Search Result

Results for "

μ-opioid-receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Opioid Receptor (126) Aminopeptidase (1) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (4) Autophagy (4) Cholinesterase (ChE) (2) Dopamine Receptor (1) Drug Metabolite (2) Endogenous Metabolite (3) Enterovirus (2) Isotope-Labeled Compounds (8) Neprilysin (1) NF-κB (4) NO Synthase (1) Sigma Receptor (4) TRP Channel (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (2) Endocrinology (1) Infection (3) Inflammation/Immunology (12) Metabolic Disease (4) Neurological Disease (114)

131

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Opioid Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155319

μ opioid receptor agonist 3	Opioid Receptor	Neurological Disease
μ opioid receptor agonist 3 (compound 20) is a potent μ opioid receptor (µOR) agonist with an EC₅₀ of 0.87 nM. μ opioid receptor agonist 3 has the potential for pain and neuropsychiatric indications research .

HY-142919

μ opioid receptor agonist 2	Opioid Receptor	Neurological Disease
μ opioid receptor agonist 2 （Compound H-3）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases .

HY-142918

μ opioid receptor agonist 1	Opioid Receptor	Neurological Disease
μ opioid receptor agonist 1 （Compound H-1a）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases .

HY-162771

Mu opioid receptor agonist 1	Opioid Receptor	Neurological Disease
Mu opioid receptor agonist 1 (compound 12) is a **Mu opioid receptor** agonist. Mu opioid receptor agonist 1 can be used in nervous system related research .

HY-162669

Mu opioid receptor antagonist 8	Opioid Receptor	Neurological Disease
Mu opioid receptor antagonist 8 (368) is a **μ-opioid receptor** antagonist. Mu opioid receptor antagonist 8 (368) significantly inhibits met-enkephalin-induced µOR activation of G_i .

HY-144609

Mu opioid receptor antagonist 4	Opioid Receptor	Neurological Disease
Mu opioid receptor antagonist 4 (compound 31) is a potent and selective μ opioid receptor (MOR) antagonist with a K_i of 0.38 nM and an EC₅₀ of 1.07 nM. Mu opioid receptor antagonist 4 has remarkable CNS antagonism against morphine, and precipitated fewer withdrawal symptoms than Naloxone. Mu opioid receptor antagonist 4 Mu opioid receptor antagonist 4 can be used for researching opioid use disorders (OUD) .

HY-144608

Mu opioid receptor antagonist 3	Opioid Receptor	Neurological Disease
Mu opioid receptor antagonist 3 (compound 26) is a potent and selective μ opioid receptor (MOR) antagonist with a K_i of 0.24 nM and an EC₅₀ of 0.54 nM. Mu opioid receptor antagonist 3 has remarkable CNS antagonism against morphine, and precipitated fewer withdrawal symptoms than Naloxone. Mu opioid receptor antagonist 3 can be used for researching opioid use disorders (OUD) .

HY-144606

Mu opioid receptor antagonist 1	Opioid Receptor	Neurological Disease
Mu opioid receptor antagonist 1 (compound 19) is a selective and orally active μ opioid receptor (MOR) ligand with an K_i value of 0.58 nM and an EC₅₀ of 1.15 nM. Orally administrating with Mu opioid receptor antagonist 1 increases intestinal motility during morphine-induced constipation. Mu opioid receptor antagonist 1 can be used for researching opioid-induced constipation (OIC) .

HY-144607

Mu opioid receptor antagonist 2	Opioid Receptor	Neurological Disease
Mu opioid receptor antagonist 2 (compound 25) is a potent, selective and blood-brain barrier (BBB) penetrant μ opioid receptor (MOR) antagonist with a K_i of 0.37 nM and an EC₅₀ of 0.44 nM. Mu opioid receptor antagonist 2 has remarkable CNS antagonism against morphine, and precipitated fewer withdrawal symptoms than Naloxone. Mu opioid receptor antagonist 2 can be used for researching opioid use disorders (OUD) .

HY-144610

Mu opioid receptor antagonist 5	Opioid Receptor	Neurological Disease
Mu opioid receptor antagonist 5 (compound NAP) is a selective and blood-brain barrier (BBB) penetrant μ opioid receptor (MOR) antagonist with an EC₅₀ value of 1.14 nM and a K_i value of 0.37 nM. Mu opioid receptor antagonist 5 can be used for researching opioid use disorders (OUD) .

HY-155320

Mu opioid receptor antagonist 7	Opioid Receptor	Neurological Disease
Mu opioid receptor antagonist 7 (compound 24) is a potent and CNS permeable antagonist of µOR (µ-opioid receptor), with an IC₅₀ of 29 ± 3.0 nM. Mu opioid receptor antagonist 7 can be used for the research of pain and opioid use disorder .

HY-147560

*σ1 Receptor/μ Opioid* receptor modulator 1**	Sigma Receptor Opioid Receptor	Neurological Disease
σ1 Receptor/μ Opioid receptor modulator 1 (Compound 44) is a potent σ1 receptor antagonist and **μ opioid receptor agonist with K_i*s of 1.86 nM and 2.1 nM, respectively.σ1 Receptor/μ Opioid* receptor modulator 1 exhibits potent analgesic activity. σ1 Receptor/μ Opioid receptor modulator 1 can be used for the research of neuropathic pain .

HY-A0118

Naloxegol NKTR-118; AZ-13337019	Opioid Receptor	Neurological Disease Cancer
Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-A0118A

Naloxegol oxalate 2 Publications Verification NKTR-118 oxalate; AZ-13337019 oxalate	Opioid Receptor	Neurological Disease Cancer
Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a *μ-opioid-receptor* antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-163065

*σ1 Receptor/μ Opioid* receptor modulator 2**	Opioid Receptor Sigma Receptor	Neurological Disease
σ1 Receptor/μ Opioid receptor modulator 2 (compound 4x) is a dual μOR agonist/σ1R antagonist, and displays picomolar μOR agonism activity (EC₅₀: 0.6 ± 0.2 nM) and good σ1R inhibitory activity (K_i: 363.7 ± 5.6 nM). σ1 Receptor/μ Opioid receptor modulator 2 exhibits robust analgesic effects in various pain models .

HY-A0118AS

Naloxegol-d5 oxalate	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease
Naloxegol-d₅ (oxalate) is deuterium labeled Naloxegol (oxalate). Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-A0118S1

Naloxegol-13C,d2 NKTR-118-¹³C_{,d₂; AZ-13337019-¹³C_,d₂}	Isotope-Labeled Compounds Opioid Receptor	Neurological Disease Cancer
Naloxegol- ¹³C,d₂ (NKTR-118- ¹³C,d₂) is ¹³C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-A0118S

Naloxegol-13C,d3 NKTR-118-¹³C_{,d₃; AZ-13337019-¹³C_,d₃}	Isotope-Labeled Compounds	Neurological Disease Cancer
Naloxegol- ¹³C,d₃ (NKTR-118- ¹³C,d₃) is ¹³C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-100122

Bevenopran 1 Publications Verification CB-5945; ADL-5945	Opioid Receptor	Neurological Disease
Bevenopran is a peripheral **μ-opioid receptor** antagonist .

HY-P1087

Adrenorphin Metorphamide	Opioid Receptor	Cancer
Adrenorphin is a opioid octapeptide, acting as a potent agonist of **μ-opioid receptor, with K_i** of 12 nM.

HY-145369

DS34942424	Opioid Receptor	Neurological Disease
DS34942424 is an orally potent analgesic without **mu opioid receptor** agonist activity.

HY-130367

U-48520	Opioid Receptor	Neurological Disease
U-48520 is an agonist for **μ-opioid receptor with EC₅₀** of 1561 nM .

HY-122681

SR-16435	Opioid Receptor	Neurological Disease
SR-16435 is a nociceptin/orphanin FQ (NOP)/μ-opioid* receptor* partial agonist, with high binding affinity (NOP receptor K_i=7.49; μ-Opioid receptor K_i=2.70). SR-16435 can relieve pain .

HY-151811

NAQ	Opioid Receptor	Neurological Disease
NAQ is a potent and selective **μ opioid receptor partial agonist, with a K_i** of 0.55 nM. NAQ shows selectivity for Mu opioid receptor over the δ receptor (K_i=132.50 nM) and the κ receptor (K_i=26.45 nM). NAQ can be used for the research of opioid withdrawal or dependence .

HY-120927

Alvimopan metabolite	Opioid Receptor	Neurological Disease
Alvimopan metabolite is a μ opioid receptor antagonist with activity that selectively interacts with μ peripheral receptors. Alvimopan metabolite can be used as a potential inhibitory drug to alleviate the side effects caused by opioids. Alvimopan metabolite was identified as a highly selective μ opioid receptor antagonist during research and development .

HY-111454

SR17018 1 Publications Verification	Opioid Receptor	Neurological Disease
SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC₅₀ of 97 nM.

HY-101386

PZM21 4 Publications Verification	Opioid Receptor	Neurological Disease
PZM21 is a potent and selective **μ opioid receptor agonist with an EC₅₀** of 1.8 nM .

HY-P1577

Dermorphin Analog	Opioid Receptor	Inflammation/Immunology
Dermorphin Analog is an analog of Dermorphin. Dermorphin is a natural heptapeptide **μ-opioid receptor** agonist found in amphibian skin.

HY-139678

SC13	Opioid Receptor	Others
SC13 is a novel mitragynine analog with low-efficacy **Mu opioid receptor** agonism that displays antinociception with attenuated adverse effects.

HY-P2018

FK 33-824	Opioid Receptor	Cardiovascular Disease
FK 33-824, a synthetic analogue of Met-enkephalin, is a selective agonist of the μ-opioid receptor (μ-OR) .

HY-P0244

Dermorphin	Opioid Receptor	Neurological Disease
Dermorphin is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-N15180

Corynantheidine (-)-Corynantheidine	Opioid Receptor	Neurological Disease
Corynantheidine ((-)-Corynantheidine) is a **mu-opioid receptor** (MOR) partial agonist that shows MOR-dependent analgesic effects in mice .

HY-P0244A

Dermorphin TFA	Opioid Receptor	Neurological Disease
Dermorphin TFA is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-P3870

DALDA	Opioid Receptor	Neurological Disease
DALDA is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA shows antinociceptive and respiratory effects .

HY-167946

CP-866087	Opioid Receptor	Others
CP-866087 is a new, highly effective, and selective antagonist of the mu-opioid receptor designed for exploring female sexual dysfunction.

HY-P3870A

DALDA acetate	Opioid Receptor	Neurological Disease
DALDA acetate is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA acetate shows antinociceptive and respiratory effects .

HY-P0210

DAMGO 5+ Cited Publications	Opioid Receptor	Cancer
DAMGO is a **μ-opioid receptor (μ-OPR ) selective agonist with a K_d** of 3.46 nM for native μ-OPR .

HY-13243

Alvimopan ADL 8-2698; LY 246736	Opioid Receptor	Neurological Disease
Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible **μ-opioid receptor antagonist, with an IC₅₀** of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (K_i=0.47 nM) over κ- and δ-opioid receptors (K_is=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus .

HY-76657

Alvimopan monohydrate ADL 8-2698 monohydrate; LY 246736 monohydrate	Opioid Receptor	Neurological Disease Cancer
Alvimopan monohydrate (ADL 8-2698 monohydrate) is a potent, selective, orally active and reversible **μ-opioid receptor antagonist, with an IC₅₀** of 1.7 nM. Alvimopan monohydrate has selectivity for μ-opioid receptor (K_i=0.47 nM) over κ- and δ-opioid receptors (K_is=100, 12 nM, respectively). Alvimopan monohydrate can be used for the research of postoperative ileus .

HY-P0210B

DAMGO TFA 5+ Cited Publications	Opioid Receptor	Cancer
DAMGO TFA is a **μ-opioid receptor (μ-OPR ) selective agonist with a K_d** of 3.46 nM for native μ-OPR .

HY-107750

Cyprodime	Opioid Receptor	Neurological Disease
Cyprodime is a selective μ opioid receptor (MOR) antagonist with K_is of 5.4, 244.6, and 2187 nM for μ, δ, and κ, respectively .

HY-P3870B

DALDA TFA	Opioid Receptor	Neurological Disease
DALDA TFA is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA TFA shows antinociceptive and respiratory effects .

HY-15122

Sinomenine Maximum Cited Publications 13 Publications Verification	NF-κB Opioid Receptor Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of **μ-opioid receptor** .

HY-N0398

Sec-O-Glucosylhamaudol	Opioid Receptor	Neurological Disease
Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of **μ-opioid receptor**, with analgesic effect .

HY-101011

Naloxonazine dihydrochloride	Opioid Receptor	Infection Neurological Disease
Naloxonazine dihydrochloride is a specific **μ-opioid receptor antagonist with an IC₅₀** of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity .

HY-76657A

Alvimopan dihydrate ADL 8-2698 dihydrate; LY 246736 dihydrate	Opioid Receptor	Neurological Disease Cancer
Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible **μ-opioid receptor antagonist, with an IC₅₀** of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (K_i=0.47 nM) over κ- and δ-opioid receptors (K_is=100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus .

HY-P3043

Bilaid A	Opioid Receptor	Neurological Disease
Bilaid A is a **μ-opioid receptor agonist that can be extracted from Penicillium. The K_i** value is 3.1 μM. Bilaid A can be used in pain research .

HY-15122A

Sinomenine hydrochloride Maximum Cited Publications 13 Publications Verification Cucoline hydrochloride	NF-κB Opioid Receptor Autophagy Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of **μ-opioid receptor** .

HY-19902

GSK1521498	Opioid Receptor	Neurological Disease
GSK1521498 is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 has the potential for disorders of compulsive consumption of food, alcohol, and agents .

HY-P0186

Endomorphin 2	Opioid Receptor	Neurological Disease
Endomorphin 2, a high affinity, highly selective agonist of the **μ-opioid receptor, displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM.

Cat. No.	Product Name	Target	Research Area

HY-P1087

Adrenorphin Metorphamide	Opioid Receptor	Cancer
Adrenorphin is a opioid octapeptide, acting as a potent agonist of **μ-opioid receptor, with K_i** of 12 nM.

HY-P0244

Dermorphin	Opioid Receptor	Neurological Disease
Dermorphin is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-P3870A

DALDA acetate	Opioid Receptor	Neurological Disease
DALDA acetate is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA acetate shows antinociceptive and respiratory effects .

HY-P0210

DAMGO Maximum Cited Publications 7 Publications Verification	Opioid Receptor	Cancer
DAMGO is a **μ-opioid receptor (μ-OPR ) selective agonist with a K_d** of 3.46 nM for native μ-OPR .

HY-P0210B

DAMGO TFA Maximum Cited Publications 7 Publications Verification	Opioid Receptor	Cancer
DAMGO TFA is a **μ-opioid receptor (μ-OPR ) selective agonist with a K_d** of 3.46 nM for native μ-OPR .

HY-P1577

Dermorphin Analog	Opioid Receptor	Inflammation/Immunology
Dermorphin Analog is an analog of Dermorphin. Dermorphin is a natural heptapeptide **μ-opioid receptor** agonist found in amphibian skin.

HY-P2018

FK 33-824	Opioid Receptor	Cardiovascular Disease
FK 33-824, a synthetic analogue of Met-enkephalin, is a selective agonist of the μ-opioid receptor (μ-OR) .

HY-P0244A

Dermorphin TFA	Opioid Receptor	Neurological Disease
Dermorphin TFA is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-P3870

DALDA	Opioid Receptor	Neurological Disease
DALDA is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA shows antinociceptive and respiratory effects .

HY-P3870B

DALDA TFA	Opioid Receptor	Neurological Disease
DALDA TFA is a potent and highly selective **μ-opioid receptor agonist with a K_i** of 1.69 nM. DALDA TFA shows antinociceptive and respiratory effects .

HY-P3043

Bilaid A	Opioid Receptor	Neurological Disease
Bilaid A is a **μ-opioid receptor agonist that can be extracted from Penicillium. The K_i** value is 3.1 μM. Bilaid A can be used in pain research .

HY-P0186

Endomorphin 2	Opioid Receptor	Neurological Disease
Endomorphin 2, a high affinity, highly selective agonist of the **μ-opioid receptor, displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM.

HY-P2199

SNF 9007	Opioid Receptor	Neurological Disease
SNF 9007 is a cholecystokinin analog. SNF 9007 induces analgesia by acting on δ-1, δ-2, and μ opioid *receptors* in the mouse brain .

HY-P0186A

Endomorphin 2 TFA	Opioid Receptor	Neurological Disease
Endomorphin 2 TFA, a high affinity, highly selective agonist of the **μ-opioid receptor, displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM .

HY-P1502

β-Endorphin, human 1 Publications Verification	Opioid Receptor	Neurological Disease
β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of **opioid receptor, with preferred affinity for μ-opioid receptor** and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.

HY-P1338

PL-017	Opioid Receptor	Neurological Disease
PL-017 is a potent and selective **μ opioid receptor agonist with an IC₅₀** of 5.5 nM for ¹²⁵I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats .

HY-P4107

Bilaid C	Opioid Receptor	Neurological Disease
Bilaid C, a tetrapeptide, can be isolated from the Australian estuarine isolate of Penicillium sp. MST-MF667. Bilaid C is also a potent and selective **μ-Opioid Receptor (MOPr**) agonist (K_i=210 nM, hMOPr) .

HY-P1329

CTOP	Opioid Receptor	Neurological Disease
CTOP is a potent and highly selective **μ-opioid receptor** antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens. CTOP dose-dependently enhances locomotor activity .

HY-P1338A

PL-017 TFA	Opioid Receptor	Neurological Disease
PL-017 TFA is a potent and selective **μ opioid receptor agonist with an IC₅₀** of 5.5 nM for ¹²⁵I-FK 33,824 binding to μ site. PL-017 TFA produces long-lasting, reversible analgesia in rats .

HY-P10177

Acetalin-3	Opioid Receptor	Neurological Disease
Acetalin-3 (Ac-RFMWMT-NH2), a hexapeptide, is a **μ opioid receptor** antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors .

HY-P0185

Endomorphin 1 2 Publications Verification	Opioid Receptor	Neurological Disease
Endomorphin 1, a high affinity, highly selective agonist of the **μ-opioid receptor (K_i: 1.11 nM), displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties .

HY-P0185A

Endomorphin 1 acetate 2 Publications Verification	Opioid Receptor	Neurological Disease
Endomorphin 1 acetate, a high affinity, highly selective agonist of the **μ-opioid receptor (K_i: 1.11 nM), displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM. Endomorphin 1 acetate has antinociceptive properties .

HY-P10175

Acetalin-1	Opioid Receptor	Neurological Disease
Acetalin-1 (Ac-RFMWMK-NH2), a hexapeptide, is a **μ opioid receptor** antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors .

HY-P1329A

CTOP TFA 1 Publications Verification	Opioid Receptor	Neurological Disease
CTOP TFA is a potent and highly selective **μ-opioid receptor** antagonist. CTOP TFA antagonizes the acute analgesic effect and hypermotility. CTOP TFA enhances extracellular dopamine levels in the nucleus accumbens. CTOP TFA dose-dependently enhances locomotor activity .

HY-P1253

α-Endorphin (human)	Opioid Receptor	Neurological Disease
α-Endorphin (human) is a neuropeptide, that acts on the central nervous system (CNS) and peripheral nervous system (PNS). α-Endorphin (human) binds **μ-opioid receptor**, and exhibits analgesic efficacy. α-Endorphin (human) regulates sexual behaviors and pleasure felling .

HY-P1335

CTAP	Opioid Receptor	Neurological Disease
CTAP is a potent, highly selective, and BBB penetrant **μ opioid receptor antagonist, with an IC₅₀** of 3.5 nM. CTAP displays over 1200-fold selectivity over δ opioid (IC₅₀=4500 nM) and somatostatin receptors. CTAP can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction .

HY-P10203

*μ/κ/δ opioid* receptor agonist 1**	Opioid Receptor	Inflammation/Immunology
μ/κ/δ opioid receptor agonist 1 is a μ opioid receptor (MOR), κ opioid receptor (KOR), and δ opioid receptor (DOR) agonist. μ/κ/δ opioid receptor agonist 1 produces a strong and long-lasting analgesic effect through peripheral MOR and KOR in the tail-flick test .

HY-P1502F

Biocytin-β-endorphin, human	Opioid Receptor	Neurological Disease
Biocytin-β-endorphin, human is abiotinylated β-Endorphin, human (HY-P1502). β-Endorphin, human, a prominent endogenous peptide, existing in the hypophysis cerebri and hypothalamus, is an agonist of **opioid receptor, with preferred affinity for μ-opioid receptor** and δ-opioid receptor; β-Endorphin, human exhibits antinociception activity.

HY-P1335A

CTAP TFA 1 Publications Verification	Opioid Receptor	Neurological Disease
CTAP TFA is a potent, highly selective, and BBB penetrant **μ opioid receptor antagonist, with an IC₅₀** of 3.5 nM. CTAP TFA displays over 1200-fold selectivity over δ opioid (IC₅₀=4500 nM) and somatostatin receptors. CTAP TFA can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction .

HY-P3517

β-Endorphin (6-31), human β-EP (6-31), human	Opioid Receptor	Neurological Disease Endocrinology
β-Endorphin, an endogenous opioid neuropeptide, is an **opioid receptor** agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation .

HY-P1300

[(pF)Phe4]Nociceptin(1-13)NH2	Opioid Receptor	Neurological Disease
[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective *NOP receptor* (OP4) agonist, with a pK_i of 10.68 and a pEC₅₀** of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold) .

HY-P10555

(D-Arg2, Sar 4)-Dermorphin (1-4)	Opioid Receptor	Neurological Disease
(D-Arg2, Sar 4)-Dermorphin (1-4) is a tetrapeptide derivative of the peptide Dermorphin (HY-P0244) found in amphibian skin. (D-Arg2, Sar 4)-Dermorphin (1-4) has significant analgesic effects by binding to the μ-opioid receptor (MOR) in the body. (D-Arg2, Sar 4)-Dermorphin (1-4) can be used in the development of analgesic drugs .

HY-P1626

Acetyl tetrapeptide-15	Opioid Receptor	Neurological Disease
Acetyl tetrapeptide-15 is a synthetic peptide. Acetyl tetrapeptide-15 is derived from endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), a human μ-opioid agonist with selective anti-nociceptive effect. Acetyl tetrapeptide-15 reduces skin hyperreactivity producing inflammatory, chronic and neuropathic pain, by increasing the threshold of neuronal excitability in μ-opioid receptor via an endorphin-like pathway. Acetyl tetrapeptide-15 is used in the cosmetics for sensitive skin .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P0244

Dermorphin	Structural Classification Natural Products Animals Source classification Phenols Polyphenols	Opioid Receptor
Dermorphin is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-15122

Sinomenine Maximum Cited Publications 13 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Sinomenium acutum(Thunb．)Rehd．Et Wils． Source classification Plants Menispermaceae Alkaloids Piperidine Alkaloids Monophenols Phenols Inflammation/Immunology Disease Research Fields	NF-κB Opioid Receptor Autophagy Apoptosis
Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of **μ-opioid receptor** .

HY-N0398

Sec-O-Glucosylhamaudol	Structural Classification Flavonoids Flavones Carpesium cernuum L. Umbelliferae Plants	Opioid Receptor
Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of **μ-opioid receptor**, with analgesic effect .

HY-15122A

Sinomenine hydrochloride Maximum Cited Publications 13 Publications Verification Cucoline hydrochloride	Structural Classification Neurological Disease Classification of Application Fields Sinomenium acutum(Thunb．)Rehd．Et Wils． Source classification Plants Menispermaceae Alkaloids Piperidine Alkaloids Monophenols Phenols Inflammation/Immunology Disease Research Fields	NF-κB Opioid Receptor Autophagy Apoptosis
Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of **μ-opioid receptor** .

HY-15122R

Sinomenine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Monophenols Sinomenium acutum(Thunb．)Rehd．Et Wils． Source classification Phenols Plants Menispermaceae	NF-κB Opioid Receptor Autophagy Apoptosis
Sinomenine (Standard) is the analytical standard of Sinomenine. This product is intended for research and analytical applications. Sinomenine, an alkaloid extracted from?Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

HY-P0185

Endomorphin 1 2 Publications Verification	Natural Products Monophenols Pyrrole Alkaloids Neurological Disease Source classification Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids	Opioid Receptor
Endomorphin 1, a high affinity, highly selective agonist of the **μ-opioid receptor (K_i: 1.11 nM), displays reasonable affinities for kappa₃ binding sites, with K_i** value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties .

HY-N15180

Corynantheidine (-)-Corynantheidine	Structural Classification Alkaloids Source classification Rubiaceae Mitragyna speciosa Korth. Plants Indole Alkaloids	Opioid Receptor
Corynantheidine ((-)-Corynantheidine) is a **mu-opioid receptor** (MOR) partial agonist that shows MOR-dependent analgesic effects in mice .

HY-P0244A

Dermorphin TFA	Structural Classification Animals Source classification Phenols Polyphenols	Opioid Receptor
Dermorphin TFA is a natural heptapeptide **μ-opioid receptor (MOR**) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-A0115R

Ramiprilat (Standard)	Structural Classification Alkaloids Pyrrole Alkaloids Source classification Endogenous metabolite	Drug Metabolite Angiotensin-converting Enzyme (ACE) Endogenous Metabolite
Alvimopan (dihydrate) (Standard) is the analytical standard of Alvimopan (dihydrate). This product is intended for research and analytical applications. Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus .

HY-15122AR

Sinomenine hydrochloride (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Monophenols Sinomenium acutum(Thunb．)Rehd．Et Wils． Source classification Phenols Plants Menispermaceae	NF-κB Opioid Receptor Autophagy Apoptosis
Sinomenine hydrochloride (Standard) is the analytical standard of Sinomenine hydrochloride. This product is intended for research and analytical applications. Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation . Sinomenine also is an activator of μ-opioid receptor .

HY-N0398R

Sec-O-Glucosylhamaudol (Standard)	Structural Classification Flavonoids Flavones Carpesium cernuum L. Umbelliferae Plants	Opioid Receptor
Sec-O-Glucosylhamaudol (Standard) is the analytical standard of Sec-O-Glucosylhamaudol. This product is intended for research and analytical applications. Sec-O-Glucosylhamaudol is a natural compound extracted from Peucedanum japonicum Thunb, decreases levels of μ-opioid receptor, with analgesic effect .

HY-N0923

Corydaline (+)-Corydaline; Corydalin	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Cholinesterase (ChE) Enterovirus Opioid Receptor
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 μM. Corydaline is a **μ-opioid receptor (K_i of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀** of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

HY-N0923R

Corydaline (Standard)	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Cholinesterase (ChE) Enterovirus Opioid Receptor
Corydaline (Standard) is the analytical standard of Corydaline. This product is intended for research and analytical applications. Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities .

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HY-P702403

	OPRM1 Protein, Human (Cell-Free, His) Mu-type opioid receptor; Mu opiate receptor; Mu opioid receptor; MOP; hMOP	Human	E. coli Cell-free
	The OPRM1 protein serves as a receptor for endogenous and synthetic opioids and undergoes conformational changes upon agonist binding, activating downstream signaling pathways. This includes coupling to G proteins, thereby regulating adenylyl cyclase, calcium channels, potassium channels, and intracellular signaling pathways. OPRM1 Protein, Human (Cell-Free, His) is the recombinant human-derived OPRM1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-A0118AS

Naloxegol-d5 oxalate
Naloxegol-d₅ (oxalate) is deuterium labeled Naloxegol (oxalate). Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is a μ-opioid-receptor antagonist. Naloxegol oxalate inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-A0118S1

Naloxegol-13C,d2
Naloxegol- ¹³C,d₂ (NKTR-118- ¹³C,d₂) is ¹³C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-A0118S

Naloxegol-13C,d3
Naloxegol- ¹³C,d₃ (NKTR-118- ¹³C,d₃) is ¹³C labeled Naloxegol. Naloxegol (NKTR-118; AZ-13337019) is a μ-opioid-receptor antagonist. Naloxegol inhibits opioid binding in μ-opioid receptors in the gastrointestinal tract and effective for alleviating opioid-induced constipation .

HY-13243S1

Alvimopan-d7

Alvimopan-d₇ (ADL 8-2698-d₇) is deuterium labeled Alvimopan. Alvimopan (ADL 8-2698) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC₅₀ of 1.7 nM. Alvimopan has selectivity for μ-opioid receptor (K_i=0.47 nM) over κ- and δ-opioid receptors (K_is=100, 12 nM, respectively). Alvimopan can be used for the research of postoperative ileus .

HY-109054AS

O-Desmethyltramadol-d6 hydrochloride
O-Desmethyltramadol-d6 (hydrochloride) is a deuterated labeled O-Desmethyltramadol (hydrochloride) . O-Desmethyltramadol (hydrochloride) is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .

HY-132428S

O-Desmethyl Tramadol-d6
O-Desmethyl Tramadol-d₆ is the deuterium labeled O-Desmethyl Tramadol.?O-Desmethyl Tramadol is a primary active metabolite of Tramadol. O-Desmethyl Tramadol is mainly responsible for its μ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme .

HY-123689S

Samidorphan-d4

Samidorphan-d4 is the deuterium labeled Samidorphan(HY-123689).Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ‐opioid, κ‐opioid, and δ‐opioid receptors. Samidorphan acts as an antagonist at μ‐opioid receptors and acts as a partial agonist at k-opioid and δ‐opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo .

HY-123689S1

Samidorphan-d5

Samidorphan-d5 (ALKS-33-d5) is is a deuterated compound of Samidorphan. Samidorphan is an orally active opioid system modulator that binds with high affinity to μ-opioid, κ-opioid, and δ-opioid receptors. Samidorphan is a μ-opioid receptor antagonist and a partial agonist at k-opioid and δ-opioid receptors. Samidorphan acts primarily as an opioid receptor antagonist in vivo .

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