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Cytotoxic payload

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (18) Akt (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (1) Bacterial (2) c-Kit (1) Caspase (1) DNA Alkylator/Crosslinker (5) Drug Derivative (2) Drug-Linker Conjugates for ADC (3) ERK (1) Eukaryotic Initiation Factor (eIF) (2) FAP (1) Ferroptosis (1) Glucocorticoid Receptor (1) Glutathione Peroxidase (1) Kinesin (1) Microtubule/Tubulin (2) Topoisomerase (2)
By Research Areas:	Cancer (25) Inflammation/Immunology (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Targets Recommended: ADC Payload CTLA-4

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101127

SGD-1882 PBD dimer	ADC Payload	Cancer
SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	ADC Payload	Cancer
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-101161

SG3199 3 Publications Verification	DNA Alkylator/Crosslinker ADC Payload	Cancer
SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .

HY-147408

Rezetecán SHR9265	Topoisomerase ADC Payload	Cancer
Rezetecán (SHR9265) is a topoisomerase I inhibitor. In addition, Rezetecán can be used to synthesize Trastuzumab rezetecan, an antineoplastic agent. Rezetecán can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-175615

RSL3-NH2	Glutathione Peroxidase Ferroptosis ADC Payload	Cancer
RSL3-NH2 is a GPX4 inhibitor and Ferroptosis inducer. RSL3-NH2 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-171081

Glucocorticoid receptor agonist-6	ADC Payload Glucocorticoid Receptor	Cancer
Glucocorticoid receptor agonist-6 (Compound A) is a Glucocorticoid receptor (GR) agonist. Glucocorticoid receptor agonist-6 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-176777

7-Methylol-9-methoxy-10-F-camptothecin	Drug Derivative ADC Payload	Cancer
7-Methylol-9-methoxy-10-F-camptothecin (Compound D6-1) is a derivative of Camptothecin (HY-16560). 7-Methylol-9-methoxy-10-F-camptothecin can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-135901

Py-MPB-amino-C3-PBD	ADC Payload Bacterial	Cancer
Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity .

HY-164107

Auristatin S	ADC Payload Microtubule/Tubulin	Cancer
Auristatin S is an Auristatin payload with potent antitumor activity. Auristatin S attenuates bystander activity with improved off-target toxicity. Auristatin S has excellent tolerability in Karpas/KarpasBVR cell models. Auristatin S can be used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types .

HY-175004

PBD dimer-4	ADC Payload DNA Alkylator/Crosslinker	Cancer
PBD dimer-4 (Compound 7) is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells (IC₅₀: 236 nM). PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine (HY-P99349) to treat several different cancer types .

HY-175203

Topi MF-6	Topoisomerase ADC Payload	Cancer
Topi MF-6 is a DNA topoisomerase I (Top1) inhibitor. Topi MF-6 has superior cytotoxicity against gastrointestinal cancer cells. Topi MF-6 can be used as an ADC payload .

HY-128952

Tesirine 5 Publications Verification SG3249	Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker	Cancer
Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .

HY-145663

HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM	Drug-Linker Conjugates for ADC	Cancer
HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is a agent-linker (peptide-cleavable) conjugate for ADC. DM indicates the maytansinoid moiety .

HY-176843

eIF4A-IN-2	Eukaryotic Initiation Factor (eIF) ADC Payload	Cancer
eIF4A-IN-2 (Compound 93) is an Eukaryotic translation initiation factor 4A (eIF4A) inhibitor. eIF4A-IN-2 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-175353

TriOncoFAP-GlyPro-MMAE	FAP	Cancer
TriOncoFAP-GlyPro-MMAE is a small molecule drug conjugate (SMDC) targeting fibroblast activation protein (FAP) with an IC₅₀ of 13 pmol/L. TriOncoFAP-GlyPro-MMAE combines a FAP-targeting ligand (TriOnco), a cleavable glycine-proline linker, and a cytotoxic payload (MMAE) .

HY-176844

eIF4A-IN-3	Eukaryotic Initiation Factor (eIF) ADC Payload	Cancer
eIF4A-IN-3 (Compound 71E) is an Eukaryotic translation initiation factor 4A (eIF4A) inhibitor. eIF4A-IN-3 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-132031

Mal-Val-Ala-PAB(C2-glucuronic acid)-DMEA-PNU-159682	Drug-Linker Conjugates for ADC	Cancer
Mal-Val-Ala-PAB(C2-glucuronic acid)-DMEA-PNU-159682 is an active molecule-conjugate for ADCs, composed of a cleavable Val-Ala linker and the potent ADC cytotoxic payload PNU-159682 (HY-16700) .

HY-135900

Aniline-MPB-amino-C3-PBD	ADC Payload Bacterial	Cancer
Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity .

HY-47820

Tesirine intermediate-1	DNA Alkylator/Crosslinker	Cancer
Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.

HY-177267

Camptothecin derivative-3	Drug Derivative ADC Payload	Cancer
Camptothecin derivative-3 (Compound 11) is a derivative of Camptothecin (HY-16560) and can serve as a payload for ADCs. Camptothecin derivative-3 has certain cytotoxicity, with IC₅₀ values of 2 nM and 0.9 nM against HSC-2 and Namalwa/luc cells, respectively. Camptothecin derivative-3 can be used in tumor-related research .

HY-103688

N-Ac-γ-Calicheamicin-AcBut-NHS ester	ADC Payload	Cancer
AcBut-N-Ac-γ-Calicheamicin is an ADC cytotoxic payload that induces cell cycle arrest and apoptosis by causing DNA double-strand breaks. AcBut-N-Ac-γ-Calicheamicin is primarily used in the synthesis of antibody-drug conjugates (ADC) and holds promise for research in the field of cancer, including acute lymphoblastic leukemia (ALL) and other hematological malignancies .

HY-24144

Tesirine intermediate-2	DNA Alkylator/Crosslinker	Cancer
Tesirine intermediate-2 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.

HY-177285

NVP-BQS481	Kinesin ADC Payload	Cancer
NVP-BQS481 (Compound 1) is a selective Kinesin spindle protein-5 (Eg5) inhibitor with an IC₅₀< 0.5 nM. NVP-BQS481 has significant antimitotic and antitumor activity (IC₅₀: 0.0.9 nM for SK-OV-3ip cells). NVP-BQS481 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .

HY-178270

PBD derivative-1	ADC Payload	Inflammation/Immunology Cancer
PBD derivative-1 (Compound 7-8) is a derivative of PBD, and PBD is the payload in antibody-drug conjugates (ADCs). PBD derivative-1 can be used for the synthesis of ADCs.

HY-177578

NN3201	Antibody-Drug Conjugates (ADCs) c-Kit Apoptosis Microtubule/Tubulin ERK Akt Caspase	Cancer
NN3201 is a c-Kit-targeting antibody-drug conjugate (ADC) with high affinity (K_D = 0.19 pM). NN3201 is composed of 4-(3-Tosyl-2-(tosylmethyl)propanoyl)benzoic acid-glu(PEG24-Me)-val-cit-NH-benzyloxyformic acid-MMAE (HY-178219) and an anti-c-Kit human monoclonal antibody NN2101 (HY-P991293). NN3201 rapidly internalizes and inhibits stem cell factor (SCF)-driven signaling, thereby delivering its payload to induce cell cycle arrest and apoptosis. NN3201 exhibits no Fc-mediated effector functions antibody-dependent cell-mediated cytotoxicity (ADCC)/complement-dependent cytotoxicity (CDC) due to reduced FcγR binding. NN3201 exhibits significant c-Kit-dependent anti-tumor efficacies in various tumor models. NN3201 can be used in small cell lung cancer (SCLC) and gastrointestinal stromal tumor (GIST) and acute myeloid leukemia (AML) research ^[1][2].

Cat. No.	Product Name

HY-L023

Toxins for Antibody-Drug Conjugate Research Library	113 compounds
Antibody-Drug Conjugates (ADCs), a new class of treatment for cancer, are composed with a monoclonal antibody, a linker and a cytotoxic agent also referred to as a payload. To date, several ADCs have received market approval and more than 60 ADCs are currently in clinical trials. ADCs are one of the fastest growing classes of oncology drugs worldwide. The payload or cytotoxic agent is the most important unit in the ADC. ADC has the capability to kill cancer cell depending on the potency of the payload. MCE provides 113 highly potent cytotoxins that contain auristatin derivatives, maytansinoids, calicheamicin, duocarmycin, pyrrolobenzodiazepines (PBDs), etc.

Toxins for Antibody-Drug Conjugate Research Library

113 compounds

Antibody-Drug Conjugates (ADCs), a new class of treatment for cancer, are composed with a monoclonal antibody, a linker and a cytotoxic agent also referred to as a payload. To date, several ADCs have received market approval and more than 60 ADCs are currently in clinical trials. ADCs are one of the fastest growing classes of oncology drugs worldwide.

The payload or cytotoxic agent is the most important unit in the ADC. ADC has the capability to kill cancer cell depending on the potency of the payload. MCE provides 113 highly potent cytotoxins that contain auristatin derivatives, maytansinoids, calicheamicin, duocarmycin, pyrrolobenzodiazepines (PBDs), etc.

Hemiasterlin (-)-Hemiasterlin; Milnamide B	Alkaloids Animals Classification of Application Fields Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	ADC Payload
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

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