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Results for "

AM ester

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acyltransferase (1) Akt (1) Amyloid-β (1) Antibiotic (20) Apelin Receptor (APJ) (2) Apoptosis (6) Autophagy (3) Bacterial (24) BCRP (1) Beta-lactamase (1) Beta-secretase (1) Biochemical Assay Reagents (7) c-Met/HGFR (1) Calcium Channel (2) Cannabinoid Receptor (19) Caspase (1) Cathepsin (1) CGRP Receptor (3) Cholinesterase (ChE) (1) COX (1) DNA/RNA Synthesis (4) Dopamine Receptor (1) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (3) E1/E2/E3 Enzyme (1) EAAT (1) Endogenous Metabolite (2) FAAH (4) FAP (1) FLAP (5) Fluorescent Dye (44) Free Fatty Acid Receptor (3) Fungal (5) Glucokinase (1) GPR119 (1) GPR55 (1) HBV (2) Histamine Receptor (1) Histone Acetyltransferase (1) Histone Methyltransferase (1) IFNAR (1) Influenza Virus (2) Insulin Receptor (1) Integrin (1) IRAK (1) Isotope-Labeled Compounds (5) JNK (1) Kinesin (3) LAG-3 (1) Leukotriene Receptor (2) Liposome (1) LPL Receptor (6) MAGL (1) MDM-2/p53 (3) MicroRNA (8) Microtubule/Tubulin (3) Mitosis (1) NF-κB (1) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (1) PD-1/PD-L1 (1) Phytohormone (2) PI3K (2) PKA (5) PKC (3) PKG (2) Potassium Channel (5) PPAR (1) Prostaglandin Receptor (3) PROTAC Linkers (1) PROTACs (1) Proteasome (1) RAR/RXR (5) Ras (3) Reactive Oxygen Species (ROS) (1) Reference Standards (10) Sodium Channel (2) STING (4) Thyroid Hormone Receptor (1) Tie (1) Toll-like Receptor (TLR) (1) Topoisomerase (11) TRP Channel (3) VEGFR (2)
By Research Areas:	Cancer (45) Cardiovascular Disease (18) Endocrinology (3) Infection (32) Inflammation/Immunology (30) Metabolic Disease (17) Neurological Disease (37)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (1) Tetrazine (1) Alkynes (1)
Oligonucleotides:	miRNA mimics (2) miRNA agomirs (2) miRNA antagomirs (2) MicroRNAs (8) Aptamers (2) Emulsifiers (1) miRNA inhibitors (2) Solubilizing Agents (1) Cationic Lipids (1)

220

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: CETP Carboxylesterase (CES)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131131

5-CFDA-AM	Fluorescent Dye	Others
5-CFDA-AM is a cell-permeable esterase substrate that can be used as an active probe to measure enzyme activity and cell membrane integrity. 5-CFDA-AM is electroneutral and can enter the cell at a lower concentration than CFDA, where it is hydrolysed by intracellular esterases to produce carboxyfluorescein. Carboxyfluorescein contains an additional negative charge and can be better retained in the cell .

HY-125967

AM 374	FAAH	Neurological Disease
AM 374 is an fatty acid amide hydrolase (FAAH) inhibitor. AM 374 inhibits amidase activity with an IC₅₀ value of 13 nM. AM 374 can be used for the research of neurological disease .

HY-139486

AM-8123	Apelin Receptor (APJ)	Cardiovascular Disease
AM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease .

HY-100221

AM-2394	Glucokinase	Metabolic Disease
AM-2394 is a structurally distinct glucokinase activator (GKA). AM-2394 activates glucokinase (GK) with an EC₅₀ of 60 nM.

HY-148674

AM-9747	Histone Methyltransferase	Cancer
AM-9747 (compound 503) is a potent PRMT5 inhibitor with an K_i value of 0.06 nM. AM-9747 shows antiproliferative .

HY-D1441

Zinquin AM ester	Fluorescent Dye	Others
Zinquin AM ester is an AM ester form of Zinquin. Zinquin, a fluorescent dye, is a commonly used sensor for cellular Zn ²⁺ status .

HY-122007

AM-0561	NF-κB	Cancer
AM-0561 is a NIK inhibitor (K_i: 0.3 nM). AM-0561 decreases p52 levels .

HY-165524

AM 92016	Potassium Channel	Cardiovascular Disease
AM 92016 is a potassium channel blocker. AM 92016 can increase the duration of action potentials in isolated ventricular cells from guinea pigs and rabbits. AM 92016 has proarrhythmic activity in guinea pigs and pigs .

HY-135495

AM-0466	Sodium Channel Histamine Receptor	Inflammation/Immunology
AM-0466 is a sodium channel inhibitor with nanomolar levels of NaV1.7 inhibitory activity. AM-0466 exhibits potent pharmacodynamic activity in a NaV1.7-dependent histamine-induced itch model. AM-0466 also showed significant analgesic effects in capsaicin-induced pain models. After optimizing its pharmacokinetic properties, AM-0466 was advanced into in vivo targeting and efficacy models for testing .

HY-12941

AM-7209	MDM-2/p53	Cancer
AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a K_d of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC₅₀ of 1.6 nM. AM-7209 shows antitumor activities .

HY-16619

AM-5262	Free Fatty Acid Receptor	Metabolic Disease
AM-5262 is a GPR40 full agonist with an EC₅₀ value of 0.081 μM. AM-5262 can be used for the research of type II diabetes .

HY-18052

AM-8553	MDM-2/p53	Cancer
AM-8553 is a MDM2/p53 inhibitor (K_D: 0.4 nM for MDM2). AM-8553 has anti-tumor activity

HY-144894

AM-5308	Kinesin Microtubule/Tubulin	Cancer
AM-5308 is the inhibitor for KIF18A (IC₅₀=47 nM) that inhibits KIF18A-mediated microtubule ATPase activity. AM-5308 activates mitotic checkpoints, regulates cell division processes, including chromosome segregation and spindle assembly. AM-5308 exhibits antitumor activity .

HY-162110A

(S)-AM-9022	Kinesin Microtubule/Tubulin Drug Isomer	Cancer
(S)-AM-9022 is the S-enantiomer of AM-9022 (HY-162110). AM-9022 is an orally active, potent, selective KIF18A inhibitor that can be used for research on cancer .

HY-126133

AM-001	Ras	Cardiovascular Disease Others
AM-001 is a non-competitive inhibitor of Epac1 that blocks the activation of Rap1, a downstream effector of Epac1, in cultured cells. AM-001 can be used in heart disease-related research .

HY-101253

AM-92016 hydrochloride 1 Publications Verification	Potassium Channel	Cardiovascular Disease
AM-92016 hydrochloride is a specific blocker of rectifier potassium current (IK). AM-92016 hydrochloride delays rectifier potassium channel (IK), repolarizes the membrane thereby restricting the duration of the nerve impulse thereby restricting the duration of the nerve impulse .

HY-12734

AM-8735	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
AM-8735 is a potent and selective MDM2 inhibitor with an IC₅₀ of 25 nM.

HY-120423

AM-6538	Cannabinoid Receptor	Neurological Disease
AM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist. AM6538 is a structural analog of rimonabant. AM6538 can be effectively used to evaluate the apparent efficacy of cannabinoid full and partial agonists. AM6538 may be useful in future studies that require temporary reductions in cannabinoid receptor availability . AM-6538 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-137103

BTC-AM	Fluorescent Dye	Others
BTC-AM is a low affinity calcium indicator. BTC-AM has substantial calcium-independent fluorescence at all excitation wavelengths. BTC-AM is readily loaded into neurons and is rapidly hydrolysed .

HY-149933

AM841	Cannabinoid Receptor	Neurological Disease
AM841 is a high-affinity electrophilic ligand. AM841 interacts covalently with a cysteine in helix six and activates the CB1 cannabinoid receptor. AM841 reduces Forskolin (HY-15371)-stimulated cAMP accumulation. AM841 also slows gastrointestinal motility .

HY-110128

Sulfidefluor 7-AM SF7-AM	Fluorescent Dye	Others
Sulfidefluor 7-AM is a stable hydrogen sulphide (H₂S) fluorescent probe . Sulfidefluor 7-AM is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-126558R

GA3-AM (Standard)	Phytohormone Reference Standards	Others
GA3-AM (Standard) is the analytical standard of GA3-AM. This product is intended for research and analytical applications. GA3-AM is a cell permeable analog of the plant hormone gibberellic acid that acts as a chemical dimerizer or chemical inducer of dimerization .

HY-178203

AM12814	Cannabinoid Receptor	Neurological Disease
AM12814 is a potent and partial CB1 and CB2 agonist with K_i values of 0.7 nM and 3.4 nM. AM12814 can inhibit cAMP accumulation and recruitse β-arrestin 2. AM12814 exhibits cannabimimetic effects. AM12814 can be used for the research of neurological disease, suah as catalepsy .

HY-13505R

AM281 (Standard)	Cannabinoid Receptor	Neurological Disease
AM281 (Standard) is the analytical standard of AM281. This product is intended for research and analytical applications. AM281 is a selective CB1 receptor antagonist with an IC50 of 9.91 nM. AM281 inhibits CB2 receptor with an IC50 of 13000 nM .

HY-126831

SBFI-AM 3 Publications Verification	Fluorescent Dye	Others
SBFI-AM is a Na ⁺ selective fluorescent indicator. SBFI-AM shows selectivity for Na ⁺ over K ⁺ .

HY-162110

AM-9022	Kinesin Microtubule/Tubulin	Cancer
AM-9022 is an orally active, potent, selective KIF18A inhibitor that can be used for research on cancer .

HY-D2482

Asante potassium green-1 AM APG-1 AM	Fluorescent Dye	Neurological Disease
Asante potassium green-1 AM (APG-1 AM) is a cell-permeable K ⁺ (potassium) sensitive fluorescent indicator (excitation/emission = 525/545 nm).

HY-118374

AM-9635	PI3K Akt	Inflammation/Immunology
AM-9635 is a selective PI3Kδ inhibitor with oral bioavailability, good in vitro and in vivo activity and pharmacodynamic properties. AM-9635 inhibits PI3Kδ-dependent B cell receptor-mediated AKT phosphorylation and suppresses the production of specific IgG and IgM antibodies in rats immunized with Aplysia leocyanin (KLH).

HY-15443R

AM251 (Standard)	Cannabinoid Receptor	Neurological Disease
AM251 (Standard) is the analytical standard of AM251. This product is intended for research and analytical applications. AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC50 of 8 nM. AM251 also acts as a potent GPR55 agonist with an EC50 of 39 nM .

HY-129683

AM3102	PPAR	Metabolic Disease
AM3102 is an oleoylethanolamide (OEA) analog. AM3102 is an endogenous high-affinity PPAR-alpha agonist. AM3102 resists enzymatic hydrolysis, activates PPAR-alpha with high potency in vitro, and persistently reduces feeding when administered in vivo either parenterally or orally .

HY-120471

AM-0687	PI3K	Inflammation/Immunology
AM-0687 is a selective inhibitor for PI3Kδ with an IC₅₀ of 2.9 nM. AM-0687 decreases the levels of IgG and IgM specific antibodies, inhibits the anti-IgM/CD40L-induced proliferation of human B cell (IC₅₀=0.8 nM) and the phosphorylation of AKT (IC₅₀=0.7 nM), and exhibits anti-inflammatory efficacy .

HY-D1776

FFP-18-AM	Fluorescent Dye	Others
FFP-18-AM is a cell-permeable fluorescent indicator for measurement of near-membrane calcium.

HY-109561

Pegaptanib sodium EYE001; NX1838	VEGFR	Metabolic Disease Inflammation/Immunology
Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .

HY-13505

AM281 1 Publications Verification	Cannabinoid Receptor	Neurological Disease
AM281 is a selective CB1 receptor antagonist with an IC₅₀ of 9.91 nM. AM281 inhibits CB2 receptor with an IC₅₀ of 13000 nM .

HY-13467

AM-1638 2 Publications Verification	Free Fatty Acid Receptor	Metabolic Disease
AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC₅₀ of 0.16 μM.

HY-122558

AM432 sodium	Prostaglandin Receptor	Neurological Disease
AM432 (sodium) is a potent and selective antagonist of the DP₂ receptor (CRTH2). AM432 (sodium) exhibits excellent potency in a human whole blood eosinophil shape change assay with prolonged incubation. AM432 (sodium) also demonstrates excellent pharmacokinetics in dog and mouse models of inflammatory disease .

HY-103338

AM1172	Others	Neurological Disease
AM1172 is metabolically stable anandamide uptake inhibitor. AM1172 inhibits [ ³H] anandamide transport in rat cortical neurons and human CCF-STTG1 astrocytoma cells with IC₅₀ values of 2.1 μM and 2.5 μM, respectively. AM1172 can significantly inhibit AEA hydrolysis and concurrently decrease AEA uptake. AM1172 can be used for the study of endocannabinoid system regulation .

HY-163291

AM4085	Bacterial	Infection
AM4085 is an orally active Antagonist for FmlH with an IC₅₀ of 0.19 μM. AM4085 reveals metabolic stability in mouse liver microsomes and blood plasma .

HY-128774

AM-6494	Beta-secretase	Neurological Disease
AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC₅₀=0.4 nM) with in vivo selectivity over BACE2 (IC₅₀=18.6 nM) . AM-6494 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-144827

AM8936	Cannabinoid Receptor	Neurological Disease Metabolic Disease
AM8936 acts as a balanced and potent cannabinoid receptor type-1 (CB1) agonist in functional assays (EC₅₀s of 8.6 and 1.4 nM for rCB1 and hCB1, respectively). AM8936 exhibits high affinity for rat CB1 (rCB1) with K_i of 0.55 nM. AM8936 is a potent and efficacious CB1 agonist in vivo. AM8936 can be used for the research of CNS and metabolic disorders, pain, glaucoma, etc .

HY-19367

MD-39-AM	Others	Cardiovascular Disease
MD-39-AM exhibits antihypertensive, diuretic and saliuretic activities with good in vivo pharmacokinetic characters .

HY-100727

AM-2099	Sodium Channel	Neurological Disease
AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC₅₀ of 0.16 μM for human Nav1.7.

HY-147367

AM-1488	Others	Neurological Disease
AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC₅₀=0.45 μM) .

HY-W777527

AM404-d4	Isotope-Labeled Compounds Cannabinoid Receptor	Neurological Disease
AM404-d₄ is the deuterium labeled AM404 (HY-101388). AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC₅₀ values in the low micromolar range . AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC₅₀ value of 7.4 (corresponding to an EC₅₀ of 0.04 μM). Neuroprotective Effect .

HY-D1681

Rhod-590 AM Ester	Fluorescent Dye	Others
Rhod-590 AM Ester is a fluorescent dye. Rhod-590 AM Ester can be used as a fluorescent indicator for calcium determination .

HY-D1700

Mag-indo-1/AM	Fluorescent Dye	Others
Mag-indo-1/AM is a cell-permeable fluorescent indicator for Mg ²⁺ and also for Ca ²⁺ (Ex=340-390 nm, Em=410-490 nm). Mag-indo-1/AM can be used to determine intracellular Mg ²⁺ and Ca ²⁺ concentrations .

HY-P991297

AM0003	LAG-3	Cancer
AM0003 is a human monoclonal antibody (mAb) targeting CD223/LAG3. AM0003 can be used in the study of advanced solid tumors .

HY-108329

AM-0902	TRP Channel	Neurological Disease Inflammation/Immunology
AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC₅₀s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.

HY-W010756

FMOC-AM	Biochemical Assay Reagents	Others
FMOC-AM is a derivative of aminomethyl resin. FMOC-AM provides a solid-phase carrier basis for peptide chain synthesis and can be used in solid-phase peptide synthesis .

HY-D1629

Calcium Orange AM	Fluorescent Dye	Others
Calcium Orange AM is an intracellular calcium reporter. Specific fluorescence can be detected when free calcium binds to Calcium Orange AM (Ex/Em=549/576 nm). Calcium Orange AM does not enter the vacuoles and does not compartmentalize into acidic vesicles .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8430

Poricoic acid AM	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Poria cocos Plants Disease Research Fields Cancer	Others
Poricoic acid AM is a triterpenoid with ant-tumor activities .

HY-15141

Staurosporine 175+ Cited Publications Antibiotic AM-2282; STS; AM-2282	Infection Alkaloids Microorganisms Classification of Application Fields Marine natural products Source classification Marine microorganism Disease Research Fields Indole Alkaloids	PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-N7697

Chitotetraose tetrahydrochloride	Polysaccharides Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields Saccharides	Others
Chitotetraose tetrahydrochloride is an arbuscular mycorrhizal (AM) fungal short-chain chitin oligomer. Chitotetraose tetrahydrochloride activates the AM fungal-dependent conserved symbiosis signaling pathway (CSSP) in actinorhizal plant species .

HY-15141R

Staurosporine (Standard) Antibiotic AM-2282 (Standard); STS (Standard); AM-2282 (Standard)	Alkaloids Microorganisms Marine natural products Source classification Marine microorganism Indole Alkaloids	Reference Standards PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine (Standard) is the analytical standard of Staurosporine. This product is intended for research and analytical applications. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5].

HY-N6777

Penicillic acid 1 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Caspase Bacterial Apoptosis Antibiotic
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 .

HY-129148

Ganoderic acid AM1 GAAM1	Triterpenes Microorganisms Terpenoids Source classification	Others
Ganoderic acid AM1 (GAAM1) is a natural product that can be found in ganoderma lucidum. Ganoderic acid AM1 shows cytotoxicity with an IC₅₀ value of 19.8 µM for HeLa cells .

HY-129291

Reductiomycin AM 6201	Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Fungal
Reductiomycin is an antibiotic, which exhibits antimicrobial activity against gram positive bacteria and fungi. Reductiomycin exhibits antitumor activity .

HY-N14134

Deoxyfrenolicin	Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Deoxyfrenolicin is a quinone antibiotic that can be isolated from the fermentation broth of the Streptomyces roseofulvus strain AM-3867. Deoxyfrenolicin belongs to the frenolicin class of antibiotics. Deoxyfrenolicin exhibits antibacterial activity in vitro and can effectively inhibit the activity of Mycoplasma gallisepticum .

HY-123379

Relomycin Tylosin D; LL-AM 684B	Microorganisms Antibiotics Source classification	Others
Relomycin is an active compound.

HY-N11472

Rhamnocitrin 3-glucoside RhAMnocitrin-3-O-β-D-glucopyranoside	Flavonoids Flavones Leguminosae Source classification Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants	Others
Rhamnocitrin 3-glucoside (Rhamnocitrin-3-O-β-D-glucopyranoside) is a natural product that can be isolated from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (AM) .

HY-N0086R

N6-Methyladenosine (Standard) 6-Methyladenosine (Standard); N-Methyladenosine (Standard)	Natural Products Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite Influenza Virus Reference Standards
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

Cat. No.	Product Name	Chemical Structure

HY-W777527

AM404-d4
AM404-d₄ is the deuterium labeled AM404 (HY-101388). AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC₅₀ values in the low micromolar range . AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC₅₀ value of 7.4 (corresponding to an EC₅₀ of 0.04 μM). Neuroprotective Effect .

HY-10581AS1

Gatifloxacin-d4 hydrochloride
Gatifloxacin-d₄ (AM-1155-d₄; BMS-206584-d₄; PD135432-d₄) hydrochloride is deuterium-labeled Gatifloxacin (hydrochloride) (HY-10581A) .

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-W700069

Gatifloxacin-d4
Gatifloxacin-d4 is the deuterium labeled Gatifloxacin .

HY-W770198

2-Linoleoyl glycerol-d5

2-Linoleoyl glycerol-d₅ (2-Monolinolein-d₅; 2-Monolinoleoylglycerol-d₅) is the deuterium labeled 2-Linoleoyl glycerol (HY-130311). 2-Linoleoyl glycerol (2-Monolinolein; 2-Monolinoleoylglycerol) is a monoacylglycerol that is an antagonist and partial agonist at the type 1 cannabinoid CB1 receptor. The potency of 2-Linoleoyl glycerol can be enhanced by JZL195 (HY-15250), an inhibitor of FAAH and MAGL, and inhibited by the CB1 antagonist AM251 (HY-15443) and Cannabidiol. As a CB1 antagonist, 2-Linoleoyl glycerol does not enhance, but only attenuates, the activity of the CB1/CB2 receptor ligands cannabinoids (AEA) and 2-arachidonoylglycerol (2-AG) .

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