Rho - rhodopsin Gene

Mus musculus

Also known as Ops; RP4; Opn2; Noerg1

Gene ID: 212541 | Gene type: protein coding

About Rho

Summary

Predicted to enable G protein-coupled photoreceptor activity; retinal binding activity; and spectrin binding activity. Involved in photoreceptor cell maintenance. Acts upstream of or within several processes, including detection of temperature stimulus involved in thermoception; thermotaxis; and visual perception. Located in several cellular components, including photoreceptor inner segment; sperm head plasma membrane; and sperm midpiece. Is expressed in several structures, including brain; eye; and heart. Used to study congenital stationary night blindness autosomal dominant 1 and retinitis pigmentosa 4. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 1; fundus albipunctatus; night blindness; retinitis pigmentosa; and retinitis pigmentosa 4. Orthologous to human RHO (rhodopsin). [provided by Alliance of Genome Resources, Apr 2022]

Rho Products(1)

mRNA	Protein	Name
NM_145383.2	NP_663358.1	rhodopsin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17881533	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to light stimulus	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within detection of light stimulus	IMP IMP: Inferred from mutant phenotype	11747369	MGI
acts upstream of or within detection of temperature stimulus involved in thermoception	IGI IGI: Inferred from genetic interaction	31924821	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	32960171	MGI
acts upstream of or within microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15976449	MGI
acts upstream of or within photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	22183357	MGI
involved in photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	32312889	MGI
acts upstream of or within phototransduction	IMP IMP: Inferred from mutant phenotype	16723493	MGI
acts upstream of or within podosome assembly	IMP IMP: Inferred from mutant phenotype	15976449	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	10097103	MGI
acts upstream of or within response to light intensity	IMP IMP: Inferred from mutant phenotype	32960171	MGI
acts upstream of or within response to light stimulus	IMP IMP: Inferred from mutant phenotype	16723493	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within rod bipolar cell differentiation	IMP IMP: Inferred from mutant phenotype	32960171	MGI
acts upstream of or within sensory perception of light stimulus	IMP IMP: Inferred from mutant phenotype	16723493	MGI
acts upstream of or within thermotaxis	IGI IGI: Inferred from genetic interaction	31924821	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	22937111	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	10399916	MGI
located in photoreceptor outer segment	IDA IDA: Inferred from direct assay	10725384	MGI
located in rod photoreceptor outer segment	IDA IDA: Inferred from direct assay	19332056	MGI
located in sperm head plasma membrane	IDA IDA: Inferred from direct assay	31924821	MGI
located in sperm midpiece	IDA IDA: Inferred from direct assay	31924821	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rhodopsin

L opsin	LWS opsin
long wavelength sensitive opsin	opsin 2
red opsin	rod opsin

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10583	Y-27632 dihydrochloride	Inhibitor	99.98%	Unkown
HY-10583R	Y-27632 (dihydrochloride) (Standard)	Inhibitor	/	Unkown
HY-12798B	Netarsudil hydrochloride	Inhibitor	99.90%	Unkown
HY-12798	Netarsudil	Inhibitor	99.94%	Unkown
HY-B0515	Ibandronate Sodium Monohydrate	Inducer	≥98.0%	Unkown
HY-12798A	Netarsudil dimesylate		99.90%	Unkown
HY-B0515B	Ibandronate Sodium	Inducer	/	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109191	Sovesudil	Inhibitor	99.91%	Phase 3
HY-109191A	Sovesudil hydrochloride	Inhibitor	99.45%	Phase 3
HY-113225B	Guanosine triphosphate tritris		/	Phase 3
HY-148808	Zelasudil	Inhibitor	99.33%	Phase 2
HY-I0400	N-Acetylneuraminic acid		99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (57)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15392	Chroman 1	Inhibitor	99.42%	Unkown
HY-12755	ML141		99.96%	Unkown
HY-12646	Rhosin hydrochloride		99.93%	Unkown
HY-16563	Narciclasine	Activator	99.88%	Unkown
HY-17543	ML-323	Inhibitor	99.51%	Unkown
HY-13991	CCG-1423		99.88%	Unkown
HY-10583G	Y-27632 dihydrochloride (GMP)	Inhibitor	/	Unkown
HY-111458	GSK2643943A	Inhibitor	98.79%	Unkown
HY-104064	1A-116		99.72%	Unkown
HY-108361	CCG-203971	Inhibitor	99.89%	Unkown
HY-121750	CCG-222740	Inhibitor	99.53%	Unkown
HY-12649	Y16	Inhibitor	98.10%	Unkown
HY-115376	Z62954982	Inhibitor	99.38%	Unkown
HY-N6012	(-)-Alkannin	Inducer	99.88%	Unkown
HY-108518	SB-772077B dihydrochloride	Inhibitor	99.33%	Unkown
HY-134817	USP7-IN-8	Inhibitor	99.04%	Unkown
HY-18990	GSK180736A	Inhibitor	98.81%	Unkown
HY-150640	Rho-Kinase-IN-2	Inhibitor	99.29%	Unkown
HY-N2438	Methylophiopogonanone B	Activator	99.84%	Unkown
HY-100270	Rho-Kinase-IN-1	Inhibitor	99.91%	Unkown
HY-117149	MLS000532223	Inhibitor	99.46%	Unkown
HY-139170	CAY10746	Inhibitor	99.77%	Unkown
HY-111432	CCG-232601	Inhibitor	99.00%	Unkown
HY-W050122	S-(+)-GABOB		/	Unkown
HY-122011	PF-4950834	Inhibitor	99.60%	Unkown
HY-15392A	Chroman 1 dihydrochloride	Inhibitor	99.11%	Unkown
HY-112362	3-(4-Pyridyl)indole	Inhibitor	≥99.0%	Unkown
HY-126913	Rhodblock 6	Inhibitor	98.94%	Unkown
HY-152095	PPI-GIT1/β-Pix interaction-IN-1	Inhibitor	99.01%	Unkown
HY-12646A	Rhosin		95.08%	Unkown
HY-103045A	CMPD101 hydrochloride	Inhibitor	/	Unkown
HY-118046	GSK2163632A	Inhibitor	/	Unkown
HY-118837	WF-536	Inhibitor	/	Unkown
HY-120429	SKLB-163	Inducer	/	Unkown
HY-123345	CRT 0105446	Inhibitor	/	Unkown
HY-129907	2-AEMP		/	Unkown
HY-130011	CCG-232964	Inhibitor	/	Unkown
HY-134913	Rhodblock 1a	Inhibitor	/	Unkown
HY-137638	Sp-5,6-DCl-cBIMPS	Activator	/	Unkown
HY-137638A	Sp-5,6-DCl-cBIMPS sodium	Activator	/	Unkown
HY-138147	DCP-Rho1		/	Unkown
HY-13991A	(S)-CCG-1423		/	Unkown
HY-145294	ROCK2-IN-5	Inhibitor	/	Unkown
HY-15720B	Glycyl H-1152 hydrochloride	Inhibitor	/	Unkown
HY-172917	Rho GTPase inhibitor 1	Inhibitor	/	Unkown
HY-173222	P-gp inhibitor 28	Inhibitor	/	Unkown
HY-P2325	Exoenzyme C3, clostridium botulinum		/	Unkown
HY-P5158	Conopeptide rho-TIA	Inhibitor	/	Unkown
HY-P5467	S6(229-239), Amide, biotinalyted	Substrate	/	Unkown
HY-RS11944	RHO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-118151	Rho-Kinase-IN-3	Inhibitor	/	Unkown
HY-130448	8-iso Prostaglandin F1β		/	Unkown
HY-158652	(R)-CCG-1423	Inhibitor	/	Unkown
HY-P10393	ERα17p	Inducer	/	Unkown
HY-P10636	Nictide		/	Unkown
HY-RS17157	Rho Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23607	Rho Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rho	NCBI	NCBI:6010
Canis familiaris	Rho	NCBI	NCBI:493763

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