2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase
  4. NARS-3′

NARS-3′ is a reversible xanthine oxidase (XO) inhibitor with the IC50 of 21.01 μM. NARS-3′ can competitively inhibit XO activity and reduce uric acid production. NARS-3′ can reduce renal damage in hyperuricemia mice. NARS-3′ can be used for the study of hyperuricemia[1].

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NARS-3′ Chemical Structure

NARS-3′ Chemical Structure

CAS No. : 2702589-46-4

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NARS-3′ Related Antibodies

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Description

NARS-3′ is a reversible xanthine oxidase (XO) inhibitor with the IC50 of 21.01 μM. NARS-3′ can competitively inhibit XO activity and reduce uric acid production. NARS-3′ can reduce renal damage in hyperuricemia mice. NARS-3′ can be used for the study of hyperuricemia[1].

In Vitro

NARS-3′ (0-100 μM) exhibits dose-dependent inhibition on XO activity[1].


NARS-3′ (0-40 μM) can bind to the active site of XO and compete with xanthine substrates during the catalytic process[1].


NARS-3′ could cause the conformational changes in XO[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NARS-3′ Related Antibodies
In Vivo

NARS-3′ (25-100 mg/kg; once daily; for a week) can effectively suppress serum XO activity and reduce serum uric acid (UA) levels in the Potassium oxonate (PO) (HY-17511) induced hyperuricemia mice. NARS-3′ exhibits significant protective effects on the kidneys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Potassium oxonate (250 mg/kg) injected the male Kunming mice (4 weeks)[1].
Dosage: 0.3 % carboxymethyl cellulose sodium solution
Administration:
Result: Reduced serum UA levels to 56.26 μM and reduced XO activity to 9.21 U/L.
Lowered serum CRE levels to 7.85 μM and reduce pathological damage to the kidneys.
Molecular Weight

374.30

Formula

C15H11NaO8S
CAS No.
SMILES

O=C1CC(OC2=CC(O)=CC(O)=C12)C3=CC(S(=O)(O[Na])=O)=C(C=C3)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NARS-3′ Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NARS-3′2702589-46-4Xanthine OxidaseXONaringeninXanthine oxidaseInhibitoryHyperuricemiaInhibitorinhibitorinhibit

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