2. Immunology/Inflammation Anti-infection
  3. STING HSV
  4. Astin C

Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Astin C Chemical Structure

Astin C Chemical Structure

CAS No. : 148057-23-2

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Based on 1 publication(s) in Google Scholar

Astin C Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers[1][2][3].

In Vitro

Astin C (10 μM; 6 h) significantly inhibits the expression of Ifnb mRNA induced by cGAS or STING in HEK293 cells[1].
Astin C (10 μM; 6 h) significantly impaires the interactions between STING and IRF3, as well as between STING and SCAP, and inhibits the aggregation of SCAP and IRF3 in HEK293T cells and MEFs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Astin C Related Antibodies

Real Time qPCR[1]

Cell Line: HEK293 treated cGAS or STING
Concentration: 10 μM
Incubation Time: 6 h
Result: Inhibited the mRNA level of Ifnb.
In Vivo

Astin C (2-4 mg/kg; tail vein injection; once every 2 days; 7 days) can make C57BL/6 mice more susceptible to HSV-1 infection. Additionally, in the autoimmune disease model of Trex1-/- mice, it exhibits anti-inflammatory activity[1].
Astin C (5.0 mg/kg; intraperitoneal injection; 5 days) achieves a tumor growth inhibition rate of 45% in male ICR mice inoculated with Sarcoma 180 ascites tumor[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Trex1-/- mice[1]
Dosage: 2 and 4 mg/kg
Administration: Tail vein injection; once every 2 days; 7 days
Result: Inhibited the expression of type I interferon and pro-inflammatory cytokines in Trex1-/- BMDMs.
Alleviated autoimmune inflammatory symptoms, decreased the abundance of sera autoantibodies, and reduced the percentage of activated CD8+ T cells in the spleen.
Molecular Weight

570.47

Formula

C25H33Cl2N5O6
CAS No.
Appearance

Solid

Color

Off-white to yellow

Sequence

Cyclo({Abu}-Pro-{Abu}-Ser-{Oaa})
Sequence Shortening

Cyclo({Abu}-P-{Abu}-S-{Oaa})
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (175.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7529 mL 8.7647 mL 17.5294 mL
5 mM 0.3506 mL 1.7529 mL 3.5059 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.77%

SDS (252 KB)

COA (257 KB) RP-HPLC (261 KB) MS (71 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7529 mL 8.7647 mL 17.5294 mL 43.8235 mL
5 mM 0.3506 mL 1.7529 mL 3.5059 mL 8.7647 mL
10 mM 0.1753 mL 0.8765 mL 1.7529 mL 4.3824 mL
15 mM 0.1169 mL 0.5843 mL 1.1686 mL 2.9216 mL
20 mM 0.0876 mL 0.4382 mL 0.8765 mL 2.1912 mL
25 mM 0.0701 mL 0.3506 mL 0.7012 mL 1.7529 mL
30 mM 0.0584 mL 0.2922 mL 0.5843 mL 1.4608 mL
40 mM 0.0438 mL 0.2191 mL 0.4382 mL 1.0956 mL
50 mM 0.0351 mL 0.1753 mL 0.3506 mL 0.8765 mL
60 mM 0.0292 mL 0.1461 mL 0.2922 mL 0.7304 mL
80 mM 0.0219 mL 0.1096 mL 0.2191 mL 0.5478 mL
100 mM 0.0175 mL 0.0876 mL 0.1753 mL 0.4382 mL
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Astin C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Astin C148057-23-2AsterinSTINGHSVStimulator of Interferon GenesTMEM173MITAERISMPYSHerpes simplex virusnonribosomal peptideTrex1-/- miceHEK293TMEFsInhibitorinhibitorinhibit

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