2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. AM12814

AM12814 is a potent and partial CB1 and CB2 agonist with Ki values of 0.7 nM and 3.4 nM. AM12814 can inhibit cAMP accumulation and recruitse β-arrestin 2. AM12814 exhibits cannabimimetic effects. AM12814 can be used for the research of neurological disease, suah as catalepsy.

For research use only. We do not sell to patients.

AM12814

AM12814 Chemical Structure

CAS No. : 3054511-18-8

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AM12814 Related Antibodies

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Description

AM12814 is a potent and partial CB1 and CB2 agonist with Ki values of 0.7 nM and 3.4 nM. AM12814 can inhibit cAMP accumulation and recruitse β-arrestin 2. AM12814 exhibits cannabimimetic effects. AM12814 can be used for the research of neurological disease, suah as catalepsy[1].

IC50 & Target[1]

rCB1-R

0.7 nM (Ki)

hCB2-R

3.4 nM (Ki)

In Vitro

AM12814 (Compound 12) binds to cannabinoid receptors with high affinity, with Ki values of 0.7 nM (rCB1) and 3.4 nM (hCB2)[1].
AM12814 (30 mins) inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in 3xHA-hCB1-CHO and 3xHA-hCB2-CHO cells with EC50 values of 8.75 nM and 22 nM[1].
AM12814 (90 mins) recruitses β-arrestin 2 in hCB1-DRx-CHO and hCB2-DRx-U2OS cells with EC50 values of 25 nM and 5.6 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AM12814 Related Antibodies
In Vivo

AM12814 (Compound 12) (0.3-3 mg/kg, i.p.) induces CB1-mediated cannabimimetic behaviors in CD1 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 mice[1]
Dosage: 0.3, 1 and 3 mg/kg
Administration: Intraperitoneally injection
Result: Increased immobility time in the ring test.
Reduced core body temperature.
Prolonged tail-flick latency in the hot water test.
Alleviated CFA (HY-153808)-induced mechanical hypersensitivity.
Molecular Weight

429.56

Formula

C24H38F3NO2
CAS No.
SMILES

O=C(N[C@H](C)CO)CCC/C=C\C/C=C\C/C=C\[C@@H](C)/C=C\CCCCC(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AM12814 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM128143054511-18-8AM 12814AM-12814Cannabinoid ReceptorCannabinoid Receptor CB1CB2cAMPβ-arrestin 2CatalepsyInhibitorinhibitorinhibit

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