CRAB

By Targets:	Antibiotic (3) Bacterial (6) Beta-lactamase (2) Biochemical Assay Reagents (2) Drug Metabolite (1) Endogenous Metabolite (2) Fungal (1) G Protein-coupled Receptor Kinase (GRK) (1) LDLR (1) NF-κB (1) PCSK9 (1) Progesterone Receptor (1)
By Research Areas:	Cardiovascular Disease (2) Infection (7) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126389

*Chitin, from crab* carapace (powder)**	Biochemical Assay Reagents Endogenous Metabolite NF-κB Fungal	Infection Inflammation/Immunology
Chitin, from crab carapace is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace is found in the exoskeleton of crabs. Chitin, from crab carapace inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace can be used in the research of gastric ulcer and candidiasis .

HY-147429

Zosurabalpin Abx MCP; RG6006	Bacterial Antibiotic	Infection
Zosurabalpin is a polypeptide antibiotic targeting LPS transporter (LptB₂FGC complex), which can block the transport of LPS and lead to endotoxin accumulation in cells, and has shown excellent antibacterial activity against Carbapenem-resistant Acinetobacter baumanni (CRAB) .

HY-147349

Pilabactam sodium ANT3310 sodium	Beta-lactamase Bacterial	Infection
Pilabactam (ANT3310) sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC₅₀ values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam sodium can be used in the research of bacterial infection .

HY-P0303

Crustacean cardioactive peptide，free acid	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease Neurological Disease
Crustacean cardioactive peptide, free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide, free acid also modulates the neuronal activity in other arthropods.

HY-B0891

17α-Hydroxyprogesterone 4 Publications Verification 17-Hydroxyprogesterone; 17-OHP	Progesterone Receptor Endogenous Metabolite	Cardiovascular Disease
17α-Hydroxyprogesterone is a steroid hormone. 17α-Hydroxyprogesterone induces ovarian growth and yolk production in female crabs and increases blood pressure in sheep. 17α-Hydroxyprogesterone is mainly used in research related to crustacean reproduction and animal hypertension .

HY-W854341

Chitotriose	Antibiotic Bacterial	Infection
Chitotriose is a chitooligosaccharide that can be isolated from crab shell chitosan. Chitotriose has antibacterial effect against salmonella .

HY-147349A

Pilabactam ANT3310	Bacterial Beta-lactamase	Infection
Pilabactam (ANT3310) is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC₅₀ values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam can be used in the research of bacterial infection .

HY-W750707

4-Hydroxyechinenone	Drug Metabolite	Others
4-Hydroxyechinenone is a trace carotenoid present in the carapaces of crabs. 4-Hydroxyechinenone is also an intermediate in the metabolism of β-Carotene (HY-N0411) to Astaxanthin (HY-B2163) .

HY-W795031

Arsenobetaine	Bacterial	Infection
Arsenobetaine is an organoarsenical and a compatible solute that has been found in various marine animals, such as lobsters and crabs, as well as terrestrial organisms, including earthworms and lichens. Arsenobetaine is protective against B. subtilis cell death induced by high osmolarity or extreme temperatures when used at a concentration of 1 mM .

HY-W145695

Chitoheptaose	Biochemical Assay Reagents	Inflammation/Immunology
Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models .

HY-174852

Antibacterial agent 285	Antibiotic Bacterial	Infection
Antibacterial agent 285 (Compound 3) is a cephalosporin antibiotic. Antibacterial agent 285 has significant antibacterial activity against gram-negative bacterium with MICs of 0.125-0.5, 0.125-0.5 and 0.125-2 μg/mL for carbapenem-resistant Acinetobacter baumannii (CRAB), Klebsiella pneumoniae (CRE) and Pseudomonas aeruginosa (CRPA), respectively. Antibacterial agent 285 can be used for bacterial infection research, such as complicated urinary tract infections (cUTI) and kidney infections .

HY-159595

PCSK9-IN-29	LDLR PCSK9	Metabolic Disease Inflammation/Immunology
PCSK9-IN-29 is a lipid-lowering agent. PCSK9-IN-29 can increase low-density lipoprotein receptor (LDLR) protein expression and decrease PCSK9 protein expression in hepG2 cells. PCSK9-IN-29 can reduce the levels of serum LDL-C, TC, and liver enzyme ALT in crab eating macaques fed a high-fat diet, lower body weight and fat, and increase bone mineral content. PCSK9-IN-29 can be used for research on non-alcoholic fatty liver disease and obesity .

Cat. No.	Product Name	Type

HY-126389

*Chitin, from crab* carapace (powder)**	Carbohydrates
Chitin, from crab carapace is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace is found in the exoskeleton of crabs. Chitin, from crab carapace inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace can be used in the research of gastric ulcer and candidiasis .

Chitin, from crab carapace (powder)

Carbohydrates

Chitin, from crab carapace is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace is found in the exoskeleton of crabs. Chitin, from crab carapace inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace can be used in the research of gastric ulcer and candidiasis .

HY-W145695

Chitoheptaose	Biochemical Assay Reagents
Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models .

Chitoheptaose

Biochemical Assay Reagents

Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models .

Cat. No.	Product Name	Target	Research Area

HY-P0303

Crustacean cardioactive peptide，free acid	G Protein-coupled Receptor Kinase (GRK)	Cardiovascular Disease Neurological Disease
Crustacean cardioactive peptide, free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide, free acid also modulates the neuronal activity in other arthropods.

HY-P0296

Gly-Phe-Arg	Peptides	Others
Gly-Phe-Arg is a superpotent synthetic tripeptide mimics of the mud-crab pumping pheromone.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126389

*Chitin, from crab* carapace (powder)**	Structural Classification Natural Products Human Gut Microbiota Metabolites Polysaccharides Animals Marine natural products Source classification Endogenous metabolite Saccharides	Biochemical Assay Reagents Endogenous Metabolite NF-κB Fungal
Chitin, from crab carapace is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace is found in the exoskeleton of crabs. Chitin, from crab carapace inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace can be used in the research of gastric ulcer and candidiasis .

HY-P0303

Crustacean cardioactive peptide，free acid	Cardiovascular Disease Structural Classification Natural Products Animals Neurological Disease Classification of Application Fields Source classification Disease Research Fields	G Protein-coupled Receptor Kinase (GRK)
Crustacean cardioactive peptide, free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide, free acid also modulates the neuronal activity in other arthropods.

HY-B0891

17α-Hydroxyprogesterone 4 Publications Verification 17-Hydroxyprogesterone; 17-OHP	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids	Progesterone Receptor Endogenous Metabolite
17α-Hydroxyprogesterone is a steroid hormone. 17α-Hydroxyprogesterone induces ovarian growth and yolk production in female crabs and increases blood pressure in sheep. 17α-Hydroxyprogesterone is mainly used in research related to crustacean reproduction and animal hypertension .

HY-W750707

4-Hydroxyechinenone	Structural Classification Natural Products Animals Source classification	Drug Metabolite
4-Hydroxyechinenone is a trace carotenoid present in the carapaces of crabs. 4-Hydroxyechinenone is also an intermediate in the metabolism of β-Carotene (HY-N0411) to Astaxanthin (HY-B2163) .

Species:	Human (4) Mouse (3)
Tag:	His (5) Tag Free (1) Avi (1) GST (1) MBP (1) Fc (1)
Source:	HEK293 (4) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P72639

	GABARAP Protein, Human (His, Fc) GABA(A) Receptor-Associated Protein; GABARAP Protein; HCG1987397 Isoform CRA_b; GABARAP	Human	E. coli
	GABARAP (gamma-aminobutyric acid receptor-associated protein) is a protein that performs multiple functions within cells. As a ubiquitin-like modifier, it participates in the intracellular transport of GABA(A) receptors and interacts with the cytoskeleton. GABARAP Protein, Human (His, Fc) is the recombinant human-derived GABARAP protein, expressed by E. coli , with N-His, C-hFc labeled tag.

HY-P70674

	MBL2/COLEC1 Protein, Mouse (HEK293) Mannose binding lectin (C); isoform CRA_b; Mannose-binding protein C; Mbl2; MBL-2; Mannose Binding Lectin 2	Mouse	HEK293
	C-type lectin domain-containing protein is a soluble mannose-binding protein in serum which belongs to the collectin family and is an important element in the innate immune system. C-type lectin domain-containing protein exerts mannose-binding, calcium-dependent protein binding and identical protein binding activity. MBL2/COLEC1 Protein, Mouse (HEK293) is the recombinant mouse-derived MBL2/COLEC1 protein, expressed by HEK293 , with tag free.

HY-P70693

	IL-2R gamma/CD132 Protein, Mouse (HEK293, His) IL-2RG; IL-2 R gamma; IL-2Rγ; IL2R γ; Interleukin 2 receptor, gamma chain, isoform CRA_b; Il2rg	Mouse	HEK293
	IL-2R gamma (CD132), a type I cytokine receptor expressed on leucocyte subsets, is a receptor for IL-2. IL-2R gamma forms heterodimer with IL-2R beta, and increases the affinity of IL-2R beta for IL-2. IL-2R gamma takes part in inflammatory response and mediates activation of the cells . IL-2R gamma plays an important role in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types. IL-2R gamma/CD132 Protein, Mouse (HEK293, His) is a recombinant mice extracellular region of IL-2R gamma with a C-Terminal 6*His tag, which is produced in HEK293 cells.

HY-P70220

	MPZL1 Protein, Human (HEK293, His) rHuMyelin protein zero-like protein 1/MPZL1, His; Myelin protein zero-like 1; isoform CRA_b; cDNA FLJ78597; highly similar to Homo sapiens myelin protein zero-like 1 (MPZL1); transcript variant 1; mRNA ; cDNA; FLJ96614; Homo sapiens myelin protein zero-like 1 (MPZL1); Mrna	Human	HEK293
	MPZL1 protein is a cell surface receptor that participates in signal transduction by recruiting PTPN11/SHP-2 to the cell membrane. MPZL1 Protein, Human (HEK293, His) is the recombinant human-derived MPZL1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76942

	GABARAP Protein, Human (His-MBP) GABA(A) Receptor-Associated Protein; HCG1987397 Isoform CRA_b	Human	E. coli
	GABARAP Protein is essential for regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) involved in RAC1 activation and downstream signaling. The D6/7 E3 ubiquitin ligase complex, where GABARAP is a key component, contributes to diverse biological processes, including cytoskeletal organization, cell migration, proliferation, and apoptosis. GABARAP Protein, Human (His-MBP) is the recombinant human-derived GABARAP protein, expressed by E. coli , with N-His, N-MBP labeled tag.

HY-P70861

	GABARAP Protein, Human (GST) GABA(A) Receptor-Associated Protein; GABARAP Protein; HCG1987397 Isoform CRA_b; GABARAP	Human	E. coli
	GABARAP (gamma-aminobutyric acid receptor-associated protein) is a protein that performs multiple functions within cells. As a ubiquitin-like modifier, it participates in the intracellular transport of GABA(A) receptors and interacts with the cytoskeleton. GABARAP Protein, Human (GST) is the recombinant human-derived GABARAP protein, expressed by E. coli , with N-GST labeled tag.

HY-P705160

	IL-2R gamma/CD132 Protein, Mouse (Biotinylated, HEK293, His-Avi) IL-2RG; IL-2 R gamma; IL-2Rγ; IL2R γ; Interleukin 2 receptor, gamma chain, isoform CRA_b; Il2rg	Mouse	HEK293

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HY-P87103

	TEAD2 Antibody (YA6796) Embryonic TEA domain containing factor antibody; Etdf antibody; ETEF 1 antibody; ETF antibody; TEA domain family member 2 antibody; TEAD 2 antibody; TEAD-2 antibody; TEAD2 antibody; Tead2 protein (TEA domain family member 2 (Mapped), isoform CRA_b) antibody; TEAD2_HUMAN antibody; Embryonic TEA domain containing factor antibody; Etdf antibody; ETEF 1 antibody; ETF antibody; TEA domain family member 2 antibody; TEAD 2 antibody; TEAD-2 antibody; TEAD2 antibody; Tead2 protein (TEA domain family member 2 (Mapped), isoform CRA_b) antibody; TEAD2_HUMAN antibody; TEF 4 antibody; TEF4 antibody; Transcriptional enhancer factor 4 antibody; Transcriptional enhancer factor TEF 4 antibody; Transcriptional enhancer factor TEF-4 antibody	WB	Human, Mouse

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CRAB

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