rhabdomyosarcoma

By Targets:	Apoptosis (5) Autophagy (1) Biochemical Assay Reagents (1) DAPK (1) Drug Metabolite (1) Endogenous Metabolite (1) Endothelin Receptor (1) Enterovirus (1) Gli (1) Hedgehog (1) Isocitrate Dehydrogenase (IDH) (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Nuclear Hormone Receptor 4A/NR4A (1) PERK (1) STAT (1)
By Research Areas:	Cancer (9) Infection (1) Metabolic Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W016407

Methyl 3,4-dihydroxyphenylacetate	Enterovirus	Infection
Methyl 3,4-dihydroxyphenylacetate is a potent enterovirus 71 (EV71) infection inhibitor. Methyl 3,4-dihydroxyphenylacetate inhibits EV71 replication in rhabdomyosarcoma (RD) cells .

HY-P99286

Drozitumab PRO 95780; rhuMAb-DR 5; Anti-Human DR5 Recombinant Antibody	Apoptosis	Cancer
Drozitumab (PRO 95780) is a human agonistic monoclonal antibody which binds the death receptor DR5. Drozitumab has potent antitumor activity against rhabdomyosarcoma .

HY-107408

SANT 2	Hedgehog Gli	Metabolic Disease Cancer
SANT 2 is a potent Hh-signaling pathway antagonist. SANT 2 interferes with the expression of Gli1. SANT 2 causes developmental delay in medaka embryos. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers .

HY-124843

LLL3 CLT-005	STAT Apoptosis	Cancer
LLL3 (CLT-005) is a STAT3 inhibitor. LLL3 inhibits dimerization and phosphorylation of STAT3, thereby preventing intraconuclear transfer of STAT3 and inhibits the expression of STAT3 dependent genes, which encode proteins such as Bcl-xL and cyclin D1. In addition, LLL3 can induce cell growth inhibition and apoptosis in human breast cancer and rhabdomyosarcoma cells via the caspase pathway. LLL3 can be used in the study of STAT3 persistent activation types of cancer .

HY-14925

Lapaquistat 1 Publications Verification T-91485	Endogenous Metabolite Drug Metabolite	Metabolic Disease
Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy .

HY-112056

DIM-C-pPhCO2Me 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis DAPK Isocitrate Dehydrogenase (IDH) PERK	Cancer
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhCO2Me induces Apoptosis. DIM-C-pPhCO2Me decreases PAX3-FOXO1A, N-Myc, Rassf4, MyoD1, Grem1, and DAPK1 proteins. DIM-C-pPhCO2Me decreases expression of TXNDC5 and IDH1, induces markers of ER stress (CHOP, ATF4 and p-PERK). DIM-C-pPhCO2Me inhibits renal cell carcinoma, breast cancer. DIM-C-pPhCO2Me can also be used in rhabdomyosarcoma research .

HY-18330

MI 63	MDM-2/p53	Cancer
MI 63 is an activator for p53, by targeting the MDM2 (K_i is 3 nM). MI 63 inhibits the proliferation of embryonic and alveolar rhabdomyosarcoma (ERMS and ARMS) cells (IC₅₀ is 0.58 μM in RH36 cells), and induces apoptosis in ERMS and ARMS .

HY-P3571

[Ala2] Endothelin-3, human	Endothelin Receptor	Cancer
[Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells .

HY-17419A

(R)-Ifosfamide	Others	Cancer
(R)-Ifosfamide is a chemotherapeutic agent primarily used in the treatment of aggressive tumors such as rhabdomyosarcoma, exhibiting alkylating activity that interferes with DNA replication.

HY-W791671

Aspergillus giganteus α-sarcin	Biochemical Assay Reagents Apoptosis	Cancer
Aspergillus giganteus α-sarcin is a ribosome-inactivating protein that induces apoptosis in rhabdomyosarcoma cells. α-Sarcin is suitable for inducing apoptosis and inhibiting protein synthesis .

HY-P99974

Nab-Paclitaxel 1 Publications Verification Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007	Microtubule/Tubulin Apoptosis Autophagy	Cancer
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11) .

Cat. No.	Product Name	Type

HY-W791671

Aspergillus giganteus α-sarcin	Cell Assay Reagents
Aspergillus giganteus α-sarcin is a ribosome-inactivating protein that induces apoptosis in rhabdomyosarcoma cells. α-Sarcin is suitable for inducing apoptosis and inhibiting protein synthesis .

Cat. No.	Product Name	Target	Research Area

HY-P3571

[Ala2] Endothelin-3, human	Endothelin Receptor	Cancer
[Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells .

Cat. No.	Product Name

HY-K6138

Rhabdomyosarcoma Organoid Kit
MCE Rhabdomyosarcoma Organoid Kit contains rhabdomyosarcoma organoid basal medium and culture supplement. This product can be used to efficiently construct rhabdomyosarcoma organoid.

Cat. No.	Product Name	Target	Research Area

HY-P99286

Drozitumab PRO 95780; rhuMAb-DR 5; Anti-Human DR5 Recombinant Antibody	Apoptosis	Cancer
Drozitumab (PRO 95780) is a human agonistic monoclonal antibody which binds the death receptor DR5. Drozitumab has potent antitumor activity against rhabdomyosarcoma .

HY-P99974

Nab-Paclitaxel 1 Publications Verification Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007	Microtubule/Tubulin Apoptosis Autophagy	Cancer
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14925

Lapaquistat 1 Publications Verification T-91485	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Drug Metabolite
Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80677

	FOXO3 Antibody (YA428) FOXO3; FKHRL1; FOXO3A; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1	WB	Human
	FOXO3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 71 kDa, targeting to FOXO3. It can be used for WB assays with tag free, in the background of Human.

HY-P80817

	Phospho-FOXO3A (Ser253) Antibody (YA197) FOXO3; FKHRL1; FOXO3A; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1	WB	Human, Mouse, Rat
	Phospho-FOXO3A (Ser253) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 71 kDa, targeting to Phospho-FOXO3A (Ser253). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P81074

	FOXO1 Antibody FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, IHC-F, IHC-P, ICC/IF, ELISA, ChIP	Human, Mouse, Rat, Pig
	FOXO1 Antibody is a rabbit-derived non-conjugated IgG antibody, targeting FOXO1, with a predicted molecular weight of 78 kDa . FOXO1 Antibody can be used for WB, IHC-F, IHC-P, ICC/IF, ELISA, ChIP experiments in human, mouse, rat, pig backgrounds.

HY-P80676

	FOXO1 Antibody (YA430) FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, IHC-F, IHC-P, ICC/IF	Human
	FOXO1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 70 kDa, targeting to FOXO1. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human.

HY-P85525

	FOXO1(C-term) Antibody (YA5217) FKH 1; FKH1; FKH1; FKHR; FKHR; Forkhead; Drosophila; homolog 1; rhabdomyosarcoma; Forkhead; Drosophila; homolog 1; rhabdomyosarcoma; Forkhead box O1; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; Forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FOXO1; FOXO1; FOXO1_HUMAN; FOXO1A; OTTHUMP00000018301.	WB	Human
	FOXO1(C-term) Antibody (YA5217) is a mouse-derived and non-conjugated monoclonal antibody, targeting to FOXO1 (C-term). It can be applicated for WB assays, in the background of human.

HY-P86548

	Phospho-FOXO3A(Ser253) Antibody (YA6240) FOXO3; FKHRL1; FOXO3A; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Phospho-FOXO3A(Ser253) Antibody (YA6240) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to phosphorylated FOXO3A (Ser253). It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

HY-P85429

	FoxO1 Antibody (YA5121) FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, ICC/IF	Human, Mouse
	FoxO1 Antibody (YA5121) is a mouse-derived and non-conjugated monoclonal antibody, targeting to FoxO1. It can be applicated for WB, ICC/IF assays, in the background of human, mouse.

HY-P86588

	FOXO1A Antibody (YA6280) FOXO1; FKHR; FOXO1A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse,
	FOXO1A Antibody (YA6280) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FOXO1A. It can be applicated for WB, IHC-P, ICC/IF, IP, ELISA assays, in the background of human, mouse.

HY-P87094

	Slow Skeletal Myosin Heavy chain Antibody (YA6787) Beta myosin heavy chain antibody; cardiac muscle beta isoform antibody; CMD1S antibody; CMH1 antibody; MPD1 antibody; MYH7 antibody; MYH7_HUMAN antibody; Myhc slow antibody; MyHC-beta antibody; MyHC-slow antibody; Beta myosin heavy chain antibody; cardiac muscle beta isoform antibody; CMD1S antibody; CMH1 antibody; MPD1 antibody; MYH7 antibody; MYH7_HUMAN antibody; Myhc slow antibody; MyHC-beta antibody; MyHC-slow antibody; MYHCB antibody; Myopathy, distal 1 antibody; Myosin heavy chain (AA 1-96) antibody; Myosin heavy chain 7 antibody; Myosin heavy chain antibody; Myosin heavy chain slow isoform antibody; Myosin heavy chain, cardiac muscle beta isoform antibody; Myosin, heavy chain 7, cardiac muscle, beta antibody; Myosin, heavy polypeptide 7, cardiac muscle, beta antibody; Myosin-7 antibody; rhabdomyosarcoma antigen MU RMS 40.7A antibody; SPMD antibody; SPMM antibody	WB, IHC-P, IF-Tissue, IHC-F	Human, Mouse, Rat

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