Vamp3 - vesicle-associated membrane protein 3 Gene

Rattus norvegicus

Gene ID: 29528 | Gene type: protein coding

About Vamp3

Summary

Enables syntaxin-1 binding activity. Involved in protein-containing complex assembly. Located in apical plasma membrane; clathrin-coated vesicle membrane; and recycling endosome. Part of SNARE complex. Is integral component of synaptic vesicle membrane. Orthologous to human VAMP3 (vesicle associated membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Vamp3 Products(1)

mRNA	Protein	Name
NM_057097.2	NP_476438.1	vesicle-associated membrane protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IPI IPI: Inferred from physical interaction	7698987	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9396746	RGD
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	7698987	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	10051443	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	10051443	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	7573412	RGD
located in clathrin-coated vesicle membrane	IDA IDA: Inferred from direct assay	7573412	RGD
located in intracellular vesicle	IDA IDA: Inferred from direct assay	12737809	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	10468577	RGD
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	17110340	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	17110340	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicle-associated membrane protein 3

CEB	VAMP-3
cellubrevin	synaptobrevin-3

Vamp3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Vamp3	P63025	Bves	Mus musculus	Q9ES83	Pull Down	20057356
Cross	Vamp3	P63025	Bves	Mus musculus	Q9ES83	Anti Tag CoIP	20057356

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10809	VAMP	Inhibitor	/	Unkown
HY-RS15595	VAMP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22908	Vamp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29422	Vamp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vamp3	NCBI	NCBI:9341

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