2. GPCR/G Protein Apoptosis
  3. LPL Receptor Apoptosis
  4. AB1

AB1 is a highly selective S1P2 receptor antagonist (IC50=3.5 nM). AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors.

For research use only. We do not sell to patients.

AB1

AB1 Chemical Structure

CAS No. : 1463912-49-3

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AB1 Related Antibodies

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

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Description

AB1 is a highly selective S1P2 receptor antagonist (IC50=3.5 nM). AB1 inhibits sphingosine-1-phosphate (S1P) signaling, suppressing tumor cell migration, angiogenesis, and profibrotic mediator CTGF expression while inducing apoptosis. AB1 is promising for research of solid tumors[1].

IC50 & Target

S1PR2

3.5 nM (IC50)

Molecular Weight

434.32

Formula

C19H21Cl2N7O
CAS No.
SMILES

C=CCN1N=C(C)C2=C(C(C)C)C=C(NNC(NC3=CC(Cl)=NC(Cl)=C3)=O)N=C21
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AB1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB11463912-49-3AB 1AB-1LPL ReceptorApoptosisLysophospholipid ReceptorS1P2 receptorS1Psolid tumorsInhibitorinhibitorinhibit

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