Search Result
Results for "
13C6
" in MedChemExpress (MCE) Product Catalog:
488
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
- HY-125296S
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- HY-W100312S
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Toluene, 2-amino-13C6 hydrochloride
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Isotope-Labeled Compounds
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Others
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o-Toluidine-13C6 hydrochloride (Toluene, 2-amino-13C6 hydrochloride) is the 13C labeled isotope of o-Toluidine hydrochloride (HY-W100312) .
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- HY-W778555
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- HY-B1781S
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Sulfachlorpyridazine-13C6
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Isotope-Labeled Compounds
Bacterial
Antibiotic
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Infection
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Sulfachloropyridazine- 13C6 is the 13C6 labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria.
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- HY-150703S
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- HY-W001138S
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- HY-34428S
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- HY-133689AS
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- HY-141909S
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- HY-141928S
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- HY-I0210S
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- HY-131501S1
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- HY-17598S
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- HY-146967S
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- HY-B0141S7
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- HY-W014375S2
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- HY-Y0264S
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Isotope-Labeled Compounds
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Infection
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4-Hydroxybenzoic acid- 13C6 is the 13C labeled isotope of 4-Hydroxybenzoic acid- 13C6.4-Hydroxybenzoic acid is a phenolic derivative of benzoic acid, which can inhibit most Gram-positive bacteria and some Gram-negative bacteria with an IC50 value of 160 μg/mL.
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- HY-W750294
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- HY-B1941S1
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- HY-W777533
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- HY-W104010S
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- HY-W013677S
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- HY-Y0931S
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- HY-Y1027S1
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- HY-W013396S
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- HY-W776938
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Nicotinic acid ethylester hydrochloride-13C6
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Isotope-Labeled Compounds
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Others
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Ethyl nicotinate hydrochloride- 13C6 (Nicotinic acid ethylester hydrochloride- 13C6) is the 13C-labeled Ethyl nicotinate (HY-W013628).
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- HY-B0273S1
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- HY-136380S
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Isotope-Labeled Compounds
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Others
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Clodinafop-propargyl- 13C6 is the 13C-labeled Clodinafop-propargyl. Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl-13C6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-B0482S1
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TVX 1322-13C6
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Isotope-Labeled Compounds
COX
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Inflammation/Immunology
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Acemetacin- 13C6 (TVX 1322- 13C6) is 13C labeled Acemetacin. Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
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- HY-W016814S
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cis-Aconitic acid-13C6
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Isotope-Labeled Compounds
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Others
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(Z)-Aconitic acid- 13C6 is the 13C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
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- HY-W097410S1
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N-phenyliodoacetamide-13C6
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Isotope-Labeled Compounds
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Others
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2-Iodo-N-phenylacetamide- 13C6 (N-phenyliodoacetamide- 13C6) is the 13C labeled 2-Iodo-N-phenylacetamide.
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- HY-128790S1
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- HY-170207S
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- HY-W715199S
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- HY-W777535S
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- HY-W777583
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Isotope-Labeled Compounds
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Others
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2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6 is the 13C labeled isotope of 2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6 (HY-W777583) .
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![2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6](//file.medchemexpress.eu/product_pic/hy-w777583.gif)
- HY-B0945S
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3,5-Dinitrobenzamide-13C6
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Isotope-Labeled Compounds
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Infection
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Nitromide- 13C6 (3,5-Dinitrobenzamide- 13C6) is the 13C-labeled Nitromide (HY-B0945). Nitromide is an anti-parasitic agent .
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- HY-W777418
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- HY-W654109
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Anthracene, 2-chloro-13C6
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Isotope-Labeled Compounds
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Others
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2-Chloroanthracene- 13C6 (Anthracene, 2-chloro- 13C6) is the 13C-labeled 2-Chloroanthracene (HY-W014272).
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- HY-W771036
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- HY-14832S1
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- HY-143704S
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Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride
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PPAR
NF-κB
PAK
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Metabolic Disease
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5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
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- HY-N0379S22
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Endogenous Metabolite
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Others
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D-Mannose- 13C6 is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific proteins .
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- HY-17359S1
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- HY-W010209S
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- HY-W750442
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- HY-B1703S
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Antibiotic
Bacterial
Parasite
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Infection
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Nifursol- 13C6 is the 13C6 labeled Nifursol (HY-B1703). Nifursol (Standard) is the analytical standard of Nifursol (HY-B1703). This product is used for research and analytical applications. Nifursol is an orally active veterinary antibiotic. Nifursol inhibits Histomonas meleagridis. Nifursol prevents histomoniasis in turkeys. Nifursol is widely used in studies of Escherichia coli gastroenteritis in Salmonella-infected poultry and aquatic animals .
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- HY-B1374S2
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- HY-W748193
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- HY-W015198S
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- HY-W654206
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- HY-W012507S1
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- HY-143843S
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- HY-150706S
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- HY-13078S
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GDC-0973-13C66 racemate; XL518-13C6 racemate
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Isotope-Labeled Compounds
MEK
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Others
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Cobimetinib- 13C6 (GDC-0973- 13C6; XL518- 13C6) racemate is the deuterium labeled Cobimetinib (racemate) (HY-13078) . Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor .
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- HY-B0122SS1
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- HY-W771037
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- HY-15036S1
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Isotope-Labeled Compounds
COX
Apoptosis
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Inflammation/Immunology
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Diclofenac- 13C6 is the 13C6 labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
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- HY-116214S1
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- HY-W753343
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2-Chloroacetanilide-13C6
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Isotope-Labeled Compounds
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Others
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2-Chloro-N-phenylacetamide- 13C6 (2-Chloroacetanilide- 13C6) is the 13C-labeled 2-Chloro-N-phenylacetamide (HY-W069522).
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- HY-150679S
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- HY-W014223S
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Ultraviolet absorber UV-0-13C6
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Isotope-Labeled Compounds
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Others
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2,4-Dihydroxybenzophenone- 13C6 (Ultraviolet absorber UV-0- 13C6) is the 13C- and deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone .
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- HY-B0211S1
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- HY-W012530S
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- HY-163422S
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- HY-163423S
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- HY-163424S
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- HY-P11199S
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- HY-W751444
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4-Methoxy-m-xylene-13C6
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Isotope-Labeled Compounds
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Others
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2,4-Dimethylanisole- 13C6 (4-Methoxy-m-xylene- 13C6) is the 13C-labeled 2,4-Dimethylanisole (HY-W100677).
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- HY-15409S1
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BI 10773-13C6
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Isotope-Labeled Compounds
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Metabolic Disease
Cancer
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Empagliflozin- 13C6 (BI 10773- 13C6) is 13C labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2 .
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- HY-N7745S2
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Glucopsychosine-13C6; Lyso-Gb1-13C6; Lyso-GL1-13C6
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Isotope-Labeled Compounds
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Others
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Glucosylsphingosine- 13C6 is an active compound. Glucosylsphingosine- 13C6 can be used for various studies .
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- HY-W746828
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- HY-76929S
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- HY-W106014S
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Biphenyl-3-amine-13C6 hydrochloride
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Isotope-Labeled Compounds
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Others
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[1,1'-Biphenyl]-3-amine-13C6 hydrochloride (Biphenyl-3-amine-13C6 hydrochloride) is the 13C labeled isotope of [1,1'-Biphenyl]-3-amine hydrochloride (HY-W106014) .
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![[1,1'-Biphenyl]-3-amine-13C6 hydrochloride](//file.medchemexpress.eu/product_pic/hy-w106014s.gif)
- HY-N6612S
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- HY-W751475
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- HY-10268S2
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PRT054021-13C6
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Isotope-Labeled Compounds
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Cardiovascular Disease
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Betrixaban- 13C6 (PRT054021- 13C6) is 13C labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect .
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- HY-N0771S
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- HY-W014225S
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- HY-W024986S
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4'-Hexyloxy-4-biphenylcarbonitrile-13C6
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Isotope-Labeled Compounds
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Others
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4-(4-Hexoxyphenyl)benzonitrile- 13C6 (4'-Hexyloxy-4-biphenylcarbonitrile- 13C6) is the 13C-labeled 4-(4-Hexoxyphenyl)benzonitrile.
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- HY-W770294
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Tetrabromophthalic acid-13C6
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Isotope-Labeled Compounds
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Others
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3,4,5,6-Tetrabromophthalic acid- 13C6 (Tetrabromophthalic acid- 13C6) is the 13C-labeled 3,4,5,6-Tetrabromophthalic acid (HY-W259069).
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- HY-176177S
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- HY-176178S
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- HY-163426S
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- HY-163425S
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- HY-163427S
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- HY-W014531S
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- HY-W074977S
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- HY-B1221S1
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Isotope-Labeled Compounds
COX
AMPK
Potassium Channel
Chloride Channel
Calcium Channel
Parasite
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Inflammation/Immunology
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Flufenamic acid- 13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca 2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
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- HY-B0975S
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Phenoxymethylpenicillin-13C6 potassium salt
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Isotope-Labeled Compounds
Bacterial
Antibiotic
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Infection
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Penicillin V- 13C6 (potassium) is the 13C6 labeled Penicillin V (potassium). Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis.
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- HY-W777581
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- HY-W778065
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- HY-143857S
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- HY-W585934S
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- HY-W013186S1
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- HY-N10004S
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- HY-W585933S
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- HY-B0892S3
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- HY-B0451AS1
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- HY-W777477
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- HY-W770952
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N-Acetyl-S-phenyl-L-cysteine-13C6
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Isotope-Labeled Compounds
Amino Acid Derivatives
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Others
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DL-Phenylmercapturic Acid- 13C6 (N-Acetyl-S-phenyl-L-cysteine- 13C6) is the 13C-labeled DL-Phenylmercapturic Acid (HY-W141770). DL-Phenylmercapturic Acid is a cysteine derivative .
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- HY-147551S
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- HY-163992S
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- HY-163993S
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- HY-W771072
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- HY-N0486S2
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- HY-W777534
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N-Acetylsulfanilyl chloride-13C6
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Isotope-Labeled Compounds
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Others
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4-Acetamidobenzene-1-sulfonyl chloride- 13C6 (N-Acetylsulfanilyl chloride- 13C6) is the 13C-labeled 4-Acetamidobenzene-1-sulfonyl chloride (HY-W012207).
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- HY-W653994
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Ethyl parahydroxybenzoate-13C6; Ethyl 4-hydroxybenzoate-13C6
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Isotope-Labeled Compounds
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Others
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Ethyl Paraben- 13C6 (Ethyl parahydroxybenzoate- 13C6) is 13C labeled Ethylparaben. Ethylparaben is the ethyl ester of paraben and is used as an antifungal preservative and food additive .
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- HY-18342S1
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MK-647-13C6
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Isotope-Labeled Compounds
COX
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Inflammation/Immunology
Cancer
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Diflunisal- 13C6 (MK-647- 13C6) is 13C labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
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- HY-N0379S18
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- HY-113252S1
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- HY-W768246
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- HY-N0473S2
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- HY-79131S
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- HY-W749199
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- HY-W749598
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3-Pyridinecarboxamide, N-methoxy-N-methyl-13C6
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Isotope-Labeled Compounds
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Others
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N-Methoxy-N-methylnicotinamide- 13C6 (3-Pyridinecarboxamide, N-methoxy-N-methyl- 13C6) is the 13C-labeled N-methoxy-N-methylnicotinamide (HY-W051270).
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- HY-76520S
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- HY-W009762S
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- HY-B0411S2
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R33812-13C6
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Isotope-Labeled Compounds
Dopamine Receptor
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Neurological Disease
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Domperidone- 13C6 (R33812- 13C6) is 13C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine .
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- HY-B0497S1
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BAY2353-13C6
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Isotope-Labeled Compounds
STAT
Parasite
Antibiotic
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Infection
Cancer
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Niclosamide- 13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
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- HY-117275S1
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Meclofenamate-13C6
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Isotope-Labeled Compounds
Gap Junction Protein
Endogenous Metabolite
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Inflammation/Immunology
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Meclofenamic acid- 13C6 is the 13C6 labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
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- HY-17430S2
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- HY-W756637
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Dytransin-13C6
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Isotope-Labeled Compounds
COX
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Inflammation/Immunology
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Ibufenac- 13C6 (Dytransin- 13C6) is the 13C-labeled Ibufenac (HY-W040672). Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .
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- HY-141919S
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- HY-W749645
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- HY-W014375S4
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- HY-156343S1
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- HY-156344S1
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- HY-P3207S
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- HY-176032S
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- HY-173087S
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- HY-156341S1
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- HY-156345S1
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- HY-173085S
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- HY-173086S
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- HY-W585890S
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![Benzo[pqr]tetraphen-3-ol-13C6](//file.medchemexpress.eu/product_pic/hy-w585890s.gif)
- HY-W007318S
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- HY-115584S
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Isotope-Labeled Compounds
Parasite
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Infection
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Lufenuron- 13C6 is a 13C-labeled Lufenuron. Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods .
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- HY-W777496
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- HY-12767S2
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- HY-W092298S
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- HY-137222S
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COX
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Inflammation/Immunology
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4',5-Dihydroxy Diclofenac-13C6 is a deuterated derivative of Diclofenac (HY-15036). Diclofenac is a potent COX inhibitor with anti-inflammatory activity .
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- HY-B0149S2
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Cyclocapron-13C6
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Isotope-Labeled Compounds
MMP
Mitophagy
IGF-1R
AMPK
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Cardiovascular Disease
Neurological Disease
Cancer
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Tranexamic acid- 13C6 (Cyclocapron- 13C6) is 13C labeled Tranexamic acid. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .
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- HY-13017S4
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VX-770-13C6
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Isotope-Labeled Compounds
CFTR
Autophagy
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Endocrinology
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Ivacaftor- 13C6 (VX-770- 13C6) is 13C labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
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- HY-17376S3
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SCH 58235-13C6
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Isotope-Labeled Compounds
Autophagy
Keap1-Nrf2
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Cancer
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Ezetimibe- 13C6 (SCH 58235- 13C6) is the 13C-labeled Ezetimibe (HY-17376). Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
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- HY-W770721
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- HY-113283S
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Isotope-Labeled Compounds
Endogenous Metabolite
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Metabolic Disease
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Homogentisic acid- 13C6 is the 13C-labeled Homogentisic acid (HY-113283). Homogentisic acid is a specific metabolite that accumulates in the urine and serum. Homogentisic acid can be used for diagnosis of alkaptonuria. Homogentisic acid is a phenolic acid .
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- HY-B2236S1
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(±)-2,6-Diaminocaproic acid-13C6 hydrochloride
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Isotope-Labeled Compounds
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Metabolic Disease
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DL-Lysine- 13C6 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6 hydrochloride) is 13C-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
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- HY-W770295
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- HY-128417S5
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- HY-150012S1
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- HY-W018386S
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3-Bromo-Tyr-13C6
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Isotope-Labeled Compounds
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Others
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3-?Bromo-?L-?tyrosine- 13C6 (3-Bromo-Tyr- 13C6) is a 13C-labeled 3-?Bromo-?L-?tyrosine (HY-W018386). 3- Bromo- L- tyrosine (3-Bromo-Tyr) is a tyrosine derivative .
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- HY-W778173
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- HY-17043S3
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- HY-15388S2
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AGN 190168-13C6
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Isotope-Labeled Compounds
RAR/RXR
Autophagy
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Inflammation/Immunology
Cancer
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|
Tazarotene- 13C6 (AGN 190168- 13C6) is 13C labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W749012
-
-
- HY-173100S
-
-
- HY-173099S
-
-
- HY-173106S
-
-
- HY-173101S
-
-
- HY-173104S
-
-
- HY-173098S
-
-
- HY-W768181
-
-
- HY-W018587S
-
-
- HY-144085S
-
-
- HY-A0070AS2
-
|
Triiodothyronine-13C6-1; 3,3',5-Triiodo-L-thyronine-13C6-1; T3-13C6-1
|
Thyroid Hormone Receptor
|
Endocrinology
Cancer
|
|
Liothyronine- 13C6-1 is a 13C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively .
|
-
- HY-N0771S9
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
L-Isoleucine- 13C6, 15N is 13C and 15N labeled L-isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid . L-Isoleucine is an essential amino acid.
|
-
- HY-128417S4
-
-
- HY-141939S
-
-
- HY-B0213S1
-
|
Sulfametoxydiazine-13C6; 5-Methoxysulfadiazine-13C6; NSC 683528-13C6
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Sulfameter- 13C6 (Sulfametoxydiazine- 13C6) is the 13C6 labeled Sulfameter (HY-B0213). Sulfameter (Sulfametoxydiazine) is an orally active long-acting sulfonamide antibiotic. Sulfameter is active against both Gram-positive and Gram-negative bacteria. Sulfameter can be used for the research of diseases such as respiratory and urinary tract infections .
|
-
- HY-17007S2
-
-
- HY-W753370
-
|
Benzene, 1,2,4-trichloro-5-nitro-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
2,4,5-Trichloronitrobenzene- 13C6 (Benzene, 1,2,4-trichloro-5-nitro- 13C6) is the 13C-labeled 2,4,5-Trichloronitrobenzene (HY-W142633).
|
-
- HY-B0363S1
-
|
R805-13C6
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
|
Nimesulide- 13C6 (R805- 13C6) is 13C labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.
|
-
- HY-B0083S1
-
-
- HY-W010696AS
-
-
- HY-W770176
-
-
- HY-P5190S
-
-
- HY-W777334
-
-
- HY-158992S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
SP-(Val- 13C5, 15)-EKNQ-(Leu- 13C6, 15)-TIDFINIVKDPVPHNEYKT TFA is a 13C- and 15N-labeled peptide containing 13C5, 15N-labeled valine (Val) and 13C6, 15N-labeled leucine (Leu).
|
-
- HY-P1032S2
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Angiotensin I-13C6,15N (human, mouse, rat) TFA is 13C and 15N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensin II and is cleaved into angiotensin II by angiotensin converting enzyme (ACE) .
|
-
- HY-137912S1
-
-
- HY-B0335S1
-
|
GEA 6414-13C6
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
Cancer
|
|
Tolfenamic acid- 13C6 is the 13C6 labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
|
-
- HY-W748688
-
|
Acetylsulfamethoxazole-13C6
|
Isotope-Labeled Compounds
Bacterial
Drug Metabolite
|
Infection
|
|
N4-Acetylsulfamethoxazole- 13C6 (Acetylsulfamethoxazole- 13C6) is the 13C-labeled N4-Acetylsulfamethoxazole (HY-W013266). N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of?Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections .
|
-
- HY-17498S3
-
-
- HY-B0512S1
-
|
RP2632-13C6
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
|
Sulfamerazine- 13C6 (RP2632- 13C6) is 13C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP-2632) is a sulfonamide antibacterial. Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.
|
-
- HY-B0227S3
-
|
RP-19583-13C6
|
Isotope-Labeled Compounds
COX
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Ketoprofen- 13C6 (RP-19583- 13C6) is 13C labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .
|
-
- HY-12726S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
Liproxstatin-1- 13C6 is the 13C labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) .
|
-
- HY-N0216S1
-
|
|
Bacterial
Fungal
Endogenous Metabolite
|
Infection
|
|
Benzoic acid- 13C6 is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
|
-
- HY-W145482S1
-
-
- HY-W777823
-
-
- HY-W768912
-
-
- HY-152039S1
-
-
- HY-W750399
-
|
Tetrabromophthalic anhydride-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
4,5,6,7-Tetrabromoisobenzofuran-1,3-dione- 13C6 (Tetrabromophthalic anhydride- 13C6) is the 13C-labeled 4,5,6,7-Tetrabromoisobenzofuran-1,3-dione (HY-W010833).
|
-
- HY-18341S4
-
-
- HY-B0337S2
-
-
- HY-W337886S
-
-
- HY-W104549S
-
-
- HY-158994S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
MEGDSRGG-(Ala- 13C3, 15N)-GGEA-(Leu- 13C6, 15N)-DPESAASSLSGAS TFA is a 13C- and 15N-labeled peptide containing 13C3, 15N-labeled alanine (Ala) and 13C6, 15N-labeled leucine (Leu).
|
-
- HY-Y0051S
-
|
2-Hydroxymethyl-5-furfural-13C6; 2-Formyl-5-hydroxymethylfuran-13C6
|
Isotope-Labeled Compounds
Fungal
|
Others
|
|
5-Hydroxymethylfurfural- 13C6 (2-Hydroxymethyl-5-furfural- 13C6; 2-Formyl-5-hydroxymethylfuran- 13C6) is a 13C labeled 5-Hydroxymethylfurfural (HY-Y0051). 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
|
-
- HY-N0469S1
-
|
|
Endogenous Metabolite
Virus Protease
|
Inflammation/Immunology
|
|
L-Lysine- 13C6 (dihydrochloride) is the 13C-labeled L-Lysine dihydrochloride. L-lysine dihydrochloride is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions .
|
-
- HY-W739894S
-
-
- HY-143679S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate-13C6 is the 13C labeled isotope of 4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate .
|
-
- HY-10450S3
-
|
BMS-512148-13C6
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Dapagliflozin- 13C6 (BMS-512148- 13C6) is 13C labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .
|
-
- HY-14397S3
-
|
Indometacin-13C6
|
Isotope-Labeled Compounds
COX
Antibiotic
Influenza Virus
Bacterial
|
Inflammation/Immunology
Cancer
|
|
Indomethacin- 13C6 (Indometacin- 13C6) is 13C labeled Indomethacin. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .
|
-
- HY-B0637S2
-
|
BM15075-13C6
|
Isotope-Labeled Compounds
PPAR
|
Cardiovascular Disease
Metabolic Disease
|
|
Bezafibrate- 13C6 (BM15075- 13C6) is 13C labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
|
-
- HY-W017522S1
-
|
Hexanedioic acid-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
HSV
|
Infection
Metabolic Disease
|
|
Adipic acid- 13C6 (Hexanedioic acid- 13C6) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc .
|
-
- HY-W768262
-
|
Gluconic acid lactone-13C6
|
Reactive Oxygen Species (ROS)
|
Others
|
|
D-(+)-Glucono-1,5-lactone- 13C6 (Gluconic acid lactone- 13C6) is the 13C-labeled D-(+)-Glucono-1,5-lactone (HY-I0301). D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.
|
-
- HY-P5190S1
-
-
- HY-N0486S8
-
-
- HY-159192S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
SADDNIKTPAE(Arg- 13C6, 15N4)LLGPLPPSADDNLKT (TFA) is the 13C and 15N labeled isotope of SADDNIKTPAE-LLGPLPPSADDNLKT (TFA) .
|
-
- HY-P4596S
-
-
- HY-108226S1
-
-
- HY-173088S
-
-
- HY-W768211
-
-
- HY-W009597S
-
-
- HY-W753344
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
2-(2,6-Dichlorophenoxy)-N-phenylacetamide- 13C6 is the 13C-labeled 2-(2,6-Dichlorophenoxy)-N-phenylacetamide (HY-W713396).
|
-
- HY-W751537
-
|
4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
4-[[(4-Fluorophenyl)imino]methyl]phenol- 13C6 (4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol- 13C6) is the 13C-labeled 4-[[(4-Fluorophenyl)imino]methyl]phenol (HY-W014178).
|
-
![4-[[(4-Fluorophenyl)imino]methyl]phenol-13C6](//file.medchemexpress.eu/product_pic/hy-w751537.gif)
- HY-10999S1
-
|
|
MEK
Autophagy
Apoptosis
|
Cancer
|
|
Trametinib- 13C6 is the 13C-labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis .
|
-
- HY-100532S
-
-
- HY-66005S3
-
-
- HY-14894S2
-
|
ASP1941-13C6
|
Isotope-Labeled Compounds
SGLT
|
Metabolic Disease
|
|
Pragliflozin- 13C6 (ASP1941- 13C6) is 13C labeled Ipragliflozin. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .
|
-
- HY-N0470S8
-
|
|
Endogenous Metabolite
Virus Protease
|
Infection
|
|
L-Lysine- 13C6 hydrochloride is the 13C labeled L-Lysine hydrochloride . L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health .
|
-
- HY-B0221S
-
|
|
Isotope-Labeled Compounds
Antibiotic
Fungal
Parasite
Bacterial
|
Cancer
|
|
Amphotericin B- 13C6 is 13C labeled Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
|
-
- HY-W777456
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Phenanthrene- 13C6 is the 13C labeled Phenanthrene (HY-B1727). Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
|
-
- HY-W754982
-
|
N-Cyclohexylbenzothiazole-2-amine-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
N-Cyclohexyl-1,3-benzothiazol-2-amine- 13C6 (N-Cyclohexylbenzothiazole-2-amine- 13C6) is the 13C-labeled N-Cyclohexyl-1,3-benzothiazol-2-amine (HY-W200757).
|
-
- HY-113248S1
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Nitro-L-tyrosine- 13C6 is the 13C labeled 3-Nitro-L-tyrosine . 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions .
|
-
- HY-138622S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
24:0 Lyso PC- 13C6 is the 13C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .
|
-
- HY-W777439
-
-
- HY-N7092S
-
|
D(-)-Fructose-13C6
|
Endogenous Metabolite
|
Others
|
|
D-Fructose- 13C6 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
|
-
- HY-14171S2
-
|
LGD1069-13C6
|
Isotope-Labeled Compounds
RAR/RXR
Autophagy
|
Cancer
|
|
Bexarotene- 13C6 (LGD1069- 13C6) is 13C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
|
-
- HY-15037S2
-
|
GP 45840-13C6
|
Isotope-Labeled Compounds
COX
Apoptosis
|
Inflammation/Immunology
|
|
Diclofenac- 13C6 (Sodium) is the 13C6 labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
|
-
- HY-101277S1
-
|
PG-1016548-13C6; AKB-6548-13C6
|
Isotope-Labeled Compounds
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
|
Vadadustat- 13C6 (PG-1016548- 13C6) is 13C labeled Vadadustat. Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .
|
-
- HY-W777546
-
|
Acetic Acid 5-Formylfurfuryl Ester-13C6; 5-Acetoxymethyl-2-furaldehyde-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
(5-Formylfuran-2-yl)methyl acetate- 13C6 (Acetic Acid 5-Formylfurfuryl Ester- 13C6) is the 13C-labeled (5-Formylfuran-2-yl)methyl acetate (HY-W111899).
|
-
- HY-143876S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
L-Argininosuccinic acid- 13C6, 15N4 (barium, dihydrate) is a 15N-labeled and 13C-labled labeled L-Argininosuccinic acid (barium, dihydrate) .
|
-
- HY-W014375S1
-
-
- HY-W768295
-
-
- HY-P4596S1
-
-
- HY-12857S
-
-
- HY-124489S
-
-
- HY-15284S3
-
|
PCR 4099-13C6
|
Isotope-Labeled Compounds
P2Y Receptor
|
Cardiovascular Disease
|
|
Prasugrel-13C6 is a deuterated labeled Prasugrel . Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .
|
-
- HY-78131S3
-
|
(±)-Ibuprofen-13C6
|
Isotope-Labeled Compounds
Apoptosis
Parasite
COX
|
Cancer
|
|
Ibuprofen- 13C6 ((±)-Ibuprofen- 13C6) is a 13C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .
|
-
- HY-B0947S1
-
|
|
P-glycoprotein
Bacterial
|
Infection
|
|
Sulfanitran- 13C6 is the 13C labeled Sulfanitran. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG).
|
-
- HY-B0843S
-
|
|
Isotope-Labeled Compounds
Fungal
|
Infection
|
|
Metalaxyl- 13C6 is the 13C-labeled Metalaxyl. Metalaxyl is a fungicide that inhibits protein synthesis in fungi. Metalaxyl inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC50s=0.3-3.9 μg/mL).
|
-
- HY-W014632S
-
|
Desacetyl triflusal-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
4-Trifluoromethylsalicylic acid- 13C6 is the 13C labeled 4-Trifluoromethylsalicylic acid . 4-Trifluoromethylsalicylic acid is a platelet aggregation inhibitor .
|
-
- HY-W654082
-
-
- HY-W751526
-
|
Sulfamethazine-n4-acetyl-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
N4-Acetylsulfamethazine- 13C6 (Sulfamethazine-n4-acetyl- 13C6) is the 13C-labeled N4-Acetylsulfamethazine (HY-W290839). N4-Acetylsulfamethazine is a metabolite of Sulfamethazine (HY-B0035). Sulfamethazine is one of the most frequently used sulfonamides in the poultry farming industry .
|
-
- HY-W008614S1
-
|
AG-1813-13C6
|
Isotope-Labeled Compounds
Proton Pump
Drug Metabolite
|
Metabolic Disease
|
|
Lansoprazole sulfone- 13C6 (AG-1813- 13C6) is 13C labeled Lansoprazole sulfone. Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H +, K +-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H +, K +-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .
|
-
- HY-B0322S1
-
|
Ro 4-2130-13C6
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
|
Sulfamethoxazole- 13C6 (Ro 4-2130- 13C6) is a 13C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .
|
-
- HY-N0832S1A
-
|
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
L-Histidine- 13C6, 15N3 hydrochloride is the 13C and 15N labled L-Histidine (HY-N0832). L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.
|
-
- HY-W747264
-
-
- HY-B0574S2
-
|
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Mefenamic acid- 13C6 is the 13C-labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
|
-
- HY-173091S
-
-
- HY-W007527S
-
|
4-Bromo-2-Chloro Phenol-13C6; 2-Chloro-4-Bromo Phenol13C6
|
Isotope-Labeled Compounds
|
Others
|
|
4-Bromo-2-chlorophenol- 13C6 (4-Bromo-2-Chloro Phenol- 13C6) is the 13C-labeled 4-Bromo-2-chlorophenol (HY-W007527).
|
-
- HY-W779345
-
-
- HY-N7092S13
-
-
- HY-N7106S2
-
|
DMP-13C6,d4
|
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Dimethyl phthalate- 13C6,d4 (DMP- 13C6,d4) is the deuterium labeled and 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .
|
-
- HY-W747703
-
-
- HY-A0067S1
-
|
Benzophenone 3-13C6
|
Isotope-Labeled Compounds
RAR/RXR
Autophagy
Apoptosis
|
Neurological Disease
|
|
Oxybenzone- 13C6 (Benzophenone 3- 13C6) is the 13C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
|
-
- HY-N7106S3
-
|
DMP-13C6
|
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Dimethyl phthalate- 13C6 (DMP- 13C6) is the 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .
|
-
- HY-17453S1
-
|
GR 33343X-13C6 xinafoate
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Inflammation/Immunology
Endocrinology
|
|
Salmeterol- 13C6 (xinafoate) is the 13C6 labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.
|
-
- HY-N0771S5
-
|
|
Endogenous Metabolite
|
Others
|
|
L-Isoleucine- 13C6, 15N,d10 is the deuterium, 13C-, and 15-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid . L-Isoleucine is an essential amino acid.
|
-
- HY-N0349S1
-
|
Methyl 4-hydroxybenzoate-13C6
|
Isotope-Labeled Compounds
Bacterial
Endogenous Metabolite
|
Infection
|
|
Methyl Paraben- 13C6 (Methyl 4-hydroxybenzoate- 13C6) is a 13C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .
|
-
- HY-W748541
-
-
![N6-[(Benzylamino)carbonothioyl]lysine-13C6,15N2](//file.medchemexpress.eu/product_pic/hy-w748541.gif)
- HY-W748540
-
-
![N6-[(Allylamino]carbonothioyl]lysine-13C6,15N2](//file.medchemexpress.eu/product_pic/hy-w748540.gif)
- HY-N0832S1
-
-
- HY-18341S2
-
|
|
Thyroid Hormone Receptor
Endogenous Metabolite
|
Endocrinology
|
|
L-Thyroxine- 13C6 is the 13C labeled L-Thyroxine . L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
|
-
- HY-17356S2
-
-
- HY-W017387S2
-
|
Sodium 4-methyl-2-oxopentanoate-13C6; 2-Ketoisocaproic acid-13C6 sodium salt
|
Isotope-Labeled Compounds
|
Others
|
|
Sodium α-ketoisocaproic acid- 13C6 is the 13C labeled Sodium α-ketoisocaproic acid .
|
-
- HY-Y0589S
-
|
3-Carboxybenzonitrile-13C6; 3-Cyanobenzoic acid-13C6; m-Carboxybenzonitrile-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
m-Cyanobenzoic acid- 13C6 is the 13C labeled m-Cyanobenzoic acid .
|
-
- HY-W778171
-
-
- HY-W778172
-
-
- HY-15206S2
-
|
Glyburide-13C6
|
Isotope-Labeled Compounds
Autophagy
Mitochondrial Metabolism
Potassium Channel
CFTR
P-glycoprotein
|
Metabolic Disease
|
|
Glibenclamide- 13C6 (Glyburide- 13C6) is 13C labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K + channel (KATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .
|
-
- HY-W766388
-
|
D-Glucosamine Hydrochloride-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
2-Amino-2-deoxyglucose hydrochloride- 13C6 (D-Glucosamine Hydrochloride- 13C6) is the 13C-labeled 2-Amino-2-deoxyglucose hydrochloride (HY-N9459). 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .
|
-
- HY-B0143S3
-
-
- HY-B1125S
-
-
- HY-B0389A
-
|
Glucose-13C6; D-(+)-Glucose-13C6; Dextrose-13C6
|
Endogenous Metabolite
|
Others
Metabolic Disease
|
|
D-Glucose- 13C6 is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose- 13C6 can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard .
|
-
- HY-P0014S2
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Liraglutide- 13C6, 15N (TFA)is the 13C and 15N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus .
|
-
- HY-112537S1
-
-
- HY-22306S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
β-D-Glucose pentaacetate- 13C6 is the 13C labeled β-D-Glucose pentaacetate[1]. β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is used in biochemical reaction.
|
-
- HY-W766332
-
|
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
7-Hydroxy coumarin glucuronide sodium- 13C6 is the 13C-labeled 7-Hydroxy coumarin glucuronide sodium (HY-120201). 7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin .
|
-
- HY-B0122S
-
-
- HY-W749377
-
|
Toluene, 2,3,4,5,6-pentabromo-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
1,2,3,4,5-Pentabromo-6-methylbenzene- 13C6 (Toluene, 2,3,4,5,6-pentabromo- 13C6) is the 13C-labeled 1,2,3,4,5-Pentabromo-6-methylbenzene (HY-W274110).
|
-
- HY-W752253
-
-
- HY-W751181
-
|
CGP62221-13C6; O-Desmethyl PKC412-13C6
|
Isotope-Labeled Compounds
PKC
|
Cancer
|
|
O-Desmethyl midostaurin- 13C6 (CGP62221- 13C6; O-Desmethyl PKC412- 13C6) is the 13C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor?with?IC50?ranging from 22-500 nM.
|
-
- HY-W008125S
-
|
Methyl acetobromo-α-D-glucuronate-13C6 methyl ester
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Acetobromo-a-D-glucuronic acid- 13C6 methyl ester (Methyl acetobromo-α-D-glucuronate- 13C6 methyl ester) is 13C labeled Acetobromo-α-D-glucuronic acid methyl ester, 98%. Acetobromo-α-D-glucuronic acid methyl ester, 98% (Acetobromo-alpha-D-glucuronic acid methyl ester, 98%) can be used in glycobiology research and can undergo glycosylation reactions with suitable glycoside receptors.
|
-
- HY-B0389S
-
-
- HY-W041171S
-
|
|
Endogenous Metabolite
|
Others
|
|
3-Chloro-L-tyrosine- 13C6 is the 13C labeled 3-Chloro-L-tyrosine . 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima .
|
-
- HY-B2236S2
-
|
(±)-2,6-Diaminocaproic acid-13C6,15N2 hydrochloride
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
DL-Lysine- 13C6, 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6, 15N2 hydrochloride) is 13C and 15N-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-W014423S2
-
|
H-His-OH-13C6 hydrochloride hydrate
|
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Histidine- 13C6 (hydrochloride hydrate) is the 13C-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-B1456AS
-
|
LILLY-53858-13C6 sodium hydrate
|
Isotope-Labeled Compounds
COX
Melanocortin Receptor
ERK
|
Inflammation/Immunology
|
|
Fenoprofen- 13C6 (LILLY-53858- 13C6) sodium hydrate is the 13C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
|
-
- HY-P3146S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
FTISADTSK- 13C6, 15N2 TFA is 13C- and 15N-labeled FTISADTSK (HY-P3146). FTISADTSK is an endogenous stable signature peptide from Trastuzumab monitored by selected reaction monitoring (SRM) .
|
-
- HY-W778240
-
|
Naphthalene-2-carboxylic acid-13C6
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
2-Naphthoic acid- 13C6 (Naphthalene-2-carboxylic acid- 13C6) is the 13C-labeled 2-Naphthoic acid (HY-W007437). 2-Naphthoic acid is an organic compound commonly used as a raw material for dyes and the production of other chemicals. It can form dyes with other organic substances and is widely used in textile, printing and manufacturing fields. In addition, the compound is also used as a photosensitive material and a lubricant.
|
-
- HY-B0190S1
-
|
|
Ser/Thr Protease
Apoptosis
SARS-CoV
|
Cardiovascular Disease
|
|
Nafamostat formate salt- 13C6 is the 13C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2 .
|
-
- HY-W777440
-
-
- HY-173089S
-
-
- HY-173090S
-
-
- HY-B1409S
-
|
ISDN-13C6
|
NO Synthase
|
Cardiovascular Disease
|
|
Isosorbide dinitrate- 13C6 is the 13C labeled Isosorbide dinitrate . Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI) .
|
-
- HY-Y0721S
-
|
m-Bromofluorobenzene-13C6; m-Fluorobromobenzene-13C6; m-Fluorophenyl bromide-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
3-Bromofluorobenzene- 13C6 is the 13C labeled 3-Bromofluorobenzene .
|
-
- HY-N0210S16
-
-
- HY-W749528
-
-
- HY-12008S1
-
|
CP-358774-13C6 hydrochloride; NSC 718781-13C6 hydrochloride; OSI-774-13C6 hydrochloride
|
EGFR
Autophagy
|
Cancer
|
|
Erlotinib- 13C6 hydrochloride is the 13C labeled Erlotinib Hydrochloride . Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM . Erlotinib- 13C6 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-13443S
-
-
- HY-N1380S2
-
-
- HY-B0580S2
-
|
RS37619-13C6
|
Isotope-Labeled Compounds
Apoptosis
COX
|
Inflammation/Immunology
Cancer
|
|
Ketorolac- 13C6 (RS37619- 13C6) is 13C labeled Ketorolac. Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research .
|
-
- HY-A0132S12
-
|
N-Acetyl-2-amino-2-deoxy-D-glucose-13C6
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
N-Acetyl-D-glucosamine- 13C6 (N-Acetyl-2-amino-2-deoxy-D-glucose- 13C6) is the 13C labled N-Acetyl-D-glucosamine (HY-A0132) . N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of glucose.
|
-
- HY-W011577S1
-
|
2,3-Benzotriphenylene-13C6
|
Isotope-Labeled Compounds
Photosensitizer
|
Cancer
|
|
Dibenzo[a,c]anthracene- 13C6 (2,3-Benzotriphenylene- 13C6) is 13C labeled Benzo[f]tetraphene. Benzo[f]tetraphene (Dibenz[a,c]anthracene) is a polycyclic aromatic hydrocarbon with significant antitumor activity. Benzo[f]tetraphene is used as a luminescent probe in cell biology research and can effectively detect reactive oxygen species in biological systems. Benzo[f]tetraphene can also be used as a potential photosensitizer and shows good application prospects in photodynamic inhibition.
|
-
![Dibenzo[a,c]anthracene-13C6](//file.medchemexpress.eu/product_pic/hy-w011577s1.gif)
- HY-W751180
-
|
CGP52421-13C6
|
Isotope-Labeled Compounds
FLT3
|
Cancer
|
|
3-Hydroxy Midostaurin- 13C6 (CGP52421- 13C6) is the 13C-labeled 3-Hydroxy Midostaurin (HY-108263). 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .
|
-
- HY-W754216
-
|
2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose-13C6
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Diacetone-β-D-fructose- 13C6 (2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose- 13C6) is the 13C-labeled Diacetone-β-D-fructose (HY-W011792). Diacetone-β-D-fructose is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-P0090S
-
|
Salmon calcitonin-13C6,15N4 TFA
|
CGRP Receptor
|
Metabolic Disease
|
|
Calcitonin- 13C6, 15N4 (salmon) (Salmon calcitonin- 13C6, 15N4) TFA is 13C and 15N-labeled Calcitonin (salmon) (HY-P0090). Calcitonin (salmon) , a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption .
|
-
- HY-N0470S3
-
-
- HY-113251S1
-
-
- HY-137522AS1
-
|
3'-Azido-3'-deoxythymidine β-D-glucuronide-13C6
|
Isotope-Labeled Compounds
Drug Metabolite
|
Others
|
|
Zidovudine Glucuronide- 13C6 (3'-Azido-3'-deoxythymidine β-D-glucuronide- 13C6) is 13C labeled Zidovudine O-β-D-glucuronide. Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .
|
-
- HY-P5168S
-
|
|
Isotope-Labeled Compounds
SARS-CoV
|
Infection
|
|
GPSVFPLAPSSK- 13C6, 15N2 is the 13C- and 15N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .
|
-
- HY-W721295S
-
-
- HY-W793608S
-
-
- HY-W777188
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
6-Hydroxy Chlorzoxazone- 13C6 is a the 13C-labeled 6-Hydroxy Chlorzoxazone (HY-W016221) . 6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort .
|
-
- HY-79128S1
-
-
- HY-N0455AS6
-
|
(S)-(+)-Arginine-13C6 hydrochloride
|
Isotope-Labeled Compounds
NO Synthase
Endogenous Metabolite
|
Others
|
|
L-Arginine- 13C6 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-P5201S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
VTSEGAGLQLQK- 13C6, 15N2 is the 13C and 15N labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA). VTSEGAGLQLQK can be used to bind anti-drug antibodies (ADA) in plasma and quantitatively analyze the therapeutic effect .
|
-
- HY-101064S1
-
|
|
Isotope-Labeled Compounds
PPAR
|
Metabolic Disease
|
|
Fmoc-leucine- 13C6, 15N is a 15N-labeled and 13C-labled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity
|
-
- HY-Y1636S1
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Fmoc-Arg(Pbf)-OH- 13C6 is the 13C labeled Fmoc-Arg(Pbf)-OH . Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
|
-
- HY-W777928
-
|
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Cyclohexane-1,3-dione- 13C6 is the 13C-labeled Cyclohexane-1,3-dione (HY-W007466). Cyclohexane-1,3-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W101298S
-
|
L-Leucyl-13C6,15N-L-isoleucine TFA
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
(Leu-13C6,15N)-Ile-OH (L-Leucyl-13C6,15N-L-isoleucine) TFA is the deuterium labeled Leu-Ile-OH. Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) synthesis .
|
-
- HY-W008253S3
-
-
- HY-W738582S
-
-
- HY-10450S5
-
|
|
Isotope-Labeled Compounds
SGLT
|
Metabolic Disease
Cancer
|
|
Dapagliflozin- 13C6-1 is 13C labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .
|
-
- HY-N0378S2
-
-
- HY-W654020
-
|
Propyl parahydroxybenzoate-13C6; Propyl 4-hydroxybenzoate-13C6
|
Isotope-Labeled Compounds
Apoptosis
Endogenous Metabolite
Bacterial
|
Infection
|
|
Propyl paraben- 13C6 (Propyl parahydroxybenzoate- 13C6) is 13C labeled Propylparaben. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats .
|
-
- HY-W749378
-
-
- HY-13966S3
-
|
2-DG-13C6; 2-Deoxy-D-arabino-hexose-13C6; D-Arabino-2-deoxyhexose-13C6
|
Isotope-Labeled Compounds
Apoptosis
Hexokinase
HSV
|
Cancer
|
|
2-Deoxy-D-glucose- 13C6 (2-DG- 13C6) is 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .
|
-
- HY-B1190S2
-
|
BL-S 578-13C6
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
EAAT
|
Infection
Neurological Disease
|
|
Cefadroxil- 13C6 (BL-S 578- 13C6) is 13C labeled Cefadroxil (HY-B1190). Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
|
-
- HY-14740S2
-
|
GS-9137-13C6 ; JTK-303-13C6 ; D06677-13C6
|
Isotope-Labeled Compounds
HIV Integrase
HIV
|
Infection
|
|
Elvitegravir- 13C6 (GS-9137- 13C6) is 13C labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
|
-
- HY-P5168AS
-
|
|
Isotope-Labeled Compounds
SARS-CoV
|
Infection
|
|
GPSVFPLAPSSK- 13C6, 15N2 TFA is the 13C- and 15N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .
|
-
- HY-P5201S1
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
VTSEGAGLQLQK- 13C6, 15N2 (TFA) is the 13C- and 15N-labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA), which can be used to bind anti-drug antibodies in plasma and quantitatively analyze the therapeutic effect .
|
-
- HY-19821S1
-
|
Fmoc-L-isoleucine-13C6,15N
|
Isotope-Labeled Compounds
|
Others
|
|
Fmoc-Ile-OH- 13C6, 15N is the 13C and 15N labeled Fmoc-Ile-OH . Fmoc-Ile-OH is an isoleucine derivative .
|
-
- HY-15550S1
-
|
|
Drug Metabolite
|
Inflammation/Immunology
|
|
4'-Hydroxy diclofenac- 13C6 is the 13C labeled 4'-Hydroxy diclofenac . 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .
|
-
- HY-W778242
-
|
3,4-Dihydro-1(2H)-naphthalenon-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
3,4-Dihydronaphthalen-1-one- 13C6 (3,4-Dihydro-1(2H)-naphthalenon- 13C6) is the 13C-labeled 3,4-Dihydronaphthalen-1(2H)-one (HY-76194). 3,4-Dihydronaphthalen-1(2H)-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-13458S2
-
|
L-DOPS-13C6; DOPS-13C6; SM5688-13C6
|
Isotope-Labeled Compounds
Adrenergic Receptor
|
Cardiovascular Disease
Neurological Disease
|
|
Droxidopa- 13C6 (L-DOPS- 13C6) is 13C labeled Droxidopa. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder) .
|
-
- HY-159193S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
DHATS(Leu- 13C6, 15N)PVTIPSAVST(Gly- 13C2, 15N)HTTPLPVTDT (TFA) is the 13C and 15N labeled isotope of DHATS-PVTIPSAVST-HTTPLPVTDT (TFA) .
|
-
- HY-W777526
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Nitisinone- 13C6 is a 13C-labeled Nitisinone (HY-B0607). Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .
|
-
- HY-W753345
-
|
2,6-Dichloro-N-phenylaniline-13C6
|
Isotope-Labeled Compounds
Bacterial
|
Cancer
|
|
2,6-Dichlorodiphenylamine- 13C6 (2,6-Dichloro-N-phenylaniline- 13C6) is the 13C-labeled 2,6-Dichlorodiphenylamine (HY-W012126). 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a?COX?inhibitor, with?IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
|
-
- HY-B0375S1
-
|
MD-805-13C6 hydrochloride; MCI-9038-13C6 hydrochloride; Argipidine-13C6 hydrochloride
|
Thrombin
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Argatroban- 13C6 hydrochloride is 13C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.
|
-
- HY-W768934
-
|
L-Gulonolactone-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Gulono-1,4-lactone- 13C6 (L-Gulonolactone- 13C6) is the 13C-labeled L-Gulono-1,4-lactone (HY-W016628). L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
|
-
- HY-N0684S3
-
-
- HY-113046S1
-
|
5-Methyl THF-13C6; 5-MTHF-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cardiovascular Disease
Metabolic Disease
|
|
5-Methyltetrahydrofolic acid- 13C6 (5-Methyl THF- 13C6) is 13C labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .
|
-
- HY-B0124S2
-
|
AD 810-13C6; CI 912-13C6
|
Isotope-Labeled Compounds
Carbonic Anhydrase
Apoptosis
|
Neurological Disease
|
|
Zonisamide- 13C6 (AD 810- 13C6) is 13C labeled Zonisamide. Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .
|
-
- HY-14520S2
-
|
L-5,6,7,8-Tetrahydrofolic acid-13C6; L-Tetrahydrofolic acid-13C6
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Tetrahydrofolic acid- 13C6 (L-5,6,7,8-Tetrahydrofolic acid- 13C6) is 13C labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
|
-
- HY-B0167S1
-
-
- HY-W779969
-
-
- HY-W769361
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
5-Hydroxymethyl-2-furancarboxylic acid- 13C6 is the 13C-labeled 5-Hydroxymethyl-2-furancarboxylic acid (HY-W005241). 5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural (HMF) in the body and eliminated renally.
|
-
- HY-113407CS
-
|
|
Isotope-Labeled Compounds
Drug Intermediate
|
Metabolic Disease
|
|
D-Fructose-6-phosphate disodium monohydrate- 13C6 is the 13C-labeled D-Fructose-6-phosphate disodium monohydrate (HY-113407C). D-Fructose-6-phosphate disodium monohydrate is an intermediate of Glycolysis. D-Fructose-6-phosphate disodium monohydrate is the precursor for the synthesis of amino sugars, such as galactosamine and glucosamine .
|
-
- HY-B1779S5
-
|
D-(+)-Saccharose-13C6
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Sucrose- 13C6 is the 13C labeled Sucrose . Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al .
|
-
- HY-W754400
-
|
1,6-Anhydro-β-D-mannopyranose-13C6
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Mannosan,95%- 13C6 (1,6-Anhydro-β-D-mannopyranose- 13C6) is the 13C-labeled Mannosan,95% (HY-124095). Mannosan,95% (1,6-Anhydro-β-D-mannopyranose,95%) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
|
-
- HY-N1394S
-
-
- HY-50896S1
-
|
CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6
|
Isotope-Labeled Compounds
EGFR
Autophagy
|
Cancer
|
|
Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR .
|
-
- HY-10574S1
-
|
R278474-13C6; TMC278-13C6; DB08864-13C6
|
Isotope-Labeled Compounds
HIV
Reverse Transcriptase
|
Infection
|
|
Rilpivirine- 13C6 (R278474- 13C6) is 13C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .
|
-
- HY-N0384S3
-
|
Vanilacetic acid-13C6,18O
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
Homovanillic acid- 13C6, 18O is the 13C-labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
|
-
- HY-B1431S1
-
|
Butyl parahydroxybenzoate-13C6; Butyl 4-hydroxybenzoate-13C6
|
Bacterial
Endogenous Metabolite
|
Infection
|
|
Butylparaben- 13C6 is the 13C labeled Butylparaben . Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.
|
-
- HY-N0470S1
-
-
- HY-B0035S2
-
|
Sulfadimidine-13C6; Sulfadimerazine-13C6
|
Antibiotic
Bacterial
Isotope-Labeled Compounds
|
Others
|
|
Sulfamethazine- 13C6 is a 13C-labeled Sulfamethazine (HY-A0178). Sulfamethazine (Sulfadimidine) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections) .
|
-
- HY-N0683S
-
-
- HY-W747879
-
|
|
Isotope-Labeled Compounds
COX
|
Inflammation/Immunology
|
|
Diclofenac Amide- 13C6 is the 13C-labeled Diclofenac amide (HY-134521). Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg) .
|
-
- HY-W768336
-
|
D-Gluconic acid-13C6 sodium; D-Gluconate-13C6 sodium
|
Isotope-Labeled Compounds
Interleukin Related
ERK
NO Synthase
Endogenous Metabolite
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
|
Gluconate sodium- 13C6 (D-Gluconic acid sodium salt- 13C6) is the 13C-labeled Gluconate sodium (HY-B1092A). Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury .
|
-
- HY-W747060
-
|
Benzyl Paraben-13C6
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Benzyl 4-hydroxybenzoate- 13C6 (Benzyl Paraben- 13C6) is the 13C-labeled Benzyl 4-hydroxybenzoate (HY-W013482). Benzyl 4-hydroxybenzoate is a prominent material. Benzyl 4-hydroxybenzoate can be used as an excipient, such as bacteriostatic agent, preservative. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
|
-
- HY-W755778
-
|
|
Isotope-Labeled Compounds
Trace Amine-associated Receptor (TAAR)
|
Metabolic Disease
|
|
3-Iodothyronamine hydrochloride- 13C6 is the 13C-labeled 3-Iodothyronamine hydrochloride (HY-135065). 3-Iodothyronamine hydrochloride is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure .
|
-
- HY-B2156S1
-
|
Vitamin K2(MK-4)-13C6; Menaquinone K4-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
Menaquinone-4- 13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
|
-
- HY-W008452S
-
-
- HY-W768340
-
|
D-(+)-Saccharose-13C6-1
|
Isotope-Labeled Compounds
|
Metabolic Disease
Cancer
|
|
Sucrose- 13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .
|
-
- HY-15037S
-
|
|
Isotope-Labeled Compounds
COX
Apoptosis
|
Inflammation/Immunology
|
|
Diclofenac- 13C6 (sodium heminonahydrate) is the 13C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
|
-
- HY-N1428S1
-
-
- HY-W014423S3
-
-
- HY-P2625S
-
|
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
GLP-2(3-33) (Leu- 13C6, 15N) is 13C and 15N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM).
|
-
- HY-W008642S
-
|
L-Leucyl-13C6,15N-L-leucine
|
Isotope-Labeled Compounds
|
Others
|
|
(Leu-13C6,15N)-Leu-OH TFA is a C13 and N15 labeled Leu-Leu-OH TFA. Leu-Leu-OH, a Leu derivative, is a dipeptide .
|
-
- HY-106950S1
-
|
Diphosphofructose-13C6 tetrasodium hydrate; Esafosfan-13C6 tetrasodium hydrate; FDP-13C6 tetrasodium hydrate
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Fosfructose- 13C6 (tetrasodium hydrate) is the 13C labeled Fosfructose (HY-106950). Fosfructose is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma .
|
-
- HY-W050145S2
-
|
1,6-Anhydro-β-D-glucopyranose-13C6; 1,6-Anhydro-β-D-glucose-13C6
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Levoglucosan- 13C6 is the 13C labeled Levoglucosan . Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature .
|
-
- HY-B0166S8
-
|
L-Ascorbate-1; Vitamin C-13C6-1
|
Isotope-Labeled Compounds
Endogenous Metabolite
Reactive Oxygen Species (ROS)
Calcium Channel
Apoptosis
|
Cancer
|
|
L-Ascorbic acid- 13C6-1 (L-Ascorbate-1; Vitamin C- 13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
|
-
- HY-109120S1
-
-
- HY-129503S
-
|
|
Isotope-Labeled Compounds
Drug Intermediate
|
Others
|
|
2-Heptyl-4-quinolone- 13C6 is the 13C-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .
|
-
- HY-126373S1
-
|
SN-38G-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
SN-38 glucuronide- 13C6 is the 13C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
|
-
- HY-W751179
-
|
PKC412-13C6; CGP 41251-13C6
|
Isotope-Labeled Compounds
Apoptosis
VEGFR
PKC
c-Kit
NO Synthase
|
Cancer
|
|
Midostaurin- 13C6 (PKC412- 13C6) is the 13C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .
|
-
- HY-N7032S1
-
|
UDP-D-Glucose-13C6 disodium
|
Isotope-Labeled Compounds
Endogenous Metabolite
P2Y Receptor
|
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
|
Uridine 5′-diphosphoglucose- 13C6 (UDP-D-Glucose- 13C6) disodium is the 13C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .
|
-
- HY-P2625S1
-
|
|
Isotope-Labeled Compounds
GCGR
|
Metabolic Disease
|
|
GLP-2(3-33) (Leu- 13C6, 15N) TFA is 13C and 15N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM).
|
-
- HY-13613S
-
|
GG 745-13C6; GI 198745-13C6
|
Apoptosis
5 alpha Reductase
|
Cancer
|
|
Dutasteride- 13C6 is the 13C labeled Dutasteride . Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
|
-
- HY-W653962
-
|
|
Isotope-Labeled Compounds
Apoptosis
Antibiotic
Fungal
Bacterial
|
Infection
Cancer
|
|
Triclosan- 13C6 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
|
-
- HY-N0455AS8
-
|
(S)-(+)-Arginine-13C6,15N4 hydrochloride
|
NO Synthase
Endogenous Metabolite
|
Others
|
|
L-Arginine- 13C6, 15N4 (hydrochloride) is the 13C- and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-W777582
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
4-tert-Octylphenol monoethoxylate- 13C6 is the 13C labeled isotope of 4-tert-Octylphenol monoethoxylate (HY-W777582) . 4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent .
|
-
- HY-Y1636S
-
-
- HY-16637S5
-
|
Vitamin B9-13C6; Vitamin M-13C6
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
Endogenous Metabolite
|
Cancer
|
|
Folic acid-13C6 is a deuterated labeled Folic acid . Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .
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-
- HY-B0252S2
-
|
HCTZ-13C6
|
TGF-beta/Smad
Potassium Channel
|
Metabolic Disease
|
|
Hydrochlorothiazide- 13C6 is the 13C labeled Hydrochlorothiazide . Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
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-
- HY-66008S2
-
|
N-Acetyl-5-aminosalicylic acid-13C6; N-Acetyl-ASA-13C6
|
Isotope-Labeled Compounds
Drug Metabolite
|
Inflammation/Immunology
Cancer
|
|
N-Acetyl mesalazine- 13C6 (N-Acetyl-5-aminosalicylic acid- 13C6) is a deuterated labeled N-Acetyl mesalazine (HY-66008). N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027). N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer .
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-
- HY-18341S1
-
-
- HY-W748418
-
|
|
Isotope-Labeled Compounds
Liposome
|
Others
|
|
1-Thio-β-D-glucose Sodium Salt Dihydrate- 13C6 is the 13C-labeled 1-Thio-β-D-glucose sodium (HY-115419). 1-Thio-β-D-glucose sodium is the sodium salt form of 1-Thio-β-D-glucose. 1-Thio-β-D-glucose forms hydrophilic self-assembled monolayer with metal, stablizes the lipid bilayer and protects the proteins from denaturation .
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-
- HY-N0098S2
-
|
p-Vanillin-13C6; m-Methoxy-p-hydroxybenzaldehyde-13C6; p-Hydroxy-m-methoxybenzaldehyde-13C6
|
Endogenous Metabolite
|
Others
|
|
Vanillin- 13C6 is the 13C labeled Vanillin . Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine .
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-
- HY-B0150S2
-
|
Niacinamide-13C6; Nicotinic acid amide-13C6
|
Endogenous Metabolite
Sirtuin
|
Neurological Disease
Cancer
|
|
Nicotinamide- 13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
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-
- HY-B0497BS
-
|
BAY2353-13C6 monohydrate
|
STAT
Parasite
Antibiotic
|
Cancer
|
|
Niclosamide- 13C6 (monohydrate) is the 13C labeled Niclosamide monohydrate . Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research . Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells . Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .
|
-
- HY-W777458
-
|
|
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Fluorene- 13C6 is the 13C-labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .
|
-
- HY-B0822S1
-
|
|
GABA Receptor
Cytochrome P450
|
Inflammation/Immunology
|
|
Fipronil- 13C6 is the 13C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.
|
-
- HY-P0119S
-
|
|
Isotope-Labeled Compounds
GCGR
MEK
Akt
MMP
JNK
|
Neurological Disease
|
|
Lixisenatide (Leu- 13C6, 15N) TFA is the 13C- and 15N-labeled Lixisenatide (HY-P0119). Lixisenatide is a GLP-1 receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways. Lixisenatide decreases atheroma plaque size and instability in Apoe ?/? Irs 2+/? mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation .
|
-
- HY-B0400S16
-
|
Sorbitol-13C6; D-Glucitol-13C6
|
Bacterial
Endogenous Metabolite
|
Others
|
|
D-Sorbitol- 13C6 is the 13C labeled D-Sorbitol . D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement .
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-
- HY-W243018S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
1,2:5,6-Di-O-isopropylidene-a-D-glucofuranose-1,2,3,4,5,6- 13C6 is the 13C labeled 1,2:5,6-Di-O-isopropylidene-a-D-glucofuranose-1,2,3,4,5,6 .
|
-
- HY-A0161S
-
|
Clofedanol-13C6; Calmotusin-13C6; NSC 113595-13C6
|
Isotope-Labeled Compounds
|
Infection
|
|
Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs) .
|
-
- HY-129974S
-
|
3,3'-T2-13C6
|
COX
Endogenous Metabolite
|
Metabolic Disease
|
|
3,3'-Diiodo-L-thyronine- 13C6 is the 13C labeled 3,3'-Diiodo-L-thyronine . 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity .
|
-
- HY-W777393
-
|
7-Hydroxycoumarin-13C6; Hydrangin-13C6; NSC 19790-13C6
|
Isotope-Labeled Compounds
Apoptosis
Fluorescent Dye
|
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Umbelliferone- 13C6 (7-Hydroxycoumarin- 13C6) is the 13C-labeled Umbelliferone (HY-N0573). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in
chronic alcohol-fed rats .
|
-
- HY-10163S2
-
|
BIBR 953-13C6; BIBR 953ZW-13C6
|
Thrombin
|
Cardiovascular Disease
|
|
Dabigatran- 13C6 is the 13C labeled Dabigatran . Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM) .
|
-
- HY-W750212
-
|
Orange II-13C6; D&C Orange NO. 4-13C6
|
Isotope-Labeled Compounds
Biochemical Assay Reagents
|
Others
|
|
Acid Orange 7- 13C6 (Orange II- 13C6) is the 13C-labeled Acid orange 7 (HY-N1442). Acid Orange 7 (Orange II; D&C Orange NO. 4) is an azo dye widely used in the textile, food and cosmetic industries. Acid Orange 7 is mainly used as a colorant by combining with fibers and other substances through azo bonds. Acid Orange 7 has a maximum absorption wavelength at 484-485 nm, and the concentration is measured using a UV-visible spectrophotometer. Acid Orange 7 is difficult to degrade and has a certain degree of toxicity. It is often used to study various sewage treatment technologies and photocatalytic degradation reactions, and to evaluate the removal effects of different treatment methods on organic pollutants .
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-
- HY-W014423S1
-
|
H-His-OH-13C6,15N3,d5 hydrochloride hydrate
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Histidine- 13C6, 15N3,d5 (hydrochloride hydrate) is the deuterium, 13C-, and 15-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
|
-
- HY-N1393S
-
|
NSC 3778-13C6; O-Methylsalicylic acid-13C6; Salicylic acid methyl ether-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Cancer
|
|
2-Methoxybenzoic acid- 13C6 is the 13C-labeled 2-Methoxybenzoic acid. 2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.
|
-
- HY-N0304S1
-
|
Levodopa-13C6; 3,4-Dihydroxyphenylalanine-13C6
|
Dopamine Receptor
Endogenous Metabolite
|
Neurological Disease
|
|
L-DOPA- 13C6 is the 13C-labled L-DOPA . L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .
|
-
- HY-W585956
-
|
3,4,4′-Trichlorocarbanilide-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
Triclocarban- 13C6 is the 13C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
|
-
- HY-10260S2
-
|
ZD6474-13C6
|
Isotope-Labeled Compounds
VEGFR
Autophagy
Apoptosis
|
Cancer
|
|
Vandetanib- 13C6 is a 13C labeled Vandetanib (HY-10260) . Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
|
-
- HY-10572S1
-
-
- HY-W269700S
-
|
L-Isoleucyl-L-leucine-13C6,15N
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
Ile-(Leu-13C6,15N)-OH (TFA) is 13C- and 15N-labeled L-Isoleucyl-L-leucine (HY-W269700). L-Isoleucyl-L-leucine has a role as a metabolite and can be used to inhibit movement-induced muscle damage and muscle defective condition.
|
-
- HY-W778408
-
|
ICI 47699-13C6; (Z)-Tamoxifen-13C6; trans-Tamoxifen-13C6
|
Isotope-Labeled Compounds
Apoptosis
Autophagy
HSP
Estrogen Receptor/ERR
|
Endocrinology
|
|
Tamoxifen- 13C6 (ICI 47699- 13C6) is the 13C-labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER transgenic mouse .
|
-
- HY-W050154S
-
|
|
Parasite
Isotope-Labeled Compounds
|
Infection
|
|
Kojic acid- 13C6 is 13C labeled Kojic acid (HY-W050154). Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .
|
-
- HY-15027S2
-
|
Mesalamine-13C6; 5-ASA-13C6; Mesalazine-13C6
|
PPAR
PAK
NF-κB
Endogenous Metabolite
|
Inflammation/Immunology
|
|
5-Aminosalicylic acid- 13C6 is the 13C labeled 5-Aminosalicylic Acid . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
|
-
- HY-N0455AS4
-
|
(S)-(+)-Arginine-13C6,15N4,d7 hydrochloride
|
Isotope-Labeled Compounds
NO Synthase
Endogenous Metabolite
|
Others
|
|
L-Arginine- 13C6, 15N4,d7 (hydrochloride) is the deuterium, 13C-, and 15-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
|
-
- HY-18569S4
-
|
Indole-3-acetic acid-13C6; 3-IAA-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Indoleacetic acid- 13C6 is the 13C labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
|
-
- HY-79576S2
-
|
Oestrone methyl ether-13C6; 3-O-Methylestrone-13C6
|
Isotope-Labeled Compounds
|
Others
|
|
Estrone 3-methyl ether- 13C6 is a 13C-labeled Estrone 3-methyl ether (HY-79576). Estrone 3-methyl ether (Oestrone methyl ether; 3-O-Methylestrone) is a synthetic intermediate useful for synthesis of estrogen receptor modulator .
|
-
- HY-W020678S
-
-
- HY-B0141S4
-
-
- HY-18572S
-
|
2,4-Dichlorophenoxyacetic acid-13C6
|
Isotope-Labeled Compounds
DNA/RNA Synthesis
|
Others
|
|
2,4-D- 13C6 is the 13C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development .
|
-
- HY-W009300S1
-
|
4-OHE1-13C6
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
4-Hydroxyestrone- 13C6 is a 13C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .
|
-
- HY-B1422S
-
|
Aminacrine-13C6
|
Bacterial
HIV
Isotope-Labeled Compounds
|
Infection
|
|
9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-13948BS
-
|
Angiotensin II-13C6,15N TFA; Ang II-13C6,15N TFA; DRVY(I-13C6,15N)HPF TFA
|
Isotope-Labeled Compounds
|
Cancer
|
|
Angiotensin II human- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
|
-
- HY-176277S
-
|
FPB,human-(Val-13C5,15N, Arg-13C6,15N4) TFA
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Fibrinopeptide B, human-(Val- 13C5, 15N, Arg- 13C6, 154) TFA is the 13C- and 15N-labeled Fibrinopeptide B, human (HY-P1493). Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin .
|
-
- HY-B0166S
-
-
- HY-N0215S8
-
|
(S)-2-Amino-3-phenylpropionic acid-13C6
|
Isotope-Labeled Compounds
Calcium Channel
iGluR
Endogenous Metabolite
|
Metabolic Disease
|
|
L-Phenylalanine- 13C6 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
|
-
- HY-13690S1
-
|
2,4′-DDD-13C6; o,p'-DDD-13C6
|
Apoptosis
|
Cancer
|
|
Mitotane- 13C6 is the 13C labeled Mitotane . Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .
|
-
- HY-114118S3
-
|
|
Isotope-Labeled Compounds
GLP Receptor
Insulin Receptor
α-synuclein
Apoptosis
p38 MAPK
Autophagy
Bcl-2 Family
|
Metabolic Disease
|
|
Semaglutide- 13C6, 15N TFA is the 13C- and 15N-labeled Semaglutide TFA (HY-114118A). Semaglutide TFA is a long-acting, selective, competitive, orally active GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide TFA also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide TFA has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide TFA can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
|
-
- HY-12033S1
-
|
2-ME2-13C6; NSC-659853-13C6
|
Isotope-Labeled Compounds
Microtubule/Tubulin
Reactive Oxygen Species (ROS)
Apoptosis
Autophagy
Endogenous Metabolite
|
Cancer
|
|
2-Methoxyestradiol- 13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .
|
-
- HY-W014901S
-
-
- HY-16561S1
-
|
trans-Resveratrol-13C6; SRT501-13C6
|
Isotope-Labeled Compounds
IKK
Autophagy
Mitophagy
Sirtuin
Apoptosis
Bacterial
Fungal
Antibiotic
Keap1-Nrf2
|
Infection
Inflammation/Immunology
Cancer
|
|
Resveratrol- 13C6 is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
|
-
- HY-78726S2
-
|
Amprenavir phosphate-13C6; GW 433908-13C6
|
Isotope-Labeled Compounds
Drug Intermediate
HIV
HIV Protease
|
Infection
|
|
Fosamprenavir- 13C6 is the 13C-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .
|
-
- HY-16938S
-
|
5'-(Methylthio)-5'-deoxyadenosine-13C6; 5'-Deoxy-5'-(methylthio)adenosine-13C6; 5'-S-Methyl-5'-thioadenosine-13C6
|
Endogenous Metabolite
Apoptosis
|
Metabolic Disease
Cancer
|
|
5'-Methylthioadenosine- 13C6 is the 13C-labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .
|
-
- HY-P99832
-
|
c13C6-FR1
|
Filovirus
|
Infection
|
|
Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP) .
|
-
- HY-112499S1
-
|
Vitamin K2-7-13C6; Vitamin K2(35)-13C6; Vitamin MK-7-13C6
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
Menaquinone-7- 13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .
|
-
- HY-16561S2
-
-
- HY-176258S
-
-
- HY-17405S
-
-
- HY-W017401S
-
|
BIT-13C6
|
Isotope-Labeled Compounds
Bacterial
|
Others
|
|
Benzisothiazolinone-13C5 (1,2-Benzothiazol-3-one-13C5) is a 13C-labeled Benzisothiazolinone. Benzisothiazolinone is widely used as an antiseptic and antibacterial agent .
|
-
- HY-W766699
-
|
6-Amino-2-thiouracil Monohydrate-13C
|
Isotope-Labeled Compounds
|
Others
|
|
6-Amino-4-hydroxy-2-mercaptopyrimidine- 13C (6-Amino-2-thiouracil Monohydrate- 13C) is the 13C-labeled 6-Amino-4-hydroxy-2-mercaptopyrimidine (HY-75601).
|
-
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-176034S
-
-
- HY-P6425S
-
-
- HY-P6423S
-
-
- HY-P6424S
-
-
- HY-P6421S
-
-
- HY-P6422S
-
-
- HY-163422S
-
-
- HY-163423S
-
-
- HY-163424S
-
-
- HY-P11199S
-
-
- HY-176177S
-
-
- HY-176178S
-
-
- HY-163426S
-
-
- HY-163425S
-
-
- HY-163427S
-
-
- HY-163992S
-
-
- HY-163993S
-
-
- HY-156343S1
-
-
- HY-156344S1
-
-
- HY-P3207S
-
-
- HY-176032S
-
-
- HY-156341S1
-
-
- HY-156345S1
-
-
- HY-158992S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
SP-(Val- 13C5, 15)-EKNQ-(Leu- 13C6, 15)-TIDFINIVKDPVPHNEYKT TFA is a 13C- and 15N-labeled peptide containing 13C5, 15N-labeled valine (Val) and 13C6, 15N-labeled leucine (Leu).
|
-
- HY-P1032S2
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Others
|
|
Angiotensin I-13C6,15N (human, mouse, rat) TFA is 13C and 15N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensin II and is cleaved into angiotensin II by angiotensin converting enzyme (ACE) .
|
-
- HY-158994S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
MEGDSRGG-(Ala- 13C3, 15N)-GGEA-(Leu- 13C6, 15N)-DPESAASSLSGAS TFA is a 13C- and 15N-labeled peptide containing 13C3, 15N-labeled alanine (Ala) and 13C6, 15N-labeled leucine (Leu).
|
-
- HY-159192S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
SADDNIKTPAE(Arg- 13C6, 15N4)LLGPLPPSADDNLKT (TFA) is the 13C and 15N labeled isotope of SADDNIKTPAE-LLGPLPPSADDNLKT (TFA) .
|
-
- HY-P0014S2
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
Liraglutide- 13C6, 15N (TFA)is the 13C and 15N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus .
|
-
- HY-P3146S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
FTISADTSK- 13C6, 15N2 TFA is 13C- and 15N-labeled FTISADTSK (HY-P3146). FTISADTSK is an endogenous stable signature peptide from Trastuzumab monitored by selected reaction monitoring (SRM) .
|
-
- HY-13443S
-
-
- HY-P0090S
-
|
Salmon calcitonin-13C6,15N4 TFA
|
CGRP Receptor
|
Metabolic Disease
|
|
Calcitonin- 13C6, 15N4 (salmon) (Salmon calcitonin- 13C6, 15N4) TFA is 13C and 15N-labeled Calcitonin (salmon) (HY-P0090). Calcitonin (salmon) , a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption .
|
-
- HY-P5168S
-
|
|
Isotope-Labeled Compounds
SARS-CoV
|
Infection
|
|
GPSVFPLAPSSK- 13C6, 15N2 is the 13C- and 15N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .
|
-
- HY-P5168AS
-
|
|
Isotope-Labeled Compounds
SARS-CoV
|
Infection
|
|
GPSVFPLAPSSK- 13C6, 15N2 TFA is the 13C- and 15N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .
|
-
- HY-P5201S1
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
VTSEGAGLQLQK- 13C6, 15N2 (TFA) is the 13C- and 15N-labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA), which can be used to bind anti-drug antibodies in plasma and quantitatively analyze the therapeutic effect .
|
-
- HY-159193S
-
|
|
Isotope-Labeled Compounds
|
Others
|
|
DHATS(Leu- 13C6, 15N)PVTIPSAVST(Gly- 13C2, 15N)HTTPLPVTDT (TFA) is the 13C and 15N labeled isotope of DHATS-PVTIPSAVST-HTTPLPVTDT (TFA) .
|
-
- HY-P2625S
-
|
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
|
GLP-2(3-33) (Leu- 13C6, 15N) is 13C and 15N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM).
|
-
- HY-P2625S1
-
|
|
Isotope-Labeled Compounds
GCGR
|
Metabolic Disease
|
|
GLP-2(3-33) (Leu- 13C6, 15N) TFA is 13C and 15N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM).
|
-
- HY-P0119S
-
|
|
Isotope-Labeled Compounds
GCGR
MEK
Akt
MMP
JNK
|
Neurological Disease
|
|
Lixisenatide (Leu- 13C6, 15N) TFA is the 13C- and 15N-labeled Lixisenatide (HY-P0119). Lixisenatide is a GLP-1 receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways. Lixisenatide decreases atheroma plaque size and instability in Apoe ?/? Irs 2+/? mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation .
|
-
- HY-176277S
-
|
FPB,human-(Val-13C5,15N, Arg-13C6,15N4) TFA
|
Isotope-Labeled Compounds
|
Inflammation/Immunology
|
|
Fibrinopeptide B, human-(Val- 13C5, 15N, Arg- 13C6, 154) TFA is the 13C- and 15N-labeled Fibrinopeptide B, human (HY-P1493). Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99832
-
|
c13C6-FR1
|
Filovirus
|
Infection
|
|
Cosfroviximab (c13C6-FR1) is a mouse/human chimeric monoclonal antibody against Ebola virus glycoprotein (EBOV-GP) .
|
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W010042S3
-
|
|
|
L-Glucose- 13C6 (L-(-)-Glucose- 13C6) is C13-labeled L-Glucose. L-Glucose is an enantiomer of D-glucose. L-Glucose enhances food intake .
|
-
-
- HY-P3003S
-
|
|
|
Cereulide-13C6 is the 13C6 labeled Cereulide.
|
-
-
- HY-W280531S
-
|
|
|
DNSAH- 13C6 is the 13C6 labeled DNSAH.
|
-
-
- HY-A0130S
-
|
|
|
Sulfalene- 13C6 is the 13C6 labeled Sulfalene. Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial .
|
-
-
- HY-W156511S
-
|
|
|
Diacetylsulfanilamide- 13C6 is the 13C6 labeled Diacetylsulfanilamide.
|
-
-
- HY-146969S
-
|
|
|
Bisdesoxyquinoceton- 13C6 is the 13C6 labeled Bisdesoxyquinoceton.
|
-
-
- HY-146968S
-
|
|
|
Alloerythro-Isoxsuprine- 13C6 (hydrochloride) is the 13C6 labeled Alloerythro-Isoxsuprine (hydrochloride).
|
-
-
- HY-W278861S
-
|
|
|
Desoxy-Mequindox- 13C6 is the 13C6 labeled Desoxy-Mequindox.
|
-
-
- HY-W780150
-
|
|
|
1-Bromobenzene-13C6 is a deuterated labeled 1-Bromobenzene-13C6 .
|
-
-
- HY-W750888
-
|
|
|
(Z)-Chlorolefin- 13C6 is the 13C-labeled (Z)-Chlorolefin- 13C6.
|
-
-
- HY-B0925S
-
|
|
|
Oxacillin- 13C6 (sodium) is the 13C6 labeled Oxacillin (sodium). Oxacillin sodium salt is a narrow-spectrum β-lactam antibiotic of the penicillin class.
|
-
-
- HY-112586S1
-
|
|
|
Sulfaethoxypyridazine- 13C6 is the 13C6 labeled Sulfaethoxypyridazine. Sulfaethoxypyridazine is a sulfonamide antibacterial agent. Sulfaethoxypyridazine is a sulfonamide that is used in veterinary medicine as feedstuffs.
|
-
-
- HY-14538S3
-
|
|
|
Haloperidol- 13C6 is the 13C6 labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
|
-
-
- HY-146966S
-
|
|
|
2-NP-DNSAH- 13C6 is the 13C6 labeled 2-NP-DNSAH.
|
-
-
- HY-B1436S1
-
|
|
|
Nifuroxazide- 13C6 is the 13C6 labeled Nifuroxazide. Nifuroxazide is an effective inhibitor of STAT3, also exerts potent anti-tumor and anti-metastasis activity.
|
-
-
- HY-W777457
-
|
|
|
Anthracene- 13C6 (Anthracin- 13C6) is 13C labeled Anthracene-13C6 (HY-W777457).
|
-
-
- HY-N0455AS11
-
|
|
|
L-Arginine-13C6,d14 hydrochloride ((S)-(+)-Arginine-13C6,d14 hydrochloride) is a deuterated derivative of L-Arginine hydrochloride (HY-N0455A) that is labeled with 13C6. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) serves as a nitrogen donor for the synthesis of nitric oxide and is a vasodilator .
|
-
-
- HY-114750S
-
|
|
|
Mebendazole-amine- 13C6 is the 13C6 labeled Mebendazole-amine. Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent.
|
-
-
- HY-B1267S1
-
|
|
|
Sulfaguanidine- 13C6 is the 13C6 labeled Sulfaguanidine. Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery.
|
-
-
- HY-18341S3
-
|
|
|
L-Thyroxine- 13C6, 15N is the 13C6 ans 15N labeled L-Thyroxine (HY-18341) .
|
-
-
- HY-B0493S1
-
|
|
|
Niflumic acid- 13C6 is the 13C6 labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.
|
-
-
- HY-W782153
-
|
|
|
Acetophenone-13C6 is a deuterated labeled Acetophenone-13C6 .
|
-
-
- HY-B0174AS
-
|
|
|
Olsalazine- 13C6 is the 13C labeled Olsalazine.
|
-
-
- HY-133694S
-
|
|
|
2-Aminoflubendazole- 13C6 is the 13C6 labeled 2-Aminoflubendazole. 2-Aminoflubendazole is the metabolite of Benzimidazoles. Benzimidazoles (BZ) are a class of agents with activities against fungi, protozoa, and helminthes.
|
-
-
- HY-W140740S
-
|
|
|
Hexabromobenzene- 13C6 (Perbromobenzene- 13C6) is 13C labeled Hexabromobenzene .
|
-
-
- HY-131622S
-
|
|
|
7-Aminoclonazepam-13C6 is a deuterated labeled 7-Aminoclonazepam .
|
-
-
- HY-W778225
-
|
|
|
Vanillic acid- 13C6 is the 13C labeled isotope of Vanillic acid- 13C6(HY-N0708 ).Vanillic acid is a flavoring agent found in edible plants and fruits, and in the root of angelica. Vanillic acid inhibits NF-κB activation. It has anti-inflammatory and antimicrobial activities.
|
-
-
- HY-W069721S1
-
|
|
|
N-Acetylsulfanilamide- 13C6 is the 13C6 labeled N-Acetylsulfanilamide.
|
-
-
- HY-121267S
-
|
|
|
Dicamba- 13C6 is the 13C labeled Dicamba .
|
-
-
- HY-122062S
-
|
|
|
Fenoxycarb- 13C6 is the 13C labeled Fenoxycarb .
|
-
-
- HY-W777964
-
|
|
|
Phloroglucinol- 13C6 is 13C labeled Phloroglucinol .
|
-
-
- HY-W770434
-
|
|
|
Octrizole- 13C6 is 13C labeled Octrizole .
|
-
-
- HY-W344468S
-
|
|
|
Adipate- 13C6 (sodium) is the 13C labeled Sodium adipate .
|
-
-
- HY-146972S
-
|
|
|
Zearalenone-14-O-β-glucoside- 13C6 is the 13C6 labeled Zearalenone-14-O-β-glucoside.
|
-
-
- HY-176034S
-
|
|
|
GPAGPQGP-Arg ( 13C6, 15N4) TFA is a peptide containing 13C6 and 15N4 labeled Arg.
|
-
-
- HY-W777681
-
|
|
|
Triflusal-13C6 is a C13-labeled Triflusal. Triflusal is a platelet aggregation inhibitor .
|
-
-
- HY-P6425S
-
|
|
|
LCADMEDV-Arg( 13C6, 15N4) TFA is a peptide containing 13C6 and 15N4 labeled Arg .
|
-
-
- HY-P6423S
-
|
|
|
CLAVYQAGA-Arg( 13C6, 15N4) TFA is a peptide containing 13C6 and 15N4 labeled Arg .
|
-
-
- HY-P6424S
-
|
|
|
LGADMEDVCG-Arg( 13C6, 15N4) TFA is a peptide containing 13C6 and 15N4 labeled Arg .
|
-
-
- HY-P6421S
-
|
|
|
LGPLVEQG-Arg( 13C6, 15N4) TFA is a peptide containing 13C6 and 15N4 labeled Arg .
|
-
-
- HY-P6422S
-
|
|
|
LAVYQAGA-Arg( 13C6, 15N4) TFA is a peptide containing 13C6 and 15N4 labeled Arg .
|
-
-
- HY-N7123S1
-
|
|
|
Sulfacetamide- 13C6 (Sulphacetamide 13C6) is the 13C6 labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities .
|
-
-
- HY-B0946S2
-
|
|
|
Sulfamonomethoxine- 13C6 is the 13C6 labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .
|
-
-
- HY-B0467AS
-
|
|
|
Amoxicillin- 13C6 is the 13C6 labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity.
|
-
-
- HY-113296S
-
|
|
|
Indoxyl Sulfate Potassium Salt- 13C6 is the 13C labeled Indoxyl Sulfate Potassium Salt .
|
-
-
- HY-B1355AS1
-
|
|
|
Oxyphenbutazone- 13C6 is the 13C6 labeled Oxyphenbutazone (HY-B1355A). Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is the metabolite of Phenylbutazone (HY-B0230). Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis .
|
-
-
- HY-17596S
-
|
|
|
Closantel- 13C6 is the 13C6 labeled Closantel. Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.
|
-
-
- HY-13553S1
-
|
|
|
Anidulafungin- 13C6 (LY303366- 13C6) is 13C labeled Anidulafungin. Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
|
-
-
- HY-150194S
-
|
|
|
Fructose-glutamic acid- 13C6 is 13C labeled Fructose-glutamic acid.
|
-
-
- HY-B0263S1
-
|
|
|
Thiabendazole- 13C6 is the 13C6 labeled Thiabendazole. Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.
|
-
- HY-125296S
-
|
|
|
Fipronil sulfone- 13C6 is the 13C-labeled Fipronil sulfone .
|
-
- HY-W100312S
-
|
|
|
o-Toluidine-13C6 hydrochloride (Toluene, 2-amino-13C6 hydrochloride) is the 13C labeled isotope of o-Toluidine hydrochloride (HY-W100312) .
|
-
- HY-B1781S
-
|
|
|
Sulfachloropyridazine- 13C6 is the 13C6 labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria.
|
-
- HY-150703S
-
|
|
|
4-Methoxyestradiol- 13C6 is the 13C labeled 4-Methoxyestradiol .
|
-
- HY-W001138S
-
|
|
|
4-Bromobenzaldehyde- 13C6 is the 13C labeled 4-Bromobenzaldehyde .
|
-
- HY-34428S
-
|
|
|
4-Fluorobenzonitrile- 13C6 is the 13C labeled 4-Fluorobenzonitrile .
|
-
- HY-133689AS
-
|
|
|
3-Nitrophenylhydrazine- 13C6 (hydrochloride) is the 13C labeled 3-Nitrophenylhydrazine hydrochloride .
|
-
- HY-141909S
-
|
|
|
4-Fluoroiodobenzene- 13C6 is the 13C labeled 4-Fluoroiodobenzene .
|
-
- HY-141928S
-
|
|
|
4-Bromoanisole- 13C6 is the 13C labeled 4-Bromoanisole .
|
-
- HY-I0210S
-
|
|
|
4-Iodoaniline- 13C6 is the 13C labeled 4-Iodoaniline .
|
-
- HY-131501S1
-
|
|
|
Menaquinone-9- 13C6 is the 13C labeled Menaquinone-9 .
|
-
- HY-17598S
-
|
|
|
Rafoxanide 13C6 is a labeled Rafoxanide (HY-17598). Rafoxanide is a salicylanilide used as an antiparasitic agent .
|
-
- HY-146967S
-
|
|
|
4-(3,6-Dimethylhept-3-yl)phenol- 13C6 is the 13C6 labeled 4-(3,6-Dimethylhept-3-yl)phenol.
|
-
- HY-B0141S7
-
|
|
|
rel-Estradiol- 13C6 is the sup>13C-labeled rel-Estradiol .
|
-
- HY-W014375S2
-
|
|
|
Arginine- 13C6 hydrochloride is 13C-labeled Arginine (hydrochloride) (HY-W014375). Arginine hydrochloride is an arginine derivative.
|
-
- HY-Y0264S
-
|
|
|
4-Hydroxybenzoic acid- 13C6 is the 13C labeled isotope of 4-Hydroxybenzoic acid- 13C6.4-Hydroxybenzoic acid is a phenolic derivative of benzoic acid, which can inhibit most Gram-positive bacteria and some Gram-negative bacteria with an IC50 value of 160 μg/mL.
|
-
- HY-W750294
-
|
|
|
δ-Hexachlorocyclohexane- 13C6 is the 13C-labeled δ-Hexachlorocyclohexane.
|
-
- HY-B1941S1
-
|
|
|
4-tert-Octylphenol- 13C6 is the 13C labeled isotope of Octylphenol .
|
-
- HY-W777533
-
|
|
|
N-Acetyl sulfadiazine- 13C6 is 13C labeled N-Acetyl sulfadiazine .
|
-
- HY-W104010S
-
|
|
|
2-Chloroaniline hydrochloride- 13C6 is the 13C labeled 2-Chloroaniline hydrochloride .
|
-
- HY-W013677S
-
|
|
|
4-Fluorobenzoic acid- 13C6 is the 13C labeled 4-Fluorobenzoic acid .
|
-
- HY-Y0931S
-
|
|
|
3-Iodobenzoic Acid- 13C6 is the 13C labeled 3-Iodobenzoic Acid .
|
-
- HY-Y1027S1
-
|
|
|
2-Chlorobenzoic acid- 13C6 is the 13C labeled 2-Chlorobenzoic acid .
|
-
- HY-W013396S
-
|
|
|
4-Iodobenzoic Acid- 13C6 is the 13C labeled 4-Iodobenzoic Acid .
|
-
- HY-W776938
-
|
|
|
Ethyl nicotinate hydrochloride- 13C6 (Nicotinic acid ethylester hydrochloride- 13C6) is the 13C-labeled Ethyl nicotinate (HY-W013628).
|
-
- HY-B0273S1
-
|
|
|
Sulfadiazine- 13C6 is a labeled Sulfadiazine (HY-B0273). Sulfadiazine is a sulfonamide?antibiotic with antimalarial activity[1].
|
-
- HY-136380S
-
|
|
|
Clodinafop-propargyl- 13C6 is the 13C-labeled Clodinafop-propargyl. Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl-13C6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-B0482S1
-
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Acemetacin- 13C6 (TVX 1322- 13C6) is 13C labeled Acemetacin. Acemetacin (TVX 1322) is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
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-
- HY-W016814S
-
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(Z)-Aconitic acid- 13C6 is the 13C-labeled (Z)-Aconitic acid (HY-W016814). (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is the cis-isomer of Aconitic acid. (Z)-Aconitic acid- 13C6 (cis-Aconitic acid) is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid.
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-
- HY-W097410S1
-
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2-Iodo-N-phenylacetamide- 13C6 (N-phenyliodoacetamide- 13C6) is the 13C labeled 2-Iodo-N-phenylacetamide.
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-
- HY-128790S1
-
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4-Methoxyestrone- 13C6 is a 13C-labeled 4-Methoxyestrone (HY-128790).
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-
- HY-170207S
-
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Aurothioglucose 70%- 13C6 is the 13C-labeled CRBN ligand-175 (HY-170207).
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-
- HY-W715199S
-
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Pentabromo benzene- 13C6 is 13C labeled 1,2,3,4,5-Pentabromobenzene .
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-
- HY-W777535S
-
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Naphthalene- 13C6 is 13C labeled Naphthalene-13C10 (HY-W777535).
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-
- HY-W777583
-
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2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6 is the 13C labeled isotope of 2-[4-(1-Ethyl-1,4-dimethylpentyl)phenoxy]ethanol-13C6 (HY-W777583) .
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-
- HY-B0945S
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Nitromide- 13C6 (3,5-Dinitrobenzamide- 13C6) is the 13C-labeled Nitromide (HY-B0945). Nitromide is an anti-parasitic agent .
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-
- HY-W777418
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Isosorbide mononitrate- 13C6 (Isosorbide-5-mononitrate- 13C6) is 13C-labeled Isosorbide mononitrate (HY-B0642) .
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-
- HY-W654109
-
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2-Chloroanthracene- 13C6 (Anthracene, 2-chloro- 13C6) is the 13C-labeled 2-Chloroanthracene (HY-W014272).
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-
- HY-W771036
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Argininic acid- 13C6 (L-Argininic Acid- 13C6) is the 13C-labeled Argininic acid (HY-113079). Argininic acid is an α-amino acid that is used in the biosynthesis of proteins.
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-
- HY-14832S1
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Ataluren- 13C6 (PTC124- 13C6) is 13C labeled Ataluren. Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.
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-
- HY-143704S
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5-Aminosalicylic acid-13C6 hydrochloride?(Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride; Mesalazine-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride?acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
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-
- HY-N0379S22
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D-Mannose- 13C6 is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific proteins .
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-
- HY-17359S1
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Deferasirox- 13C6 (ICL 670- 13C6) is 13C labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .
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-
- HY-W010209S
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DL-Histidine- 13C6, 15N3 N-Acetyl-S-allyl-L-cysteine
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-
- HY-W750442
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4-Bromophenoxytriisopropylsilane- 13C6 is the 13C-labeled (4-Bromophenoxy)triisopropylsilane (HY-W702226).
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-
- HY-B1703S
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Nifursol- 13C6 is the 13C6 labeled Nifursol (HY-B1703). Nifursol (Standard) is the analytical standard of Nifursol (HY-B1703). This product is used for research and analytical applications. Nifursol is an orally active veterinary antibiotic. Nifursol inhibits Histomonas meleagridis. Nifursol prevents histomoniasis in turkeys. Nifursol is widely used in studies of Escherichia coli gastroenteritis in Salmonella-infected poultry and aquatic animals .
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-
- HY-B1374S2
-
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Florfenicol- 13C6 (SCH-25298- 13C6) is 13C labeled Florfenicol. Florfenicol ((-)-Florfenicol) is an orally active broad-spectrum antibacterial antibiotic with anti-inflammatory, pro apoptotic, and immunomodulatory functions .
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-
- HY-W748193
-
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2,5-Furandicarboxylic acid- 13C6 is the 13C-labeled 2,5-Furandicarboxylic acid.
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-
- HY-W015198S
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4-(Trifluoromethyl)benzoic acid- 13C6 is the 13C labeled 4-(Trifluoromethyl)benzoic acid .
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-
- HY-W654206
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D-Glucose 6-Phosphate Sodium Salt Hydrate- 13C6 is the 13C-labeled D-Glucose 6-Phosphate Sodium Salt Hydrate.
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-
- HY-W012507S1
-
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2,6-Dichlorobenzoic acid- 13C6 is 13C labeled 2,6-Dichlorobenzoic acid .
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-
- HY-143843S
-
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Isosorbide-2-mononitrate- 13C6 is the 13C labeled Isosorbide-2-mononitrate .
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-
- HY-150706S
-
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D-fructose-6-phosphate- 13C6 is the 13C labeled D-fructose-6-phosphate .
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-
- HY-13078S
-
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Cobimetinib- 13C6 (GDC-0973- 13C6; XL518- 13C6) racemate is the deuterium labeled Cobimetinib (racemate) (HY-13078) . Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor .
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-
- HY-B0122SS1
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Topiramate- 13C6-1 (McN 4853- 13C6-1; RWJ 17021- 13C6-1) is 13C-labeled Topiramate (HY-B0122) .
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-
- HY-W771037
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2-Oxoarginine- 13C6 (δ-Guanido-α-ketovaleric Acid- 13C6) is the 13C-labeled 2-Oxoarginine (HY-113417).
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-
- HY-15036S1
-
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Diclofenac- 13C6 is the 13C6 labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
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-
- HY-116214S1
-
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Cyprodinil- 13C6 (CGA-219417- 13C6) is the 13C6 labeled Cyprodinil (HY-116214). Cyprodinil (CGA-219417) is a broad-spectrum anilinopyrimidine fungicide and an activator of the aryl hydrocarbon receptor. Cyprodinil also has anti-androgenic and androgenic activities. Cyprodinil can inhibit the biosynthesis of methionine in plant-pathogenic fungi and protect fruits and vegetables from a variety of pathogens .
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-
- HY-W753343
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2-Chloro-N-phenylacetamide- 13C6 (2-Chloroacetanilide- 13C6) is the 13C-labeled 2-Chloro-N-phenylacetamide (HY-W069522).
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-
- HY-150679S
-
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Remdesivir- 13C6 is the 13C labeled Remdesivir .
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-
- HY-W014223S
-
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2,4-Dihydroxybenzophenone- 13C6 (Ultraviolet absorber UV-0- 13C6) is the 13C- and deuterium labeled (2,4-Dihydroxyphenyl)(phenyl)methanone .
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-
- HY-B0211S1
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Riluzole- 13C6 (PK 26124- 13C6) is 13C labeled Riluzole. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na + channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM.
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-
- HY-W012530S
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Phenylpyruvic acid- 13C6 sodium is the 13C-labeled Phenylpyruvic acid. Phenylpyruvic acid is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase .
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- HY-163422S
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PHSHPALTPEQK-(Lys- 13C6, 15N2) is 13C and 15N labeled PHSHPALTPEQK-(Lys).
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-
- HY-163423S
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TELAEPTSTR-(Arg- 13C6, 15N4) is 13C and 15N labeled TELAEPTSTR-(Arg).
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-
- HY-163424S
-
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SSVFVADPK-(Lys- 13C6, 15N2) is 13C and 15N labeled SSVFVADPK-(Lys).
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-
- HY-P11199S
-
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IVLIGNAGVG-(Lys- 13C6, 15N2) is the 13C- and 15N-labeled IVLIGNAGVG.
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-
- HY-W751444
-
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2,4-Dimethylanisole- 13C6 (4-Methoxy-m-xylene- 13C6) is the 13C-labeled 2,4-Dimethylanisole (HY-W100677).
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-
- HY-15409S1
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Empagliflozin- 13C6 (BI 10773- 13C6) is 13C labeled Empagliflozin. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2 .
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-
- HY-N7745S2
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Glucosylsphingosine- 13C6 is an active compound. Glucosylsphingosine- 13C6 can be used for various studies .
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-
- HY-W746828
-
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Oxindole-3-acetic acid- 13C6 is 13C labeled Oxindole-3-acetic acid .
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-
- HY-76929S
-
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tert-Butyl 4-aminobenzoate- 13C6 is the 13C labeled tert-Butyl 4-aminobenzoate .
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-
- HY-W106014S
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[1,1'-Biphenyl]-3-amine-13C6 hydrochloride (Biphenyl-3-amine-13C6 hydrochloride) is the 13C labeled isotope of [1,1'-Biphenyl]-3-amine hydrochloride (HY-W106014) .
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-
- HY-N6612S
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D-Glucuronic acid sodium monohydrate- 13C6 is the 13C-labeled D-Glucuronic acid sodium salt monohydrate (HY-N6612A). D-Glucuronic acid sodium salt monohydrate is an endogenous metabolite.
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-
- HY-W751475
-
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1-(Methoxymethoxy)benzene- 13C6 is the 13C-labeled 1-(Methoxymethoxy)benzene (HY-W642289).
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-
- HY-10268S2
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Betrixaban- 13C6 (PRT054021- 13C6) is 13C labeled Betrixaban. Betrixaban (PRT054021) is a highly potent, selective, and orally efficacious factor Xa (fXa) inhibitor with an IC50 of 1.5 nM. Betrixaban shows antithrombotic effect .
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-
- HY-N0771S
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L-Isoleucine- 13C6 is the 13C-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid . L-Isoleucine is an essential amino acid.
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-
- HY-W014225S
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3-Phenoxybenzoic acid- 13C6 is the 13C6 labeled 3-Phenoxybenzoic acid. 3-Phenoxybenzoic acid is the metabolite of pyrethroid insecticides. 3-Phenoxybenzoic acid induces immunotoxicity and oxidative stress, and inhibits the phagocytic ability of macrophages .
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-
- HY-W024986S
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4-(4-Hexoxyphenyl)benzonitrile- 13C6 (4'-Hexyloxy-4-biphenylcarbonitrile- 13C6) is the 13C-labeled 4-(4-Hexoxyphenyl)benzonitrile.
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-
- HY-W770294
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3,4,5,6-Tetrabromophthalic acid- 13C6 (Tetrabromophthalic acid- 13C6) is the 13C-labeled 3,4,5,6-Tetrabromophthalic acid (HY-W259069).
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- HY-176177S
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DEKM(Leu- 13C6, 15N)VLWVVALSGISTLFFAA is the 13C- and 15N-labeled DEKMVLWVVALSGISTLFFAA.
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- HY-176178S
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LFVFAVCFSCWV(Leu- 13C6, 15N)PQGQYGR is the 13C- and 15N-labeled LFVFAVCFSCWVPQGQYGR.
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-
- HY-163426S
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AFFGHYLYEVAR-(Arg- 13C6, 15N4) is 13C and 15N labeled AFFGHYLYEVAR-(Arg) .
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- HY-163425S
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AILNYVANK-(Lys- 13C6, 15N2) is 13C and 15N labeled AILNYVANK-(Lys) .
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- HY-163427S
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FNLEALVTHTLPFEK-(Lys- 13C6, 15N2) is 13C and 15N labeled FNLEALVTHTLPFEK-(Lys) .
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-
- HY-W014531S
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2,6-Dichloro-4-nitrophenol-sup>13C6 is the 13C-labeled 2,6-Dichloro-4-nitrophenol.
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- HY-W074977S
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2,6-Dibromo-4-nitrophenol-sup>13C6 is the 13C-labeled 2,6-Dibromo-4-nitrophenol.
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- HY-B1221S1
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Flufenamic acid- 13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca 2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.
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- HY-B0975S
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Penicillin V- 13C6 (potassium) is the 13C6 labeled Penicillin V (potassium). Penicillin V Potassium (Phenoxymethylpenicillin potassium salt) is an orally active antibiotic. Penicillin V Potassium inhibits the growth of Streptococci, C. difficile and S. aureus. Penicillin V Potassium can be used for the research of otitis, sinusitis, pharyngitis and tonsillitis.
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-
- HY-W777581
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4-tert-Octylphenol-diethoxylate- 13C6 is the 13C labeled isotope of 4-tert-Octylphenol-diethoxylate .
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- HY-W778065
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N-(tert-Butoxycarbonyl)aniline- 13C6 is the 13C-labeled tert-Butyl phenylcarbamate (HY-W009968).
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-
- HY-143857S
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22:0 Lyso PC- 13C6 is a 13C-labeled and deuterium labeled 22:0 Lyso PC .
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-
- HY-W585934S
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Fructose-phenylalanine- 13C6 is 13C labeled Fructose-phenylalanine.
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-
- HY-W013186S1
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Lansoprazole sulfide- 13C6 is a deuterated labeled Lansoprazole sulfide .
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-
- HY-N10004S
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Fructose-proline- 13C6 is 13C labeled Fructose-proline.
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-
- HY-W585933S
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Fructose-alanine- 13C6 is 13C labeled Fructose-alanine.
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-
- HY-B0892S3
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Benzyl alcohol- 13C6 is the 13C labeled Benzyl alcohol .
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-
- HY-B0451AS1
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Dopamine- 13C6 (hydrochloride) is the 13C labeled Dopamine hydrochloride (ASL279) .
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-
- HY-W777477
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Homovanillic Acid- 13C6 (Vanilacetic acid- 13C6) is the 13C-labeled Homovanillic acid (HY-N0384). Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
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-
- HY-W770952
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DL-Phenylmercapturic Acid- 13C6 (N-Acetyl-S-phenyl-L-cysteine- 13C6) is the 13C-labeled DL-Phenylmercapturic Acid (HY-W141770). DL-Phenylmercapturic Acid is a cysteine derivative .
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- HY-147551S
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3-Iodo-L-thyronine- 13C6 is the 13C-labeled 3-Iodo-L-thyronine (HY-W588264).
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-
- HY-163992S
-
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VTMTRDTSISTAYMELSR-(Ile-13C6,15N) is the 13C and 15N labeled isotope of VTMTRDTSISTAYMELSR .
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-
- HY-163993S
-
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GMDRWGQGTLVTVSS-(Leu-13C6,15N) is the 13C and 15N labeled isotope of GMDRWGQGTLVTVSS .
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-
- HY-W771072
-
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4-Hydroxybenzenesulfonic Acid- 13C6 is the 13C-labeled 4-Hydroxybenzenesulfonic acid,65+% in water (HY-W016793).
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- HY-N0486S2
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Leucine- 13C6 is the 13C-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .
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-
- HY-W777534
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4-Acetamidobenzene-1-sulfonyl chloride- 13C6 (N-Acetylsulfanilyl chloride- 13C6) is the 13C-labeled 4-Acetamidobenzene-1-sulfonyl chloride (HY-W012207).
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-
- HY-W653994
-
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Ethyl Paraben- 13C6 (Ethyl parahydroxybenzoate- 13C6) is 13C labeled Ethylparaben. Ethylparaben is the ethyl ester of paraben and is used as an antifungal preservative and food additive .
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- HY-18342S1
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Diflunisal- 13C6 (MK-647- 13C6) is 13C labeled Diflunisal. Diflunisal (MK-647) is a salicylate derivative with nonsteroidal anti-inflammatory and uricosuric properties, which is used alone as an analgesic and in rheumatoid arthritis patients. The mechanism of action of diflunisal is as a Cyclooxygenase (COX) Inhibitor.
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-
- HY-N0379S18
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D-mannose- 13C6,d7 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote .
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- HY-113252S1
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2-Methoxyestrone- 13C6 is the 13C-labeled 2-Methoxyestrone. 2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.
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-
- HY-W768246
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Galactose 1-phosphate- 13C6 potassium is the 13C-labeled Galactose 1-phosphate Potassium salt (HY-113143A). Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sugars.
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- HY-N0473S2
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L-Tyrosine- 13C6 is the 13C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
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-
- HY-79131S
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Fmoc-Phe-OH- 13C6 is a 13C-labeled Fmoc-Phe-OH (HY-79131). Fmoc-Phe-OH is a phenylalanine derivative .
|
-
- HY-W749199
-
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2-Ethyl toluene- 13C6 is the 13C-labeled 1-Ethyl-2-methylbenzene (HY-W008826).
|
-
- HY-W749598
-
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N-Methoxy-N-methylnicotinamide- 13C6 (3-Pyridinecarboxamide, N-methoxy-N-methyl- 13C6) is the 13C-labeled N-methoxy-N-methylnicotinamide (HY-W051270).
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-
- HY-76520S
-
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Sitaxsentan- 13C6 (IPI 1040- 13C6) is 13C labeled Sitaxsentan (HY-76520). Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist.
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-
- HY-W009762S
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L-Lysine- 13C6, 15N2 (dihydrochloride) is a 15N-labeled and 13C-labled L-Lysine dihydrochloride .
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-
- HY-B0411S2
-
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Domperidone- 13C6 (R33812- 13C6) is 13C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine .
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-
- HY-B0497S1
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Niclosamide- 13C6 is the 13C6 labeled Niclosamide. Niclosamide (BAY2353) is an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Niclosamide (BAY2353) inhibits STAT3 with IC50 of 0.25 μM in HeLa cells and inhibits DNA replication in a cell-free assay.
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-
- HY-117275S1
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Meclofenamic acid- 13C6 is the 13C6 labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.
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-
- HY-17430S2
-
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Amprenavir- 13C6 (VX-478- 13C6) is 13C labeled Amprenavir. Amprenavir (VX-478) is a HIV protease inhibitor (Ki=0.6 nM) used to treat HIV infection. Amprenavir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 1.09 μM.
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-
- HY-W756637
-
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Ibufenac- 13C6 (Dytransin- 13C6) is the 13C-labeled Ibufenac (HY-W040672). Ibufenac (Dytransin) is an orally active nonsteroidal anti-inflammatory agent. Ibufenac exerts anti-inflammatory, analgesic and antipyretic effects. Ibufenac is being studied for the treatment of rheumatic diseases such as rheumatoid arthritis .
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-
- HY-141919S
-
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1-Bromo-4-iodobenzene- 13C6 is the 13C labeled 1-Bromo-4-iodobenzene .
|
-
- HY-W749645
-
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Acrolein 2,4-Dinitrophenylhydrazone- 13C6 is the 13C-labeled Acrolein 2,4-dinitrophenylhydrazone (HY-W414289).
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-
- HY-W014375S4
-
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Arginine- 13C6, 15N4 hydrochloride is 13C and 15N-labeled Arginine (hydrochloride) (HY-W014375). Arginine hydrochloride is an arginine derivative.
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-
- HY-156343S1
-
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SNNYATHYAESVK-(Lys- 13C6, 15N2) (TFA) is the peptide containing 13C- and 15N-labeled Lys.
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-
- HY-156344S1
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GLEWVAEIR-(Arg- 13C6, 15N4) (TFA) is the peptide containing 13C- and 15N-labeled Arg.
|
-
- HY-P3207S
-
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DLPLTFGGGT-Lys-13C6,15N2 (TFA) is a deuterated labeled DLPLTFGGGTK .
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-
- HY-176032S
-
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GPAAGPQGP-Arg( 13C6, 15N4) TFA is the 13C- and 15N-labeled GPAAGPQGP-Arg TFA.
|
-
- HY-173087S
-
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TPPSSGEPPKSGDR-(Arg- 13C6, 15N4) TFA is a is the 13C- and 15N-labeled TPPSSGEPPKSGDR-(Arg) TFA.
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-
- HY-156341S1
-
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LLIYYTSSLHSGVPSR-(Arg- 13C6, 15N4) (TFA) is the peptide containing 13C- and 15N-labeled Arg.
|
-
- HY-156345S1
-
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LPFTFGQGTK-(Lys- 13C6, 15N2) TFA is the peptide containing 13C- and 15N-labeled Lys.
|
-
- HY-173085S
-
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|
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TPPSSGEPPK-(Lys- 13C6, 15N2) TFA is the 13C- and 15N-labeled TPPSSGEPPK-(Lys) TFA.
|
-
- HY-173086S
-
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|
|
TPSLPTPPTR-(Arg- 13C6, 15N4) TFA is the 13C- and 15N-labeled TPSLPTPPTR-(Arg) TFA.
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-
- HY-W585890S
-
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|
Benzo[pqr]tetraphen-3-ol- 13C6 is 13C labeled Benzo[pqr]tetraphen-3-ol.
|
-
- HY-W007318S
-
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2-Iodoaniline- 13C6 is the 13C labeled 2-Iodoaniline .
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-
- HY-115584S
-
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Lufenuron- 13C6 is a 13C-labeled Lufenuron. Lufenuron is a lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods .
|
-
- HY-W777496
-
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Saccharin- 13C6 is the 13C-labeled Saccharin (HY-Y0272). Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties .
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-
- HY-12767S2
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Carvedilol metabolite 4-Hydroxyphenyl Carvedilol- 13C6 (4-Hydroxycarvedilol Carvedilol- 13C6) is 13C labeled Carvedilol metabolite 4-Hydroxyphenyl Carvedilol.
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-
- HY-W092298S
-
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Methyl 4-(2-hydroxyethyl)benzoate- 13C6,d2 is 13C and deuterated labeled Methyl 4-(2-hydroxyethyl)benzoate (HY-W092298).
|
-
- HY-137222S
-
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4',5-Dihydroxy Diclofenac-13C6 is a deuterated derivative of Diclofenac (HY-15036). Diclofenac is a potent COX inhibitor with anti-inflammatory activity .
|
-
- HY-B0149S2
-
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Tranexamic acid- 13C6 (Cyclocapron- 13C6) is 13C labeled Tranexamic acid. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .
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-
- HY-13017S4
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Ivacaftor- 13C6 (VX-770- 13C6) is 13C labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.
|
-
- HY-17376S3
-
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Ezetimibe- 13C6 (SCH 58235- 13C6) is the 13C-labeled Ezetimibe (HY-17376). Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
|
-
- HY-W770721
-
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Phenylboronic acid- 13C6 is the 13C-labeled Phenylboronic acid (HY-W001090). Phenylboronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-113283S
-
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Homogentisic acid- 13C6 is the 13C-labeled Homogentisic acid (HY-113283). Homogentisic acid is a specific metabolite that accumulates in the urine and serum. Homogentisic acid can be used for diagnosis of alkaptonuria. Homogentisic acid is a phenolic acid .
|
-
- HY-B2236S1
-
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|
DL-Lysine- 13C6 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6 hydrochloride) is 13C-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
|
-
- HY-W770295
-
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|
2,3,4,5-Tetrabromobenzoic acid- 13C6 is 13C labeled 2,3,4,5-Tetrabromobenzoic acid .
|
-
- HY-128417S5
-
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|
|
alpha-D-glucose- 13C6,d7 is deuterium and 13C-labeled alpha-D-glucose (HY-128417). alpha-D-glucose is an endogenous metabolite.
|
-
- HY-150012S1
-
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N-Lactoyl-Phenylalanine- 13C6 (Lac-Phe- 13C6) is 13C labeled N-Lactoyl-Phenylalanine. N-Lactoyl-Phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-Phenylalanine can reduce obesity and improve glucose tolerance .
|
-
- HY-W018386S
-
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3-?Bromo-?L-?tyrosine- 13C6 (3-Bromo-Tyr- 13C6) is a 13C-labeled 3-?Bromo-?L-?tyrosine (HY-W018386). 3- Bromo- L- tyrosine (3-Bromo-Tyr) is a tyrosine derivative .
|
-
- HY-W778173
-
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2-Benzyloxy-benzoic Acid Benzyl Ester- 13C6 is the 13C-labeled Benzyl 2-(benzyloxy)benzoate (HY-W702475).
|
-
- HY-17043S3
-
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Loratadine- 13C6 (SCH 29851- 13C6) is 13C labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
|
-
- HY-15388S2
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Tazarotene- 13C6 (AGN 190168- 13C6) is 13C labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W749012
-
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(2,4,6-Trichlorophenoxy)acetic acid- 13C6 is the 13C labeled isotope of (2,4,6-Trichlorophenoxy)acetic acid .
|
-
- HY-173100S
-
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GIFP(Leu- 13C6, 15N)AER TFA is the 13C- and 15N-labeled GIFP(Leu)AER TFA.
|
-
- HY-173099S
-
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GNSP(Ile- 13C6, 15N)SQR TFA is the 13C- and 15N-labeled GNSP(Ile)SQR TFA.
|
-
- HY-173106S
-
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YTASD(Leu- 13C6, 15N)FR TFA is the 13C- and 15N-labeled YTASD(Leu)FR TFA.
|
-
- HY-173101S
-
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GHFP(Leu- 13C6, 15N)AER TFA is the 13C- and 15N-labeled GHFP(Leu)AER TFA.
|
-
- HY-173104S
-
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SLPAS(Leu- 13C6, 15N)QR TFA is the 13C- and 15N-labeled SLPAS(Leu)QR TFA.
|
-
- HY-173098S
-
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YLPNPA(Leu- 13C6, 15N)QR TFA is the 13C- and 15N-labeled YLPNPA(Leu)QR TFA.
|
-
- HY-W768181
-
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1,5-Anhydrosorbitol- 13C6 (1,5-Anhydro-D-glucitol- 13C6) is the 13C-labeled 1,5-Anhydrosorbitol (HY-113075). 1,5-Anhydrosorbitol is a short-term marker for glycemic control.
|
-
- HY-W018587S
-
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Bis(2-Ethylhexyl)-tetrabromo phthalate- 13C6,d34 is 13C labeled Bis(2-ethylhexyl) 3,4,5,6-tetrabromophthalate .
|
-
- HY-144085S
-
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|
D-Fructose-6-phosphate- 13C6 disodium x.hydrate is a 13C-labeled D-Fructose-6-phosphate disodium x.hydrate .
|
-
- HY-A0070AS2
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Liothyronine- 13C6-1 is a 13C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively .
|
-
- HY-N0771S9
-
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L-Isoleucine- 13C6, 15N is 13C and 15N labeled L-isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid . L-Isoleucine is an essential amino acid.
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-
- HY-128417S4
-
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|
alpha-D-glucose- 13C6 is 13C-labeled alpha-D-glucose (HY-128417). alpha-D-glucose is an endogenous metabolite.
|
-
- HY-141939S
-
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Triiodothyronine- 13C6 (hydrochloride) is the 13C labeled Triiodothyronine .
|
-
- HY-B0213S1
-
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Sulfameter- 13C6 (Sulfametoxydiazine- 13C6) is the 13C6 labeled Sulfameter (HY-B0213). Sulfameter (Sulfametoxydiazine) is an orally active long-acting sulfonamide antibiotic. Sulfameter is active against both Gram-positive and Gram-negative bacteria. Sulfameter can be used for the research of diseases such as respiratory and urinary tract infections .
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-
- HY-17007S2
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Saquinavir- 13C6 (Ro 31-8959- 13C6) is 13C labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells .
|
-
- HY-W753370
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2,4,5-Trichloronitrobenzene- 13C6 (Benzene, 1,2,4-trichloro-5-nitro- 13C6) is the 13C-labeled 2,4,5-Trichloronitrobenzene (HY-W142633).
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-
- HY-B0363S1
-
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Nimesulide- 13C6 (R805- 13C6) is 13C labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.
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-
- HY-B0083S1
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Leflunomide- 13C6 (HWA486- 13C6) is 13C labeled Leflunomide. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.
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-
- HY-W010696AS
-
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Reverse T3- 13C6 (hydrochloride) is the 13C labeled Reverse T3 .
|
-
- HY-W770176
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2-Benzyl-5-chlorobenzaldehyde- 13C6 is the 13C-labeled 2-Benzyl-5-chlorobenzaldehyde (HY-W332685).
|
-
- HY-P5190S
-
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|
RQIK-(Lys-fructosyl)-QTA-(Leu- 13C6, 15N)-VE is the 13C and 15N labeled compound .
|
-
- HY-W777334
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2,5-Dioxopyrrolidin-1-yl nicotinate- 13C6,d4 is the deuterium and 13C labeled 2,5-Dioxopyrrolidin-1-yl nicotinate.
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-
- HY-158992S
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SP-(Val- 13C5, 15)-EKNQ-(Leu- 13C6, 15)-TIDFINIVKDPVPHNEYKT TFA is a 13C- and 15N-labeled peptide containing 13C5, 15N-labeled valine (Val) and 13C6, 15N-labeled leucine (Leu).
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-
- HY-P1032S2
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Angiotensin I-13C6,15N (human, mouse, rat) TFA is 13C and 15N labeled Angiotensin I (human, mouse, rat) TFA. Angiotensin I-13C6,15N (human, mouse, rat) TFA is a precursor of angiotensin II and is cleaved into angiotensin II by angiotensin converting enzyme (ACE) .
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-
- HY-137912S1
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Resveratrol-3-O-beta-D-glucuronide- 13C6 is deuterium labeled trans-Resveratrol-3-O-β-D-Glucuronide.
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-
- HY-B0335S1
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Tolfenamic acid- 13C6 is the 13C6 labeled Tolfenamic acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
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-
- HY-W748688
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N4-Acetylsulfamethoxazole- 13C6 (Acetylsulfamethoxazole- 13C6) is the 13C-labeled N4-Acetylsulfamethoxazole (HY-W013266). N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of?Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections .
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-
- HY-17498S3
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Atenolol- 13C6 ((RS)-Atenolol- 13C6) is 13C labeled Atenolol. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a Ki of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .
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-
- HY-B0512S1
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Sulfamerazine- 13C6 (RP2632- 13C6) is 13C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP-2632) is a sulfonamide antibacterial. Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.
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-
- HY-B0227S3
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Ketoprofen- 13C6 (RP-19583- 13C6) is 13C labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .
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-
- HY-12726S
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Liproxstatin-1- 13C6 is the 13C labled Liproxstatin-1 (HY-12726). Liproxstatin-1 is a potent ferroptosis inhibitor and inhibits ferroptotic cell death (IC50=22 nM) .
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-
- HY-N0216S1
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Benzoic acid- 13C6 is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi.
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-
- HY-W145482S1
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3-O-Methyl-D-glucopyranose- 13C6 is 13C-labeled 3-O-Methyl-D-glucopyranose (HY-W145482) .
|
-
- HY-W777823
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N-(a,a-Dimethylbenzyl)benzenesulfonamide- 13C6 is the 13C-labeled N-(2-Phenylpropan-2-yl)benzenesulfonamide (HY-W701611).
|
-
- HY-W768912
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Paclitaxel- 13C6 is the 13C-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes?tubulin?polymerization. Paclitaxel can cause both mitotic arrest and?apoptotic?cell death. Paclitaxel also induces?autophagy .
|
-
- HY-152039S1
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6PPD-quinone- 13C6 is the 13C labeled 6PPD-quinone .
|
-
- HY-W750399
-
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4,5,6,7-Tetrabromoisobenzofuran-1,3-dione- 13C6 (Tetrabromophthalic anhydride- 13C6) is the 13C-labeled 4,5,6,7-Tetrabromoisobenzofuran-1,3-dione (HY-W010833).
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-
- HY-18341S4
-
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L-Thyroxine- 13C6-1 (Levothyroxine- 13C6-1; T4- 13C6-1) is a 13C labeled L-Thyroxine (HY-18341). L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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-
- HY-B0337S2
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Sulfadimethoxine- 13C6 is the 13C-labeled Sulfadimethoxine. Sulfadimethoxine (Sulphadimethoxine) is a sulfonamide antibiotic used to treat many infections .
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-
- HY-W337886S
-
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2-Ethylhexyl 2,3,4,5-tetrabromobenzoate- 13C6,d17 is 13C labeled 2-Ethylhexyl 2,3,4,5-tetrabromobenzoate .
|
-
- HY-W104549S
-
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|
|
3,6-Dichloro-2-hydroxybenzoic acid- 13C6 is the 13C labeled 3,6-Dichloro-2-hydroxybenzoic acid .
|
-
- HY-158994S
-
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MEGDSRGG-(Ala- 13C3, 15N)-GGEA-(Leu- 13C6, 15N)-DPESAASSLSGAS TFA is a 13C- and 15N-labeled peptide containing 13C3, 15N-labeled alanine (Ala) and 13C6, 15N-labeled leucine (Leu).
|
-
- HY-Y0051S
-
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5-Hydroxymethylfurfural- 13C6 (2-Hydroxymethyl-5-furfural- 13C6; 2-Formyl-5-hydroxymethylfuran- 13C6) is a 13C labeled 5-Hydroxymethylfurfural (HY-Y0051). 5-Hydroxymethylfurfural (2-Hydroxymethyl-5-furfural), derived from Cornus officinalis, inhibits yeast growth and fermentation as stressors.
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-
- HY-N0469S1
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L-Lysine- 13C6 (dihydrochloride) is the 13C-labeled L-Lysine dihydrochloride. L-lysine dihydrochloride is an essential amino acid with important roles in connective tissues and carnitine synthesis, energy production, growth in children, and maintenance of immune functions .
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-
- HY-W739894S
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Diclofenac metabolite- 13C6 is the 13C-labeled 1-(2,6-Dichloro-4-hydroxphenyl)-1,3-dihydroindol-2-one (HY-W739894).
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-
- HY-143679S
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4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate-13C6 is the 13C labeled isotope of 4-(3',6'-Dimethyl-3'-heptyl)phenol diethoxylate .
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-
- HY-10450S3
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Dapagliflozin- 13C6 (BMS-512148- 13C6) is 13C labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .
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-
- HY-14397S3
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Indomethacin- 13C6 (Indometacin- 13C6) is 13C labeled Indomethacin. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research .
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-
- HY-B0637S2
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Bezafibrate- 13C6 (BM15075- 13C6) is 13C labeled Bezafibrate. Bezafibrate is an agonist of PPAR, with EC50s of 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, and 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, respectively; Bezafibrate is used as an hypolipidemic agent.
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-
- HY-W017522S1
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Adipic acid- 13C6 (Hexanedioic acid- 13C6) is the 13C labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc .
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-
- HY-W768262
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D-(+)-Glucono-1,5-lactone- 13C6 (Gluconic acid lactone- 13C6) is the 13C-labeled D-(+)-Glucono-1,5-lactone (HY-I0301). D-(+)-Glucono-1,5-lactone is a polyhydroxy (PHA) that is capable of metal chelating, moisturizing and antioxidant activity.
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-
- HY-P5190S1
-
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RQIK-(Lys-fructosyl)-QTA-(Leu- 13C6, 15N)-VE TFA is the 13C and 15N labeled compound .
|
-
- HY-N0486S8
-
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L-Leucine- 13C6, 15N is the 13C- and 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway .
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-
- HY-159192S
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SADDNIKTPAE(Arg- 13C6, 15N4)LLGPLPPSADDNLKT (TFA) is the 13C and 15N labeled isotope of SADDNIKTPAE-LLGPLPPSADDNLKT (TFA) .
|
-
- HY-P4596S
-
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H-Gly-Arg-OH (Arg- 13C6, 15N4) is the deuterium labeled H-Gly-Arg-OH (HY-P4596) .
|
-
- HY-108226S1
-
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Regorafenib N-oxide and N-desmethyl (M5)- 13C6 is the 13C-labeled Regorafenib N-oxide and N-desmethyl (M5) .
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-
- HY-173088S
-
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IPAK(pT)PPAPK-(Lys- 13C6, 15N2) TFA is the 13C- and 15N-labeled IPAK(pT)PPAPK-(Lys) TFA.
|
-
- HY-W768211
-
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2-Deoxy-2-fluoro-D-glucose- 13C6 is the 13C-labeled 2-Deoxy-2-fluoro-D-glucose.
|
-
- HY-W009597S
-
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1,5-Dichloro-2,4-dinitrobenzene- 13C6 is the 13C labeled 1,5-Dichloro-2,4-dinitrobenzene .
|
-
- HY-W753344
-
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2-(2,6-Dichlorophenoxy)-N-phenylacetamide- 13C6 is the 13C-labeled 2-(2,6-Dichlorophenoxy)-N-phenylacetamide (HY-W713396).
|
-
- HY-W751537
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4-[[(4-Fluorophenyl)imino]methyl]phenol- 13C6 (4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol- 13C6) is the 13C-labeled 4-[[(4-Fluorophenyl)imino]methyl]phenol (HY-W014178).
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-
- HY-10999S1
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Trametinib- 13C6 is the 13C-labeled Trametinib. Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib activates autophagy and induces apoptosis .
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-
- HY-100532S
-
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CD437- 13C6 is the 13C- and deuterium labeled CD437. CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.
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- HY-66005S3
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Acetaminophen-13C6 (Paracetamol-13C6) is the 13C-labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent . Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .
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- HY-14894S2
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Pragliflozin- 13C6 (ASP1941- 13C6) is 13C labeled Ipragliflozin. Ipragliflozin (ASP1941) is an orally active and selective SGLT2 inhibitor with IC50s of 7.38 and 1876 nM, 6.73 and 1166 nM, 5.64 and 1380 nM for human SGLT2 and SGLT1, rat SGLT2 and SGLT1, mouse SGLT2 and SGLT1, respectively. Antidiabetic agent .
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- HY-N0470S8
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L-Lysine- 13C6 hydrochloride is the 13C labeled L-Lysine hydrochloride . L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health .
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- HY-B0221S
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Amphotericin B- 13C6 is 13C labeled Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
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- HY-W777456
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Phenanthrene- 13C6 is the 13C labeled Phenanthrene (HY-B1727). Phenanthrene is an orally active polycyclic aromatic hydrocarbon (PAH) that induces inflammation, oxidative stress, and apoptosis. Additionally, phenanthrene is commonly used to detect or assess PAH pollution in the environment .
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- HY-W754982
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N-Cyclohexyl-1,3-benzothiazol-2-amine- 13C6 (N-Cyclohexylbenzothiazole-2-amine- 13C6) is the 13C-labeled N-Cyclohexyl-1,3-benzothiazol-2-amine (HY-W200757).
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- HY-113248S1
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3-Nitro-L-tyrosine- 13C6 is the 13C labeled 3-Nitro-L-tyrosine . 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions .
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- HY-138622S
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24:0 Lyso PC- 13C6 is the 13C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP). 24:0 Lyso PC could be used for mRNA drug delivery .
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- HY-W777439
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4-Chloro-6-nitrosoresorcinol- 13C6 is the 13C-labeled 4-Chloro-6-nitrosobenzene-1,3-diol (HY-W699627).
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- HY-N7092S
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D-Fructose- 13C6 is the 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants.
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- HY-14171S2
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Bexarotene- 13C6 (LGD1069- 13C6) is 13C labeled Bexarotene. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
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- HY-15037S2
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Diclofenac- 13C6 (Sodium) is the 13C6 labeled Diclofenac (Sodium). Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.
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- HY-101277S1
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Vadadustat- 13C6 (PG-1016548- 13C6) is 13C labeled Vadadustat. Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .
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- HY-W777546
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(5-Formylfuran-2-yl)methyl acetate- 13C6 (Acetic Acid 5-Formylfurfuryl Ester- 13C6) is the 13C-labeled (5-Formylfuran-2-yl)methyl acetate (HY-W111899).
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- HY-143876S
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L-Argininosuccinic acid- 13C6, 15N4 (barium, dihydrate) is a 15N-labeled and 13C-labled labeled L-Argininosuccinic acid (barium, dihydrate) .
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- HY-W014375S1
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Arginine- 13C6, 15N4,d7 hydrochloride is 13C and 15N-labeled Arginine (hydrochloride) (HY-W014375). Arginine hydrochloride is an arginine derivative.
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- HY-W768295
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D-Lactose monohydrate- 13C6 is the 13C-labeled D-Lactose (hydrate) (HY-W115740). D-Lactose monohydrate is a type of lactose. D-Lactose is composed of D-galactose and D-glucose. D-Lactose monohydrate can be used as sweetener or excipient .
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- HY-P4596S1
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H-Gly-Arg-OH (Arg- 13C6, 15N4) TFA is the deuterium labeled H-Gly-Arg-OH (HY-P4596) .
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- HY-12857S
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Brigatinib- 13C6 is the 13C-labeled Brigatinib. Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor, with an IC50 of 0.6 nM .
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- HY-124489S
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2-Hydroxyestradiol- 13C6 is the 13C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .
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- HY-15284S3
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Prasugrel-13C6 is a deuterated labeled Prasugrel . Prasugrel (PCR 4099), a thienopyridine and proagent, inhibits platelet function. Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation .
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- HY-78131S3
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Ibuprofen- 13C6 ((±)-Ibuprofen- 13C6) is a 13C labeled Ibuprofen (HY-78131). Ibuprofen ((±)-Ibuprofen) is a potent, orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen ((±)-Ibuprofen) can be used in the research of pain, swelling, inflammation, infection, immunology, cancers .
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- HY-B0947S1
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Sulfanitran- 13C6 is the 13C labeled Sulfanitran. Sulfanitran is an antibacterial and anticoccidial agent used in poultry feeds. Sulfanitran also is a multidrug resistance protein 2 (MRP2) stimulator that can increase the affinity of MRP2 for estradiol-17-β-D-glucuronide (E217βG).
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- HY-B0843S
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Metalaxyl- 13C6 is the 13C-labeled Metalaxyl. Metalaxyl is a fungicide that inhibits protein synthesis in fungi. Metalaxyl inhibits the growth of potato blight (P. infestans) fungal isolates from Serbian potato fields (EC50s=0.3-3.9 μg/mL).
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- HY-W014632S
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4-Trifluoromethylsalicylic acid- 13C6 is the 13C labeled 4-Trifluoromethylsalicylic acid . 4-Trifluoromethylsalicylic acid is a platelet aggregation inhibitor .
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- HY-W654082
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Bisphenol e- 13C6 is 13C labeled Bisphenol E. Bisphenol E (4,4'-Ethylidenediphenol) is a biochemical reagent .
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- HY-W751526
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N4-Acetylsulfamethazine- 13C6 (Sulfamethazine-n4-acetyl- 13C6) is the 13C-labeled N4-Acetylsulfamethazine (HY-W290839). N4-Acetylsulfamethazine is a metabolite of Sulfamethazine (HY-B0035). Sulfamethazine is one of the most frequently used sulfonamides in the poultry farming industry .
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- HY-W008614S1
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Lansoprazole sulfone- 13C6 (AG-1813- 13C6) is 13C labeled Lansoprazole sulfone. Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H +, K +-ATPase. Lansoprazole sulfone can significantly stimulates gastric acid secretion by inhibiting H +, K +-ATPase. Lansoprazole sulfone has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .
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- HY-B0322S1
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Sulfamethoxazole- 13C6 (Ro 4-2130- 13C6) is a 13C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .
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- HY-N0832S1A
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L-Histidine- 13C6, 15N3 hydrochloride is the 13C and 15N labled L-Histidine (HY-N0832). L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.
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- HY-W747264
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P-Hydroxybenzaldehyde- 13C6 is the 13C-labeled p-Hydroxybenzaldehyde (HY-Y0313). p-Hydroxybenzaldehyde is a one of the major components in vanilla aroma, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations.
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- HY-B0574S2
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Mefenamic acid- 13C6 is the 13C-labeled Mefenamic acid. Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.
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- HY-173091S
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pyroE-QEAVEGGC(Cam)SHLGQSYADR-(Arg- 13C6, 15N4) TFA is the 13C- and 15N-labeled pyroE-QEAVEGGC(Cam)SHLGQSYADR-(Arg) TFA.
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- HY-W007527S
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4-Bromo-2-chlorophenol- 13C6 (4-Bromo-2-Chloro Phenol- 13C6) is the 13C-labeled 4-Bromo-2-chlorophenol (HY-W007527).
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- HY-W779345
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3,3',5'-Triiodo-L-thyronine- 13C6 is 13C labeled 3,3',5'-Triiodo-L-thyronine .
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- HY-N7092S13
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D-Fructose- 13C6,d7 is the deuterium and 13C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants .
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- HY-N7106S2
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Dimethyl phthalate- 13C6,d4 (DMP- 13C6,d4) is the deuterium labeled and 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .
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- HY-W747703
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Hippuric acid- 13C6 (Benzoylglycine- 13C6) is 13C labeled Hippuric acid. Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research .
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- HY-A0067S1
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Oxybenzone- 13C6 (Benzophenone 3- 13C6) is the 13C-labeled Oxybenzone (HY-A0067). Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells .
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- HY-N7106S3
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Dimethyl phthalate- 13C6 (DMP- 13C6) is the 13C-labeled Dimethyl phthalate (HY-N7106). Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats .
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- HY-17453S1
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Salmeterol- 13C6 (xinafoate) is the 13C6 labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.
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- HY-N0771S5
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L-Isoleucine- 13C6, 15N,d10 is the deuterium, 13C-, and 15-labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid . L-Isoleucine is an essential amino acid.
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- HY-N0349S1
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Methyl Paraben- 13C6 (Methyl 4-hydroxybenzoate- 13C6) is a 13C labeled Methyl Paraben (HY-N0349) . Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, agents and cosmetics. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity .
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- HY-W748541
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N6-[(Benzylamino)carbonothioyl]lysine- 13C6, 15N2 is the 13C- and 15N-labeled N6-[(Benzylamino)carbonothioyl]lysine.
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- HY-W748540
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N6-[(Allylamino]carbonothioyl]lysine- 13C6, 15N2 is the 13C- and 15N-labeled N6-[(Allylamino]carbonothioyl]lysine.
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- HY-N0832S1
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L-Histidine- 13C6, 15N3 is 13C and 15N-labeled L-Histidine (HY-N0832). L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport.
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- HY-18341S2
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L-Thyroxine- 13C6 is the 13C labeled L-Thyroxine . L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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- HY-17356S2
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Fenofibrate-13C6 is a deuterated labeled Fenofibrate . Fenofibrate is a selective PPARα agonist with an EC50 of 30 μM. Fenofibrate also inhibits human cytochrome P450 isoforms, with IC50s of 0.2, 0.7, 9.7, 4.8 and 142.1 μM for CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4, respectively.
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- HY-W017387S2
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Sodium α-ketoisocaproic acid- 13C6 is the 13C labeled Sodium α-ketoisocaproic acid .
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- HY-Y0589S
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m-Cyanobenzoic acid- 13C6 is the 13C labeled m-Cyanobenzoic acid .
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- HY-W778171
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2-Benzyloxy-5-nitro-benzoic Acid Benzyl Ester- 13C6 is the 13C-labeled Benzyl 2-(benzyloxy)-5-nitrobenzoate (HY-W702473).
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- HY-W778172
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2-Benzyloxy-3-nitro-benzoic Acid Benzyl Ester- 13C6 is the 13C-labeled Benzyl 2-(benzyloxy)-3-nitrobenzoate (HY-W702474).
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- HY-15206S2
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Glibenclamide- 13C6 (Glyburide- 13C6) is 13C labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K + channel (KATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .
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- HY-W766388
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2-Amino-2-deoxyglucose hydrochloride- 13C6 (D-Glucosamine Hydrochloride- 13C6) is the 13C-labeled 2-Amino-2-deoxyglucose hydrochloride (HY-N9459). 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .
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- HY-B0143S3
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Niacin- 13C6 is the 13C-labeled Niacin. Niacin (Nicotinic acid) is a vitamin and is part of the vitamin B group.
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- HY-B1125S
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Glucosamine- 13C6 (D-Glucosamine- 13C6) is 13C labeled Glucosamine. Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .
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- HY-B0389A
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Maximum Cited Publications
8 Publications Verification
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D-Glucose- 13C6 is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose- 13C6 can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard .
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- HY-P0014S2
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Liraglutide- 13C6, 15N (TFA)is the 13C and 15N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus .
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- HY-112537S1
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D-Glucose 6-Phosphate- 13C6 disodium xhydrate is the 13C labeled D-Glucose 6-phosphate (HY-112537) . D-Glucose 6-phosphate is a glucose sugar phosphorylated at the hydroxy group on carbon 6 .
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- HY-22306S
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β-D-Glucose pentaacetate- 13C6 is the 13C labeled β-D-Glucose pentaacetate[1]. β-D-Glucose Pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is used in biochemical reaction.
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- HY-W766332
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7-Hydroxy coumarin glucuronide sodium- 13C6 is the 13C-labeled 7-Hydroxy coumarin glucuronide sodium (HY-120201). 7-Hydroxy coumarin glucuronide sodium is a benzopyrone and a metabolite of 7-hydroxy coumarin .
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- HY-B0122S
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Topiramate-13C6 (McN 4853-13C6) is the 13C labeled isotope of Topiramate (HY-B0122). Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase .
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- HY-W749377
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1,2,3,4,5-Pentabromo-6-methylbenzene- 13C6 (Toluene, 2,3,4,5,6-pentabromo- 13C6) is the 13C-labeled 1,2,3,4,5-Pentabromo-6-methylbenzene (HY-W274110).
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- HY-W752253
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N-2-Naphthalenyl-N-phenyl-2-naphthalenamine- 13C6 is the 13C-labeled N-2-Naphthalenyl-N-phenyl-2-naphthalenamine.
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- HY-W751181
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O-Desmethyl midostaurin- 13C6 (CGP62221- 13C6; O-Desmethyl PKC412- 13C6) is the 13C-labeled O-Desmethyl Midostaurin (HY-129491). O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo . Midostaurin is a multi-targeted protein kinase inhibitor?with?IC50?ranging from 22-500 nM.
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- HY-W008125S
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Acetobromo-a-D-glucuronic acid- 13C6 methyl ester (Methyl acetobromo-α-D-glucuronate- 13C6 methyl ester) is 13C labeled Acetobromo-α-D-glucuronic acid methyl ester, 98%. Acetobromo-α-D-glucuronic acid methyl ester, 98% (Acetobromo-alpha-D-glucuronic acid methyl ester, 98%) can be used in glycobiology research and can undergo glycosylation reactions with suitable glycoside receptors.
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- HY-B0389S
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D-Glucose- 13C6,d7 is the deuterium and 13C labeled D-Glucose .
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- HY-W041171S
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3-Chloro-L-tyrosine- 13C6 is the 13C labeled 3-Chloro-L-tyrosine . 3-Chloro-L-tyrosine is a specific marker of myeloperoxidase-catalyzed oxidation, and is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima .
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- HY-B2236S2
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DL-Lysine- 13C6, 15N2 hydrochloride ((±)-2,6-Diaminocaproic acid- 13C6, 15N2 hydrochloride) is 13C and 15N-labeled DL-Lysine (HY-B2236). DL-Lysine is a racemic mixture of the D-Lysine and L-Lysine. Lysine is an α-amino acid that is used in the biosynthesis of proteins.
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- HY-W014423S2
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L-Histidine- 13C6 (hydrochloride hydrate) is the 13C-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
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- HY-B1456AS
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Fenoprofen- 13C6 (LILLY-53858- 13C6) sodium hydrate is the 13C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .
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- HY-P3146S
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FTISADTSK- 13C6, 15N2 TFA is 13C- and 15N-labeled FTISADTSK (HY-P3146). FTISADTSK is an endogenous stable signature peptide from Trastuzumab monitored by selected reaction monitoring (SRM) .
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- HY-W778240
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2-Naphthoic acid- 13C6 (Naphthalene-2-carboxylic acid- 13C6) is the 13C-labeled 2-Naphthoic acid (HY-W007437). 2-Naphthoic acid is an organic compound commonly used as a raw material for dyes and the production of other chemicals. It can form dyes with other organic substances and is widely used in textile, printing and manufacturing fields. In addition, the compound is also used as a photosensitive material and a lubricant.
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- HY-B0190S1
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Nafamostat formate salt- 13C6 is the 13C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2 .
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- HY-W777440
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4-Chloro resorcinol- 13C6 is the 13C-labeled 4-Chlororesorcinol (HY-W015658). 4-Chlorobenzene-1,3-diol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-173089S
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TPSLP(pT)PP(pT)REPK-(Lys- 13C6, 15N2) TFA is the 13C- and 15N-labeled TPSLP(pT)PP(pT)REPK-(Lys) TFA.
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- HY-173090S
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VAVVR(pT)PPK(pS)PSSAK-(Lys- 13C6, 15N2) TFA is the 13C- and 15N-labeled VAVVR(pT)PPK(pS)PSSAK-(Lys) TFA.
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- HY-B1409S
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Isosorbide dinitrate- 13C6 is the 13C labeled Isosorbide dinitrate . Isosorbide dinitrate (ISDN) is an NO donor that prevents LV remodeling and degradation of cardiac function following myocardial infarction (MI) .
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- HY-Y0721S
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3-Bromofluorobenzene- 13C6 is the 13C labeled 3-Bromofluorobenzene .
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- HY-N0210S16
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D-Galactose- 13C6 is the C13 labeled D-Galactose (HY-N0210). D-Galactose is a natural aldohexose and C-4 epimer of glucose .
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- HY-W749528
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3-Deoxyglucosone- 13C6 is the 13C-labeled (5s,6r)-2,5-dihydroxy-6-(hydroxymethyl)dihydro-2h-pyran-3(4h)-one (HY-W759076).
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- HY-12008S1
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Erlotinib- 13C6 hydrochloride is the 13C labeled Erlotinib Hydrochloride . Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM . Erlotinib- 13C6 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-13443S
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Exendin-4 (Leu- 13C6, 15N) (Exenatide (Leu- 13C6, 15N)) TFA is the 13C- and 15N-labeled Exendin-4 TFA (HY-13443). Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM .
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- HY-N1380S2
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Guaiacol- 13C6 is the 13C labeled Guaiacol . Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation . Anti-inflammatory activity .
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- HY-B0580S2
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Ketorolac- 13C6 (RS37619- 13C6) is 13C labeled Ketorolac. Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research .
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- HY-A0132S12
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N-Acetyl-D-glucosamine- 13C6 (N-Acetyl-2-amino-2-deoxy-D-glucose- 13C6) is the 13C labled N-Acetyl-D-glucosamine (HY-A0132) . N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose) is a monosaccharide derivative of glucose.
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- HY-W011577S1
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Dibenzo[a,c]anthracene- 13C6 (2,3-Benzotriphenylene- 13C6) is 13C labeled Benzo[f]tetraphene. Benzo[f]tetraphene (Dibenz[a,c]anthracene) is a polycyclic aromatic hydrocarbon with significant antitumor activity. Benzo[f]tetraphene is used as a luminescent probe in cell biology research and can effectively detect reactive oxygen species in biological systems. Benzo[f]tetraphene can also be used as a potential photosensitizer and shows good application prospects in photodynamic inhibition.
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- HY-W751180
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3-Hydroxy Midostaurin- 13C6 (CGP52421- 13C6) is the 13C-labeled 3-Hydroxy Midostaurin (HY-108263). 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .
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- HY-W754216
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Diacetone-β-D-fructose- 13C6 (2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose- 13C6) is the 13C-labeled Diacetone-β-D-fructose (HY-W011792). Diacetone-β-D-fructose is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-P0090S
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Calcitonin- 13C6, 15N4 (salmon) (Salmon calcitonin- 13C6, 15N4) TFA is 13C and 15N-labeled Calcitonin (salmon) (HY-P0090). Calcitonin (salmon) , a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption .
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- HY-N0470S3
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L-Lysine- 13C6, 15N2 (hydrochloride) is the 13C- and 15N-labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
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- HY-113251S1
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2-Hydroxyestrone- 13C6 is the 13C-labeled 2-Hydroxyestrone. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic .
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- HY-137522AS1
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Zidovudine Glucuronide- 13C6 (3'-Azido-3'-deoxythymidine β-D-glucuronide- 13C6) is 13C labeled Zidovudine O-β-D-glucuronide. Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection .
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- HY-P5168S
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GPSVFPLAPSSK- 13C6, 15N2 is the 13C- and 15N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .
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- HY-W721295S
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N-(1-Deoxy-D-fructos-1-yl)-L-methionine- 13C6 is 13C labeled N-(1-Deoxy-D-fructos-1-yl)-L-methionine.
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- HY-W793608S
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N-(1-Deoxy-D-fructos-1-yl)-L-asparagine- 13C6 is 13C labeled N-(1-Deoxy-D-fructos-1-yl)-L-asparagine.
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- HY-79128S1
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Fmoc-L-Lys (Boc)-OH- 13C6, 15N2 is a 15N-labeled and 13C-labled Fmoc-L-Lys (Boc)-OH (HY-79128). Fmoc-L-Lys (Boc)-OH is a lysine derivative .
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- HY-N0455AS6
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L-Arginine- 13C6 (hydrochloride) is the 13C-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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- HY-P5201S
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VTSEGAGLQLQK- 13C6, 15N2 is the 13C and 15N labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA). VTSEGAGLQLQK can be used to bind anti-drug antibodies (ADA) in plasma and quantitatively analyze the therapeutic effect .
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- HY-101064S1
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Fmoc-leucine- 13C6, 15N is a 15N-labeled and 13C-labled Fmoc-leucine. Fmoc-leucine is a selective PPARγ modulator. Fmoc-leucine activates PPARγ with a lower potency but a similar maximal efficacy than rosiglitazone. Fmoc-leucine improves insulin sensitivity
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- HY-Y1636S1
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Fmoc-Arg(Pbf)-OH- 13C6 is the 13C labeled Fmoc-Arg(Pbf)-OH . Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
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- HY-W777928
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Cyclohexane-1,3-dione- 13C6 is the 13C-labeled Cyclohexane-1,3-dione (HY-W007466). Cyclohexane-1,3-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-W101298S
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(Leu-13C6,15N)-Ile-OH (L-Leucyl-13C6,15N-L-isoleucine) TFA is the deuterium labeled Leu-Ile-OH. Leu-Ile-OH protects against neuronal death by inducing brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) synthesis .
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- HY-W008253S3
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5-Hydroxyindole-3-acetic acid- 13C6 is the 13C-labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
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- HY-W738582S
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N-(1-Deoxy-D-fructos-1-yl) -L-threonine- 13C6 is 13C labeled N-(1-Deoxy-D-fructos-1-yl)-L-methionine.
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- HY-10450S5
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Dapagliflozin- 13C6-1 is 13C labeled Dapagliflozin. Dapagliflozin (BMS-512148), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine . Dapagliflozin induces HIF1 expression and attenuates renal IR injury .
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- HY-N0378S2
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D-Mannitol- 13C6 is the 13C labeled D-Mannitol . D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator .
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- HY-W654020
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Propyl paraben- 13C6 (Propyl parahydroxybenzoate- 13C6) is 13C labeled Propylparaben. Propylparaben (Propyl parahydroxybenzoate) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben is commonly used in cosmetics, pharmaceuticals and foods. Propylparaben disrupts follicular growth and steroidogenic function by altering cell cycle, apoptosis and steroidogenic pathways. Propylparaben also reduced sperm count and motility in rats .
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- HY-W749378
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1,2,3,4,5-Pentabromo-6-ethylbenzene- 13C6 is the 13C-labeled 1,2,3,4,5-Pentabromo-6-ethylbenzene (HY-W715201).
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- HY-13966S3
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2-Deoxy-D-glucose- 13C6 (2-DG- 13C6) is 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .
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- HY-B1190S2
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Cefadroxil- 13C6 (BL-S 578- 13C6) is 13C labeled Cefadroxil (HY-B1190). Cefadroxil is an orally active broad-spectrum cephalosporin antibiotic. Cefadroxil inhibits bacterial cell wall synthesis and enhances the expression of glutamate transporter-1. Cefadroxil is dependent on the intestinal peptide transporter PepT1 for small intestinal absorption. Cefadroxil has inhibitory and bactericidal activity against a variety of Gram-positive and Gram-negative bacteria and has analgesic effects on neuropathic pain .
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- HY-14740S2
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Elvitegravir- 13C6 (GS-9137- 13C6) is 13C labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
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- HY-P5168AS
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GPSVFPLAPSSK- 13C6, 15N2 TFA is the 13C- and 15N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .
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- HY-P5201S1
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VTSEGAGLQLQK- 13C6, 15N2 (TFA) is the 13C- and 15N-labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA), which can be used to bind anti-drug antibodies in plasma and quantitatively analyze the therapeutic effect .
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- HY-19821S1
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Fmoc-Ile-OH- 13C6, 15N is the 13C and 15N labeled Fmoc-Ile-OH . Fmoc-Ile-OH is an isoleucine derivative .
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- HY-15550S1
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4'-Hydroxy diclofenac- 13C6 is the 13C labeled 4'-Hydroxy diclofenac . 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties .
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- HY-W778242
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3,4-Dihydronaphthalen-1-one- 13C6 (3,4-Dihydro-1(2H)-naphthalenon- 13C6) is the 13C-labeled 3,4-Dihydronaphthalen-1(2H)-one (HY-76194). 3,4-Dihydronaphthalen-1(2H)-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-13458S2
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Droxidopa- 13C6 (L-DOPS- 13C6) is 13C labeled Droxidopa. Droxidopa (L-DOPS; SM5688) is a potent, orally active norepinephrine precursor. Droxidopa increases standing blood pressure, ameliorates symptoms of orthostatic hypotension and improves standing ability. Droxidopa has the potential for the research of neurogenic orthostatic hypotension (nOH) and alternative ADHD (attention deficit hyperactivity disorder) .
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- HY-159193S
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DHATS(Leu- 13C6, 15N)PVTIPSAVST(Gly- 13C2, 15N)HTTPLPVTDT (TFA) is the 13C and 15N labeled isotope of DHATS-PVTIPSAVST-HTTPLPVTDT (TFA) .
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- HY-W777526
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Nitisinone- 13C6 is a 13C-labeled Nitisinone (HY-B0607). Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC50 of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism .
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- HY-W753345
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2,6-Dichlorodiphenylamine- 13C6 (2,6-Dichloro-N-phenylaniline- 13C6) is the 13C-labeled 2,6-Dichlorodiphenylamine (HY-W012126). 2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium (HY-15037) and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a?COX?inhibitor, with?IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells.
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- HY-B0375S1
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Argatroban- 13C6 hydrochloride is 13C labeled Argatroban (HY-B0375). Argatroban (MD-805) is a direct, selective thrombin inhibitor.
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- HY-W768934
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L-Gulono-1,4-lactone- 13C6 (L-Gulonolactone- 13C6) is the 13C-labeled L-Gulono-1,4-lactone (HY-W016628). L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.
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- HY-N0684S3
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Vitamin K1- 13C6 is the 13C-labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
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- HY-113046S1
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5-Methyltetrahydrofolic acid- 13C6 (5-Methyl THF- 13C6) is 13C labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases .
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- HY-B0124S2
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Zonisamide- 13C6 (AD 810- 13C6) is 13C labeled Zonisamide. Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy .
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- HY-14520S2
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Tetrahydrofolic acid- 13C6 (L-5,6,7,8-Tetrahydrofolic acid- 13C6) is 13C labeled Tetrahydrofolic acid. Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid .
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- HY-B0167S1
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Salicylic acid- 13C6 is the 13C-labeled Salicylic acid (HY-B0167). Salicylic acid is a precursor to and a metabolite of Aspirin (HY-14654), can inhibit cyclo-oxygenase-2 (COX-2) activity .
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- HY-W779969
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2-Acetyl-4-tetrahydroxybutyl imidazole- 13C6 is the 13C-labeled 2-Acetyl-4-tetrahydroxybutyl imidazole (HY-14113). 2-Acetyl-5-tetrahydroxybutyl imidazole is a potent sphingosine-1-phosphate (S1P) lyase inhibitor in vivo.
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- HY-W769361
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5-Hydroxymethyl-2-furancarboxylic acid- 13C6 is the 13C-labeled 5-Hydroxymethyl-2-furancarboxylic acid (HY-W005241). 5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural (HMF) in the body and eliminated renally.
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- HY-113407CS
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D-Fructose-6-phosphate disodium monohydrate- 13C6 is the 13C-labeled D-Fructose-6-phosphate disodium monohydrate (HY-113407C). D-Fructose-6-phosphate disodium monohydrate is an intermediate of Glycolysis. D-Fructose-6-phosphate disodium monohydrate is the precursor for the synthesis of amino sugars, such as galactosamine and glucosamine .
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- HY-B1779S5
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Sucrose- 13C6 is the 13C labeled Sucrose . Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al .
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- HY-W754400
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Mannosan,95%- 13C6 (1,6-Anhydro-β-D-mannopyranose- 13C6) is the 13C-labeled Mannosan,95% (HY-124095). Mannosan,95% (1,6-Anhydro-β-D-mannopyranose,95%) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .
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- HY-N1394S
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p-Anisic acid- 13C6 is the 13C-labeled p-Anisic acid. p-Anisic acid (4-Methoxybenzoic acid) is one of the isomers of anisic acid, with anti-bacterial and antiseptic properties .
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- HY-50896S1
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Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR .
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- HY-10574S1
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Rilpivirine- 13C6 (R278474- 13C6) is 13C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .
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- HY-N0384S3
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Homovanillic acid- 13C6, 18O is the 13C-labeled Homovanillic acid. Homovanillic acid is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
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- HY-B1431S1
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Butylparaben- 13C6 is the 13C labeled Butylparaben . Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.
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- HY-N0470S1
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L-Lysine- 13C6, 15N2,d9 (dihydrochloride) is the deuterium, 13C-, and 15-labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
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- HY-B0035S2
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Sulfamethazine- 13C6 is a 13C-labeled Sulfamethazine (HY-A0178). Sulfamethazine (Sulfadimidine) is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections) .
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- HY-N0683S
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α-Vitamin E- 13C6 is the 13C-labeled α-Vitamin E. α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant .
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- HY-W747879
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Diclofenac Amide- 13C6 is the 13C-labeled Diclofenac amide (HY-134521). Diclofenac amide is a prodrug for Diclofenac sodium (HY-15037). Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474)-induced rat paw edema model without causing gastric ulcer (300 μmol/kg) .
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- HY-W768336
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Gluconate sodium- 13C6 (D-Gluconic acid sodium salt- 13C6) is the 13C-labeled Gluconate sodium (HY-B1092A). Gluconate sodium (D-Gluconic acid sodium salt) is an orally active glucose derivative. Gluconate sodium reduces nitric oxide and inflammatory cytokines (IL-1β and IL-6). Gluconate sodium inhibits ERK phosphorylation. Gluconate sodium has antioxidant and antiplatelet activation activities. Gluconate sodium has antitumor activity against colorectal cancer. Gluconate sodium improves osteoarthritis, intestinal damage and acute lung injury .
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- HY-W747060
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Benzyl 4-hydroxybenzoate- 13C6 (Benzyl Paraben- 13C6) is the 13C-labeled Benzyl 4-hydroxybenzoate (HY-W013482). Benzyl 4-hydroxybenzoate is a prominent material. Benzyl 4-hydroxybenzoate can be used as an excipient, such as bacteriostatic agent, preservative. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
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- HY-W755778
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3-Iodothyronamine hydrochloride- 13C6 is the 13C-labeled 3-Iodothyronamine hydrochloride (HY-135065). 3-Iodothyronamine hydrochloride is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure .
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- HY-B2156S1
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Menaquinone-4- 13C6 is the 13C-labeled Menaquinone-4. Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
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- HY-W008452S
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H-Tyr(3-I)-OH- 13C6 is the 13C-labeled H-Tyr(3-I)-OH. H-Tyr(3-I)-OH is a potent and effective tyrosine hydroxylase inhibitor. H-Tyr(3-I)-OH is an intermediate in the production of thyroid hormones and has a role as a human or mouse metabolite .
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- HY-W768340
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Sucrose- 13C6-1 is 13C labeled Sucrose. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose?can be applied in some animal models, including metabolic disease, obesity,?diet on preference,?and diabetes, et al .
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- HY-15037S
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Diclofenac- 13C6 (sodium heminonahydrate) is the 13C-labeled Diclofenac Sodium. Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells , and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively . Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade .
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- HY-N1428S1
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Citric acid- 13C6 is the 13C-labeled Citric acid (HY-N1428). Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries .
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- HY-W014423S3
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L-Histidine- 13C6, 15N3 (hydrochloride hydrate) is the 13C- and 15N-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
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- HY-P2625S
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GLP-2(3-33) (Leu- 13C6, 15N) is 13C and 15N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM).
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- HY-W008642S
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(Leu-13C6,15N)-Leu-OH TFA is a C13 and N15 labeled Leu-Leu-OH TFA. Leu-Leu-OH, a Leu derivative, is a dipeptide .
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- HY-106950S1
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Fosfructose- 13C6 (tetrasodium hydrate) is the 13C labeled Fosfructose (HY-106950). Fosfructose is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma .
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- HY-W050145S2
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Levoglucosan- 13C6 is the 13C labeled Levoglucosan . Levoglucosan (1,6-Anhydro-β-D-glucopyranose) is an anhydrosugar produced through glucan pyrolysis and is widely found in nature .
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- HY-B0166S8
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L-Ascorbic acid- 13C6-1 (L-Ascorbate-1; Vitamin C- 13C6-1) is a 13C labeled L-Ascorbic acid (HY-B0166) . L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
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- HY-109120S1
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Odevixibat- 13C6 is 13C labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .
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- HY-129503S
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2-Heptyl-4-quinolone- 13C6 is the 13C-labeled 2-Heptyl-4-quinolone (HY-129503). 2-Heptyl-4-quinolone is an intermediate in the synthesis of the Pseudomonas quinolone signal (PQS) that controls swarming by positively regulating phenazine production. 2-Heptyl-4-quinolone induces the production of the phenazine-1-carboxylic acid (PCA) .
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- HY-126373S1
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SN-38 glucuronide- 13C6 is the 13C labeled SN-38 glucuronide (HY-126373) . SN-38 glucuronide is an inactive metabolite of the cancer agent Irinotecan. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer .
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- HY-W751179
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Midostaurin- 13C6 (PKC412- 13C6) is the 13C-labeled Midostaurin (HY-10230). Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM . Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects .
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- HY-N7032S1
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Uridine 5′-diphosphoglucose- 13C6 (UDP-D-Glucose- 13C6) disodium is the 13C labeled Uridine 5′-diphosphoglucose disodium (HY-N7032) . Uridine 5’-diphosphoglucose (UDP-glucose) disodium, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue .
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- HY-P2625S1
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GLP-2(3-33) (Leu- 13C6, 15N) TFA is 13C and 15N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC50=5.8 nM).
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- HY-13613S
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Dutasteride- 13C6 is the 13C labeled Dutasteride . Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
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- HY-W653962
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Triclosan- 13C6 is 13C labeled Triclosan. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
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- HY-N0455AS8
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L-Arginine- 13C6, 15N4 (hydrochloride) is the 13C- and 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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- HY-W777582
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4-tert-Octylphenol monoethoxylate- 13C6 is the 13C labeled isotope of 4-tert-Octylphenol monoethoxylate (HY-W777582) . 4-tert-Octylphenol monoethoxylate is an alkylphenolethoxylate (APE) and a degradation product of non-ionic surfactants (such as 4-tert-octylphenol polyethoxylate). 4-tert-Octylphenol monoethoxylate also possesses non-steroidal estrogenic activity. Additionally, 4-tert-Octylphenol monoethoxylate has been found in wastewater effluent .
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- HY-Y1636S
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Fmoc-Arg(Pbf)-OH- 13C6, 15N4 is the 13C-labeled and 15N-labeled Fmoc-Arg(Pbf)-OH (HY-Y1636). Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis) .
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- HY-16637S5
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Folic acid-13C6 is a deuterated labeled Folic acid . Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency .
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- HY-B0252S2
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Hydrochlorothiazide- 13C6 is the 13C labeled Hydrochlorothiazide . Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect .
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- HY-66008S2
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N-Acetyl mesalazine- 13C6 (N-Acetyl-5-aminosalicylic acid- 13C6) is a deuterated labeled N-Acetyl mesalazine (HY-66008). N-Acetyl mesalazine (N-Acetyl-5-aminosalicylic acid) is the primary intestinal metabolite of 5-Aminosalicylic Acid (HY-15027) and serves as a biomarker for evaluating the efficacy of 5-Aminosalicylic Acid (HY-15027). N-Acetyl mesalazine can scavenge free radicals, reduce DNA base hydroxylation, and ameliorate mucosal inflammation. N-Acetyl mesalazine can be used in the study of diseases such as colitis and colon cancer .
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- HY-18341S1
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Thyroxine hydrochloride- 13C6 is the 13C-labeled L-Thyroxine. L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4) .
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- HY-W748418
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1-Thio-β-D-glucose Sodium Salt Dihydrate- 13C6 is the 13C-labeled 1-Thio-β-D-glucose sodium (HY-115419). 1-Thio-β-D-glucose sodium is the sodium salt form of 1-Thio-β-D-glucose. 1-Thio-β-D-glucose forms hydrophilic self-assembled monolayer with metal, stablizes the lipid bilayer and protects the proteins from denaturation .
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- HY-N0098S2
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Vanillin- 13C6 is the 13C labeled Vanillin . Vanillin (p-Vanillin) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine .
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- HY-B0150S2
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Nicotinamide- 13C6 is the 13C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
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- HY-B0497BS
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Niclosamide- 13C6 (monohydrate) is the 13C labeled Niclosamide monohydrate . Niclosamide (BAY2353) monohydrate is an orally active antihelminthic agent used in parasitic infection research . Niclosamide monohydrate is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells . Niclosamide monohydrate has biological activities against cancer, and inhibits DNA replication in Vero E6 cells .
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- HY-W777458
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Fluorene- 13C6 is the 13C-labeled Fluorene (HY-W026772). Fluorene is an orally active polycyclic aromatic hydrocarbon (PAH) and a precursor to other fluorene-based compounds. Fluorene and its derivatives serve as dye precursors for fluorene synthesis. In A549 cells, Fluorene induces oxidative stress and inflammatory responses by increasing ROS and SOD generation, exacerbating lipid peroxidation, modulating antioxidant enzyme activity, and upregulating the expression of pro-inflammatory factors TNF-α and IL-6. In vivo, Fluorene exhibits anxiolytic activity. Fluorene holds potential for research in inflammation and neurological disorders .
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- HY-B0822S1
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Fipronil- 13C6 is the 13C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.
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- HY-P0119S
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Lixisenatide (Leu- 13C6, 15N) TFA is the 13C- and 15N-labeled Lixisenatide (HY-P0119). Lixisenatide is a GLP-1 receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of proinflammatory cytokines, and blocks of cellular signaling pathways. Lixisenatide decreases atheroma plaque size and instability in Apoe ?/? Irs 2+/? mice by reprogramming macrophages towards an M2 phenotype, which leads to reduced inflammation .
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- HY-B0400S16
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D-Sorbitol- 13C6 is the 13C labeled D-Sorbitol . D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement .
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- HY-W243018S
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1,2:5,6-Di-O-isopropylidene-a-D-glucofuranose-1,2,3,4,5,6- 13C6 is the 13C labeled 1,2:5,6-Di-O-isopropylidene-a-D-glucofuranose-1,2,3,4,5,6 .
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- HY-A0161S
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Chlophedianol- 13C6 is the 13C labeled Chlophedianol (HY-A0161). Chlophedianol is an orally active and potent antitussive agent. Chlophedianol can be used for the research of acute cough due to upper respiratory tract infections (URIs) .
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- HY-129974S
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3,3'-Diiodo-L-thyronine- 13C6 is the 13C labeled 3,3'-Diiodo-L-thyronine . 3,3'-Diiodo-L-thyronine (3,3'-T2) is an endogenous metabolite of thyroid hormone. 3,3'-Diiodo-L-thyronine significantly enhances COX activity .
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- HY-W777393
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Umbelliferone- 13C6 (7-Hydroxycoumarin- 13C6) is the 13C-labeled Umbelliferone (HY-N0573). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in
chronic alcohol-fed rats .
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- HY-10163S2
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Dabigatran- 13C6 is the 13C labeled Dabigatran . Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive direct thrombin inhibitor (Ki=4.5 nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10 nM) .
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- HY-W750212
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Acid Orange 7- 13C6 (Orange II- 13C6) is the 13C-labeled Acid orange 7 (HY-N1442). Acid Orange 7 (Orange II; D&C Orange NO. 4) is an azo dye widely used in the textile, food and cosmetic industries. Acid Orange 7 is mainly used as a colorant by combining with fibers and other substances through azo bonds. Acid Orange 7 has a maximum absorption wavelength at 484-485 nm, and the concentration is measured using a UV-visible spectrophotometer. Acid Orange 7 is difficult to degrade and has a certain degree of toxicity. It is often used to study various sewage treatment technologies and photocatalytic degradation reactions, and to evaluate the removal effects of different treatment methods on organic pollutants .
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- HY-W014423S1
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L-Histidine- 13C6, 15N3,d5 (hydrochloride hydrate) is the deuterium, 13C-, and 15-labeled L-Histidine hydrochloride hydrate. L-Histidine hydrochloride hydrate (H-His-OH.HCl.H2O) is an endogenous metabolite.
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- HY-N1393S
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2-Methoxybenzoic acid- 13C6 is the 13C-labeled 2-Methoxybenzoic acid. 2-Methoxybenzoic acid (NSC 3778) is used as an internal standard of salicylic acid and its putative biosynthetic precursors in cucumber leaves. Another known use is in the synthesis of Benextramine.
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- HY-N0304S1
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L-DOPA- 13C6 is the 13C-labled L-DOPA . L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .
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- HY-W585956
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Triclocarban- 13C6 is the 13C labeled isotope of Triclocarban (HY-B1805). Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes .
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- HY-10260S2
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Vandetanib- 13C6 is a 13C labeled Vandetanib (HY-10260) . Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM) .
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- HY-10572S1
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Efavirenz- 13C6 is the 13C-labeled Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture .
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- HY-W269700S
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Ile-(Leu-13C6,15N)-OH (TFA) is 13C- and 15N-labeled L-Isoleucyl-L-leucine (HY-W269700). L-Isoleucyl-L-leucine has a role as a metabolite and can be used to inhibit movement-induced muscle damage and muscle defective condition.
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- HY-W778408
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Tamoxifen- 13C6 (ICI 47699- 13C6) is the 13C-labeled Tamoxifen (HY-13757A). Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells . Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.1 μM and 1.8 μM, respectively . Tamoxifen activates autophagy and induces apoptosis . Tamoxifen also can induce gene knockout of CreER transgenic mouse .
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- HY-W050154S
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Kojic acid- 13C6 is 13C labeled Kojic acid (HY-W050154). Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .
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- HY-15027S2
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5-Aminosalicylic acid- 13C6 is the 13C labeled 5-Aminosalicylic Acid . 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB .
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- HY-N0455AS4
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L-Arginine- 13C6, 15N4,d7 (hydrochloride) is the deuterium, 13C-, and 15-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.
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- HY-18569S4
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3-Indoleacetic acid- 13C6 is the 13C labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division .
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- HY-79576S2
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Estrone 3-methyl ether- 13C6 is a 13C-labeled Estrone 3-methyl ether (HY-79576). Estrone 3-methyl ether (Oestrone methyl ether; 3-O-Methylestrone) is a synthetic intermediate useful for synthesis of estrogen receptor modulator .
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- HY-W020678S
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2-Methylbutanal- 13C6 is 13C labeled 2-Methylbutanal (HY-W020678).
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- HY-B0141S4
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Estradiol- 13C6 is the 13C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway .
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- HY-18572S
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2,4-D- 13C6 is the 13C-labeled 2,4-D. 2,4-D (2,4-Dichlorophenoxyacetic acid) is a selective systemic herbicide for the control of broad-leaved weeds. 2,4-D acts as a plant hormone, causing uncontrolled growth in the meristematic tissues. 2,4-D inhibits DNA and protein synthesis and thereby prevents normal plant growth and development .
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- HY-W009300S1
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4-Hydroxyestrone- 13C6 is a 13C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .
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- HY-B1422S
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9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
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- HY-13948BS
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Angiotensin II human- 13C6, 15N TFA (Ang II- 13C6, 15N TFA) is 13C- and 15N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .
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- HY-176277S
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Fibrinopeptide B, human-(Val- 13C5, 15N, Arg- 13C6, 154) TFA is the 13C- and 15N-labeled Fibrinopeptide B, human (HY-P1493). Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin .
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- HY-B0166S
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L-Ascorbic acid- 13C6 is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor . L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells .
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- HY-N0215S8
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L-Phenylalanine- 13C6 is the 13C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .
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- HY-13690S1
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Mitotane- 13C6 is the 13C labeled Mitotane . Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions .
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- HY-114118S3
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Semaglutide- 13C6, 15N TFA is the 13C- and 15N-labeled Semaglutide TFA (HY-114118A). Semaglutide TFA is a long-acting, selective, competitive, orally active GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide TFA also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide TFA has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide TFA can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .
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- HY-12033S1
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2-Methoxyestradiol- 13C6 is the 13C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .
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- HY-W014901S
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Bisphenol F- 13C6 is the 13C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260) .
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- HY-16561S1
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Resveratrol- 13C6 is the 13C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .
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- HY-78726S2
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Fosamprenavir- 13C6 is the 13C-labeled Fosamprenavir (HY-78726). Fosamprenavir is an orally active inhibitor targeting HIV-1 protease and is a prodrug of Amprenavir (HY-17430). Fosamprenavir is hydrolyzed into Amprenavir (VX-478) by cell phosphatases in the intestinal epithelium. Amprenavir binds to the active site of HIV-1 protease, preventing the processing of viral gag and gag-pol polyprotein precursors, thereby inhibiting the formation of mature infectious virus particles and exerting anti-HIV-1 infection activity. Fosamprenavir can be used for the study of human immunodeficiency virus (HIV-1) infection .
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- HY-16938S
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5'-Methylthioadenosine- 13C6 is the 13C-labeled 5'-Methylthioadenosine. 5'-Methylthioadenosine (5'-(Methylthio)-5'-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis . 5'-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5'-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis .
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- HY-112499S1
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Menaquinone-7- 13C6 is the 13C-labeled Menaquinone-7. Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors . Menaquinone-7 (Vitamin K2-7) is identified as the most bioactive cofactor for the carboxylation reaction of Gla-proteins . Supplementation with Menaquinone-7 (Vitamin K2-7) is a pharmacological option for activating matrix Gla protein and intervening in the progression of calcific aortic valve stenosis (CAVS) .
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- HY-16561S2
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Resveratrol-(4-Hydroxyphenyl)- 13CN6 is the 13C labeled Resveratrol-(4-Hydroxyphenyl) .
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- HY-176258S
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- HY-17405S
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Alarelin-(Leu-sup>13C10, 15N) TFA is the 13C- and 15N-labeled Alarelin TFA.
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- HY-W017401S
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Benzisothiazolinone-13C5 (1,2-Benzothiazol-3-one-13C5) is a 13C-labeled Benzisothiazolinone. Benzisothiazolinone is widely used as an antiseptic and antibacterial agent .
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- HY-W766699
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6-Amino-4-hydroxy-2-mercaptopyrimidine- 13C (6-Amino-2-thiouracil Monohydrate- 13C) is the 13C-labeled 6-Amino-4-hydroxy-2-mercaptopyrimidine (HY-75601).
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- HY-136380S
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Alkynes
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Clodinafop-propargyl- 13C6 is the 13C-labeled Clodinafop-propargyl. Clodinafop-propargyl, a main member of aryloxyphenoxy-propionate herbicides, is used for postemergence control of annual grasses in cereals, including Avena, Lolium, Setaria, Phalaris and Alopecurus spp . Clodinafop-propargyl-13C6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-12008S1
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CP-358774-13C6 hydrochloride; NSC 718781-13C6 hydrochloride; OSI-774-13C6 hydrochloride
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Alkynes
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Erlotinib- 13C6 hydrochloride is the 13C labeled Erlotinib Hydrochloride . Erlotinib Hydrochloride (CP-358774 Hydrochloride) inhibits purified EGFR kinase with an IC50 of 2 nM . Erlotinib- 13C6 hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-50896S1
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CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6
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Alkynes
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Erlotinib- 13C6 is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR .
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