Bves - blood vessel epicardial substance Gene

Mus musculus

Also known as Pop1; mBVES; Popdc1

Gene ID: 23828 | Gene type: protein coding

About Bves

Summary

Enables cAMP binding activity. Involved in several processes, including positive regulation of receptor recycling; response to ischemia; and substrate adhesion-dependent cell spreading. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; regulation of heart rate; and sinoatrial node cell development. Located in several cellular components, including bicellular tight junction; lateral plasma membrane; and sarcolemma. Is integral component of membrane. Is expressed in several structures, including gut; heart; leg muscle; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2X. Orthologous to human BVES (blood vessel epicardial substance). [provided by Alliance of Genome Resources, Apr 2022]

Bves Products(1)

mRNA	Protein	Name
NM_024285.3	NP_077247.1	blood vessel epicardial substance

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cAMP binding	IDA IDA: Inferred from direct assay	22354168	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16188940	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration involved in heart development	IMP IMP: Inferred from mutant phenotype	24048452	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IGI IGI: Inferred from genetic interaction	24029230	MGI
involved in positive regulation of locomotion	IDA IDA: Inferred from direct assay	18541910	MGI
involved in positive regulation of receptor recycling	IDA IDA: Inferred from direct assay	20057356	MGI
involved in regulation of GTPase activity	IDA IDA: Inferred from direct assay	18541910	MGI
involved in regulation of cell shape	IDA IDA: Inferred from direct assay	18541910	MGI
involved in regulation of endocytic recycling	IMP IMP: Inferred from mutant phenotype	24048452	MGI
acts upstream of or within regulation of heart rate	IMP IMP: Inferred from mutant phenotype	22354168	MGI
acts upstream of or within regulation of membrane potential	IGI IGI: Inferred from genetic interaction	22354168	MGI
involved in response to ischemia	IMP IMP: Inferred from mutant phenotype	24066022	MGI
acts upstream of or within sinoatrial node cell development	IMP IMP: Inferred from mutant phenotype	22354168	MGI
involved in substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	20057356	MGI
involved in vesicle docking	IMP IMP: Inferred from mutant phenotype	24048452	MGI
involved in vesicle-mediated transport	IDA IDA: Inferred from direct assay	20057356	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	16188940	MGI
located in caveola	IDA IDA: Inferred from direct assay	24066022	MGI
located in cell projection membrane	IDA IDA: Inferred from direct assay	24048452	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	16188940	MGI
located in membrane	IDA IDA: Inferred from direct assay	10882522	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18541910	MGI
located in sarcolemma	IDA IDA: Inferred from direct assay	24066022	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

blood vessel epicardial substance

popeye 1	popeye domain-containing protein 1
popeye protein 1

Bves Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Bves	Q9ES83	Arhgef25	Mus musculus	Q9CWR0	Y2H	18541910
Intra	Bves	Q9ES83	Arhgef25	Mus musculus	Q9CWR0	Pull Down	18541910
Cross	Bves	Q9ES83	Vamp3	Rattus norvegicus	P63025	IF	20057356

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01687	BVES Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bves	NCBI	NCBI:11149

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