2. Signaling Pathways
  3. Immunology/Inflammation
    Metabolic Enzyme/Protease
    NF-κB
  4. Reactive Oxygen Species (ROS)

Reactive Oxygen Species (ROS)

Reactive Oxygen Species (ROS)

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Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N1980
    3'-Hydroxypuerarin
    		Inhibitor 99.95%
    3'-Hydroxypuerarin is an isoflavone isolated from the roots of Pueraria lobata (Willd.) Ohwi. 3'-Hydroxypuerarin is a antioxidant, which shows marked ONOO(-), NO•, total ROS scavenging activities.
    3'-Hydroxypuerarin
  • HY-153873
    MSU38225
    		Inducer 99.52%
    MSU38225 is an Nrf-2 inhibitor that increases levels of reactive oxygen species (ROS). MSU38225 inhibits the growth of human lung cancer cells and enhances the sensitivity of human lung cancer cells to chemotherapy in vitro and in vivo. MSU38225 can be used in cancer research.
    MSU38225
  • HY-W014901
    Bisphenol F
    		Activator 99.83%
    Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260).
    Bisphenol F
  • HY-50936S
    Trabectedin-d3
    		Activator 99.08%
    Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment.
    Trabectedin-d<sub>3</sub>
  • HY-161601
    Ferroptosis inducer-2
    		Inducer ≥98.0%
    Ferroptosis inducer-2 (Compound 24) is an inducer for heme oxygenase-1 (HO-1). Ferroptosis inducer-2 exhibits anticancer activity against triple-negative breast cancer (TNBC) cells through induction of ferroptosis.
    Ferroptosis inducer-2
  • HY-147817
    Heme Oxygenase-2-IN-1
    		Inhibitor 99.37%
    Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective heme oxygenase-2 (HO-2) inhibitor with IC50 values of 0.9 μM and 14.9 μM against HO-2 and HO-1, respectively.
    Heme Oxygenase-2-IN-1
  • HY-N8253
    Spiraeoside
    		Inhibitor 99.46%
    Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities.
    Spiraeoside
  • HY-136706
    Luciferase-IN-1
    		Inhibitor 99.59%
    Luciferase-IN-1 is a luciferase inhibitor.
    Luciferase-IN-1
  • HY-134900
    Allyl methyl trisulfide
    		Inhibitor
    Allyl methyl trisulfide is a volatile organic compound and a component of garlic (Allium sativum L.) essential oil, which has antibacterial, antioxidant and antitumor activities.
    Allyl methyl trisulfide
  • HY-N6711
    Equisetin
    		Activator 99.40%
    Equisetin is an N-methylserine-derived acyl tetramic acid, quorum sensing inhibitor (QSI), herbicides and antibiotics. Equisetin specifically inhibits the anionic carriers of substrates in the inner mitochondrial membrane. Equisetin inhibits the activity of HIV-1 integrase, 11β-HSD1, and 2,4-dinitrophenol (Dnp)-stimulated ATPase (IC50 = ~8 nmol per mg of protein). Equisetin exhibits growth inhibition of bacteria, anti-inflammatory, amelioration of lipid-associated disorders, and cytotoxic effects.
    Equisetin
  • HY-114977
    Avenanthramide A
    		Inducer 99.20%
    Avenanthramide A is a phytoalexin, which can be found in oats (Avena sativa L.). Avenanthramide A targets the RNA helicase DDX3, leads to mitochondrial swelling and increased ROS production, and induces apoptosis in CRC cells. Avenanthramide A exhibits antitumor efficacy in mouse model. Avenanthramide A orally active.
    Avenanthramide A
  • HY-W014225
    3-Phenoxybenzoic acid
    		Inducer 99.81%
    3-Phenoxybenzoic acid is the metabolite of pyrethroid insecticides. 3-Phenoxybenzoic acid induces immunotoxicity and oxidative stress, and inhibits the phagocytic ability of macrophages.
    3-Phenoxybenzoic acid
  • HY-B2130R
    Uric acid (Standard)
    Uric acid (Standard) is the analytical standard of Uric acid. This product is intended for research and analytical applications. Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.
    Uric acid (Standard)
  • HY-13619A
    Efaproxiral sodium
    		99.90%
    Efaproxiral sodium (RSR13 sodium) is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.
    Efaproxiral sodium
  • HY-N1408
    trans-Trimethoxyresveratrol
    		99.62%
    Trans-Trimethoxyresveratrol is a derivative of Resveratrol (RSV),and it may be a more potent anti-inflammatory, antiangiogenic and vascular-disrupting agent when compared with resveratrol.
    trans-Trimethoxyresveratrol
  • HY-136651
    BNTA
    		99.68%
    BNTA, a potent extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3). BNTA shows a promising potential for osteoarthritis alleviation by modulating cartilage generation.
    BNTA
  • HY-107744
    Nalmefene
    		Inhibitor 99.70%
    Nalmefene is a BBB-penetrable opioid receptor modulator. Nalmefene is an antagonist of MOR and DOR, and a partial agonist of KOR. Nalmefene has anti-inflammatory and neuroprotective activities. Nalmefene can be used in the research of reducing alcohol-dependent disorders.
    Nalmefene
  • HY-B0166G
    L-Ascorbic acid (GMP)
    		Inhibitor
    L-Ascorbic acid (L-Ascorbate) (GMP) is L-Ascorbic acid (HY-B0166) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. L-Ascorbic acid is an inhibitor of Cav 3.2 channels.
    L-Ascorbic acid (GMP)
  • HY-A0272
    Sodium laureth sulfate (70% in water)
    		Activator
    Sodium laureth sulfate (70% in water) (Sodium lauryl polyoxyethylene ether sulfate) is an anionic active agent with excellent decontamination, emulsification, dispersion, wetting, antifungal and other properties.
    Sodium laureth sulfate (70% in water)
  • HY-Y1322
    Triphenyl phosphate
    		Activator 99.67%
    Triphenyl phosphate is an organic phosphate flame retardant. Triphenyl phosphate can disrupt placental tryptophan metabolism by activating MAOA/ROS/NFκB, leading to abnormal neurological behavior. Triphenyl phosphate promotes oxidative stress by inducing inflammatory factors like nuclear factor kappa B (NFκB), interleukin-6, and tumor necrosis factor α. Triphenyl phosphate can also cause allergic contact dermatitis.
    Triphenyl phosphate
Cat. No. Product Name / Synonyms Application Reactivity