2. Others Metabolic Enzyme/Protease NF-κB Anti-infection
  3. Biochemical Assay Reagents Endogenous Metabolite NF-κB Fungal
  4. Chitin, from crab carapace (powder)

Chitin, from crab carapace is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace is found in the exoskeleton of crabs. Chitin, from crab carapace inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace can be used in the research of gastric ulcer and candidiasis.

For research use only. We do not sell to patients.

Chitin, from crab carapace (powder) Chemical Structure

Chitin, from crab carapace (powder) Chemical Structure

CAS No. : 1398-61-4

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Chitin, from crab carapace (powder) Related Antibodies

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Description

Chitin, from crab carapace is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace is found in the exoskeleton of crabs. Chitin, from crab carapace inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace can be used in the research of gastric ulcer and candidiasis[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Chitin, from crab carapace shows antifungal activity against 20 clinical isolates of Candida spp.[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chitin, from crab carapace (powder) Related Antibodies
In Vivo

Chitin, from crab carapace (150-600 mg/kg BW; 13 days) significantly reduces the percentage of gastric ulcer index and inhibits NF-κB p65 expression in the Wistar rat model of ethanol-induced gastric ulcer[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (10-12 weeks old, 190-210 g) with Ethanol-induced gastric ulcer[2]
Dosage: 150, 300, 600 mg/kg
Administration: 13 days
Result: Decreased necrotic cells and fat degeneration, and increased normal cells in gastric mucosa.
Clinical Trial
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[Chitin, from crab carapace (powder)]
Structure Classification
Initial Source

Holotrichia parallela
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

SDS (393 KB)

COA (241 KB)

Handling Instructions (2659 KB)
References
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Chitin, from crab carapace (powder) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chitin, from crab carapace (powder)1398-61-4Biochemical Assay ReagentsEndogenous MetaboliteNF-κBFungalNuclear factor-κBNuclear factor-kappaBbiochemical assayWistar ratgastric ulcermantifungalCandidaInhibitorinhibitorinhibit

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