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Isoforms Recommended:	CXCR3

Results for "

CXCR3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arrestin (1) CCR (1) CXCR (25) HIV (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (3) Endocrinology (5) Infection (1) Inflammation/Immunology (18)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128063

CXCR3 antagonist 1	CXCR	Inflammation/Immunology
CXCR3 antagonist 1 (compound 6c) is a selective and non-cytotoxic *CXCR3* antagonist (IC₅₀=0.06 µM). CXCR3 antagonist 1 has potential in researching inflammatory diseases (including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes) .

HY-P990254

*Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)*	CXCR	Inflammation/Immunology Cancer
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) is an anti-mouse *CXCR3/CD183* IgG monoclonal antibody. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) weakens the immune response by reducing the infiltration of CD4 ⁺ and CD8 ⁺ T cells. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) significantly prolongs the survival time of heart or islet transplants in mice. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) can be used for research on immunology and cancer such as pancreatic cancer ^[3].

HY-P990394

*Anti-CXCR3/GPR9/CD183 Antibody*	CXCR	Inflammation/Immunology
Anti-CXCR3/GPR9/CD183 Antibody is a human-derived antibody expressed in CHO, targeting *CXCR3/GPR9/CD183. The Anti-CXCR3/GPR9/CD183 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For the isotype control of Anti-CXCR3*/GPR9/CD183 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-110269

VUF 11222	CXCR	Inflammation/Immunology
VUF 11222 (Compound 38) is a *CXCR3* non-peptide-like agonist. VUF 11222 can be used in the study of inflammation .

HY-15319

AMG 487 Maximum Cited Publications 28 Publications Verification	CXCR	Inflammation/Immunology Endocrinology Cancer
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 *(CXCR3)* which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC₅₀s of 8.0 and 8.2 nM, respectively .

HY-110099

(±)-NBI-74330	CXCR	Inflammation/Immunology
(±)-NBI-74330 is a potent and selective *CXCR3* antagonist. (±)-NBI-74330 not only reduces tactile and thermal hypersensitivity but also enhances the analgesic properties of morphine. (±)-NBI-74330 can reduce microglial cell activation, increase astroglial cell activation, and downregulate the expression of some CXCR3 ligands in a rat neuropathic pain model .

HY-RS03404

Cxcr3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CXCR	Others
Cxcr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cxcr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cxcr3 Mouse Pre-designed siRNA Set A Cxcr3 Mouse Pre-designed siRNA Set A

HY-RS03405

Cxcr3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CXCR	Others
Cxcr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cxcr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cxcr3 Rat Pre-designed siRNA Set A Cxcr3 Rat Pre-designed siRNA Set A

HY-RS03403

CXCR3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) CXCR	Others
CXCR3 Human Pre-designed siRNA Set A contains three designed siRNAs for CXCR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CXCR3 Human Pre-designed siRNA Set A CXCR3 Human Pre-designed siRNA Set A

HY-15319A

(±)-AMG 487	CXCR	Cancer
(±)-AMG 487 is a racemate of AMG 487. AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 *(CXCR3)* which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC₅₀s of 8.0 and 8.2 nM, respectively .

HY-113730

VUF5834	CXCR	Others
VUF5834 is a non-peptide chemokine receptor CXCR3 antagonist with non-competitive antagonistic and inverse agonistic activities. VUF5834 blocks the effects of CXCL10 and CXCL11 on human CXCR3, exhibits non-competitive antagonistic and inverse agonistic properties to CXCR3, and, except for TAK-779, has a slightly lower affinity for rodent CXCR3 than for primate CXCR3.

HY-118037

VUF10132	CXCR	Inflammation/Immunology
VUF10132 is a non-peptide *CXCR3* receptor antagonist with anti-inflammatory activity, inhibiting diseases such as rheumatoid arthritis, multiple sclerosis, and psoriasis. VUF10132 has high affinity for the human CXCR3 receptor but slightly lower affinity for the murine CXCR3 receptor. Additionally, VUF10132 exhibits inverse agonist properties at the CXCR3 receptor .

HY-153240

ACT-672125	CXCR	Inflammation/Immunology
ACT-672125 is a potent *CXCR3* antagonist with IC₅₀ value of 239 nM in human blood. ACT-672125 has activity for hERG with IC₅₀ value of 18μM. ACT-672125 can be used for the research of autoimmune diseases .

HY-10017

SCH 546738 10+ Cited Publications	CXCR	Inflammation/Immunology Endocrinology
SCH 546738 is a potent, orally active and non-competitive *CXCR3* antagonist, the affinity constant (K_i) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.

HY-10017A

(R)-SCH 546738	CXCR	Inflammation/Immunology Endocrinology
(R)-SCH 546738 is the R-isomer of SCH 546738 (HY-10017). SCH 546738 is an orally active and non-competitive antagonist for *CXCR3* with K_i of 0.4 nM for human CXCR3 receptor .

HY-165428

SCH-900875	CXCR Arrestin	Inflammation/Immunology
SCH-900875 is an orally active, brain-penetrant and selective CXCR3 receptor inhibitor, which also shows high selectivity over *CXCR1* and CXCR2 receptors. SCH-900875 binds to CXCR3, blocking the binding of ligands CXCL9, CXCL10, and CXCL11, inhibiting downstream G protein and β-arrestin signaling pathways to suppress inflammatory cell migration. SCH-900875 is promising for research of autoimmune diseases (rheumatoid arthritis, multiple sclerosis) and inflammatory disorders (psoriasis, inflammatory bowel disease) .

HY-119208

VUF11211	CXCR	Others
VUF11211 is an allosteric inverse *CXCR3* agonist with a K_d of 0.65 nM .

HY-117823

VUF11418	CXCR	Inflammation/Immunology
VUF11418 is a *CXCR3* activator. VUF11418 can be used in inflammation research .

HY-15319B

AMG 487 (S-enantiomer)	CXCR	Others
AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an antagonist of the chemokine receptor *CXCR3*.

HY-111149A

PS372424 hydrochloride 1 Publications Verification	CXCR	Inflammation/Immunology
PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human *CXCR3* agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation .

HY-111149

PS372424	CXCR	Inflammation/Immunology
PS372424, a three amino-acid fragment of CXCL10, is a specific human *CXCR3* agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation .

HY-15320

NBI-74330 5+ Cited Publications	CXCR	Inflammation/Immunology Endocrinology
NBI-74330 is a potent antagonist for *CXCR3, and exhibits potent inhibition of ( ¹²⁵I)CXCL10 and ( ¹²⁵I)CXCL11 specific binding with K_i* of 1.5 and 3.2 nM, respectively.

HY-149055

ACT-777991	CXCR	Inflammation/Immunology
ACT-777991 is an orally active and selective *CXCR3* antagonist. ACT-777991 has microsomes and hepatocytes stability across animal models. ACT-777991 inhibits the migration of activated T cells toward CXCL11 .

HY-151096

ACT-660602	CXCR	Inflammation/Immunology
ACT-660602 is an orally active antagonist of chemokine receptor (CXCR3) with an IC₅₀ value of 204 nM. ACT-660602 inhibits T-cell migration and shows efficacy in acute lung ingury model. ACT-660602 can be used for autoimmune diseases research .

HY-13406

TAK-779 4 Publications Verification Takeda 779	CCR HIV CXCR	Infection Inflammation/Immunology Endocrinology
TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and *CXCR3, with a K_i* of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC₅₀ and EC₉₀ of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells.

Cat. No.	Product Name	Target	Research Area

HY-P990254

*Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173)*	CXCR	Inflammation/Immunology Cancer
Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) is an anti-mouse *CXCR3/CD183* IgG monoclonal antibody. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) weakens the immune response by reducing the infiltration of CD4 ⁺ and CD8 ⁺ T cells. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) significantly prolongs the survival time of heart or islet transplants in mice. Anti-Mouse CXCR3/CD183 Antibody (CXCR3-173) can be used for research on immunology and cancer such as pancreatic cancer ^[3].

HY-P990394

*Anti-CXCR3/GPR9/CD183 Antibody*	CXCR	Inflammation/Immunology
Anti-CXCR3/GPR9/CD183 Antibody is a human-derived antibody expressed in CHO, targeting *CXCR3/GPR9/CD183. The Anti-CXCR3/GPR9/CD183 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For the isotype control of Anti-CXCR3*/GPR9/CD183 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Recombinant Proteins Recommended:

CXCR3

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	HEK293 (1) E. coli Cell-free (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P700539A

	CXCR3 Protein, Human (C-His) G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine C-X-C receptor 3; interferon-inducible protein 10 receptor; GPR9; CD182; Mig-R; CKR-L2; IP10-R;	Human	E. coli
	CXCR3 Protein, Human (C-His) is the recombinant human-derived CXCR3, expressed by E. coli , with C-His tag.

HY-P700539

	CXCR3 Protein, Human (Cell-Free, His) G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine C-X-C receptor 3; interferon-inducible protein 10 receptor; GPR9; CD182; Mig-R; CKR-L2; IP10-R	Human	E. coli Cell-free
	The CXCR3 protein acts as a receptor for CXC chemokines (CXCL9, CXCL10, and CXCL11), affecting human mesangial cells (HMC) through G protein signaling. It binds CCL21 and may promote cell chemotaxis. CXCR3 Protein, Human (Cell-Free, His) is the recombinant human-derived CXCR3 protein, expressed by E. coli Cell-free , with C-10*His labeled tag.

HY-P704558

	CXCR3 Protein-VLP, Human (HEK293) G protein coupled receptor 9 , GPR9; C-X-C chemokine receptor type 3; CD183; CKR L2; CMKAR3; IP10 R; MigR; CXC-R3; CXCR-3; Mig receptor; IP10 receptor; IP-10 receptor; G protein-coupled receptor 9; chemokine C-X-C receptor 3; interferon-inducible protein 10 receptor; GPR9; CD182; Mig-R; CKR-L2; IP10-R;	Human	HEK293
	The CXCR3 protein acts as a receptor for CXC chemokines (CXCL9, CXCL10, and CXCL11), affecting human mesangial cells (HMC) through G protein signaling. It binds CCL21 and may promote cell chemotaxis. CXCR3 Protein-VLP, Human (HEK293) is the recombinant human-derived CXCR3 protein, expressed by HEK293, with tag free.

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HY-P81188

	CXCR3 Antibody CXCR3_HUMAN; Interferon-inducible protein 10 receptor; IP-10 receptor; C-X-C chemokine receptor type 3; CD 183; CD183; CD183 antigen; G protein-coupled receptor 9; G Protein Coupled Receptor 9; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; C-X-C Chemokine receptor; CXC Motif Receptor 3; Chemokine CXC Motif Receptor 3; CKRL2; CKR L2; CKR-L2; GPR9; CXC-R3; CXCR-3; IP10 receptor.	WB	Human, Mouse, Rat
	CXCR3 Antibody is an unconjugated, approximately 40 kDa, rabbit-derived, anti-CXCR3 polyclonal antibody. CXCR3 Antibody can be used for: WB expriments in human, mouse, rat, and predicted: dog, pig, cow, rabbit, guinea pig background without labeling.

HY-P83692

	CXCR3 Antibody (YA3426) CXCR3_HUMAN; Interferon-inducible protein 10 receptor; IP-10 receptor; C-X-C chemokine receptor type 3; CD 183; CD183; CD183 antigen; G protein-coupled receptor 9; G Protein Coupled Receptor 9; Chemokine (C X C motif) receptor 3; Chemokine (C X C) receptor 3; C-X-C Chemokine receptor; CXC Motif Receptor 3; Chemokine CXC Motif Receptor 3; CKRL2; CKR L2; CKR-L2; GPR9; CXC-R3; CXCR-3; IP10 receptor.	WB, ICC/IF, IP	Human
	CXCR3 Antibody is an unconjugated, approximately 41 kDa, rabbit-derived, anti-CXCR3 monoclonal antibody. CXCR3 Antibody can be used for: WB expriments in human background without labeling.

HY-P84355

	CD183 Antibody (YA4052) CXCR3; GPR9; MigR; CD182; Mig-R; CKR-L2; CMKAR3; IP10-R	WB, IHC-P, FC, ELISA	Human
	CD183 Antibody (YA4052) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CD183. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human.

HY-P84971

	CD183 Antibody (YA4663) CXCR3; G protein-coupled receptor 9; GPR9; CKR-L2; IP10 receptor; IP10-R; Mig receptor; Mig-R; C-X-C chemokine receptor type 3 antibody; CD 183 antibody; CD182 antibody; CD183 antibody; Chemokine; C X C motif; receptor 3 antibody; Chemokine; C X C; receptor 3 antibody; Chemokine CXC Motif Receptor 3 antibody; CKR L2 antibody; CKR-L2 antibody; CKRL2 antibody; CMKAR3 antibody; CXC-R3 antibody; CXCR-3 antibody; CXCR3 antibody; CXCR3_HUMAN antibody; G Protein Coupled Receptor 9 antibody; G protein-coupled receptor 9 antibody; GPR9 antibody; Interferon-inducible protein 10 receptor antibody; IP-10 receptor antibody; IP10 antibody; IP10 R antibody; IP10 receptor antibody; IP10-R antibody; IP10R antibody; Mig R antibody; Mig receptor antibody; Mig-R antibody; MIGR antibody
	CD183 Antibody (YA4663) is a non-conjugated antibody, targeting to CD183.

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Cxcr3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Cxcr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cxcr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Cxcr3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Cxcr3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cxcr3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

CXCR3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CXCR3 Human Pre-designed siRNA Set A contains three designed siRNAs for CXCR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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