteins and may affect NK cell function and APC-NK cell interactions. Notably, arylsulfonamide anticancer drugs alter the substrate specificity of the complex, promoting ubiquitination and degradation of RBM39, RBM23, and PRPF39. DCAF15 Protein, Human (sf9) is the recombinant human-derived DCAF15 protein, expressed by sf9 insect cells , with tag free.

HY-P701518

	DCAF16 Protein, Human (sf9, His) DCAF16; DDB1- and CUL4-associated factor 16	Human	Sf9 insect cells
	DCAF16 Protein, a vital component in the CUL4-DDB1 E3 ubiquitin-protein ligase complex, serves as a crucial substrate recognition element. It plays a central role in ubiquitination and subsequent proteasome-dependent degradation of nuclear proteins, emphasizing its key involvement in protein modification processes, particularly in the regulation of protein ubiquitination. DCAF16 Protein, Human (sf9, His) is the recombinant human-derived DCAF16 protein, expressed by sf9 insect cells , with N-6*His labeled tag.

HY-P701521

	DCAF7 Protein, Human (sf9) DCAF7; DDB1- and CUL4-associated factor 7; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog	Human	Sf9 insect cells
	The DCAF7 protein occupies a central position in craniofacial development and is critical for the EDN1 pathway and maxillary formation. Its nuanced involvement suggests different requirements for EDN1 function in the first and second arches. DCAF7 Protein, Human (sf9) is the recombinant human-derived DCAF7 protein, expressed by sf9 insect cells , with tag free.

HY-P702817

	*Cereblon-DDB1-Cul4A-Rbx1 Complex Protein, Human (HEK293, Flag, His)* Cereblon-DDB1-Cul4A-Rbx1 Complex	Human	HEK293
	Cereblon-DDB1-Cul4A-Rbx1 Complex Protein, Human (HEK293, Flag, His) is the recombinant human-derived Cereblon, expressed by HEK293 , with N-6*His, N-Flag labeled tag. ,

HY-P702826

	*CRBN-DDB1-CUL4A-RBX1 Complex Protein, Human (sf9, His, Avi)* Cereblon-DDB1-Cul4A-Rbx1 Complex	Human	Sf9 insect cells

HY-P703365

	*DCAF11-DDB1* Protein, Human (sf9, His, Strep)** WDR23	Human	Sf9 insect cells

HY-P703363

	*DCAF10-DDB1* Protein, Human (Active, sf9, His, Strep)** WDR32	Human	Sf9 insect cells

HY-P703562

	*DCAF9/DDB1* Protein, Human (Active, sf9, His, Strep)** KIAA1037	Human	Sf9 insect cells
	DCAF9/DDB1 Protein, Human (Active, sf9, His, Strep) is the recombinant human-derived DCAF9/DDB1, expressed by sf9 insect cells , with Strep, His labeled tag. ,

HY-P703472

	*DCAF16-DDB1* Protein, Human (Active, sf9, Biotinylated)** C4orf30	Human	Sf9 insect cells

HY-P703561

	*DCAF8-DDB1* Protein, Human (Active, sf9, His, Strep)** H326; WDR42A	Human	Sf9 insect cells

HY-P703464

	*DCAF12-DDB1* Protein, Human (sf9, His, Strep)** KIAA1892; TCC52; WDR40A	Human	Sf9 insect cells

HY-P703559

	*DCAF16-DDB1-CUL4A-RBX1 Protein, Human (sf9)* C4orf30	Human	Sf9 insect cells

HY-P703560

	*DCAF2-DDB1* Protein, Human (sf9, His, Strep)** CDT2; CDW1; DCAF2; L2DTL; RAMP	Human	Sf9 insect cells

HY-P702851

	*CRBN-DDB1* Protein, Human (sf9, Avi)** Protein cereblon; CRBN; AD-006; DNA damage-binding protein 1; DDB p127 subunit; XAP1; UV-damaged DNA-binding factor; HBV X-associated protein 1 (XAP-1); Damage-specific DNA-binding protein 1; DDBa	Human	Sf9 insect cells
	CRBN-DDB1 Protein, Human (sf9, Avi) is the recombinant human-derived CRBN-DDB1, expressed by Sf9 insect cells , with Avi labeled tag. ,

HY-P702825

	*CRBN-DDB1* Protein, Human (sf9, His, Avi)** Protein cereblon; CRBN; AD-006; DNA damage-binding protein 1; DDB p127 subunit; XAP1; UV-damaged DNA-binding factor; HBV X-associated protein 1 (XAP-1); Damage-specific DNA-binding protein 1; DDBa	Human	Sf9 insect cells
	CRBN-DDB1 Protein, Human (sf9, His, Avi) is the recombinant human-derived CRBN-DDB1, expressed by Sf9 insect cells , with N-His, N-Avi labeled tag. ,

HY-P702850

	*CRBN-DDB1* Protein, Human (Biotinylated, sf9, Avi)** Protein cereblon; CRBN; AD-006; DNA damage-binding protein 1; DDB p127 subunit; XAP1; UV-damaged DNA-binding factor; HBV X-associated protein 1 (XAP-1); Damage-specific DNA-binding protein 1; DDBa	Human	Sf9 insect cells
	CRBN-DDB1 Protein, Human (Biotinylated, sf9, Avi) is the recombinant human-derived CRBN-DDB1, expressed by Sf9 insect cells , with Avi labeled tag. ,

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HY-14658S

Thalidomide-d4
Thalidomide-d₄ is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties ^[1] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80641

	DDB1 Antibody (YA785) XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1	WB	Human, Mouse, Rat, Monkey
	DDB1 Antibody (YA785) is a non-conjugated and Mouse origined monoclonal antibody about 127 kDa, targeting to DDB1 (2D6). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.

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Cat. No.	Product Name		Classification

HY-133870

Itaconate-alkyne 2 Publications Verification ITalk		Alkynes
Itaconate-alkyne (ITalk) is a specific bioorthogonal probe for quantitative and site-specific chemoproteomic profiling of Itaconation in living cells. Itaconate-alkyne, a functional analogue of Itaconate, exhibits comparable antiinflammatory effect with Itaconate and enables the labeling of bona fide targets of Itaconate ^[1]. Itaconate-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS03606

DDB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
DDB1 Human Pre-designed siRNA Set A contains three designed siRNAs for DDB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24422

Ddb1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ddb1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ddb1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17951

Ddb1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ddb1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ddb1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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