2. Academic Validation
  3. Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus

Cyclic peptides from higher plants. XXVIII. Antitumor activity and hepatic microsomal biotransformation of cyclic pentapeptides, astins, from Aster tataricus

  • Chem Pharm Bull (Tokyo). 1996 May;44(5):1026-32. doi: 10.1248/cpb.44.1026.
H Morita 1,  S Nagashima,  Y Uchiumi,  O Kuroki,  K Takeya,  H Itokawa
Affiliations

Affiliation

  • 1 Department of Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
PMID: 8689717 DOI: 10.1248/cpb.44.1026
Abstract

Antitumor activities on Sarcoma 180A of a series of cyclic pentapeptides, astins, isolated from the roots of Aster tataricus, were examined. The activities on various congeners of the dichlorinated proline residues prepared by chemical conversion and a hepatic microsomal biotransformation in rats suggested that 1,2-cis dichlorinated proline residues of astins A, B and C play an important role in the antitumor activity of astins.

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