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Brain angiogenesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (1) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (1) COX (1) DNA Alkylator/Crosslinker (1) Dopamine Receptor (4) Drug Metabolite (1) Endogenous Metabolite (4) Ferroptosis (4) GSK-3 (1) IAP (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Molecular Glues (1) NF-κB (2) p38 MAPK (1) PI3K (1) Reference Standards (2) STAT (1) Survivin (1) TAM Receptor (1) VEGFR (1) β-catenin (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (3) Neurological Disease (6)

By Targets:

Akt (1)

Apoptosis (1)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Caspase (1)

COX (1)

DNA Alkylator/Crosslinker (1)

Dopamine Receptor (4)

Drug Metabolite (1)

Endogenous Metabolite (4)

Ferroptosis (4)

GSK-3 (1)

IAP (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

Molecular Glues (1)

NF-κB (2)

p38 MAPK (1)

PI3K (1)

Reference Standards (2)

STAT (1)

Survivin (1)

TAM Receptor (1)

VEGFR (1)

β-catenin (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (2)

Endocrinology (1)

Inflammation/Immunology (3)

Neurological Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0451

Dopamine 10+ Cited Publications ASL279 free base	Dopamine Receptor Endogenous Metabolite Ferroptosis	Neurological Disease
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body . Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-B0451A

Dopamine hydrochloride 10+ Cited Publications ASL279	Dopamine Receptor Endogenous Metabolite Ferroptosis	Neurological Disease
Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-B0451AS7

Dopamine-d5 hydrochloride	Isotope-Labeled Compounds Dopamine Receptor Endogenous Metabolite Ferroptosis	Neurological Disease
Dopamine-d₅ (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-131031

KCC-07	DNA Alkylator/Crosslinker	Cancer
KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity .

HY-B0451AR

Dopamine hydrochloride (Standard) ASL279 (Standard)	Reference Standards Dopamine Receptor Endogenous Metabolite Ferroptosis	Neurological Disease
Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-108775A

Sodium thiosulfate (99%, water≤1.0%) Sodium hyposulfite (99%, water≤1.0%)	Biochemical Assay Reagents GSK-3 β-catenin Interleukin Related COX NF-κB	Cardiovascular Disease Neurological Disease Inflammation/Immunology Endocrinology Cancer
Sodium thiosulfate is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease .

HY-P99463

Batiraxcept AVB-500; AVB-S6-500	TAM Receptor PI3K Akt p38 MAPK	Cancer
Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and GAS6 inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((K_D <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis .

HY-N3001

Isolinderalactone	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase	Neurological Disease Inflammation/Immunology Cancer
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .

HY-175599

Z6466608628	Molecular Glues	Cardiovascular Disease Cancer
Z6466608628 is a selective PPIL4 molecular glue degrader with an EC₅₀ of 0.34  μM. PPIL4 is a regulator of the B ^ACR spliceosome and it is essential for brain angiogenesis. Z6466608628 can be used for intracranial aneurysm (IA) research .

HY-W778608R

Quercetin 7-glucuronide (Standard) Quercetin 7-O-β-glucuronide (Standard)	Drug Metabolite Reference Standards	Inflammation/Immunology
Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

Cat. No.	Product Name	Type

HY-108775A

Sodium thiosulfate (99%, water≤1.0%) Sodium hyposulfite (99%, water≤1.0%)	Buffer Reagents
Sodium thiosulfate is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease .

Sodium thiosulfate (99%, water≤1.0%)

Sodium hyposulfite (99%, water≤1.0%)

Buffer Reagents

Sodium thiosulfate is an antioxidant. Sodium thiosulfate inhibits the expression of p-GSK-3β and β-catenin proteins, reduces IL-1β, COX-2, and Iba-1, and inhibits NFκB activation. Sodium thiosulfate promotes angiogenesis, inhibits inflammation, and improves acute lung injury. Sodium thiosulfate also exhibits anti-cancer activity against melanoma. Sodium thiosulfate also exerts renal protective effects. Sodium thiosulfate can be used in the research of osteoarthritis, brain inflammation, cancer (such as breast cancer, melanoma), and kidney disease .

Cat. No.	Product Name	Target	Research Area

HY-P99463

Batiraxcept AVB-500; AVB-S6-500	TAM Receptor PI3K Akt p38 MAPK	Cancer
Batiraxcept (AVB-500; AVB-S6-500) is a selective, soluble AXL receptor and GAS6 inhibitor that targets the GAS6-AXL signaling axis. Batiraxcept is orally inactive and does not cross the blood-brain barrier. Batiraxcept competitively binds to GAS6 ((K_D <1 nM), preventing its interaction with the AXL receptor tyrosine kinase, thereby inhibiting downstream PI3K/AKT and MAPK signaling pathways, reducing tumor cell glycolysis, angiogenesis, and metastatic potential. Batiraxcept has demonstrated antitumor activity in preclinical models of endometrial, cholangiocarcinoma, and ovarian cancer by inhibiting tumor growth, invasion, and metastasis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0451

Dopamine 10+ Cited Publications ASL279 free base	Structural Classification Phenols Polyphenols Endogenous metabolite	Dopamine Receptor Endogenous Metabolite Ferroptosis
Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body . Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-B0451A

Dopamine hydrochloride 10+ Cited Publications ASL279	Structural Classification Microorganisms Source classification Phenols Polyphenols Endogenous metabolite	Dopamine Receptor Endogenous Metabolite Ferroptosis
Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-B0451AR

Dopamine hydrochloride (Standard) ASL279 (Standard)	Structural Classification Microorganisms Source classification Phenols Polyphenols Endogenous metabolite	Reference Standards Dopamine Receptor Endogenous Metabolite Ferroptosis
Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

HY-N3001

Isolinderalactone	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm. Disease Research Fields Cancer	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .

HY-W778608R

Quercetin 7-glucuronide (Standard) Quercetin 7-O-β-glucuronide (Standard)	Structural Classification Flavonols Flavonoids Source classification Pedaliaceae Plants Uncarina grandidieri (Baill.) Ihlenf. & Straka	Drug Metabolite Reference Standards
Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

Species:	Human (2)
Tag:	His (1) Fc (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P7675

	BAI3 Protein, Human (HEK293, His) rHuBAI3, His; Brain-Specific angiogenesis Inhibitor 3; BAI3	Human	HEK293
	BAI3 Protein, Human (HEK293, His) is a recombinant human brain-specific angiogenesis inhibitor 3 produced in HEK293 cells. Brain-specific angiogenesis inhibitor 3 (BAI3) is a member of the cell-adhesion class of G protein-coupled receptors that are expressed at high levels in the brain. BAI3 is a high-affinity receptor for C1q-like proteins.

HY-P79380

	BAI2 Protein, Human (HEK293, hFc) Adhesion G protein-coupled receptor B2; ADGRB2; Brain-specific angiogenesis inhibitor 2; BAI2	Human	HEK293
	The BAI2 protein is an orphan G protein-coupled receptor involved in cell adhesion and possible cell-cell interactions. It activates the NFAT signaling pathway through the G protein GNAZ and contributes to transcriptional regulation. BAI2 Protein, Human (HEK293, hFc) is the recombinant human-derived BAI2 protein, expressed by HEK293 , with C-hFc labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0451AS7

Dopamine-d5 hydrochloride
Dopamine-d₅ (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

Dopamine-d5 hydrochloride

Dopamine-d₅ (hydrochloride) is the deuterium labeled Dopamine (hydrochloride). Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body . Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis .

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