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Calcium increase

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130

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2

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6

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3

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11

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19

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12

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1

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0764A
    Bucladesine calcium
    Maximum Cited Publications
    34 Publications Verification

    Dibutyryl cAMP Calcium salt; DBcAMP Calcium salt

    		 PKA Phosphodiesterase (PDE) Apoptosis Others
    Bucladesine calcium salt (Dibutyryl-cAMP calcium salt;DC2797 calcium salt) is a cell-permeable cyclic AMP (cAMP) analog and selectively activates cAMP dependent protein kinase (PKA) by increasing the intracellular level of cAMP. Bucladesine calcium salt acts as a phosphodiesterase (PDE) inhibitor.
    Bucladesine calcium
  • HY-100813
    Saclofen
    4 Publications Verification

    		 GABA Receptor Neurological Disease Inflammation/Immunology
    Saclofen is an orally active and a competitive GABAB receptor antagonist with an IC50 of 7.8 μM. Saclofen has weak antagonistic effects on GABAB1b and GABAB2 heterodimeric recombinant receptors. Saclofen inhibits the binding of Baclofen (HY-B0007) to rat cerebellar membranes and blocks Baclofen-induced circadian phase shifts, and exhibits anti-inflammatory and analgesic effects in rats .
    Saclofen
  • HY-106844
    EMD 53998

    		Phosphodiesterase (PDE) Cardiovascular Disease
    EMD 53998 is a cardiotonic agent that increases myocardial contractility as an inhibitor for phosphodiesterase III (PDE III) and a calcium sensitizer. EMD 53998 increases myocardial contractility, reduces energy consumption and the risk of inducing arrhythmias .
    EMD 53998
  • HY-P1492
    Substance P (7-11)

    		Neurokinin Receptor Neurological Disease Endocrinology
    Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.
    Substance P (7-11)
  • HY-B0288B
    Fenoprofen Calcium hydrate
    1 Publications Verification

    LILLY-53858 Calcium hydrate

    		 COX Melanocortin Receptor ERK Inflammation/Immunology
    Fenoprofen (LILLY-53858) Calcium hydrate is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium hydrate is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium hydrate also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium hydrate has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
    Fenoprofen Calcium hydrate
  • HY-100813R
    Saclofen (Standard)

    		Reference Standards GABA Receptor Neurological Disease Inflammation/Immunology
    Saclofen (Standard) is the analytical standard of Saclofen.
    Saclofen (Standard)
  • HY-N7875
    Celangulin

    		Others Others
    Celangulin is an insecticidal component isolated from Celastrus angulatus. Celangulin activates the calcium channel on the plasma membrane with increasing the intracellular Ca 2+ after influx from the external. Celangulin activates the calcium channel in the ER .
    Celangulin
  • HY-169819
    Calcium influx inducer compound 634

    		Calcium Channel CD28 Inflammation/Immunology
    Calcium influx inducer compound 634 is a calcium influx inducer. Calcium influx inducer compound 634 (10 µM) enhances the release of extracellular vesicles (EVs) from mouse bone marrow-derived dendritic cells (mBMDCs). Calcium influx inducer compound 634 (10 µM) also increases the levels of CD86 and CD80 on the surface of mBMDCs, an effect that can be blocked by the calcium release-activated calcium channel inhibitor YM-58483 (HY-100831) .
    Calcium influx inducer compound 634
  • HY-19003
    Isomazole

    323MHb; Isosulmazole

    		 Phosphodiesterase (PDE) Cardiovascular Disease
    Isomazole is a new cardiotonic agent. Isomazole increases the calcium sensitivity in atrial fibers and has a direct effect on contractile proteins .
    Isomazole
  • HY-B0288A
    Fenoprofen Calcium

    LILLY-53858 Calcium

    		 COX Melanocortin Receptor ERK Inflammation/Immunology
    Fenoprofen (LILLY-53858) Calcium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
    Fenoprofen Calcium
  • HY-137311A
    (S)-Albuterol

    		Calcium Channel Phospholipase mAChR Neurological Disease
    (S)-Albuterol is a muscarinic receptor and phospholipase C activator. (S)-Albuterol increases intracellular free calcium in airway smooth muscle .
    (S)-Albuterol
  • HY-19003A
    Isomazole hydrochloride

    323MHb hydrochloride; Isosulmazole hydrochloride

    		 Phosphodiesterase (PDE) Cardiovascular Disease
    Isomazole (323MHb) hydrochloride is a cardiotonic agent. Isomazole hydrochloridei increases the calcium sensitivity in atrial fibers and has a direct effect on contractile proteins .
    Isomazole hydrochloride
  • HY-D0716
    Fluo-3AM
    5+ Cited Publications

    Fluo-3-pentaacetoxymethyl ester

    		 Fluorescent Dye Others
    Fluo-3 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
    Fluo-3AM
  • HY-137325
    2-Chloro-ATP

    		Guanylate Cyclase Others
    2-Chloro-ATP is a soluble guanylate cyclase inhibitor that increases intracellular calcium concentration at low concentrations through a mechanism independent of inositol phosphate production .
    2-Chloro-ATP
  • HY-N0470
    L-Lysine hydrochloride
    5+ Cited Publications

    		 Virus Protease Endogenous Metabolite Infection Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine hydrochloride
  • HY-17611
    Etripamil

    MSP-2017; (-)-MSP-2017

    		 Calcium Channel Cardiovascular Disease
    Etripamil (MSP-2017) is a short-acting, L-type calcium-channel antagonist. Etripamil inhibits calcium influx through slow calcium channels, thereby slowing AV node conduction and prolonging the AV node refractory period. Etripamil increases heart rate and decreases systolic blood pressure. Etripamil can be used in the study of paroxysmal supraventricular tachycardia (PSVT) .
    Etripamil
  • HY-101902
    Quin-2AM

    Quin-2 acetoxymethyl ester

    		 Fluorescent Dye Others
    Quin-2AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
    Quin-2AM
  • HY-D1498
    Mag-Fluo-4 AM
    1 Publications Verification

    		 Fluorescent Dye Others
    Mag-Fluo-4 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
    Mag-Fluo-4 AM
  • HY-112650
    12-OxoETE

    12-KETE

    		 Endogenous Metabolite Inflammation/Immunology
    12-OxoETE induces a rapid, dose dependent increase of cytoplasmic free calcium via leukotriene B4 receptor or a common activation sequence .
    12-OxoETE
  • HY-108576
    Linopirdine dihydrochloride

    DuP 996 dihydrochloride

    		 TRP Channel Neurological Disease
    Linopirdine dihydrochloride is a agonist of capsaicin receptor TRPV1. Linopirdine increases the intracellular calcium concentration in HEK293 cells. Linopirdine dihydrochloride exerts an excitatory action on mammalian nociceptors .
    Linopirdine dihydrochloride
  • HY-170424
    D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium

    		Biochemical Assay Reagents Others
    D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium increases the extracellular Ca 2+ entry through upregulation of voltage-gated calcium channels .
    D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium
  • HY-Y0537E
    Potassium chloride, for cell culture

    		Biochemical Assay Reagents Potassium Channel Calcium Channel Neurological Disease
    Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells .
    Potassium chloride, for cell culture
  • HY-N7395
    Cyclic ADP-​ribose

    cADPR

    		 Calcium Channel TRP Channel Endogenous Metabolite Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
    Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD + by an ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .
    Cyclic ADP-​ribose
  • HY-D1701
    Mag-Fura-2 AM

    		Fluorescent Dye Others
    Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
    Mag-Fura-2 AM
  • HY-101898
    Indo-1 AM
    1 Publications Verification

    Indo-1 Acetoxymethyl ester

    		 Fluorescent Dye Others
    Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues. MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
    Indo-1 AM
  • HY-N7395A
    Cyclic ADP-​ribose ammonium

    cADPR ammonium

    		 Calcium Channel TRP Channel Endogenous Metabolite Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology
    Cyclic ADP-ribose ammonium (cADPR ammonium) is a potent second messenger for calcium mobilization that is synthesized from NAD + by an ADP-ribosyl cyclase. Cyclic ADP-ribose ammonium increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels .
    Cyclic ADP-​ribose ammonium
  • HY-117931
    NS004

    		Potassium Channel Neurological Disease
    NS004 is a potassium (BK) channel activator that increases Iberiotoxin (HY-P0190) or Tetraethylammonium (HY-B1793)-sensitive whole-cell efflux currents. NS004 also significantly increased the activity of individual GH3 cell BK channels and rat brain BK channels reorganized into planar lipid bilayers, causing an increase in channel mean open time, a decrease in intermittent time, and an increase in channel voltage/calcium sensitivity .
    NS004
  • HY-10167A
    Tecalcet Hydrochloride
    5+ Cited Publications

    R-568 hydrochloride; NPS R-568

    		 CaSR Others
    Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca 2+ .
    Tecalcet Hydrochloride
  • HY-118518
    Ronipamil

    		Calcium Channel Cardiovascular Disease Cancer
    Ronipamil is a calcium ion antagonist. Ronipamil increases the specific binding and internalization of human 125I-LDL in human skin fibroblasts (HSF) and the human hepatoma cell line Hep G2 .
    Ronipamil
  • HY-138875
    Tetraacetylphytosphingosine

    		p38 MAPK Apoptosis Cardiovascular Disease Cancer
    Tetraacetylphytosphingosine is a sphingolipid metabolite produced by phytosphingosine acetylation. Tetraacetylphytosphingosine exerts its inhibitory action on angiogenesis through the inhibition of MAPK activation and intracellular calcium increase . Tetraacetylphytosphingosine induces apoptosis in HaCaT cells .
    Tetraacetylphytosphingosine
  • HY-147979
    CXCR4 antagonist 9

    		CXCR Infection Cancer
    CXCR4 antagonist 9 (Compound 2) is a CXCR4 antagonist with an IC50 of 15 nM. CXCR4 antagonist 9 inhibits CXCL12 induced cytosolic calcium increase with an IC50 of 1.3 nM .
    CXCR4 antagonist 9
  • HY-10167
    Tecalcet

    R-568; NPS R-568 free base

    		 CaSR Others
    Tecalcet (R 568), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet (R 568) increases the sensitivity to activation by extracellular Ca 2+ .
    Tecalcet
  • HY-137672A
    2',3'-Cyclic NADP disodium

    2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate

    		 Phosphodiesterase (PDE) Calcium Channel Neurological Disease
    2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundant in myelin. It has been used in a coupled enzyme assay to quantify CNP activity. 2',3'-Cyclic NADP disodium (5 μM) increases calcium overload-induced calcium release and prevents calcium-induced swelling in rat brain mitochondria.
    2',3'-Cyclic NADP disodium
  • HY-117763
    A-39355

    		Calcium Channel Others
    A-39355 is a compound that can overcome multidrug resistance and has the activity of reversing multidrug resistance. A-39355 can enhance the cytotoxicity of antitumor compounds in multidrug-resistant cells, increase the accumulation of compounds in cells, inhibit the efflux of compounds, and compared with calcium antagonists, it has no serious hypotensive effect. Its activity may be unrelated to the ability to block calcium transport.
    A-39355
  • HY-120768
    A-30312

    		Drug Derivative Others
    A-30312 is a compound that can overcome multidrug resistance and has the activity of reversing multidrug resistance. A-30312 can enhance the cytotoxicity of antitumor compounds in multidrug-resistant cells, increase the accumulation of compounds in cells, inhibit the efflux of compounds, and compared with calcium antagonists, it has no serious hypotensive effect. Its activity may be unrelated to the ability to block calcium transport.
    A-30312
  • HY-P2168
    Demoxytocin

    		Oxytocin Receptor Endocrinology
    Demoxytocin, a heterodetic cyclic peptide, is an analog of oxytocin. Demoxytocin affects the permeability of the cell membrane, increasing the content of calcium ions in smooth muscle cells, increasing its contraction. Demoxytocin also stimulates the contraction of smooth muscles of the uterus. Demoxytocin has the function of oxytocin. Demoxytocin can be used to research stimulation of labor in cases of premature rupture .
    Demoxytocin
  • HY-P1168
    [Orn8]-Urotensin II (human)

    		Urotensin Receptor Cardiovascular Disease
    [Orn8]-Urotensin II (human), a peptide analog of urotensin II, is a UT receptor agonist. [Orn8]-Urotensin II (human) increases intracellular calcium levels in HEK293 .
    [Orn8]-Urotensin II (human)
  • HY-126821
    Fluo-3

    		Fluorescent Dye Others
    Fluo-3 and related molecule Fluo3/AM are used as a fluorescence indicator of intracellular calcium (Ca 2+). Fluo-3 may be use for flow cytometry and confocal laser scanning microscopy using visible light excitation (compatible with argon laser sources operating at 488 nm). Fluorescence intensity increases about 40-fold after calcium binding.
    Fluo-3
  • HY-P4823
    pTH (1-37) (human)

    		Thyroid Hormone Receptor Metabolic Disease
    pTH (1-37) (human) is a fragment of parathyroid hormone (PTH). pTH (1-37) (human) induces the cAMP formation and increases alkaline phosphatase activity. pTH (1-37) (human) increases growth, bone calcium content, and bone mineral density (BMD) in uremic animals. pTH (1-37) (human) has the potential for the research of osteoporosis .
    pTH (1-37) (human)
  • HY-N0470S6
    L-Lysine-d4 hydrochloride

    		Virus Protease Endogenous Metabolite Infection
    L-Lysine-d4 (hydrochloride) is the deuterium labeled L-Lysine. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine-d4 hydrochloride
  • HY-121018
    Daltroban

    BM-13505; SKF 96148

    		 Prostaglandin Receptor Cardiovascular Disease
    Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury .
    Daltroban
  • HY-N0470S4
    L-Lysine-d8 hydrochloride

    		Isotope-Labeled Compounds Virus Protease Endogenous Metabolite Infection Cardiovascular Disease Inflammation/Immunology Endocrinology
    L-Lysine-d8 (hydrochloride) is the deuterium labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine-d8 hydrochloride
  • HY-N11691
    Thapsigargicin

    Thapsigargicine

    		 Others Inflammation/Immunology
    Thapsigargicin (Thapsigargicine) is a activator of mast cells and leukocytes. Thapsigargicin induces histamine release from rat peritoneal mast cells and human basophil leukocytes. Thapsigargicin increases the cytoplasmic free calcium level in intact human blood platelets .
    Thapsigargicin
  • HY-111018
    FPL 62129

    		Calcium Channel Cardiovascular Disease
    FPL 62129 is an antagonist for calcium channel. FPL 62129 reduces blood pressure and total peripheral resistance, increases the cardiac contractility and cardiac output in anarsthetised beagle model. FPL 62129 also serves as a vasodilator and a direct decelerator .
    FPL 62129
  • HY-N0470S5
    L-Lysine-d9 hydrochloride

    		Virus Protease Endogenous Metabolite Infection
    L-Lysine-d9 (hydrochloride) is the deuterium labeled L-Lysine. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine-d9 hydrochloride
  • HY-101390B
    Niguldipine free base

    		Calcium Channel Cardiovascular Disease
    Niguldipine free base is a calcium channel blocker with activity in regulating cardiovascular function. Niguldipine free base can reduce systolic and diastolic blood pressure, thereby increasing heart rate and cardiac output. Niguldipine free base exhibits dose-dependent and sustained increases in coronary blood flow. Niguldipine free base also increases perfusion in the kidneys and femoral arteries, but the effect is temporary and to a lesser extent. The effect of Niguldipine free base on myocardial metabolism is not significant .
    Niguldipine free base
  • HY-N6687
    Calcimycin
    10+ Cited Publications

    A-23187; Antibiotic A-23187

    		 Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic Infection Cancer
    Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca 2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .
    Calcimycin
  • HY-N0470S2
    L-Lysine-13C dihydrochloride

    		Virus Protease Endogenous Metabolite Infection Cardiovascular Disease Inflammation/Immunology Endocrinology
    L-Lysine- 13C (dihydrochloride) is the 13C-labeled L-Lysine dihydrochloride. L-lysine dihydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine-13C dihydrochloride
  • HY-N0470S
    L-Lysine-15N2 hydrochloride

    		Virus Protease Endogenous Metabolite Infection Cardiovascular Disease Inflammation/Immunology Endocrinology
    L-Lysine- 15N2 (hydrochloride) is the 15N-labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine-15N2 hydrochloride
  • HY-N0470R
    L-Lysine hydrochloride (Standard)

    		Reference Standards Virus Protease Endogenous Metabolite Infection Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    L-Lysine hydrochloride (Standard) is the analytical standard of L-Lysine hydrochloride. This product is intended for research and analytical applications. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
    L-Lysine hydrochloride (Standard)

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