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Results for "

ARA-S

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Receptor (2) Antibiotic (4) Apoptosis (5) Autophagy (1) Biochemical Assay Reagents (1) CD38 (2) Complement System (1) DNA/RNA Synthesis (7) Drug Intermediate (1) Drug Metabolite (2) Endogenous Metabolite (2) Fluorescent Dye (1) GSK-3 (3) HBV (2) HSV (2) Isotope-Labeled Compounds (1) Mitochondrial Metabolism (1) Nucleoside Antimetabolite/Analog (16) Orthopoxvirus (3) Reference Standards (3) Toll-like Receptor (TLR) (1) Transmembrane Glycoprotein (1) WDR5 (1)
By Research Areas:	Cancer (24) Infection (4) Inflammation/Immunology (1) Metabolic Disease (5) Neurological Disease (5)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	A (1) Nucleosides and their Analogs (9) Nucleoside Phosphoramidites (1) Adenine (1) Cytosine (1) Uracil (5) Guanine (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
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Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120965

N-Palmitoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered. N-Palmitoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling. Its function is currently under investigation.

HY-120964

N-Stearoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Stearoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling.

HY-134358A

Ara-F-NAD+ sodium	CD38	Neurological Disease
Ara-F-NAD+ sodium is an arabino analogue of NAD ⁺. Ara-F-NAD+ sodium is a potent, reversible and slow-binding CD38 NADase inhibitor .

HY-129522

*Sulfo-ara-F-NMN* 4 Publications Verification CZ-48	Toll-like Receptor (TLR)	Neurological Disease
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC₅₀ around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production .

HY-120960A

N-Arachidonoyl-L-Serine sodium ARA-S sodium	Biochemical Assay Reagents	Others
N-Arachidonoyl-L-Serine sodium is an anandamide.

HY-154971

Ara-SH	Apoptosis	Cancer
Ara-SH is a Cytarabine mercaptopropionic acid-substituted derivative. Ara-SH is used as the trigger to fabricate a smart Cytarabine and Venetoclax-coloaded nanoparticle (AV-NP) through self-assembly. Ara-SH exhibits remarkable synergistic antileukemia effects in vitro and in vivo .

HY-10512S

AR-A014418-d3 AR 0133418-d₃; GSK 3β inhibitor VIII-d₃; AR 014418-d₃	Isotope-Labeled Compounds GSK-3	Metabolic Disease Cancer
AR-A014418-d₃ is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC₅₀=104 nM; K_i=38 nM) .

HY-134358

Ara-F-NAD+	CD38	Neurological Disease
Ara-F-NAD+ is an arabino analogue of NAD ⁺. Ara-F-NAD+ is a potent, reversible and slow-binding CD38 NADase inhibitor .

HY-10512R

AR-A014418 (Standard) AR 0133418 (Standard); GSK 3β inhibitor VIII (Standard); AR 014418 (Standard)	Reference Standards GSK-3	Metabolic Disease Cancer
AR-A014418 (Standard) is the analytical standard of AR-A014418. This product is intended for research and analytical applications. AR-A014418 is a potent, selective and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM) .

HY-106218A

Flurocitabine hydrochloride 5-Fluorocyclocytidine hydrochloride; 5'-Fluorocyclocytidine hydrochloride	Nucleoside Antimetabolite/Analog	Cancer
Flurocitabine hydrochloride (5-Fluorocyclocytidine hydrochloride; 5'-Fluorocyclocytidine hydrochloride) is the hydrochloride form of Flurocitabine (HY-106218). Flurocitabine hydrochloride exhibits antitumor activity through hydrolysation in vivo into two active antitumor substances arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU) .

HY-158057

A2AR/A2BR antagonist 1	Adenosine Receptor	Cancer
A_2AR/A_2BR antagonist 1 (compound 7ai) has a dual antagonistic effect on *A_2AR/A_2BR, with the IC₅₀* values of 11.2 nM and 6.4 nM for A_2AR and A_2BR, respectively. A_2AR/A_2BR antagonist 1 promotes T cell-mediated cancer cell death .

HY-P10929

*Fmoc-Lys(tBuO-Ara-Glu(AEEA-AEEA)-OtBu)-OH*	Drug Intermediate	Others
Fmoc-Lys(tBuO-Ara-Glu(AEEA-AEEA)-OtBu)-OH is a side chain of tirzepatide.

HY-134031

Ara-ATP	DNA/RNA Synthesis	Others
Ara-ATP, a structural analog of ATP, inhibits poly(A) polymerase activity by competing with ATP .

HY-131561

Ara-UTP ARA-uridine triphosphate	DNA/RNA Synthesis	Others
Ara-UTP is a sugar-modified nucleotide triphosphate that deceives RNA polymerases and blocks chain extension.

HY-W704973

*F-ara-EdU*	DNA/RNA Synthesis	Cancer
F-ara-EdU is a low-toxic, highly stable probe for DNA synthesis that is used as a marker for cell proliferation and DNA replication by binding to DNA or RNA in cells. F-ara-EdU can also be used to detect the rate of DNA synthesis within cells, as well as to study the mechanisms of DNA repair and damage .

HY-106218

Flurocitabine 5-Fluorocyclocytidine; 5'-Fluorocyclocytidine	Nucleoside Antimetabolite/Analog	Cancer
Flurocitabine (5-Fluorocyclocytidine) is a fluorinated anlydride analog of cytosine arabinoside, partially hydrolysecl in vivo into two active antitumor substances (arabinosyl-tluorocytosine (ara-FC) and arabinosyl-fluorouracil (ara-FU)). Flurocitabine (5-Fluorocyclocytidine) has antitumor activity during phase I studies in acute leukemia and solid tumors .

HY-P0168

Cibinetide 5 Publications Verification ARA290	Transmembrane Glycoprotein	Neurological Disease
Cibinetide (ARA290) is an EPO-derivative, acting as a specific agonist of erythropoietin/CD131 heteroreceptor, and used for neurological disease treatment.

HY-B0277A

Vidarabine phosphate ARA-AMP; ARA-A 5'-monophosphate	HBV Antibiotic	Infection
Vidarabine phosphate (Ara-AMP), an antiviral agent, inhibits chronic HBV infection . Vidarabine phosphate also against herpes simplex and varicella zoster viruses .

HY-10512

AR-A014418 Maximum Cited Publications 17 Publications Verification AR 0133418; GSK 3β inhibitor VIII; AR 014418	GSK-3	Metabolic Disease Cancer
AR-A014418 is a potent, selective and ATP-competitive GSK3β inhibitor (IC₅₀=104 nM; K_i=38 nM) .

HY-D1247

Hydroxynaphthol Blue	Fluorescent Dye	Others
Hydroxynaphthol Blue enables visual tube closure detection. Hydroxynaphthol Blue shows high specificity for the gene encoding Ara h 1 for visual field detection of peanut allergens .

HY-115740

Cytarabine triphosphate ARA-CTP	DNA/RNA Synthesis	Cancer
Cytarabine triphosphate (Ara-CTP), an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine .

HY-115740A

Cytarabine triphosphate trisodium ARA-CTP trisodium	DNA/RNA Synthesis	Cancer
Cytarabine triphosphate (Ara-CTP) trisodiu, an active metabolite of Cytarabine, is a competitive inhibitor of DNA synthesis. Intracellular Cytarabine triphosphate trisodiu levels can be used to predict chemosensitivity of leukemic blasts to Cytarabine .

HY-107093A

MBC-11 trisodium	Apoptosis	Cancer
MBC-11 trisodium is a first-in-class conjugate of the bone-targeting bisphosphonate HEDP covalently linked to the antimetabolite Ara-C. MBC-11 trisodium has the potential for tumor-induced bone disease (TIBD) research .

HY-W416300

6-Methoxypurine arabinoside ARA-m	Orthopoxvirus	Others
6-Methoxypurine arabinoside (Ara-m) is a potent varicella-zoster virus inhibitor. 6-Methoxypurine arabinoside has 50% inhibitory concentrations ranging from 0.5 to 3 microM against eight strains of VZV .

HY-152385

*5,6-Dihydro-ara-uridine*	Nucleoside Antimetabolite/Analog	Others
5,6-Dihydro-ara-uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-B0277AR

Vidarabine phosphate (Standard) ARA-AMP (Standard); ARA-A 5'-monophosphate (Standard)	Reference Standards HBV Antibiotic	Infection
Vidarabine phosphate (Standard) is the analytical standard of Vidarabine phosphate. This product is intended for research and analytical applications. Vidarabine phosphate (Ara-AMP), an antiviral agent, inhibits chronic HBV infection[1][2]. Vidarabine phosphate also against herpes simplex and varicella zoster viruses[3].

HY-154294

*N1-Methyl ara-uridine*	Nucleoside Antimetabolite/Analog	Cancer
N1-Methyl ara-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-129393

Etrumadenant 5+ Cited Publications AB928	Adenosine Receptor	Inflammation/Immunology Cancer
Etrumadenant (AB928) is an orally bioavailable, selective dual adenosine receptor *(A2aR/A2bR)* antagonist. Etrumadenant relieves adenosine-mediated immune suppression. Etrumadenant has immunomodulatory and antitumor activities .

HY-107018

AR-A 2 AR-A 000002	5-HT Receptor	Neurological Disease
AR-A 2 is a selective 5-HT_1B receptor antagonist, with high affinity to guinea pig cortex 5HT_1B/1D and recombinant guinea pig 5-HT_1B receptors (K_i=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT_1D receptor (K_i, 5 nM), and shows an EC₅₀ of 4.5 nM for the guinea pig 5-HT_1B receptor; AR-A 2 can be used in the research of depression and anxiety.

HY-154296

*2'-Deoxy-2'-fluoro-ara-uridine*	Nucleoside Antimetabolite/Analog	Cancer
2’-Deoxy-2’-fluoro-ara-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-12220A

MM-102 TFA 4 Publications Verification HMTase Inhibitor IX TFA	WDR5	Cancer
MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM with an estimated Ki < 1 nM in WDR5 binding assay, which is >200 times more potent than the ARA peptide.

HY-48973

*2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite*	Nucleoside Antimetabolite/Analog	Others
2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents .

HY-152369

*1,N6-Etheno-ara-adenosine*	Nucleoside Antimetabolite/Analog	Others
1,N6-Etheno-ara-adenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-154414

*2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite*	Nucleoside Antimetabolite/Analog	Cancer
2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152611

*N1-Methyl-5-methyl ara-uridine*	Nucleoside Antimetabolite/Analog	Cancer
N1-Methyl-5-methyl ara-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-B0277

Vidarabine 5 Publications Verification ARA-A; Adenine ARAbinoside; 9-β-D-ARAbinofuranosyladenine	HSV Nucleoside Antimetabolite/Analog Orthopoxvirus Antibiotic	Infection
Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses . Vidarabine has IC₅₀s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2 . Vidarabine also has anti-orthopoxvirus activity .

HY-N1464A

Aristolone	Complement System Apoptosis	Cancer
Aristolone is a sesquiterpene that can be isolated from Aristolochia debilis, Rosmarinus officinalis and Ficus Auriculata. Aristolone in Ara Fruit can be used as a prediction of apoptosis in HeLa cells. Aristolone inhibits the C1 complement component. Aristolone produces cytotoxicity effects on cells. Aristolone has anticancer properties and can be studied in research for cervical cancer .

HY-135231

NL-1 4 Publications Verification	Mitochondrial Metabolism Autophagy	Cancer
NL-1 is a mitoNEET inhibitor with antileukemic effect. NL-1 inhibits REH and REH/Ara-C cells growth with IC₅₀s of 47.35 μM and 56.26 μM, respectively. NL-1-mediated death in leukemic cells requires the activation of the autophagic pathway .

HY-152532

*2’-Deoxy-2’-fluoro-6-S-Methyl-6-thio-ara-guanosine*	Nucleoside Antimetabolite/Analog	Cancer
2’-Deoxy-2’-fluoro-6-S-Methyl-6-thio-ara-guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-136650

Fludarabine triphosphate F-ARA-ATP	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

HY-154606

*2'-F-2'-ara-N2-ibu-dG Phosphoramidite*	Nucleoside Antimetabolite/Analog	Cancer
2'-F-2'-ara-N2-ibu-dG Phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) .

HY-B0277R

Vidarabine (Standard) ARA-A (Standard); Adenine ARAbinoside (Standard); 9-β-D-ARAbinofuranosyladenine (Standard)	Reference Standards HSV Nucleoside Antimetabolite/Analog Orthopoxvirus Antibiotic	Infection
Vidarabine (Standard) is the analytical standard of Vidarabine. This product is intended for research and analytical applications. Vidarabine (Ara-A) an antiviral agent which is active against herpes simplex and varicella zoster viruses . Vidarabine has IC₅₀s of 9.3 μg/ml for HSV-1 and 11.3 μg/ml for HSV-2 . Vidarabine also has anti-orthopoxvirus activity .

HY-136650A

Fludarabine triphosphate trisodium 1 Publications Verification F-ARA-ATP trisodium	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

HY-154409

*2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite*	Nucleoside Antimetabolite/Analog	Cancer
2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277) .

Cat. No.	Product Name

HY-L145

Antihypertensive Compound Library	777 compounds
The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death. Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs). MCE offers a unique collection of 777 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Antihypertensive Compound Library

777 compounds

The majority of hypertensive patients have primary (or essential) hypertension, that is, hypertension in which secondary causes are not present. Management aims to control arterial pressure, prevent end-organ damage (cerebrovascular, cardiovascular, and renal), and reduce the risk of premature death.

Antihypertensive drugs may be divided into two broad groups, the first group being those which directly or indirectly block the renin–angiotensin system (RAS), for example, ACEIs, angiotensin receptor antagonists (ARAs), direct renin inhibitors (DRIs), and to a lesser extent β-blockers. The second group of drugs works by increasing water and sodium excretion, thereby reducing intravascular volume, or by causing vasodilatation through non-RAS pathways, for example, diuretics and calcium channel blockers (CCBs).

MCE offers a unique collection of 777 compounds with identified and potential antihypertensive activity. MCE Antihypertensive Compound Library is critical for antihypertensive drug discovery and development.

Cat. No.	Product Name	Category	Target	Chemical Structure