2. Apoptosis
  3. TNF Receptor
  4. ABI793

ABI793 is a human IgG1 antihuman CD154 (CD40 ligand) monoclonal antibody. ABI793 inhibits immune response by blocking the CD154-CD40 (IC50 = 75 nM) signaling pathway. ABI793 effectively prevents kidney transplant rejection. ABI793 can be used for research on immunological rejection.

For research use only. We do not sell to patients.

ABI793 Chemical Structure

ABI793 Chemical Structure

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ABI793 Related Antibodies

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TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Description

ABI793 is a human IgG1 antihuman CD154 (CD40 ligand) monoclonal antibody. ABI793 inhibits immune response by blocking the CD154-CD40 (IC50 = 75 nM) signaling pathway. ABI793 effectively prevents kidney transplant rejection. ABI793 can be used for research on immunological rejection[1][2].

IC50 & Target

TNFSF5/CD40L/CD154
In Vitro

ABI793 inhibits CD154 and CD40 binding in a concentration dependent manner (IC50 = 75 nM)[1].
ABI793 (4 days) inhibits IL-4 stimulated B cell proliferation (IC50 = 73 nM)[1].
ABI793 (5 days) inhibits human mixed lymphocyte reaction (MLR) (IC50 = 320 ng/mL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ABI793 Related Antibodies
In Vivo

ABI793 (20 mg/kg, i.v., On postoperative days 0, 1, 4, 11, 18, 28, 56, and 84) significantly prolongs the survival time of transplanted kidneys and effectively prevents transplant rejection reactions in Cynomolgus monkeys[1].
ABI793 (20 mg/kg, i.v., on postoperative days 0, 1, 4, 11, 18, 28, 56, and 84) significantly prolongs the survival time of kidney transplantation in rhesus monkeys[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Renal allograft or autograft transplantation in Cynomolgus monkeys (3-8 kg)[1]
Dosage: 20 mg/kg
Administration: Intravenous injection (i.v.) on postoperative days 0, 1, 4, 11, 18, 28, 56, and 84
Result: Significantly prolonged the survival time of transplanted kidneys (median survival of 108 days). Did not cause acute tubular necro-sis (ATN) or thrombocytopenia in autograft transplantation.
Animal Model: Renal allograft transplantation in rhesus monkeys (4-6 years, 4-7 kg)[2]
Dosage: 20 mg/kg
Administration: Intravenous injection (i.v.) on postoperative days 0, 1, 4, 11, 18, 28, 56, and 84
Result: Significantly prolonged kidney transplant survival time (median survival of 149 days). Did not cause abnormal liver and kidney function or hematological toxicity.
Gene ID

959  [NCBI]

Accession
Target

TNFSF5/CD40L/CD154
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

N/A
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ABI793 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABI793ABI 793ABI-793TNF ReceptorTumor Necrosis Factor ReceptorTNFRCD154immunological rejectionrenal transplantInhibitorinhibitorinhibit

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