2. Gene
  3. Irf3 - interferon regulatory factor 3 Gene

Irf3 - interferon regulatory factor 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 292892 | Gene type: protein coding

About Irf3

Summary

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and protein homodimerization activity. Involved in cellular response to exogenous dsRNA; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of cytokine production. Predicted to be located in cytosol and mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Irf3 Products(1)

mRNA Protein Name
NM_001006969.1 NP_001006970.1 interferon regulatory factor 3
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to exogenous dsRNA IEP
IEP: Inferred from expression pattern
18223009 RGD
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
20670634 RGD
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
20670634 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 3

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-176426 Subquinocin / Phase 4
HY-10249 GSK-690693 99.03% Phase 1
Pre-clinical Phase
Bioactive Molecules (35)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12326A c-di-AMP disodium Agonist 99.71% Unkown
HY-P1934 Cyclo(Phe-Pro) Inhibitor 98.77% Unkown
HY-101950 KIN1148 Inhibitor ≥98.0% Unkown
HY-P1680 Astin C Inhibitor 99.47% Unkown
HY-113469 Cyclic GMP Activator 99.43% Unkown
HY-139056 SU0268 Inhibitor 99.96% Unkown
HY-113469A Cyclic GMP sodium Activator 99.89% Unkown
HY-160225 ISD sodium Activator 98.02% Unkown
HY-W140974 SN-001 Inhibitor 98.94% Unkown
HY-152956 STING agonist-23 Agonist 99.16% Unkown
HY-D0162 Malachite green hemioxalate ≥98.0% Unkown
HY-124652 TBK1/IKKε-IN-4 Inhibitor 99.42% Unkown
HY-112951 ChX710 99.91% Unkown
HY-156449 STING-IN-7 Inhibitor 98.75% Unkown
HY-12326B c-di-AMP diammonium Agonist 99.36% Unkown
HY-126113 KIN101 Inhibitor 99.44% Unkown
HY-12326 c-di-AMP Agonist 99.29% Unkown
HY-123805 KIN1400 98.1% Unkown
HY-152959 STING agonist-26 Agonist 99.56% Unkown
HY-113469B Cyclic GMP (TBAOH) Activator 99.07% Unkown
HY-148606 STING modulator-3 Inhibitor / Unkown
HY-148645 STING modulator-4 Modulator / Unkown
HY-152957 STING agonist-24 Agonist / Unkown
HY-152958 STING agonist-25 Agonist / Unkown
HY-152961 STING agonist-28 Agonist / Unkown
HY-160222 HSV-60mer sodium Activator / Unkown
HY-173399 hSTING activator-1 / Unkown
HY-173462 TBK1-IN-2 Inhibitor / Unkown
HY-176192 SMU-14a Inhibitor / Unkown
HY-RS06907 IRF3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W767865 Cyclic GMP sodium-13C5 / Unkown
HY-149724 Anti-inflammatory agent 65 Inhibitor / Unkown
HY-N3548 Catalpalactone Inhibitor / Unkown
HY-RS16587 Irf3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23022 Irf3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf3 NCBI NCBI:3661
Mus musculus Irf3 NCBI NCBI:54131