Succinate Dehydrogenase

Succinate Dehydrogenase (SDH), also known as electron transport chain complex II, is a vital enzyme involved in both the citric acid cycle and oxidative phosphorylation. It catalyzes the oxidation of succinate to fumarate, transferring electrons to ubiquinone in the electron transport chain, which is essential for ATP generation and mitochondrial function. In eukaryotes, SDH is composed of four subunits (SDHA-D), localized to the inner mitochondrial membrane, while in prokaryotes, it is found in the cytoplasmic membrane. SDH deficiency can lead to an abnormal accumulation of succinate, contributing to age-related organ degeneration in tissues expressing SUCNR1. Elevated succinate levels have been linked to skeletal diseases such as osteoporosis, rheumatoid arthritis, and osteoarthritis. This highlights the importance of SDH in maintaining cellular homeostasis and preventing metabolic disorders^[1]^[2]^[3].

References:

[1]. Zhao Y, et al. Role of succinate dehydrogenase deficiency and oncometabolites in gastrointestinal stromal tumors. World J Gastroenterol. 2020 Sep 14;26(34):5074-5089. [Content Brief]

[2]. Matlac DM, et al. Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas. Front Endocrinol (Lausanne). 2021 Mar 12;12:589451. [Content Brief]

[3]. Moosavi B, et al. The assembly of succinate dehydrogenase: a key enzyme in bioenergetics. Cell Mol Life Sci. 2019 Oct;76(20):4023-4042. [Content Brief]

Succinate Dehydrogenase Inhibitors (32)

Succinate Dehydrogenase Related Products (33)
Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-119459

Fluopyram	Inhibitor	99.76%
Fluopyram is an orally active succinate dehydrogenase inhibitor, antifungal and nematicide. Fluopyram inhibits succinate dehydrogenase activity, activates CAR/PXR nuclear receptors, and increases caspase-3, TNF-α and NF-κB. Fluopyram inhibits the growth of F. virguliforme, Botrytis cinerea and Alternaria solani with EC₅₀ values of 3.35, 5.389 and 0.244 µg/mL, respectively. Fluopyram induces liver and thyroid tumor formation. Fluopyram is nephrotoxic and embryotoxic.

HY-135549

Fluxapyroxad	Inhibitor	99.96%
Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. Fluxapyroxad inhibits succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species.

HY-44178

Diethyl butylmalonate	Inhibitor	99.79%
Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC₅₀^-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease.

HY-B2011

Flutolanil	Inhibitor	99.44%
Flutolanil is a broad-spectrum fungicide. Flutolanil inhibits mycelial oxygen consumption and succinate dehydrogenase in mitochondria Complex II. Flutolanil causes endocrine disruption and reproductive disorders in zebrafish after long-term exposure. Flutolanil can be used to control the fungal pathogens induced plant disease.

HY-W753375

Fluindapyr	Inhibitor	≥98.0%
Fluindapyr is a broad-spectrum pyrazolamide chiral fungicide of succinate dehydrogenase inhibitor (SDHIs) with broad bactericidal spectrum and good efficacy. Fluopimomide is effective against M. incognita in vitro and application of fuopimomide shows some growth promotion effect in cucumber.

HY-172804

SDH-IN-26	Inhibitor
SDH-IN-26 (Compound C3) is a succinate dehydrogenase (SDH) inhibitor. SDH-IN-26 exhibits significant inhibitory activity against multiple phytopathogenic fungi, such as Rhizoctonia solani and Botrytis cinerea, with an EC₅₀ value of 0.270 μg/mL against Rhizoctonia solani. SDH-IN-26 damages the integrity of the fungal cell membrane, increases membrane permeability, disrupts cell structure, and reduces the number of mitochondria, thus affecting the normal growth of mycelia. SDH-IN-26 leads to a decrease in mitochondrial membrane potential, and induces cell apoptosis. SDH-IN-26 is promising for research of plant diseases caused by fungi.

HY-176140

Succinate dehydrogenase-IN-9	Inhibitor
Succinate dehydrogenase-IN-9 (Compound Iik) is a succinate dehydrogenase inhibitor (IC₅₀: 3.6 μM). Succinate dehydrogenase-IN-9 exhibits potent inhibitory activity against various fungal species (eg: inhibits S. sclerotiorum with an EC₅₀ value of 1.14 μg/mL. Succinate dehydrogenase-IN-9 enhances the nitrate reductase activity, thereby facilitating plant growth.

HY-172810

Succinate dehydrogenase-IN-8	Inhibitor
Succinate dehydrogenase-IN-8 (compound i19) is a potent succinate dehydrogenase (SDH) inhibitor. Succinate dehydrogenase-IN-8, an indene amino acid derivative, demonstrates potent in vitro antifungal activity against Rhizoctonia solani (EC₅₀=0.1843 mg/L), Botrytis cinerea (EC₅₀=0.4829 mg/L), and Sclerotinia sclerotiorum (EC₅₀=0.1349 mg/L).

HY-163890

Succinate dehydrogenase-IN-2	Inhibitor
Succinate dehydrogenase-IN-2 (Compound 12x) is an inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 1.22 mg/L. Succinate dehydrogenase-IN-2 exhibits antifungal activity, that inhibits S. sclerotiorum, V. mali, G. graminis, R. solani and B. cinerea with EC₅₀ of 0.52-3.42 mg/L.

HY-163284

SDH-IN-12	Inhibitor
SDH-IN-12 (compound 9b) is a succinate dehydrogenase inhibitor, which exhibits activity against S. sclerotiorum and C. arachidicola, with EC₅₀s of 0.97 and 2.07 μM, respectively. SDH-IN-12 reveals no significant herbicidal activity against monocotyledonous and dicotyledonous plants.

HY-44178S

Diethyl butylmalonate-d₉	Inhibitor
Diethyl butylmalonate-d₉ is the deuterium labeled Diethyl butylmalonate (HY-44178). Diethyl butylmalonate is a competitive inhibitor of succinate dehydrogenase. Diethyl butylmalonate exerts anti-inflammatory effects by inhibiting ROS production. Diethyl butylmalonate also has neuroprotective activity. In addition, Diethyl butylmalonate shows toxicity to T. pyriformis, with its log(IGC₅₀^-1) being 0.557. Diethyl butylmalonate can be used in the research of diseases such as Alzheimer's disease.

HY-164573

Cyclobutrifluram	Inhibitor
Cyclobutrifluram is a succinate dehydrogenase inhibitor (SDHI) with mean EC₅₀ of 0.025 μg/mL for F. fujikuroi. Cyclobutrifluram has superior antifungal activity and significantly inhibits mycelial growth of sensitive F. fujikuroi, but it induces resistance risk of F. fujikuroi, especially in mutations of amino acid substitutions H248L/Y of FfSdhB and G80R or A83V of FfSdhC2. Cyclobutrifluram can be used for rice bakanae disease (RBD) research.

HY-162142

BB2-50F	Inhibitor	99.52%
BB2-50F, a potent *M. tuberculosis* inhibitor, is a succinate dehydrogenase and F1Fo-ATP synthase inhibitor. BB2-50F rapidly sterilizes both replicating and non-replicating cultures of M. tuberculosis. BB2-50F inhibits succinate oxidation, decreases the activity of the tricarboxylic acid (TCA) cycle, and results in succinate secretion from M. tuberculosis. BB2-50F induces reactive oxygen species (ROS) in M. tuberculosis.

HY-159486

SDH-IN-18	Inhibitor
SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC₅₀ of 0.48 and 1.4 mg/L.

HY-172362

SDH-IN-22	Inhibitor
SDH-IN-22 (Compound SEZC7) is the inhibitor for succinate dehydrogenase (SDH) with an IC₅₀ of 16.6 μM. SDH-IN-22 exhibits antifungal activity that inhibits Magnaporthe grisea with an EC₅₀ of 0.5 mg/L.

HY-158321

SDH-IN-15	Inhibitor
SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC₅₀=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death.

HY-W775091

Isofetamid	Inhibitor
Isofetamid (IKF-5411) is a succinate dehydrogenase inhibitor and a fungicide. Isofetamid exhibits good control effects against various fungal diseases such as gray mold, white mold, and powdery mildew. Isofetamid is promising for research of plant fungal diseases.

HY-172363

Succinate dehydrogenase-IN-6	Inhibitor
Succinate dehydrogenase-IN-6 (Compound E23) is the inhibitor for succinate dehydrogenase that inhibits SDH in Rhizoctonia solani with an IC₅₀ of 11.76 μM. Succinate dehydrogenase-IN-6 disrupts fungal cell membrane, exhibits board-spectrum antifungal activity that inhibits R. solani, V. dahliae, A. solani and C. gloeosporioides with EC₅₀s of 0.41, 0.27, 1.15, 0.27 μg/mL, respectively. Succinate dehydrogenase-IN-6 exhibits no significant toxicity in rice and zebrafish (LC₅₀ > 12.5 μg/mL).

HY-162776

Succinate dehydrogenase-IN-3	Inhibitor
Succinate dehydrogenase-IN-3 (Ig) is an inhibitor of Succinate dehydrogenase (SDH). Succinate dehydrogenase-IN-3 has antifungal activity.

HY-169965

Succinate dehydrogenase-IN-4	Inhibitor
Succinate dehydrogenase-IN-4 (Compound 4b) is the inhibitor for succinate dehydrogenase with an IC₅₀ of 3.38 μM. Succinate dehydrogenase-IN-4 exhibits antifungal activity against Physalospora piricola and Colletotrichum orbiculare with EC₅₀ of 16.33 μM and 18.06 μM.

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Succinate Dehydrogenase

Succinate Dehydrogenase Related Products (33)

Antibodies (1)

Succinate Dehydrogenase Related Products (33):