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Antitussive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (3) Antibiotic (1) Apoptosis (8) Autophagy (2) Bacterial (4) Calcium Channel (2) Carboxylesterase (CES) (2) Cholinesterase (ChE) (1) Cytochrome P450 (3) DNA/RNA Synthesis (3) Dopamine Receptor (1) Drug Derivative (2) Drug Metabolite (1) Endogenous Metabolite (1) Fungal (1) GABA Receptor (2) Histamine Receptor (5) Influenza Virus (3) Isotope-Labeled Compounds (5) mAChR (6) MMP (1) Neurokinin Receptor (1) NF-κB (1) Opioid Receptor (9) P-glycoprotein (1) P2X Receptor (2) Parasite (2) Phosphodiesterase (PDE) (2) Potassium Channel (6) Reactive Oxygen Species (ROS) (2) Reference Standards (17) Sigma Receptor (6) Sodium Channel (3) STAT (3) TRP Channel (2) α-synuclein (2)
By Research Areas:	Cancer (18) Cardiovascular Disease (5) Endocrinology (6) Infection (14) Inflammation/Immunology (44) Metabolic Disease (2) Neurological Disease (30)

By Targets:

Adrenergic Receptor (3)

Antibiotic (1)

Apoptosis (8)

Autophagy (2)

Bacterial (4)

Calcium Channel (2)

Carboxylesterase (CES) (2)

Cholinesterase (ChE) (1)

Cytochrome P450 (3)

DNA/RNA Synthesis (3)

Dopamine Receptor (1)

Drug Derivative (2)

Drug Metabolite (1)

Endogenous Metabolite (1)

Fungal (1)

GABA Receptor (2)

Histamine Receptor (5)

Influenza Virus (3)

Isotope-Labeled Compounds (5)

mAChR (6)

MMP (1)

Neurokinin Receptor (1)

NF-κB (1)

Opioid Receptor (9)

P-glycoprotein (1)

P2X Receptor (2)

Parasite (2)

Phosphodiesterase (PDE) (2)

Potassium Channel (6)

Reactive Oxygen Species (ROS) (2)

Reference Standards (17)

Sigma Receptor (6)

Sodium Channel (3)

STAT (3)

TRP Channel (2)

α-synuclein (2)

By Research Areas:

Cancer (18)

Cardiovascular Disease (5)

Endocrinology (6)

Infection (14)

Inflammation/Immunology (44)

Metabolic Disease (2)

Neurological Disease (30)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Levodropropizine (S)-(-)-Dropropizine; DF-526	Histamine Receptor	Neurological Disease Inflammation/Immunology Endocrinology
Levodropropizine (DF-526) is an orally active histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent .

Pipazethate SKF 70230A; SQ 15874; Pipazetate	GABA Receptor	Others
Pipazethate (SKF 70230A), a pyridobenzothiazine derivative, is a potent GABA antagonist. Pipazethate has antitussive activity. Pipazethate can be used in research in cough supressant .

Melitidin	Others	Inflammation/Immunology
Melitidin is a flavanone glycoside, that can be isolated from Citrus grandis 'Tomentosa'. Melitidin shows a good antitussive effect on cough induced by citric acid in Guinea pig .

Zhebeirine 25-Epieduardine; Puqiedinone	Others	Others
Zhebeirine (Puqiedinone), a steroidal alkaloid, is isolated from the bulbs of Fritillaria puqiensis. Zhebeirine exhibits antitussive and expectorant properties .

Vadocaine OR K-242	Adrenergic Receptor	Neurological Disease
Vadocaine (OR K-242), an orally active antitussive compound, is a local agent that can suppress or relieve pain .

Viminol	Opioid Receptor	Neurological Disease
Viminol is a centrally acting analgesic agent. Viminol also shows antitussive activity .

Stemoninine	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
Stemoninine is a lycoris alkaloid that can be used as an antitussive. Stemoninine has significant inhibitory activity against human acetylcholinesterase (AChE) (IC₅₀=5.52 μM) .

Piperidylthiambutene	Opioid Receptor	Neurological Disease
Piperidylthiambutene is a potent µ-opioid receptor (MOR) agonist with a K_i of 2.75 nM. Piperidylthiambutene exhibits analgesic and antitussive properties and can be utilized in relevant research .

Levodropropizine (Standard) (S)-(-)-Dropropizine (Standard); DF-526 (Standard)	Reference Standards Histamine Receptor	Neurological Disease Inflammation/Immunology Endocrinology
Levodropropizine (Standard) is the analytical standard of Levodropropizine. This product is intended for research and analytical applications. Levodropropizine (DF-526) is an orally active histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent .

Chlophedianol Clofedanol; Calmotusin; NSC 113595	Others	Infection
Chlophedianol (Clofedanol) is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs) .

Neostenine (+)-Neostenine	P-glycoprotein	Cancer
Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application .

Tipepidine	Potassium Channel	Neurological Disease
Tipepidine reversibly inhibits dopamine (DA) D₂ receptor-mediated GIRK currents (I_DA(GIRK)) with an IC₅₀ of 7.0 μM. Tipepidine subsequently activates VTA dopamine neuron . Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect .

Dropropizine (±)-Dropropizine; UCB-196	Others	Neurological Disease
Dropropizine ((±)-Dropropizine; UCB-196) is an orally effective, peripherally selective antitussive that inhibits the activity of peripheral receptors and afferent nerves in the respiratory tract. Dropropizine acts on the cough reflex pathway, does not pass the blood-brain barrier, and has no central nervous system side effects. Dropropizine mainly regulates the level of sensory neuropeptides and inhibits the afferent signal transmission of the cough reflex, thereby alleviating the symptoms of dry cough, and has both mild local anesthetic and antihistamine activity. Dropropizine is mainly used for symptomatic research on dry cough caused by respiratory diseases .

Chlophedianol hydrochloride Clofedanol hydrochloride; Calmotusin hydrochloride; NSC 113595 hydrochloride	Others	Infection
Chlophedianol (Clofedanol) hydrochloride is an orally active and potent antitussive agent. Chlophedianol hydrochloride can be used for the research of acute cough due to upper respiratory tract infections (URIs) .

Benzonatate Benzononatine	Sodium Channel	Neurological Disease
Benzonatate (Benzononatine) is an orally active and non-narcotic peripheral antitussive agent. Benzonatate is a reversible voltage-gated Na ⁺ channels inhibitor. Benzonatate dampens the activity of cough stretch receptors .

Noscapine 1 Publications Verification (S,R)-Noscapine	Opioid Receptor Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

Noscapine hydrochloride 1 Publications Verification (S,R)-Noscapine hydrochloride	Opioid Receptor Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Noscapine ((S,R)-Noscapine) hydrochloride is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine hydrochloride exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine hydrochloride disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine hydrochloride possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier .

Noscapine (Standard) (S,R)-Noscapine (Standard)	Reference Standards Opioid Receptor Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier [4] .

Chlophedianol hydrochloride (Standard)	Sigma Receptor	Infection
Chlophedianol (hydrochloride) (Standard) is the analytical standard of Chlophedianol (hydrochloride). This product is intended for research and analytical applications. Chlophedianol (Clofedanol) hydrochloride is an orally active and potent antitussive agent. Chlophedianol hydrochloride can be used for the research of acute cough due to upper respiratory tract infections (URIs) .

Benzonatate (Standard) Benzononatine (Standard)	Reference Standards Sodium Channel	Neurological Disease
Benzonatate (Standard) (Benzononatine (Standard)) is the analytical standard of Benzonatate (HY-B155). This product is intended for research and analytical applications. Benzonatate (Benzononatine) is an orally active and non-narcotic peripheral antitussive agent. Benzonatate is a reversible voltage-gated Na ⁺ channels inhibitor. Benzonatate dampens the activity of cough stretch receptors.

Eprazinone dihydrochloride	Neurokinin Receptor	Inflammation/Immunology
Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen .

Spiradoline mesylate U-62066 mesylate	Opioid Receptor	Neurological Disease
Spiradoline mesylate (U-62066 mesylate), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a K_i of 8.6 nM in guinea pig. The K_i values of Spiradoline mesylate for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline mesylate has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier .

Spiradoline U-62066	Opioid Receptor	Neurological Disease
Spiradoline (U-62066), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a K_i of 8.6 nM in guinea pig. The K_i values of Spiradoline for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier .

BKCa activator-1	Potassium Channel	Others
BKCa activator-1 (Compound 51b) is the orally active activator for the calcium-activated potassium channel BKCa with an EC₅₀ of 2.82 μM. BKCa activator-1 increases K+ efflux, leads to cell membrane hyperpolarization, thereby inhibiting smooth muscle contraction. BKCa activator-1 alleviates urinary incontinence in spontaneously hypertensive rat (SHR) model, exhibits antitussive effect in puinea pig cough model .

NPD9948	DNA/RNA Synthesis	Others
NPD9948 is an antitussive agent with antitussive activity in a guinea pig antitussive test. Its half antitussive dose (AtD50) is 14.5 mg/kg and 22.6 mg/kg when injected intraperitoneally and orally, respectively.

Guaiapate Klamar; Mg 5454	Others	Inflammation/Immunology
Guaiapate is an antitussive agent.

Glaucine (Standard) O,O-Dimethylisoboldine (Standard); S-(+)-Glaucine (Standard); NSC 34396 (Standard)	Reference Standards Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus	Infection Inflammation/Immunology
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .

Dimemorfan phosphate 2 Publications Verification	Sigma Receptor	Neurological Disease Inflammation/Immunology
Dimemorfan phosphate is a sigma 1 receptor agonist, used as a potent antitussive.

Obtucarbamate A	Others	Inflammation/Immunology Cancer
Obtucarbamate A isolated from Disporum cantoniense has antitussive activity .

Carcainium chloride QX 572; RSD 931	Histamine Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Carcainium chloride (QX 572) is a quaternary derivative of Lidocaine. Antitussive effect .

Moguisteine 1 Publications Verification BBR-2173	Opioid Receptor	Neurological Disease Cancer
Moguisteine???(BBR-2173) is an antitussive compound but has no significant affinity for opiate receptors.

Epigambogic acid	Others	Cancer
Epigambogic acid is a natural anti-tumor, antitussive, expectorant and anti-inflammatory compound .

Pentoxyverine Carbetapentane	Sigma Receptor mAChR	Neurological Disease Inflammation/Immunology
Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with K_is of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .

Pentoxyverine citrate Carbetapentane citrate	Sigma Receptor mAChR	Neurological Disease Inflammation/Immunology
Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with K_is of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .

Pentoxyverine (Standard) Carbetapentane (Standard)	Reference Standards Sigma Receptor mAChR	Neurological Disease Inflammation/Immunology
Pentoxyverine (Standard) is the analytical standard of Pentoxyverine. This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) is an orally active sigma-1 receptor agonist, with K_is of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membran σ1, respectively. Pentoxyverine is a muscarinic antagonist. Pentoxyverine is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance .

Nepinalone	Drug Derivative	Others
Nepinalone, an alchilaminate derivative of β-tetralone and an orally active cough suppressant, possesses a non-opioid antitussive activity .

Nepinalone hydrochloride	Drug Derivative	Others
Nepinalone hydrochloride, an alchilaminate derivative of β-tetralone and an orally active cough suppressant, possesses a non-opioid antitussive activity .

Pentoxyverine citrate (Standard) Carbetapentane citrate (Standard)	Reference Standards Sigma Receptor mAChR	Neurological Disease Inflammation/Immunology
Pentoxyverine (citrate) (Standard) is the analytical standard of Pentoxyverine (citrate). This product is intended for research and analytical applications. Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance [4].

Benzonatate (PEGn)	Sodium Channel	Neurological Disease Inflammation/Immunology
Benzonatate (PEGn) is a unique non-narcotic antitussive agent that has sodium channel-blocking properties and anesthetic effects on the respiratory stretch receptors .

Neotuberostemonine	Bacterial	Infection Inflammation/Immunology
Neotuberostemonine, one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages .

Pipazethate hydrochloride SKF 70230A hydrochloride; SQ 15874 hydrochloride; Pipazetate hydrochloride	GABA Receptor	Inflammation/Immunology
Pipazethate (SKF 70230A; SQ 15874) hydrochloride is a potent GABA antagonist. Pipazethate hydrochloride shows antitussive activity and can be used in research in cough suppressant .

Clobutinol	Potassium Channel	Cardiovascular Disease Inflammation/Immunology
Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research .

Clobutinol hydrochloride	Potassium Channel	Cardiovascular Disease Inflammation/Immunology
Clobutinol hydrochloride is a compound that has anti-tussive effects. Clobutinol hydrochloride affects heart rate and blood pressure, it can be used for cough related research .

Liquiritin apioside (Standard)	Reference Standards Others	Inflammation/Immunology
Liquiritin apioside (Standard) is the analytical standard of Liquiritin apioside. This product is intended for research and analytical applications. Liquiritin apioside, a main flavonoid component of licorice, possesses antitussive effects .

Noscapine-13C,d3	Isotope-Labeled Compounds Apoptosis Opioid Receptor	Cancer
Noscapine- ¹³C,d₃ is a ¹³C- labeled and deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

Cat. No.	Product Name

HY-L223

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

878 compounds

Antitussive and antiasthmatic method is a type of treatment strategy in traditional Chinese medicine, mainly used to alleviate symptoms such as coughing and asthma. These symptoms may be caused by various factors, such as: Bronchial asthma, chronic obstructive pulmonary disease, asthmatic bronchitis, cough-induced asthma, and others. Based on existing research in traditional Chinese medicine, many types of Chinese medicinal herbs showed antitussive and antiasthmatic effects. For example: Ardisiae Japonicae Herba, Ginkgo Semen, Amygdalus Communis Vas, Farfarae Flos, Viticis Cannabifoliae Fructus, Eriobotryae Folium etc. Therefore, the active ingredients derived from these traditional Chinese medicine have high medicinal value and have the potential to be developed into drugs for related diseases.

MCE can provide 878 active ingredients that can be obtained from traditional Chinese medicine with antitussive and antiasthmatic functions, which can be applied to drug development and research on disease mechanisms.

Cat. No.	Product Name	Type

HY-W354753

Homatropine hydrochloride	Biochemical Assay Reagents
Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs .

HY-W354753R

Homatropine hydrochloride (Standard)

Biochemical Assay Reagents

Homatropine (hydrochloride) (Standard) is the analytical standard of Homatropine (hydrochloride). This product is intended for research and analytical applications. Homatropine hydrochloride is an orally active anticholinergic agent that rapidly dilates pupils and has cycloplegic effects. Homatropine hydrochloride also has antitussive activity. Homatropine hydrochloride can be used in research on eye diseases and coughs .

Cat. No.	Product Name	Chemical Structure

HY-B1895S

Levodropropizine-d8
Levodropropizine-d₈ is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent.

HY-13716S

Noscapine-13C,d3

Noscapine- ¹³C,d₃ is a ¹³C- labeled and deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-B1895S1

Levodropropizine-d5
Levodropropizine-d₅ ((S)-(-)-Dropropizine-d₅) is deuterium labeled Levodropropizine. Levodropropizine (DF-526) is an orally active histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive agent .

HY-A0161S

Chlophedianol-13C6
Chlophedianol- ¹³C₆ is the ¹³C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs) .

HY-W767656

Dropropizine-d4
Dropropizine-d₄ ((±)-Dropropizine-d₄) is deuterium labeled Dropropizine. Dropropizine ((±)-Dropropizine) belongs to the phenylpiperazine group of organic compounds. Dropropizine is a peripheral antitussive agent that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors .

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Antitussive

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products