AB-1

By Targets:	Akt (1) Apoptosis (4) Bcl-2 Family (2) c-Myc (2) Caspase (2) CDK (3) DNA/RNA Synthesis (2) DYRK (3) EGFR (1) Estrogen Receptor/ERR (3) HCV (1) HSP (1) LPL Receptor (1) PARP (2) PROTAC-Linker Conjugates for PAC (3) Small Interfering RNA (siRNA) (4) STING (1)
By Research Areas:	Cancer (8) Endocrinology (1) Inflammation/Immunology (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120409

*AB1*	LPL Receptor Apoptosis	Cancer
AB1 is a highly selective S1P2 receptor antagonist (IC₅₀=3.5 nM). AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors ^[1].

HY-P990368

*Anti-CLDN6 Antibody (AB1-11)* AB1-11	HCV	Inflammation/Immunology
Anti-CLDN6 Antibody (AB1-11) is a CHO-expressed human antibody that targets CLDN6. Anti-CLDN6 Antibody (AB1-11) has an IgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 78.42 kDa. The isotype control for Anti-CLDN6 Antibody (AB1-11) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-RS18017

Hsp90ab1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90ab1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsp90ab1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90ab1 Mouse Pre-designed siRNA Set A Hsp90ab1 Mouse Pre-designed siRNA Set A

HY-RS05954

H2AB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
H2AB1 Human Pre-designed siRNA Set A contains three designed siRNAs for H2AB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

H2AB1 Human Pre-designed siRNA Set A H2AB1 Human Pre-designed siRNA Set A

HY-RS24490

Hsp90ab1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Hsp90ab1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsp90ab1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Hsp90ab1 Rat Pre-designed siRNA Set A Hsp90ab1 Rat Pre-designed siRNA Set A

HY-RS06418

HSP90AB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HSP90AB1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90AB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HSP90AB1 Human Pre-designed siRNA Set A HSP90AB1 Human Pre-designed siRNA Set A

HY-144168

STING agonist-8	STING	Inflammation/Immunology
STING agonist-8 is a potent STING agonist with an EC₅₀ of 27 nM in THP1-Dual KI-hSTING-R232 cells (WO2021239068A1, compound 5-AB) .

HY-128527

PROTAC ER Degrader-3	PROTAC-Linker Conjugates for PAC Estrogen Receptor/ERR	Cancer
PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .

HY-128528

PROTAC ER Degrader-2	PROTAC-Linker Conjugates for PAC Estrogen Receptor/ERR	Cancer
PROTAC ER Degrader-2 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .

HY-176484

CDK9-IN-39	CDK Apoptosis	Cancer
CDK9-IN-39 (1-7a-B1) is an orally active cyclin-dependent kinase 9 (CDK9) inhibitor with an IC₅₀ of 6.51 nM. CDK9-IN-39 induces cell apoptosis by inhibiting the phosphorylation of RNA polymerase II at Ser2 and can be used for study of colorectal cancer ^[1].

HY-144617

JH-XIV-68-3	DYRK	Cancer
JH-XIV-68-3 is a selective macrocyclic inhibitor of *DYRK1A/B*. JH-XIV-68-3 displays selectivity for DYRK1A and close family member DYRK1B in biochemical and cellular assays. JH-XIV-68-3 demonstrates antitumor efficacy in head and neck squamous cell carcinoma (HNSCC) cell lines ^[1].

HY-112100

MC-Val-Cit-PAB-PROTAC ERα Degrader-1	PROTAC-Linker Conjugates for PAC Estrogen Receptor/ERR	Cancer
MC-Val-Cit-PAB-PROTAC ERα Degrader-1 (compound LP2) consists an ADC linker and a PROTAC, whcih can be conjugated to an antibody to form PACs. MC-Val-Cit-PAB-PROTAC ERα Degrader-1 conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab) .

HY-X0009

Tambiciclib 1 Publications Verification GFH009; JSH-009; SLS009	CDK DYRK Apoptosis Bcl-2 Family c-Myc Caspase PARP DNA/RNA Synthesis	Cancer
Tambiciclib (GFH009, JSH-009) is an orally active, highly potent and selective CDK9 inhibitor (IC₅₀ = 1 nM), demonstrating >200-fold selectivity over other CDKs, >100-fold selectivity over *DYRK1A*/B, and excellent selectivity over 468 kinases/mutants. Tambiciclib demonstrates potent in vitro and in vivo antileukemic efficacy in acute myeloid leukemia (AML) mouse models by inhibiting RNA Pol II phosphorylation, downregulating *MCL1* and MYC, and inducing apoptosis. Tambiciclib can be used for AML research ^[1].

HY-X0009A

Tambiciclib dimaleate GFH009 dimaleate; JSH-009 dimaleate; SLS009 dimaleate	CDK DYRK Apoptosis Bcl-2 Family c-Myc Caspase PARP DNA/RNA Synthesis	Cancer
Tambiciclib (GFH009, JSH-009) dimaleate is an orally active, highly potent and selective CDK9 inhibitor (IC₅₀ = 1 nM), demonstrating >200-fold selectivity over other CDKs, >100-fold selectivity over *DYRK1A*/B, and excellent selectivity over 468 kinases/mutants. Tambiciclib dimaleate demonstrates potent in vitro and in vivo antileukemic efficacy in acute myeloid leukemia (AML) mouse models by inhibiting RNA Pol II phosphorylation, downregulating *MCL1* and MYC, and inducing apoptosis. Tambiciclib dimaleate can be used for AML research ^[1].

HY-123035

Gamendazole	HSP Akt EGFR	Endocrinology
Gamendazole, an indazole carboxylic acid (ICA), is an orally active, selective HSP90AB1 (HSP90BETA) and EEF1A1 (eEF1A) inhibitor. Gamendazole binds to the C-terminal nucleotide binding pocket of HSP90 and cause downregulation of clients AKT1 and ERBB2, but stabilizes the HSP90 heterocomplex. Gamendazole specifically inhibits the actin bundling function of EEF1A1, but does not bind to the nucleotide docking pocket nor inhibits the ribosome charging or protein translation functions of EEF1A1. Gamendazole, an antispermatogenic compound with antifertility effects, has the potential for reversible non-hormonal male contraceptive agent research ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P990368

*Anti-CLDN6 Antibody (AB1-11)* AB1-11	HCV	Inflammation/Immunology
Anti-CLDN6 Antibody (AB1-11) is a CHO-expressed human antibody that targets CLDN6. Anti-CLDN6 Antibody (AB1-11) has an IgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 78.42 kDa. The isotype control for Anti-CLDN6 Antibody (AB1-11) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990162

Anti-Mouse T15 VH and T15 VL regions of IgM Antibody (HB33) AB1-2	Inhibitory Antibodies	Others
Anti-Mouse T15 VH and T15 VL regions of IgM Antibody (HB33) is an anti-mouse T15 VH and T15 VL regions of IgM IgG1 monoclonal antibody. Anti-Mouse T15 VH and T15 VL regions of IgM Antibody (HB33) is used in studies of the MHC class I heavy chain FcRn heterodimers and their interaction with IgG ^[1].

Cat. No.	Compare	Product Name	Species	Source

HY-P72238

	HSP90AA1 Protein, Human (His-SUMO) 2 Publications Verification Heat shock 86 kDa; Heat shock protein 90kDa alpha cytosolic class A member 1; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein HSP 90 alpha ; Heat shock protein HSP 90 beta; Heat shock protein HSP 90-alpha; HS90A_HUMAN; HSP 84; HSP 86; Hsp 90; HSP86; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSPC1; HSPC2; HSPCAL1 ; HSPCAL4; Renal carcinoma antigen NY-REN-38	Human	E. coli
	The HSP90AA1 protein is an important molecular chaperone that coordinates the maturation and regulation of specific target proteins critical for cell cycle control and signal transduction. Its ATPase activity drives a functional cycle that induces conformational changes in client proteins for activation. HSP90AA1 Protein, Human (His-SUMO) is the recombinant human-derived HSP90AA1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

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HY-P80714

	Hsp90 alpha/beta Antibody (YA356) HSP90AA1; HSP90A; HSPC1; HSPCA; Heat shock protein HSP 90-alpha; Heat shock 86 kDa; HSP 86; HSP86; Renal carcinoma antigen NY-REN-38; HSP90AB1; HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Hsp90 alpha/beta Antibody (YA356) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp90 alpha/beta.

HY-P85205

	Hsp90 beta Antibody (YA4897) HSP90AB1; HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
	Hsp90 beta Antibody (YA4897) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsp90 beta.

HY-P86644

	Hsp90 beta Antibody (YA6336) HSP90AB1; HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; HSP 90; Heat shock 84 kDa; HSP 84; HSP84	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Hsp90 beta Antibody (YA6336) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp90 beta.

HY-P85596

	Hsp90 beta Antibody (YA5288) HSP90AB1; 90 kda heat shock protein beta HSP90 beta; D6S182; FLJ26984; Heat shock 84 kDa; Heat shock 90kD protein 1, beta; Heat shock 90kDa protein 1 beta; Heat shock protein 90kDa alpha; cytosolic; class B member 1; Heat shock protein beta; Heat shock protein HSP 90 beta; Heat shock protein HSP 90-beta; HS90B_HUMAN; HSP 84; HSP 90; HSP 90 b; HSP 90b; HSP84; HSP90 BETA; hsp90AB1; HSP90B; HSPC2; HSPCB.	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey, Hamster
	Hsp90 beta Antibody (YA5288) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hsp90 beta.

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Cat. No.	Product Name		Classification

HY-RS18017

Hsp90ab1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Hsp90ab1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hsp90ab1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS05954

H2AB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
H2AB1 Human Pre-designed siRNA Set A contains three designed siRNAs for H2AB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24490

Hsp90ab1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Hsp90ab1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hsp90ab1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06418

HSP90AB1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
HSP90AB1 Human Pre-designed siRNA Set A contains three designed siRNAs for HSP90AB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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