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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

CD40 antibody

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug-Linker Conjugates for ADC (4) Glucocorticoid Receptor (3) PI3K (1) Target Protein Ligand-Linker Conjugates (1) TNF Receptor (21)
By Research Areas:	Cancer (13) Infection (1) Inflammation/Immunology (16) Metabolic Disease (2)

Inhibitors & Agonists

Inhibitory Antibodies

Antibodies

Targets Recommended: ADC Antibody Antibody-Drug Conjugates (ADCs) ADC Linker PROTAC-Linker Conjugates for PAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99321

Teneliximab BMS 224819; Chi220; Anti-Human CD40 Recombinant antibody	TNF Receptor	Inflammation/Immunology Cancer
Teneliximab (BMS-224819) is a chimeric monoclonal antibody, blocks the CD40-CD40L interaction. Teneliximab (BMS-224819) has partial agonist activity resulting in some signaling through CD40 and peripheral B cell depletion .

HY-P99325

Toralizumab IDEC-131; Anti-Human CD40 ligand Recombinant antibody	TNF Receptor	Inflammation/Immunology
Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against *CD40L* (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab is an immunosuppressive agent. Toralizumab can lead to increased thrombosis. Toralizumab can be studied in research for diseases such as multiple sclerosis, systemic lupus erythematosus (SLE), and Crohn’s disease .

HY-P99049

Sotigalimab APX005M; APX005M; EPI-0050	TNF Receptor	Inflammation/Immunology
Sotigalimab, a *CD40* agonistic monoclonal antibody. Sotigalimab binds CD40 with high affinity and activates antigen-presenting cells, thereby stimulating cancer-specific T cell responses. Sotigalimab is mainly used in the study of metastatic pancreatic cancer and metastatic melanoma .

HY-P99046

Selicrelumab	TNF Receptor	Cancer
Selicrelumab is an agonist *CD40* antibody, induces changes in the tumor microenvironment. Selicrelumab can be used for the research of pancreatic cance and neoadjuvant study .

HY-P99625

Frexalimab SAR441344; INX-021	TNF Receptor	Metabolic Disease Inflammation/Immunology
Frexalimab (SAR441344) is a second-generation monoclonal antibody targeting the **CD40 ligand (CD40L)** with a good safety profile. Frexalimab inhibits the binding between CD40 and CD40L to modulate immune response. Frexalimab is likely to help prevent the process of β-cell destruction. Frexalimab is proming for multiple sclerosis, lupus erythematosus, Sj gren’s syndrome and type I diabetes research .

HY-P99257

Bleselumab ASKP 1240	TNF Receptor	Inflammation/Immunology
Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (K_d: 0.24 nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection .

HY-P99167

Lucatumumab HCD122	TNF Receptor	Cancer
Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research .

HY-P99315

Ruplizumab BG 9588; Anti-Human CD40L Recombinant antibody; Hu5c8	TNF Receptor	Inflammation/Immunology
Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1κ monoclonal antibody. By binding to *CD40L, Ruplizumab blocks its interaction with the CD40* receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P99663

Inezetamab	TNF Receptor	Cancer
Inezetamab is a bispecific anti-CD40 and anti-MSLN IgG1 monoclonal antibody .

HY-P991126

Ciltistotug	TNF Receptor	Inflammation/Immunology Cancer
Ciltistotug is a monoclonal antibody targeting human CD40 (TNFRSF5). Ciltistotug activates immune cells after binding to CD40, exerting immunostimulatory and antitumor activities. Ciltistotug is promising for research of cancer immunotherapy .

HY-P990083

Tegoprubart	TNF Receptor	Cancer
Tegoprubart is a monoclonal antibody directed against CD40 ligand (CD40L), a key mediator of costimulation. Inhibition of CD40L reduces cellular and antibody-mediated immunity and creates a more tolerant immune environment. Tegoprubart was demonstrated to have in vivo efficacy in transplantation animal models.

HY-P991460

Sym029	TNF Receptor	Cancer
Sym029 is a human IgG monoclonal antibody (mAb) targeting *TNFRSF5/CD40*. Sym029 can be used in cancer research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P99670

Iscalimab CFZ-533; OM11-62MF	TNF Receptor	Metabolic Disease Inflammation/Immunology
Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting *CD40* (K_D: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases .

HY-49382

Fluocinolone acetonide 3-benzylaniline	Target Protein Ligand-Linker Conjugates	Others
Fluocinolone acetonide 3-benzylaniline (Precursor Example 1) is a glucocorticoid receptor agonist-linker conjugate, which can be used for the synthesis of anti-CD40 antibody-drug conjugates (ADCs) .

HY-P99572

Tecaginlimab BNT-312; DuoBody-CD40x-4-1BB; GEN1042	TNF Receptor	Inflammation/Immunology Cancer
Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of *CD40* and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity .

HY-P990726

Abiprubart	TNF Receptor	Inflammation/Immunology
Abiprubart is an anti-CD40 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-153345

Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br	Drug-Linker Conjugates for ADC Glucocorticoid Receptor	Inflammation/Immunology
Glucocorticoid receptor agonist-1 phosphate(2,6-difluoro) Ala-Ala-Br is an Drug-linker conjugates for ADC that can be used as a reaction reagent for the synthesis of anti-CD40 antibody agent conjugates (ADCs) .

HY-P99015

Dacetuzumab	TNF Receptor	Cancer
Dacetuzumab (SGN-40) is a humanized IgG1, *anti-CD40* monoclonal antibody with anti-lymphoma activity. Dacetuzumab kills tumor cells via immune effector functions (antibody-dependent cellular cytotoxicity and phagocytosis [ADCC/ADCP]). Dacetuzumab ((SGN-40) can be used for multiple myeloma research .

HY-148459

ATAC21	Drug-Linker Conjugates for ADC	Cancer
ATAC21, a linker-immune-stimulatory compound that can be formed by conjugating a noncleavable maleimide-PEG4 linker containing a succinimide group with an immune- stimulatory compound. ATAC21 can be combined with SBT-040 (anti-CD40 antibody) to form a conjugate .

HY-P990134

*Anti-Mouse CD40L/CD154 Antibody* (MR-1)**	TNF Receptor	Others
Anti-Mouse CD40L/CD154 Antibody (MR-1) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD40L/CD154.

HY-400878

Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal	Glucocorticoid Receptor Drug-Linker Conjugates for ADC	Cancer
Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal, a glucocorticoid receptor agonist, is a drug-linker conjugate for ADC. Glucocorticoid receptor agonist-1 phosphate Gly-Glu-Mal can be used to synthesize the anti-CD40 antibody agent conjugates (WO2019106608A1; example 9) .

HY-P990133

*Anti-Monkey/Human CD40L/CD154 Antibody* (5C8)**	TNF Receptor	Others
Anti-Monkey/Human CD40L/CD154 Antibody (5C8) is a mouse-derived IgG2a type antibody inhibitor, targeting to monkey/human CD40L/CD154.

HY-P990269

*Anti-Mouse CD40L/CD154 (LALA-PG) Antibody* (MR-1)**	TNF Receptor	Others
Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to mouse CD40L/CD154.

HY-P990270

*Anti-Mouse CD40L/CD154 (D265A) Antibody* (MR-1)**	TNF Receptor	Others
Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse CD40L/CD154.

HY-152121

Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal	Glucocorticoid Receptor Drug-Linker Conjugates for ADC	Infection Inflammation/Immunology
Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal is a glucocorticoid receptor agonist. Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal can be used in anti-CD40 antibody agent conjugate (ADC). Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal can be used for the research of inflammation and immune regulation .

HY-P99701

Letolizumab BMS-986004	TNF Receptor	Inflammation/Immunology
Letolizumab (BMS-986004) is a monoclonal antibody targeting *CD40L*, which is produced to express mutant IgG1 lacking effector function, including Fc binding and complement fixation. Letolizumab reduces rejection, thromboembolism and prolongs the survival time .

HY-120471

AM-0687	PI3K	Inflammation/Immunology
AM-0687 is a selective inhibitor for PI3Kδ with an IC₅₀ of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC₅₀=0.8 nM) and the phosphorylation of AKT (IC₅₀=0.7 nM), and exhibits anti-inflammatory efficacy .

Cat. No.	Product Name	Target	Research Area

HY-P990680

Anti-Mouse CD40 Antibody (FGK4.5/FGK45)	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) is a rat-derived IgG2a monoclonal antibody targeting mouse CD40. CD40 is a type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 can act as a co-stimulatory molecule to activate B cells, dendritic cells, monocytes, and other APCs, promoting anti-tumor T cell responses.

HY-P99321

Teneliximab BMS 224819; Chi220; Anti-Human CD40 Recombinant antibody	TNF Receptor	Inflammation/Immunology Cancer
Teneliximab (BMS-224819) is a chimeric monoclonal antibody, blocks the CD40-CD40L interaction. Teneliximab (BMS-224819) has partial agonist activity resulting in some signaling through CD40 and peripheral B cell depletion .

HY-P99325

Toralizumab IDEC-131; Anti-Human CD40 ligand Recombinant antibody	TNF Receptor	Inflammation/Immunology
Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against *CD40L* (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab is an immunosuppressive agent. Toralizumab can lead to increased thrombosis. Toralizumab can be studied in research for diseases such as multiple sclerosis, systemic lupus erythematosus (SLE), and Crohn’s disease .

HY-P990860

*Anti-CD40* Antibody (G28.5)**	Inhibitory Antibodies	Others
Anti-CD40 Antibody (G28.5) is a kind of mouse IgG1, κ chimeric antibody, targeting to human *CD40. The recommend isotype control of Anti-CD40* Antibody (G28.5): Mouse IgG1 kappa, Isotype Control (HY-P99977).

HY-P99049

Sotigalimab APX005M; APX005M; EPI-0050	TNF Receptor	Inflammation/Immunology
Sotigalimab, a *CD40* agonistic monoclonal antibody. Sotigalimab binds CD40 with high affinity and activates antigen-presenting cells, thereby stimulating cancer-specific T cell responses. Sotigalimab is mainly used in the study of metastatic pancreatic cancer and metastatic melanoma .

HY-P99046

Selicrelumab	TNF Receptor	Cancer
Selicrelumab is an agonist *CD40* antibody, induces changes in the tumor microenvironment. Selicrelumab can be used for the research of pancreatic cance and neoadjuvant study .

HY-P99625

Frexalimab SAR441344; INX-021	TNF Receptor	Metabolic Disease Inflammation/Immunology
Frexalimab (SAR441344) is a second-generation monoclonal antibody targeting the **CD40 ligand (CD40L)** with a good safety profile. Frexalimab inhibits the binding between CD40 and CD40L to modulate immune response. Frexalimab is likely to help prevent the process of β-cell destruction. Frexalimab is proming for multiple sclerosis, lupus erythematosus, Sj gren’s syndrome and type I diabetes research .

HY-P99257

Bleselumab ASKP 1240	TNF Receptor	Inflammation/Immunology
Bleselumab (ASKP 1240) is a human anti-CD40 monoclonal antibody (mAb). Bleselumab binds to human CD40 with high affinity (K_d: 0.24 nM). Bleselumab inhibits immune responses by blocking the interaction of CD40 with its ligand CD40L. Bleselumab prevents organ transplant rejection .

HY-P99603

Cifurtilimab SEA-CD40	Inhibitory Antibodies	Cancer
Cifurtilimab (SEA-CD40) is an agonistic nonfucosylated, human IgG1 monoclonal antibody directed against *CD40*. Cifurtilimab shows antitumor activities .

HY-P99167

Lucatumumab HCD122	TNF Receptor	Cancer
Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research .

HY-P991126

Ciltistotug	TNF Receptor	Inflammation/Immunology Cancer
Ciltistotug is a monoclonal antibody targeting human CD40 (TNFRSF5). Ciltistotug activates immune cells after binding to CD40, exerting immunostimulatory and antitumor activities. Ciltistotug is promising for research of cancer immunotherapy .

HY-P990044

Dalnicastobart LVGN-7409	Inhibitory Antibodies	Cancer
Dalnicastobart (LVGN-7409) is a human IgG1κ antibody targeting *CD40/TNFRSF5* .

HY-P99315

Ruplizumab BG 9588; Anti-Human CD40L Recombinant antibody; Hu5c8	TNF Receptor	Inflammation/Immunology
Ruplizumab (BG 9588) is a humanized anti-CD40L IgG1κ monoclonal antibody. By binding to *CD40L, Ruplizumab blocks its interaction with the CD40* receptor, inhibits T-B cell costimulatory signals, and mediates the depletion of activated T cells via the Fc segment. Ruplizumab has immunosuppressive effects. Ruplizumab can be used in the study of systemic lupus erythematosus, organ transplant rejection, and autoimmune diseases. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P99663

Inezetamab	TNF Receptor	Cancer
Inezetamab is a bispecific anti-CD40 and anti-MSLN IgG1 monoclonal antibody .

HY-P990083

Tegoprubart	TNF Receptor	Cancer
Tegoprubart is a monoclonal antibody directed against CD40 ligand (CD40L), a key mediator of costimulation. Inhibition of CD40L reduces cellular and antibody-mediated immunity and creates a more tolerant immune environment. Tegoprubart was demonstrated to have in vivo efficacy in transplantation animal models.

HY-P991460

Sym029	TNF Receptor	Cancer
Sym029 is a human IgG monoclonal antibody (mAb) targeting *TNFRSF5/CD40*. Sym029 can be used in cancer research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-P99670

Iscalimab CFZ-533; OM11-62MF	TNF Receptor	Metabolic Disease Inflammation/Immunology
Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting *CD40* (K_D: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases .

HY-P99572

Tecaginlimab BNT-312; DuoBody-CD40x-4-1BB; GEN1042	TNF Receptor	Inflammation/Immunology Cancer
Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of *CD40* and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity .

HY-P990726

Abiprubart	TNF Receptor	Inflammation/Immunology
Abiprubart is an anti-CD40 human IgG4 κ monoclonal antibody . Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P99015

Dacetuzumab	TNF Receptor	Cancer
Dacetuzumab (SGN-40) is a humanized IgG1, *anti-CD40* monoclonal antibody with anti-lymphoma activity. Dacetuzumab kills tumor cells via immune effector functions (antibody-dependent cellular cytotoxicity and phagocytosis [ADCC/ADCP]). Dacetuzumab ((SGN-40) can be used for multiple myeloma research .

HY-P990134

*Anti-Mouse CD40L/CD154 Antibody* (MR-1)**	TNF Receptor	Others
Anti-Mouse CD40L/CD154 Antibody (MR-1) is a Armenian hamster-derived IgG type antibody inhibitor, targeting to mouse CD40L/CD154.

HY-P990133

*Anti-Monkey/Human CD40L/CD154 Antibody* (5C8)**	TNF Receptor	Others
Anti-Monkey/Human CD40L/CD154 Antibody (5C8) is a mouse-derived IgG2a type antibody inhibitor, targeting to monkey/human CD40L/CD154.

HY-P990269

*Anti-Mouse CD40L/CD154 (LALA-PG) Antibody* (MR-1)**	TNF Receptor	Others
Anti-Mouse CD40L/CD154 (LALA-PG) Antibody (MR-1) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to mouse CD40L/CD154.

HY-P990270

*Anti-Mouse CD40L/CD154 (D265A) Antibody* (MR-1)**	TNF Receptor	Others
Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse CD40L/CD154.

HY-P990527

Anti-TNFRSF5/CD40 Antibody	Inhibitory Antibodies	Inflammation/Immunology

HY-P99701

Letolizumab BMS-986004	TNF Receptor	Inflammation/Immunology
Letolizumab (BMS-986004) is a monoclonal antibody targeting *CD40L*, which is produced to express mutant IgG1 lacking effector function, including Fc binding and complement fixation. Letolizumab reduces rejection, thromboembolism and prolongs the survival time .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80056

	CD40 Antibody (YA805)	WB, ICC/IF, IHC-P	Human
	CD40 Antibody is a non-conjugated and Mouse origined monoclonal antibody about 31 kDa, targeting to CD40. It can be used for WB,ICC,IHC-P assays with tag free, in the background of Human.

HY-P80057

	CD40L Antibody (YA536)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	CD40L Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 29 kDa, targeting to CD40L. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P84215

	CD40 Antibody (YA3912) p50; Bp50; CDW40; TNFRSF5	WB, IHC-P, FC, ELISA	Human

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