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71

Inhibitors & Agonists

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39

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Inhibitory Antibodies

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1513A

    Bacterial Infection
    LL-37 scrambled peptide acetate is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide acetate can be used as a negative control of LL-37 peptide studies.
    LL-37 scrambled peptide acetate
  • HY-P4744

    Bacterial Infection Cancer
    LL-37 amide is a positively charged antimicrobial peptide. LL-37 amide has anticancer activity and can be used for cancer research .
    LL-37 amide
  • HY-P5729

    Fungal Infection
    LL-25 is a fragment of LL-37 (HY-P1222) but devoid of the immunomodulatory properties of LL-37. LL-25 has antifungal and candidacidal activity .
    LL-25
  • HY-P4746

    Bacterial Infection
    LL-37 FKR is the C-terminal fragment of LL-37. LL-37 FKR plays an important role in antibacterial performance .
    LL-37 FKR
  • HY-P4128

    Bacterial Antibiotic Others
    LL-37 SKE is an active fragment of LL-37 .
    LL-37 SKE
  • HY-P4751

    Bacterial Others
    LL-37 RKS is an active fragment of LL-37 .
    LL-37 RKS
  • HY-P4747

    Antibiotic Bacterial Infection
    LL-37 GKE is an active domain of LL-37. LL-37 GKE has antibacterial activity and has potential applications in antibiotics .
    LL-37 GKE
  • HY-P1513

    Bacterial Infection
    LL-37 scrambled peptide is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide can be used as a negative control of LL-37 peptide studies.
    LL-37 scrambled peptide
  • HY-P10262

    Drug Derivative Others
    LL-37-Cys is a LL-37 (HY-P1222) with a C-terminal reduced cystein residue [1][.
    LL-37-Cys
  • HY-18234C

    Biochemical Assay Reagents Inflammation/Immunology Cancer
    Leupeptin Ac-LL (hydrochloride) is the hydrochloride form of Leupeptin Ac-LL (HY-18234B). Leupeptin Ac-LL (hydrochloride) has better inhibition than Leupeptin Ac-LL .
    Leupeptin Ac-LL hydrochloride
  • HY-P5837

    Interleukin Related Enterovirus Inflammation/Immunology
    Citrullinated LL-37 2cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 2cit reduces LL-37 activity against HRV at 10 μg/mL and reduces the antibacterial effect of LL-37. Citrullinated LL-37 2cit causes a reduction in the levels of IL-8, CCL5, and IL-6 mRNA induced by RV1B. Citrullinated LL-37 2cit shows a moderate loss in the ability to reduce HRV-induced CCL5 secretion .
    Citrullinated LL-37 2cit
  • HY-P5843

    Enterovirus Infection
    Citrullinated LL-37 3cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 3cit lacks all antiviral activity at 10 μg/mL and retains some activity against HRV at 30 μg/mL. Citrullinated LL-37 3cit reduces the immunomodulatory activity of LL-37. Citrullinated LL-37 3cit shows a moderate loss in the ability to reduce HRV-induced CCL5 secretion .
    Citrullinated LL-37 4cit
  • HY-P5838

    Bacterial Inflammation/Immunology
    Citrullinated LL-37 5cit is a citrullinated LL-37 (HY-P1222) peptide. The antiviral and antibacterial effects of Citrullinated LL-37 5cit are significantly reduced compared to native LL-37. Citrullinated LL-37 5cit is unable to reduce LPS-mediated release of TNF-α due to a lack of LPS-binding capacity .
    Citrullinated LL-37 5cit
  • HY-P5836

    Interleukin Related Bacterial Enterovirus Inflammation/Immunology
    Citrullinated LL-37 1cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 1cit does not alter the antiviral effect of LL-37 toward human rhinovirus. Citrullinated LL-37 1cit shows antibacterial activity toward S. aureus. Citrullinated LL-37 1cit causes a reduction in the levels of IL-8, CCL5, and IL-6 mRNA induced by RV1B .
    Citrullinated LL-37 1cit
  • HY-P4744A

    Bacterial Infection Cancer
    LL-37 amide TFA is a positively charged antimicrobial peptide. LL-37 amide TFA has anticancer activity and can be used for cancer research .
    LL-37 amide TFA
  • HY-P1884

    Bacterial Infection
    LL-37, acetylated, amidated is a cathelicidin peptide LL-37 acetylated on the N-terminus and amidated on the C-terminus. The single human cathelicidin peptide LL-37 has antimicrobial and anti-biofilm activity against multiple Gram-positive and Gram-negative human pathogens, and has wound-healing effects on the host .
    LL-37, acetylated,amidated
  • HY-P4836A

    Parasite Infection
    LL-37 FK-13 TFA is the TFA salt form of LL-37 FK-13 (HY-P4836). LL-37 FK-13 TFA is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 TFA exhibits minimal hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
    LL-37 FK-13 TFA
  • HY-P5391

    Bacterial Others
    LL-37(17-32) is a biological active peptide. (This peptide is an active segment of LL-37, a peptide derived from the C-terminal domain of human cathelicidin antimicrobial peptide. It has been reported that the LL17-32 peptide exhibits reversal effect on ABCG2-mediated multidrug resistance in cancer cell lines.)
    LL-37(17-32)
  • HY-P1222
    LL-37, human
    2 Publications Verification

    Bacterial Infection
    LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing .
    LL-37, human
  • HY-P1222B
    LL-37, human acetate
    2 Publications Verification

    Bacterial Infection Inflammation/Immunology
    LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing .
    LL-37, human acetate
  • HY-P5057

    Fluorescent Dye Bacterial Others
    5-FAM-LL-37 is afluorescent labeled LL-37, human (HY-P1222).
    5-FAM-LL-37
  • HY-P4836

    Parasite Infection
    LL-37 FK-13 is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 exhibits slight hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
    LL-37 FK-13
  • HY-128464

    Others Metabolic Disease
    LL320 is a selective NNMT inhibitor with a Ki,app of 6.8 nM. LL320 exhibits interactions with RNMT, DPH5, and SAHH .
    LL320
  • HY-P4799

    Drug Derivative Others
    LL-37 KR20 is aLL 37 derivative.
    LL-37 KR20
  • HY-P5057A

    Fluorescent Dye Bacterial Infection
    5-FAM-LL-37 TFA is the TFA salt form of 5-FAM-LL-37 (HY-P5057). 5-FAM-LL-37 TFA is a LL-37 peptide labeled with fluorescein, which retains the antibacterial and immunomodulatory activities of LL-37. 5-FAM-LL-37 TFA binds to the bacterial cell membrane, destroys the integrity of the membrane, and exhibits board-spectrum antibacterial efficacy .
    5-FAM-LL-37 TFA
  • HY-18234B

    Ser/Thr Protease Metabolic Disease Inflammation/Immunology Cancer
    Leupeptin Ac-LL is a protease inhibitor from actinomycetes. Leupeptin Ac-LL has antiplasmin activity .
    Leupeptin Ac-LL
  • HY-14990A

    LL 3858 hydrochloride

    Bacterial Infection
    Sudoterb (LL 3858) hydrochloride is an orally active anti-Tuberculosis agent .
    Sudoterb hydrochloride
  • HY-14990

    LL 3858

    Bacterial Infection
    Sudoterb (LL 3858) is an orally active anti-Tuberculosis agent .
    Sudoterb
  • HY-P1222A
    LL-37, human TFA
    2 Publications Verification

    Bacterial Infection
    LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing .
    LL-37, human TFA
  • HY-P10306

    Bacterial Infection
    Cys-LL37 is a biomaterial with antimicrobial properties developed by covalently fixing to the surface of titanium. Cys-LL37 uses a flexible hydrophilic polyethylene glycol spacer and selective n-terminal coupling LL37, a surface peptide layer that kills bacteria on contact is formed. Cys-LL37 can be used in research to develop new antimicrobial biomaterials .
    Cys-LL37
  • HY-P5842

    Bacterial Influenza Virus Infection
    Citrullinated LL-37 3cit is a host defense peptide (HDP) with broad immunomodulatory and antimicrobial activities. Citrullinated LL-37 3cit exhibits direct antiviral effects against human rhinoviruses (HRV) .
    Citrullinated LL-37 3cit
  • HY-120349

    p38 MAPK JNK Apoptosis Reactive Oxygen Species Cancer
    LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4 .
    LL-Z1640-4
  • HY-P1425

    Ser/Thr Protease Neurological Disease
    (Z-LL)2 ketone is an inhibitor of ketone with an IC50 value of 50 nM. (Z-LL)2 ketone promotes the release of an N-terminal fragment into the cytosol .
    (Z-LL)2 ketone
  • HY-P5057B

    Fluorescent Dye Bacterial Infection
    5-FAM-Ahx-LL-37 TFA is a 5-FAM (HY-66022) labeled LL-37, human (HY-P1222). The carboxyfluorescein group is attached via a 6-carbon spacer, 6-Aminohexanoic acid (Ahx, HY-B0236). LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity .
    5-FAM-Ahx-LL-37 TFA
  • HY-136828

    Antibiotic Bacterial Infection
    LL-BM123α is a basic antibiotic isolated from Nocardia sp. LL-BM123α exhibits moderate activity against Gram-negative bacteria.
    LL-BM123α
  • HY-156084

    CDK PROTACs Apoptosis c-Myc Cancer
    LL-K9-3 is a potent small-molecule degrader of CDK9-cyclin T1. LL-K9-3 has anti-proliferative and pro-apoptotic activities and suppresses downstream signaling of CDK9 and AR. Moreover, LL-K9-3 inhibits AR and Myc-driven oncogenic transcriptional programs .
    LL-K9-3
  • HY-P99464

    IMMU-LL 2

    CD22 Cancer
    Bectumomab (IMMU-LL 2) is an humanized IgG2a mAb against human CD22 (antigen). Bectumomab is also an anti-lymphoma antibody fragment. Bectumomab can be used for imaging in combination with technetium 99 (Tc99m LL2 Fab). Moreover, Bectumomab examines in the staging of recurrent or newly diagnosed non-Hodgkin's lymphoma (NHL) and to assess targeting before radioimmunoresearch (RIT) .
    Bectumomab
  • HY-136954

    Bacterial Infection
    LL-BM123γ2 is an antibacterial agent which is active against a variety of microorganisms. LL-BM123γ2 can be used for antibacterial research .
    LL-BM123γ2
  • HY-149209

    PROTACs CDK STAT Early 2 Factor (E2F) Cancer
    LL-K8-22 is a potent, selective and durable PROTAC CDK8-cyclin C dual degrader, with DC50 values of 2.52 and 2.64 μM, respectively. LL-K8-22 also suppresses STAT1 Ser 727 phosphorylation. LL-K8-22 inhibits E2F- and MYC-driven carcinogenic transcriptional programs. LL-K8-22 can be used for triplenegative breast cancer (TNBC) research. (Pink: Ligand for target protein (HY-168683); Black: Linker (HY-Y0340); Blue: Ligand for E3 ligase (HY-N2427)) .
    LL-K8-22
  • HY-114749

    Antibiotic Bacterial Infection Cancer
    LL-C 10037α is an antitumor antibiotic and can be isolated from Streptomyces .
    LL-C 10037α
  • HY-115843

    Antibiotic Bacterial Infection Cancer
    LL-D05139β is a potent antibacterial antibiotic and antitumor agent .
    LL-D05139β
  • HY-163944

    Molecular Glues CDK Cancer
    LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the CDK12-DDB1 complex, stabilizing the CDK12-DDB1 complex and promoting the degradation of cyclin K (EC50=0.37 nM). LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research .
    LL-K12-18
  • HY-136953

    Antibiotic Infection
    LL-BM123γ1 is a potent broad spectrum glycocinnamoylspermidine antibiotic .
    LL-BM123γ1
  • HY-130214

    LL-P880β

    Endogenous Metabolite Others
    7-Hydroxypestalotin (LL-P880β) is a fungal metabolite .
    7-Hydroxypestalotin
  • HY-109963

    Histone Methyltransferase Cancer
    PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50= 7.5 μM). Anti-tumor activies .
    PR5-LL-CM01
  • HY-113561

    LL-AF283α

    Antibiotic Bacterial Infection
    Biphenomycin A (LL-AF283α) is a cyclic peptide antibiotic that can be found in Streptomyces griseorubiginosus 43708. It has antibacterial activity and can be used in research in the field of anti-infection .
    Biphenomycin A
  • HY-118132

    Antibiotic Infection
    LL-Z1220 is a novel antibiotic with the structure of 2-(3,8-dioxopentacyclo[5.1.0.0^~^~]oct-5-en-5-yl)-4H-pyran-4-one. This appears to be the first reported natural product containing a benzene dioxide group. This antibiotic readily undergoes valence isomerization to form 1,4-dioxopentacyclo. The chemical and spectroscopic properties of the antibiotic suggest that the benzene dioxide has a cis configuration.
    LL-Z1220
  • HY-117845

    LL-E19085α

    Bacterial Antibiotic Infection
    Citreamicin alpha (LL-E 19085-alpha) is an antibiotic whose in vitro antimicrobial activity against 429 clinical isolates of Gram-positive cocci has been tested by the agar dilution method. These microorganisms included 313 strains of Staphylococci and 116 strains of Streptococci. The in vitro activity of Citreamicin alpha was compared with that of ampicillin, amoxicillin, ceftriaxone, erythromycin, and vancomycin. For Staphylococci, the MIC values of Citreamicin alpha ranged from 0.12-4.0 μg/ml, and for Streptococcus pyogenes of the genus Streptococcus, it was 0.03-0.12 μg/ml. However, enterococci were relatively resistant, requiring 2.0 μg/ml of the agent to inhibit 64% of the 62 tested strains. The in vitro activity of this antibiotic was much better than that of ampicillin, amoxicillin, ceftriaxone, and erythromycin, but comparable or slightly inferior to that of vancomycin.
    Citreamicin alpha
  • HY-N9366
    Tumulosic acid
    1 Publications Verification

    Others Inflammation/Immunology
    Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM .
    Tumulosic acid
  • HY-P10345

    Bacterial Infection
    OP-145, an cathelicidin LL-37 derivative, is an antimicrobial peptide, and shows antibacterial activity against several MRSA strains. OP-145 can be used for research of chronic suppurative otitis media .
    OP-145

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