2. Signaling Pathways
  3. Apoptosis
  4. Transferrin Receptor

Transferrin Receptor

TfR; CD71

Transferrin Receptor is a transmembrane glycoprotein. Transferrin Receptor consists of two isoforms, TfR1 and TfR2. Transferrin Receptor mediates the uptake of transferrin-iron complexes. Transferrin Receptor plays an important role in iron homeostasis as a gatekeeper regulating transferrin iron uptake. Transferrin Receptor is also considered as a proliferation marker and an attractive target for anticancer agents (e.g., a marker of poor prognosis in breast cancer). Transferrin Receptor is associated with a variety of cancers including acute leukemia and breast cancer[1][2][3][4][5][6].

Transferrin Receptor Related Products (37):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1651R
    Iron(II) fumarate (Standard)
    Iron(II) fumarate (Standard) is the analytical standard of Iron(II) fumarate. This product is intended for research and analytical applications. Iron(II) fumarate (Ferrous fumarate) is the iron(II) salt of fumaric acid. Iron(II) fumarate is an orally active dietary supplement and has the potential for iron deficiency anemia treatment.
    Iron(II) fumarate (Standard)
  • HY-NP0221
    Rabbit Transferrin
    Rabbit Transferrin is the major iron-containing protein in plasma, responsible for transporting iron absorbed from the digestive tract and iron released by erythrocyte degradation.
    Rabbit Transferrin
  • HY-115832
    Ap44mSe
    Ap44mSe is a selenosemicarbazone that effectively depletes cellular Fe, resulting in transferrin receptor-1 up-regulation, ferritin down-regulation, and increased expression of the potent metastasis suppressor, N-myc downstream regulated gene-1. Ap44mSe forms redox active Cu complexes that target the lysosome to induce lysosomal membrane permeabilization.
    Ap44mSe
  • HY-NP0205
    Sheep transferrin
    Sheep transferrin is a sheep-derived protein that transports iron from the absorption site to cells, where it is stored or utilized.
    Sheep transferrin
  • HY-P991380
    TXB4
    		Inhibitor
    TXB4 is a brain-permeable human monoclonal antibody (mAb) targeting CD71. TXB4 prevents 6-OHDA-induced death of TH-positive neurons in the SNc in a 6-OHDA mouse model of Parkinson's disease (PD). TXB4 can be used in neurodegenerative diseases, acute brain and spinal cord injury, and depression research.
    TXB4
  • HY-NP0237
    Cynomolgus Monkey transferrin
    Cynomolgus Monkey transferrin is a cynomolgus monkey-derived protein. Transferrin is the transport of iron in the bloodstream. Transferrin can also act as a growth factor.
    Cynomolgus Monkey transferrin
  • HY-177820
    XQ-2d sodium
    XQ-2d sodium is an aptamer that targets TfR/CD71. XQ-2d binds to PL45 cells through recognizing CD71 protein.
    XQ-2d sodium
  • HY-173444
    HDAC11-IN-3
    		Activator
    HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 μM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research.
    HDAC11-IN-3
  • HY-NP0210
    Rat Transferrin
    Rat Transferrin is a rat-derived protein. Transferrin is the transport of iron in the bloodstream. Transferrin can also act as a growth factor.
    Rat Transferrin
  • HY-177483
    OART
    OART (Oxaliplatin-artesunate) is a ferroptosis inducer. OART significantly inhibits tumor cell proliferation. OART induces cytoplasmic and mitochondrial LPO to promote tumor ferroptosis, via destroying glutathione-mediated ferroptosis defense system and enhancing iron-dependent Fenton reaction. OART enhances tumor immunogenicity, transforming tumor environment from immunosuppressive to immunosensitive. OART has strong tumor regression in tumor-bearing mouse models. OART can be used for cancer immunotherapy research.
    OART
  • HY-NP0208
    Chicken Serum Transferrin
    Chicken Serum Transferrin is a major serum protein in chicken serum. Chicken Serum Transferrin is primarily responsible for transporting iron.
    Chicken Serum Transferrin
  • HY-P990791
    Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)
    		Inhibitor
    Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse CD71/TfR1. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can deplete CD71+ cells and inhibit transferrin receptor. Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3) can be used for the researches of cancer, infection, inflammation and immunology, such as lung cancer, lymphocytic choriomeningitis virus (LCMV) infection and Cardiac allograft.
    Anti-Mouse CD71/TfR1 Antibody (R17 217.1.3)
  • HY-P10928A
    BCY17901
    		Ligand
    BCY17901 is a potent and selective bicyclic peptide targeting transferrin receptor 1 (TfR1) (Ki=2 nM). BCY17901 selectively delivers antisense oligonucleotides (ASOs) or small interfering RNAs (siRNAs) to skeletal muscle myofibers and cardiomyocytes. BCY17901 can be used in the research of skeletal muscle and cardiac diseases.
    BCY17901
  • HY-P990780
    Zeleciment
    		98.85%
    Zeleciment is an anti-TFRC IgG1κ monoclonal antibody.
    Zeleciment
  • HY-P991381
    JST-TfR09
    		Inhibitor
    TXB4 (PPMX-T003) is a human monoclonal antibody (mAb) targeting CD71. JST-TfR09 can induce ferroptosis by reducing ferritin levels in ATLL cell lines, increasing the generation of ferrous iron and reactive oxygen species (ROS), and inducing lipid peroxidation via malondialdehyde. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
    JST-TfR09
  • HY-P99694
    Lepunafusp alfa
    		Inhibitor
    Lepunafusp alfa (JR-171) is a BBB-penetrable fusion protein consisting of J-Brain Cargo and IDUA (a lysosomal enzyme, α-L-iduronidase). Lepunafusp alfa can reduce concentration of heparan sulfate (HS) and dermatan sulfate (DS). Lepunafusp alfa can be used for research of mucopolysaccharidosis type I.
    Lepunafusp alfa
  • HY-D2426
    Cy3-Transferrin
    Cy3-Transferrin is a fluorescent labeling reagent that combines Cy3 (HY-D0822) fluorescent dye and Transferrin (HY-P3267). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. Transferrin, a blood-plasma glycoprotein, is a target ligand for transferrin receptor. Transferrin can bind to and mediate the transport of iron.
    Cy3-Transferrin