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Results for "

xanthine oxidase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Monoamine Oxidase (1) Xanthine Oxidase (76) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (7) Autophagy (1) Bacterial (3) COX (1) Drug Metabolite (15) Endogenous Metabolite (6) Ferroptosis (3) Fungal (2) HDAC (1) HIV (1) Influenza Virus (3) Isotope-Labeled Compounds (8) Lipoxygenase (1) Necroptosis (1) NF-κB (1) NO Synthase (1) Nucleoside Antimetabolite/Analog (7) Reactive Oxygen Species (3) Reference Standards (1) Reverse Transcriptase (1) Ser/Thr Protease (3) Thrombopoietin Receptor (3) TNF Receptor (3) Toll-like Receptor (TLR) (1) URAT1 (2)
By Research Areas:	Cancer (25) Cardiovascular Disease (6) Infection (10) Inflammation/Immunology (29) Metabolic Disease (37) Neurological Disease (13)
Oligonucleotides:	Nucleosides and their Analogs (4) Nucleoside Phosphoramidites (2) I (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Xanthine Oxidase Lysyl Oxidase Amino Acid Oxidase Pyruvate Oxidase NADPH Oxidase Monoamine Oxidase Protoporphyrinogen IX oxidase VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162961

Xanthine oxidase-IN-16	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-16 is potent and orally active xanthine oxidase (XO) inhibitor with an IC₅₀ of 102 nM. Xanthine oxidase-IN-16 shows significant efficacy in hyperuricemia rats .

HY-123383

Renierol	Xanthine Oxidase	Metabolic Disease
Renierol is an orally active xanthine oxidase (XO) inhibitor. Renierol has urate-lowering activity .

HY-161455

Xanthine oxidase-IN-13	Xanthine Oxidase	Inflammation/Immunology
Xanthine oxidase-IN-13 (Compound 10) is a selective **xanthine oxidase** inhibitor (IC₅₀: 149.56 μM for bovine xanthine oxidase). Xanthine oxidase-IN-13 can be used for research of inflammatory arthritis .

HY-150257A

Xanthine oxidase-IN-11	Xanthine Oxidase	Others
Xanthine oxidase-IN-11 (XO8 analog) is an **xanthine oxidase** (XO) inhibitor .

HY-150257

Xanthine oxidase-IN-10	Xanthine Oxidase	Others
Xanthine oxidase-IN-10 (XO8 analog) is an **xanthine oxidase** (XO) inhibitor .

HY-156360

Xanthine oxidase-IN-12	Xanthine Oxidase Reactive Oxygen Species	Inflammation/Immunology
Xanthine oxidase-IN-12 (Compound 11) is a xanthine oxidase (XO) inhibitor with an IC₅₀ of 91 nM. Xanthine oxidase-IN-12 also has antioxidant activity and reduces intracellular ROS .

HY-161514

Xanthine oxidase-IN-15	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-15 (Compound 6c) is a selective inhibitor of Xanthine oxidase (XO) (IC₅₀=0.13 μM). Xanthine oxidase-IN-15 inhibits XO catalysis by forming a stable interaction with the active site of XO. Xanthine oxidase-IN-15 is mainly used in the study of hyperuricemia and gout .

HY-146273

Xanthine oxidase-IN-7	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-7 (compound1h) is a potent andorally active XO (xanthine oxidase) inhibitor with an IC₅₀ of 0.36 µM. Xanthine oxidase-IN-7 effectively reduces serum uric acid levels. Xanthine oxidase-IN-7 has the potential for the research of hyperuricemia and gout .

HY-144303

Xanthine oxidase-IN-4	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC₅₀ of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research .

HY-N10433

Xanthine oxidase-IN-9 Icarisids E	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC₅₀ of 31.81 μM .

HY-146560

Xanthine oxidase-IN-6	Xanthine Oxidase NF-κB Toll-like Receptor (TLR) TNF Receptor	Metabolic Disease Inflammation/Immunology
Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity .

HY-W560574

Xanthine oxidase-IN-14	Xanthine Oxidase	Cancer
Xanthine oxidase-IN-14 (Compound 3f) is an inhibitor for xanthine oxidase, with IC₅₀ >100 μM. Xanthine oxidase-IN-14 inhibits proliferations of cancer cells MCF-7, NCI-H460 and SF-268, with IC₅₀ greater than 150 μM .

HY-144456

Xanthine oxidase-IN-5	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-5 is an effective and orally active **xanthine oxidase** (XO) inhibitor with IC₅₀ value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model .

HY-U00288

Xanthine oxidase-IN-1 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-1 is a **xanthine oxidase** inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC₅₀ of 6.5 nM.

HY-19164

BOF-4272	Xanthine Oxidase	Metabolic Disease
BOF-4272 is a xanthine oxidase/xanthine dehydrogenase inhibitor. BOF-4272 can be used for hyperuricemia research .

HY-N7397

Forsythoside F Arenarioside	Xanthine Oxidase	Metabolic Disease
Forsythoside F (Arenarioside) is a **xanthine oxidase** inhibitor and possesses antihyperuricemic effects in vivo .

HY-W008550

8-Azaadenine	Xanthine Oxidase	Metabolic Disease
8-Azaadenine is a **Xanthine Oxidase** inhibitor (IC₅₀ = 0.54 μM) .

HY-131267

Febuxostat sec-butoxy acid	Drug Metabolite	Others
Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

HY-131269

Febuxostat impurity 7	Drug Metabolite	Others
Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

HY-131273

Febuxostat amide impurity	Drug Metabolite	Others
Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM

HY-131270

Febuxostat impurity 8	Drug Metabolite	Others
Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

HY-N3906

Fraxamoside	Xanthine Oxidase	Metabolic Disease
Fraxamoside is a competitive **xanthine oxidase** inhibitor with an IC₅₀ of 16.1 μM and a K_i of 0.9 μM .

HY-131253

Febuxostat isopropyl isomer	Drug Metabolite	Others
Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

HY-131271

Febuxostat impurity 6	Drug Metabolite Xanthine Oxidase	Others
Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

HY-131272

Febuxostat dicarboxylic acid impurity	Drug Metabolite	Others
Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

HY-N0196

Baicalein Maximum Cited Publications 25 Publications Verification 5,6,7-Trihydroxyflavone	Xanthine Oxidase Influenza Virus Ferroptosis	Cancer
Baicalein (5,6,7-Trihydroxyflavone) is a **xanthine oxidase** inhibitor with an IC₅₀ value of 3.12 μM.

HY-131266

Febuxostat n-butyl isomer	Drug Metabolite	Others
Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

HY-14268S

Febuxostat-d9	Isotope-Labeled Compounds Xanthine Oxidase	Cancer
Febuxostat-d₉ is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.

HY-131268

O-Desisobutyl-O-n-propyl Febuxostat	Xanthine Oxidase	Metabolic Disease
O-Desisobutyl-O-n-propyl Febuxostat, extracted from the patent CN 103467412, is an **xanthine oxidase** inhibitor .

HY-N10432

Xanthine oxidase-IN-8 Icarisids J	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM .

HY-14268S1

Febuxostat-d7 TEI 6720-d₇; TMX 67-d₇	Isotope-Labeled Compounds Xanthine Oxidase	Metabolic Disease Cancer
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

HY-119955

Amflutizole LY-141894	Xanthine Oxidase	Others
Amflutizole (LY-141894) is an inhibitor of **xanthine oxidase**. Amflutizole abolishes free radical formation and release in cerebral ischemia/reperfusion mice .

HY-N8600

7,8,3′,4′-Tetrahydroxyflavone	Xanthine Oxidase	Metabolic Disease
7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 10.488 µM .

HY-19657

Oxypurinol Oxipurinol	Drug Metabolite Endogenous Metabolite Xanthine Oxidase	Metabolic Disease Inflammation/Immunology
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of **xanthine oxidase**. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-N14414

5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione	Xanthine Oxidase	Infection
5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione is a xanthine oxidase (XO) inhibitor found in Peniophora sanguinea .

HY-W104467

(+/-)-Epicatechin (+/-)-Epicatechol; (+/-)-epi-Catechin	Xanthine Oxidase	Metabolic Disease
(+/-)-Epicatechin is a **xanthine oxidase** inhibitor with an IC₅₀ of 982.14 μM, and can be found in Semen Plantaginis (Plantago seed). (+/-)-Epicatechin can be used in research on diseases such as hyperuricemia and gout .

HY-14268A

Febuxostat sodium TEI 6720 sodium; TMX 67 sodium	Xanthine Oxidase	Cardiovascular Disease Metabolic Disease Cancer
Febuxostat (TEI 6720) sodium is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a K_i value of 0.6 nM. Febuxostat sodium has the potential for the research of hyperuricemia and gout .

HY-14268

Febuxostat 5+ Cited Publications TEI 6720; TMX 67	Xanthine Oxidase	Cardiovascular Disease Metabolic Disease Cancer
Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a K_i value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout .

HY-129889

Febuxostat acyl glucuronide Febuxostat acyl-β-D-glucuronide	Drug Metabolite Xanthine Oxidase	Metabolic Disease
Febuxostat acyl glucuronide (Febuxostat acyl-β-D-glucuronide) is a metabolite of Febuxostat (HY-14268). Febuxostat is a potent, selective and non-purine xanthine oxidase (XO) inhibitor .

HY-163322

MAO-A inhibitor 2	Monoamine Oxidase	Neurological Disease
MAO-A inhibitor 2 (compound HT4) is a *monoamine oxidase* A (MAO-A)** inhibitor with an IC₅₀ of 14.3 µM. MAO-A inhibitor 2 shows a less effect on MAO-B (IC₅₀ of 106 µM) and shows almost ineffective on xanthine oxidase (XO). MAO-A inhibitor 2 can be used for the neurodegenerative disorders and oxidative stress research .

HY-N0196R

Baicalein (Standard)	Xanthine Oxidase Influenza Virus Ferroptosis	Cancer
Baicalein (Standard) is the analytical standard of Baicalein. This product is intended for research and analytical applications. Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.

HY-153972

URAT1&XO inhibitor 2	URAT1 Xanthine Oxidase	Metabolic Disease Inflammation/Immunology
URAT1&XO inhibitor 2 (Compound BDEO) is a dual inhibitor of **xanthine oxidase and URAT1, with IC₅₀** of 3.3 μM for xanthine oxidase. URAT1&XO inhibitor 2 blocks uptake of uric acid in HEK293 cells expressing URAT1, with a K_i value of 0.145 μM. URAT1&XO inhibitor 2 decreases serum urate level and uric acid excretion in hyperuricemic mice. URAT1&XO inhibitor 2 can be used for research of hyperuricemia .

HY-N10741

Ellagic acid 4-O-β-D-xylopyranoside	Xanthine Oxidase Bacterial	Infection
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an **xanthine oxidase** inhibitor with an ₅₀ of 2.1 μg/mL .

HY-131270R

Febuxostat impurity 8 (Standard)	Drug Metabolite	Others
Febuxostat impurity 8 (Standard) is the analytical standard of Febuxostat impurity 8. This product is intended for research and analytical applications. Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM .

HY-131272R

Febuxostat dicarboxylic acid impurity (Standard)	Drug Metabolite	Others
Febuxostat dicarboxylic acid impurity (Standard) is the analytical standard of Febuxostat dicarboxylic acid impurity. This product is intended for research and analytical applications. Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM .

HY-N1162

Tetrahydroamentoflavone Amentoflavanone	Xanthine Oxidase	Infection Inflammation/Immunology
Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC₅₀ and K_i values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout .

HY-131273R

Febuxostat amide impurity (Standard)	Drug Metabolite	Others
Febuxostat amide impurity (Standard) is the analytical standard of Febuxostat amide impurity. This product is intended for research and analytical applications. Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM

HY-N3220

Myricetin 3-O-galactoside 1 Publications Verification	Xanthine Oxidase	Metabolic Disease
Myricetin 3-O-galactoside inhibits xanthine oxidase (XO) activity, lipid peroxidation and scavenges the free radical. Myricetin 3-O-galactoside inhibits lipid peroxidation with an IC₅₀ of 160 μg/mL. Antioxidant activity .

HY-B0219S

Allopurinol-d2	Isotope-Labeled Compounds Xanthine Oxidase	Infection Inflammation/Immunology
Allopurinol-d₂ is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC₅₀ values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect .

HY-113978

6-Formylpterin	Xanthine Oxidase Apoptosis Reactive Oxygen Species	Metabolic Disease
6-Formylpterin is an inhibitor of **Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis** in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells .

Cat. No.	Product Name	Type

HY-D0837

Imidazole

2 Publications Verification

Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene

Cell Assay Reagents

Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

HY-D0837R

Imidazole (Standard)

Glyoxaline (Standard); 1,3-Diaza-2,4-cyclopentadiene (Standard)

Cell Assay Reagents

Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

Cat. No.	Product Name	Target	Research Area

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology Cancer
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0196

Baicalein Maximum Cited Publications 25 Publications Verification 5,6,7-Trihydroxyflavone	Structural Classification Classification of Application Fields Flavones Anti-aging Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Labiatae Phenols Polyphenols Medicago truncatula Gaertn. Disease Research Fields Cancer	Xanthine Oxidase Influenza Virus Ferroptosis
Baicalein (5,6,7-Trihydroxyflavone) is a **xanthine oxidase** inhibitor with an IC₅₀ value of 3.12 μM.

HY-N8600

7,8,3′,4′-Tetrahydroxyflavone	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Acacia confusa Merr.	Xanthine Oxidase
7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 10.488 µM .

HY-19657

Oxypurinol Oxipurinol	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Drug Metabolite Endogenous Metabolite Xanthine Oxidase
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of **xanthine oxidase**. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-N10433

Xanthine oxidase-IN-9 Icarisids E	Flavonoids Juglandaceae Source classification Cyclocarya paliurus (Batal.) Iljinsk. Plants	Xanthine Oxidase
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC₅₀ of 31.81 μM .

HY-N7397

Forsythoside F Arenarioside	Classification of Application Fields Oleaceae Simple Phenylpropanols Source classification Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields	Xanthine Oxidase
Forsythoside F (Arenarioside) is a **xanthine oxidase** inhibitor and possesses antihyperuricemic effects in vivo .

HY-N3906

Fraxamoside	Structural Classification Oleaceae Source classification Phenols Polyphenols Plants Fraxinus americana L.	Xanthine Oxidase
Fraxamoside is a competitive **xanthine oxidase** inhibitor with an IC₅₀ of 16.1 μM and a K_i of 0.9 μM .

HY-N10432

Xanthine oxidase-IN-8 Icarisids J	Flavonols Flavonoids Juglandaceae Source classification Cyclocarya paliurus (Batal.) Iljinsk. Plants	Xanthine Oxidase
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM .

HY-N14414

5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione	Structural Classification Natural Products Microorganisms Source classification	Xanthine Oxidase
5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione is a xanthine oxidase (XO) inhibitor found in Peniophora sanguinea .

HY-W104467

(+/-)-Epicatechin (+/-)-Epicatechol; (+/-)-epi-Catechin	Malvaceae Structural Classification Flavonoids Flavanols Source classification Phenols Polyphenols Plants Scaphium wallichii	Xanthine Oxidase
(+/-)-Epicatechin is a **xanthine oxidase** inhibitor with an IC₅₀ of 982.14 μM, and can be found in Semen Plantaginis (Plantago seed). (+/-)-Epicatechin can be used in research on diseases such as hyperuricemia and gout .

HY-N0196R

Baicalein (Standard)	Structural Classification Human Gut Microbiota Metabolites Flavonoids Flavones Labiatae Source classification Phenols Polyphenols Plants Endogenous metabolite Medicago truncatula Gaertn.	Xanthine Oxidase Influenza Virus Ferroptosis
Baicalein (Standard) is the analytical standard of Baicalein. This product is intended for research and analytical applications. Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.

HY-N10741

Ellagic acid 4-O-β-D-xylopyranoside	Structural Classification Natural Products Source classification Plants Cunoniaceae Cunonia macrophylla Brongn. & Gris	Xanthine Oxidase Bacterial
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an **xanthine oxidase** inhibitor with an ₅₀ of 2.1 μg/mL .

HY-N1162

Tetrahydroamentoflavone Amentoflavanone	Structural Classification Flavonoids Source classification Plants Biflavones Semecarpus anacardium L.f. Anacardiaceae	Xanthine Oxidase
Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC₅₀ and K_i values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout .

HY-N3220

Myricetin 3-O-galactoside 1 Publications Verification	Flavonols Structural Classification Flavonoids Rhododendron dauricum Linn. Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Ericaceae Plants Disease Research Fields	Xanthine Oxidase
Myricetin 3-O-galactoside inhibits xanthine oxidase (XO) activity, lipid peroxidation and scavenges the free radical. Myricetin 3-O-galactoside inhibits lipid peroxidation with an IC₅₀ of 160 μg/mL. Antioxidant activity .

HY-19657R

Oxypurinol (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Drug Metabolite Endogenous Metabolite Xanthine Oxidase
Oxypurinol (Standard) is the analytical standard of Oxypurinol. This product is intended for research and analytical applications. Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-N10108

Protosappanin A dimethyl acetal	Structural Classification Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants	Xanthine Oxidase
Protosappanin A dimethyl acetal is a homoisoflavonoid. Protosappanin A dimethyl acetal can be isolated from Caesalpinia sappan. Protosappanin A dimethyl acetal is also a competive inhibitor with significant **xanthine oxidase inhibitory activity (IC₅₀**=50.7 μM) .

HY-N0196A

Baicalein hydrate 5,6,7-Trihydroxyflavone hydrate	Structural Classification Flavonoids Labiatae Flavonones Source classification Plants Medicago truncatula Gaertn.	Influenza Virus Ferroptosis Xanthine Oxidase
Baicalein hydrate (ALA; C18:3 (9Z,12Z,15Z); C18:3 n-3) is a **xanthine oxidase** inhibitor with an IC₅₀ value of 3.12 μM.

HY-N4136

Lonicerin 1 Publications Verification Veronicastroside	Infection Structural Classification Flavonoids Caprifoliaceae Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields	Bacterial Apoptosis Xanthine Oxidase Fungal
Lonicerin (Veronicastroside) is a flavonoid with multiple biological activities. Lonicerin inhibits **xanthine oxidase with an IC₅₀** of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties .

HY-N0358

1,4-Dicaffeoylquinic acid 1 Publications Verification 1,4-DCQA	Structural Classification Caprifoliaceae Classification of Application Fields Lonicera japonica Thunb. Source classification Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	TNF Receptor Xanthine Oxidase
1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid compound that can be isolated from Xanthii fructus and an inhibitor of **xanthine oxidase (IC₅₀*: 7.36 μM). 1,4-Dicaffeoylquinic acid has anti-inflammatory activity and can inhibit* the production of TNF-α induced by LPS (HY-D1056) .

HY-N0814B

Phytic acid hexasodium Inositol hexaphosphate hexasodium; SNF472	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	Xanthine Oxidase Endogenous Metabolite
Phytic acid (Inositol hexaphosphate) hexasodium is a phosphorus storage compound of seeds and cereal grains. Phytic acid hexasodium has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid hexasodium inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects.

HY-N0244

Theaflavin-3'-gallate 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae Cancer	Xanthine Oxidase Apoptosis Necroptosis
Theaflavin-3'-gallate is a monomer of theaflavins found in black tea, which has anti-UVB damage activity and inhibits cell apoptosis and necroptosis. Theaflavin-3'-gallate acts as a pro-oxidant and induces oxidative stress in cancer cells, inhibiting xanthine oxidase (OX), with an IC₅₀ of 7.6 μM .

HY-142125

Broussochalcone A	Structural Classification Chalcones Flavonoids Source classification Plants Moraceae Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat	Xanthine Oxidase Reactive Oxygen Species Apoptosis
Broussochalcone A is an antioxidant and an inhibitor of **Xanthine Oxidase (IC₅₀*=2.21 μM), with free radical scavenging activity. Broussochalcone A inhibits* iron-induced lipid peroxidation and nitric oxide synthesis in lipopolysaccharide (LPS) -activated macrophages. Broussochalcone A also induces Apoptosis of human renal carcinoma cells by increasing ROS levels and activating FOXO3 signaling pathways .

HY-141508

Flazin	Simaroubaceae Source classification Plants Indole Alkaloids Brucea javanica (L.) Merr.	Xanthine Oxidase NO Synthase
Flazin is a non-enzymatic protein glycation inhibitor, also inhibits peroxynitrite (ONOO ^-), with an IC₅₀ value of 85.31 μM for bovine serum albumin (BSA) glycation and an EC₅₀ value of 71.99 μM for ONOO ^-. Flazin can be used for researching diabetes and neuronal disorders. Flazin also can used as a lipid droplet (LD) regulator against lipid disorders, and a xanthine oxidase (XOD) inhibitor .

HY-N0814A

Phytic acid dodecasodium hydrate 1 Publications Verification Inositol hexaphosphate dodecasodium hydrate; SNF472 dodecasodium hydrate	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite	Xanthine Oxidase Endogenous Metabolite
Phytic acid (Inositol hexaphosphate) dodecasodium hydrate is a phosphorus storage compound of seeds and cereal grains. Phytic acid dodecasodium hydrate is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid dodecasodium hydrate inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects .

HY-N4136R

Lonicerin (Standard) Veronicastroside (Standard)	Structural Classification Flavonoids Caprifoliaceae Flavones Source classification Phenols Polyphenols Plants	Bacterial Apoptosis Xanthine Oxidase Fungal
Lonicerin (Standard) (Veronicastroside (Standard)) is the analytical standard of Lonicerin (HY-N4136). This product is intended for research and analytical applications. Lonicerin is a flavonoid with multiple biological activities. Lonicerin inhibits **xanthine oxidase with an IC₅₀** of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties.

HY-N0814

Phytic acid (50% in water) 1 Publications Verification Inositol hexaphosphate; SNF472 free acid	Structural Classification other families Neurological Disease Classification of Application Fields Food Preservation Research Ketones, Aldehydes, Acids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Agricultural Research	Xanthine Oxidase Endogenous Metabolite
Phytic acid (Inositol hexaphosphate) (50% in water) is a phosphorus storage compound of seeds and cereal grains. Phytic acid (50% in water) is known as a food inhibitor, which has a strong ability to chelate multivalent metal ions, specially zinc, calcium, iron and as with protein residue. Phytic acid (50% in water) inhibits the enzymatic superoxide source xanthine oxidase (XO), and has antioxidative, neuroprotective, anti-inflammatory effects .

HY-N0327

Lobetyolin 2 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Campanulaceae Metabolic Disease Codonopsis pilosula Plants Disease Research Fields	Apoptosis Xanthine Oxidase
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and **xanthine oxidase** inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism . Lobetyolin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N0358R

1,4-Dicaffeoylquinic acid (Standard) 1,4-DCQA (Standard)	Structural Classification Caprifoliaceae Lonicera japonica Thunb. Source classification Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants	TNF Receptor Xanthine Oxidase
1,4-Dicaffeoylquinic acid (Standard) (1,4-DCQA (Standard)) is the analytical standard of 1,4-Dicaffeoylquinic acid (HY-N0358). This product is intended for research and analytical applications. 1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid compound that can be isolated from Xanthii fructus and an inhibitor of **xanthine oxidase (IC₅₀*: 7.36 μM). 1,4-Dicaffeoylquinic acid has anti-inflammatory activity and can inhibit* the production of TNF-α induced by LPS (HY-D1056) .

Cat. No.	Product Name	Chemical Structure

HY-14268S

Febuxostat-d9
Febuxostat-d₉ is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.

HY-B0219S

Allopurinol-d2
Allopurinol-d₂ is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC₅₀ values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect .

HY-14268S1

Febuxostat-d7
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

HY-19657S

Oxypurinol-13C,15N2
Oxypurinol- ¹³C, ¹⁵N₂ is ¹⁵N and ¹³C labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of **xanthine oxidase**. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-14268S2

Febuxostat-d3
Febuxostat-d₃ (TEI 6720-d₃) is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a K_i value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout .

HY-14268S3

Febuxostat-d5
Febuxostat-d₅ (TEI 6720-d₅) is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a K_i value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout .

HY-W777649

Oxypurinol-13C,15N2-1
Oxypurinol- ¹³C, ¹⁵N₂-1 (Oxipurinol- ¹³C, ¹⁵N₂-1) is ¹⁵N and ¹³C labeled Oxypurinol (HY-19657). Oxipurinol, the major active metabolite of Allopurinoll (HY-B0219), is an inhibitor of **xanthine oxidase**. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-W699983

Imidazole-15N2

Imidazole- ¹⁵N₂ (Glyoxaline- ¹⁵N₂) is ¹⁵N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

Cat. No.	Product Name		Classification

HY-W141392

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite		Nucleoside Phosphoramidites I
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-W392836

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite		Nucleoside Phosphoramidites I
2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-152696

6-O-Methylinosine		Nucleosides and their Analogs I
6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-154017

2′-C-Methyl-6-O-methylinosine		Nucleosides and their Analogs I
2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-154393

2-Chloro-2'-deoxy-6-O-methylinosine		Nucleosides and their Analogs I
2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-152678

6-Methoxypurine-9-β-D-5’(R)-C-methylriboside		Nucleosides and their Analogs
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

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