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  3. Biochemical Assay Reagents ROCK
  4. Exoenzyme C3, clostridium botulinum

Exoenzyme C3, clostridium botulinum, is a mono-ADP-ribosylating enzyme. Exoenzyme C3, clostridium botulinum specifically modifies RhoA, B, and C by transferring ADP-ribose to them, thereby inactivating these GTPases. Exoenzyme C3, clostridium botulinum can induce neuronal axonal and dendritic growth, inhibit macrophage migration, and regulate cytoskeletal dynamics. Exoenzyme C3, clostridium botulinum can be used in the research of spinal cord injury and diabetic painful neuropathy.

For research use only. We do not sell to patients.

Exoenzyme C3, clostridium botulinum

Exoenzyme C3, clostridium botulinum Chemical Structure

CAS No. : 58319-92-9

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25 μg In-stock

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Exoenzyme C3, clostridium botulinum Related Antibodies

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Description

Exoenzyme C3, clostridium botulinum, is a mono-ADP-ribosylating enzyme. Exoenzyme C3, clostridium botulinum specifically modifies RhoA, B, and C by transferring ADP-ribose to them, thereby inactivating these GTPases. Exoenzyme C3, clostridium botulinum can induce neuronal axonal and dendritic growth, inhibit macrophage migration, and regulate cytoskeletal dynamics. Exoenzyme C3, clostridium botulinum can be used in the research of spinal cord injury and diabetic painful neuropathy[1][2][3][4][5].

In Vitro

Exoenzyme C3, Clostridium botulinum (10 nM-1 μM; 7-24 h) induces bipolar protrusions in J774A.1 macrophages via RhoA ADP-ribosylation[2].
Exoenzyme C3, Clostridium botulinum (1 μM; 72 h) alters the abundance of 55 proteins in SH-SY5Y cells[3].
Exoenzyme C3, Clostridium botulinum (1 μM; 24-144 h) causes significant proteome changes in HT22 cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Exoenzyme C3, clostridium botulinum Related Antibodies
In Vivo

Exoenzyme C3, Clostridium botulinum (1-10 pg; intrathecal injection) can dose-dependently prolong the tail-flick latency and increase the mechanical threshold of diabetic mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Normal and Streptozotocin (HY-13753)-induced diabetic male ICR mice (weighing about 20 g) aged 4 weeks[5]
Dosage: 1 pg, 3 pg, 10 pg
Administration: Intrathecal injection
Result: Dose-dependently prolonged the tail-flick latency of diabetic mice at 24, 48 and 72 h after treatment and increased their mechanical threshold at 48 h after treatment.
Had no effect on the tail-flick latency and mechanical threshold of non-diabetic mice.
CAS No.
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White to off-white

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[Exoenzyme C3, clostridium botulinum]
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Exoenzyme C3, clostridium botulinum Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Exoenzyme C3, clostridium botulinum58319-92-9Biochemical Assay ReagentsROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKGrowth coneNeuroneNeuronal injuryRhoneuro-regenerationpost-traumaticInhibitorinhibitorinhibit

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