2. Immunology/Inflammation Stem Cell/Wnt Cytoskeleton Cell Cycle/DNA Damage TGF-beta/Smad
  3. IFNAR ROCK
  4. Centaureidin

Centaureidin is an orally active IFN-promoter that can be isolated from Bidens pilosa with an EC50 of 0.9 μg/mL. Centaureidin activates the Rho signal pathway, leading to actin and tubulin disassembly, and resulting in dendrite retraction and stress fiber formation in melanocytes. Centaureidin shows high tumor cell growth inhibitory activities. Centaureidin significantly inhibits paw edema in mice[1][2][3][4][5].

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Centaureidin Chemical Structure

Centaureidin Chemical Structure

CAS No. : 17313-52-9

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Centaureidin Related Antibodies

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Description

Centaureidin is an orally active IFN-promoter that can be isolated from Bidens pilosa with an EC50 of 0.9 μg/mL. Centaureidin activates the Rho signal pathway, leading to actin and tubulin disassembly, and resulting in dendrite retraction and stress fiber formation in melanocytes. Centaureidin shows high tumor cell growth inhibitory activities. Centaureidin significantly inhibits paw edema in mice[1][2][3][4][5].

In Vitro

Centaureidin (2 μg/mL, 24-72 h) can stimulate IFN-γ transcription in a T cell line and Jurkat cells[1].

Centaureidin (0.5 μM, 6 days) inhibits melanosome transfer and induces cell morphological change in NHEM cells[2].

Centaureidin (0.5 μM, 24-72 h) reduces dendricity and stress fiber formation of NHEM cells [2].

Centaureidin (0.5 μM, 30-240 min) activates the Rho signal pathway, but not Rac or CDC42 in NHEM cells [2].

Centaureidin (72 h) shows high cell growth inhibitory activities with IC50s of 0.0819 μM (HeLa cells), 0.1250 μM (MCF-7 cells), 0.3540 μM (A-431 cells)[3].

Centaureidin (10-100 μM) completely relaxes, in a concentration-dependent fashion, the contractions induced by Norepinephrine (NA) (HY-13715) (IC50 = 16.7 μM) or by a high K concentration (IC50 = 16.1 μM ) in intact rat aortic rings[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Centaureidin Related Antibodies

Western Blot Analysis[2]

Cell Line: NHEM cells
Concentration: 0.5 μM
Incubation Time: 30, 60, 240 min
Result: Increased GTP-bound Rho content nearly 200% at 30 min, whereas GTP-Rac content showed only a slight increase.
Elevated GTP-Rho at 4 h.
Decreased the level of GTP CDC42.
In Vivo

Centaureidin (25 mg/kg, p.o.) significantly inhibits paw edema induced by Carrageenan (HY-125474) in mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Swiss mice (15-25 g) injected with 0.05 mL 3% Carrageenan (Type IV) in saline[5]
Dosage: 25 mg/kg
Administration:
Result: Inhibited paw edema by 55.5% at 5 h post-carrageenan injection.
Molecular Weight

360.31

Formula

C18H16O8
CAS No.
SMILES

O=C1C(OC)=C(C2=CC(O)=C(OC)C=C2)OC3=CC(O)=C(C(O)=C13)OC
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Centaureidin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Centaureidin17313-52-9IFNARROCKInterferon-α/β receptorInterferon-alpha/beta receptor Rho-associated protein kinaseRho-associated kinaseRho-kinaseROKRhomelanosomeactintubulinHeLaMCF-7IFNγNHEMInhibitorinhibitorinhibit

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